Grifola frondosa

Ethnobotanical Studies

Studies

A novel angiotensin I-converting enzyme inhibitory peptide APPLRP from Grifola frondosa ameliorated the Ang II-induced vascular modeling in zebrafish model by mediating smooth muscle cells.

Song T et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134998
PubMed:
39181368

Establishment and application of a SNP molecular identification system in Grifola frondosa.

Diao B et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1417014
PubMed:
39176275

Investigating immune-modulatory function of α-glucopyranose-rich compound polysaccharides by MC38-N4/OT-I co-culture system.

Xu Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134941
PubMed:
39173810

Isolation of bacteria from Grifola frondosa cultivation on wood logs to find mycelial growth-promoting bacteria.

Chen FC and Kamei I (2024).
Biosci Biotechnol Biochem.
DOI:
10.1093/bbb/zbae116
PubMed:
39164218

Synthesis and characterization of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

Zhang J et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134787
PubMed:
39153675

The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus.

Summary

Plant polysaccharide GFP can prevent skeletal muscle atrophy in T2DM by improving intestinal barrier function and reducing inflammation. Offers new treatment option for T2DM patients.

Diabetes
She Y et al (2024).
Life (Basel).
DOI:
10.3390/life14070784
PubMed:
39063539

Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?

Summary

Study highlights the potential of medicinal mushrooms as adjuvant therapy for triple-negative breast cancer, offering immunomodulatory and anticancer benefits. Innovative strategies aim to improve treatment efficacy and patient quality of life.

Review Cancer
De Luca F et al (2024).
Curr Issues Mol Biol.
DOI:
10.3390/cimb46070450
PubMed:
39057091

A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition.

Summary

Grifola frondosa boosts immune system, triggers cell death in cancer. Further research needed on its potential in slowing tumor growth with nutrient restriction.

CancerGastroenterology
Xu Y et al (2024).
Mol Nutr Food Res.
DOI:
10.1002/mnfr.202400023
PubMed:
38924315

GFPBW1, a β-glucan from Grifola frondosa as vaccine adjuvant: APCs activation and maturation.

He X et al (2024).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-024-01330-8
PubMed:
38907048

Bone protective effects of the polysaccharides from Grifola frondosa on ovariectomy-induced osteoporosis in mice via inhibiting PINK1/Parkin signaling, oxidative stress and inflammation.

ArthritisImmunology
Liu Q et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.132370
PubMed:
38763253

Selective impact of three homogenous polysaccharides with different structural characteristics from Grifola frondosa on human gut microbial composition and the structure-activity relationship.

Gastroenterology
Bai G et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.132143
PubMed:
38729493

Unveiling the full spectrum of maitake mushrooms: A comprehensive review of their medicinal, therapeutic, nutraceutical, and cosmetic potential.

Review
Camilleri E et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e30254
PubMed:
38707308

Positive effect of peptide-calcium chelates from Grifola frondosa on a mouse model of senile osteoporosis.

Arthritis
Xiong Y et al (2024).
J Food Sci.
DOI:
10.1111/1750-3841.17073
PubMed:
38685878

Selenochemical modification of low molecular weight polysaccharides from Grifola frondosa and the mechanism of their inhibitory effects on gastric cancer cells.

Summary

Selenium enhances LMW-GFP polysaccharide's antitumor effect by binding to it, significantly improving in vitro activity against BGC-823 and MFC cells, suggesting potential for cancer treatment and selenium supplementation development.

CancerGastroenterology
Huo Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.131812
PubMed:
38670197

Maitake Beta-Glucan Enhances the Therapeutic Effect of Trastuzumab via Antibody-Dependent Cellular Cytotoxicity and Complement-Dependent Cytotoxicity.

Masuda Y et al (2024).
Biol Pharm Bull.
DOI:
10.1248/bpb.b23-00802
PubMed:
38616114

Expression of cellobiose dehydrogenase gene in Aspergillus niger C112 and its effect on lignocellulose degrading enzymes.

Summary

Researchers improved cellulase production in strain C112 by expressing CDH from a white-rot fungus. Recombinant strain showed increased lignocellulase activity, suggesting potential for more efficient biomass conversion.

Genetics
Zhong Y et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1330079
PubMed:
38562472

Chitosan and Grifola Frondosa nanoparticles insulate liver dysfunction in EAC-bearing mice.

Radwan AM et al (2024).
Toxicol Res (Camb).
DOI:
10.1093/toxres/tfae050
PubMed:
38559757

Potential Antiviral Effect of Korean Forest Wild Mushrooms against Feline Coronavirus (FCoV).

Summary

Wild forest mushrooms such as Pleurotus ostreatus and Phallus luteus show promise as antiviral agents against coronaviruses, including SARS-CoV-2. Controlling CoV infections in animals is crucial for preventing human outbreaks. This research suggests a potential new avenue for coronavirus treatment using natural resources.

AntimicrobialCOVID-19
Ryoo R, Lee H and Park Y (2024).
Int J Med Mushrooms.
DOI:
10.1615/IntJMedMushrooms.2024052483
PubMed:
38523445

A newly discovered glycosyltransferase gene UGT88A1 affects growth and polysaccharide synthesis of Grifola frondosa.

Summary

Researchers found that UGT88A1 enzyme influences Grifola frondosa's growth, polysaccharide production, and antioxidant activity. Understanding this enzyme's role can lead to better understanding of polysaccharide synthesis and metabolic regulation.

Genetics
Li J et al (2024).
Appl Microbiol Biotechnol.
DOI:
10.1007/s00253-024-13062-0
PubMed:
38421403

Isolation and identification of active components from Grifola frondosa and its anti-EV71 virus effect.

Xiong W et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13332
PubMed:
38323723

Identification and Characterization of a Predominant Hydrophobin in the Edible Mushroom Grifola frondosa.

Song B et al (2023).
J Fungi (Basel).
DOI:
10.3390/jof10010025
PubMed:
38248935

Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses.

Summary

extracted from effectively suppresses breast tumor growth in mice by reducing the accumulation of MDSCs, which promote tumor growth. It also restores and activates CD8T cells, enhancing the antitumor immune response. Promising therapeutic agent for breast cancer.

Cancer
Li X et al (2024).
Int J Biol Sci.
DOI:
10.7150/ijbs.85276
PubMed:
38169590

Structural characterization and immunomodulatory effect of a starch-like Grifola frondosa polysaccharides on cyclophosphamide-induced immunosuppression in mice.

Immunology
Ni J et al (2023).
Carbohydr Res.
DOI:
10.1016/j.carres.2023.109011
PubMed:
38150753

Grifola frondosa polysaccharides: A review on structure/activity, biosynthesis and engineering strategies.

Review
Cui FJ et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.128584
PubMed:
38056754

Biochemical and structural characterization of a glucan synthase GFGLS2 from edible fungus Grifola frondosa to synthesize β-1, 3-glucan.

Yang YM et al (2023).
Biotechnol Biofuels Bioprod.
DOI:
10.1186/s13068-023-02380-6
PubMed:
37904199

Regulatory Effects of Ganoderma lucidum, Grifola frondosa, and American ginseng Extract Formulation on Gut Microbiota and Fecal Metabolomics in Mice.

Gastroenterology
Zhang F, Huang W and Zhao L (2023).
Foods.
DOI:
10.3390/foods12203804
PubMed:
37893697

Genetic and Molecular Evidence of a Tetrapolar Mating System in the Edible Mushroom Grifola frondosa.

Zhang SS et al (2023).
J Fungi (Basel).
DOI:
10.3390/jof9100959
PubMed:
37888215

Anti-α-glucosidase, Anti-proliferative and Anti-enterovirus 71 Activity of Secondary Metabolites Identified from Grifola Frondosa.

Summary

Researchers found that compounds derived from Grifola frondosa, an edible and medicinal resource, show inhibitory activity against α-glucosidase, tumor cells, and enterovirus 71 (EV71). This discovery could lead to potential treatments for diabetes, cancer, and EV71 infections.

Cancer
He J et al (2023).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-023-01106-1
PubMed:
37812276

Preparation and structural analysis of fucomannogalactan and β-1,6-glucan from Grifola frondosa mycelium.

Geng J et al (2023).
Front Chem.
DOI:
10.3389/fchem.2023.1227288
PubMed:
37608863

Gastrointestinal metabolism characteristics and mechanism of a polysaccharide from Grifola frondosa.

Zhang Y et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126357
PubMed:
37595710

Antioxidant and Immunomodulatory Activities of Polysaccharides from Fermented Wheat Products of Grifola frondosa: In Vitro Methods.

Immunology
Xu X et al (2023).
Int J Food Sci.
DOI:
10.1155/2023/3820276
PubMed:
37593692

Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota.

Gastroenterology
Sun R et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1172963
PubMed:
37351508

Long-term consumption of different doses of Grifola frondosa affects immunity and metabolism: correlation with intestinal mucosal microbiota and blood lipids.

Gastroenterology
Liu J et al (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03617-9
PubMed:
37193332

Fungi as a source of bioactive molecules for the development of longevity medicines.

Review
Shevchuk Y, Kuypers K and Janssens GE (2023).
Ageing Res Rev.
DOI:
10.1016/j.arr.2023.101929
PubMed:
37031727

Maitake Medicinal Mushroom, Grifola frondosa (Agaricomycetes), and Its Neurotrophic Properties: A Mini-Review.

Review
Naguib AM et al (2023).
Int J Med Mushrooms.
DOI:
10.1615/IntJMedMushrooms.2022046849
PubMed:
36749053

Current Advancements in Antitumor Properties and Mechanisms of Medicinal Components in Edible Mushrooms.

Review Cancer
Xu J et al (2022).
Nutrients.
DOI:
10.3390/nu14132622
PubMed:
35807802

Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases.

Review Neuroscience
Rai SN et al (2021).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2021.111377
PubMed:
33601145

Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake).

Review
Wu JY, Siu KC and Geng P (2021).
Foods.
DOI:
10.3390/foods10010095
PubMed:
33466429

Antitumor, Anti-Inflammatory and Antiallergic Effects of Agaricus blazei Mushroom Extract and the Related Medicinal Basidiomycetes Mushrooms, Hericium erinaceus and Grifola frondosa: A Review of Preclinical and Clinical Studies.

Review CancerImmunology
Hetland G et al (2020).
Nutrients.
DOI:
10.3390/nu12051339
PubMed:
32397163

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.

Review Cancer
Wong JH et al (2020).
Appl Microbiol Biotechnol.
DOI:
10.1007/s00253-020-10476-4
PubMed:
32274562

Grifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China.

Review Cancer
He Y et al (2018).
Discov Med.
PubMed:
29723488