Gymnema sylvestre

Common Names: miracle fruit

Ethnobotanical Studies

Clinical Trials

Efficacy and Tolerability of a Food Supplement Based on Zea mays L., Gymnema sylvestre (Retz.) R.br.ex Sm, Zinc and Chromium for the Maintenance of Normal Carbohydrate Metabolism: A Monocentric, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Buccato DG et al (2024).
Nutrients.
PubMed:
39125340

Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study.

GS and BBR are natural alternatives to synthetic drugs for obesity and diabetes management. Research on their impact on adipokine gene expression is lacking. Important for potential therapeutic developments.

Bandala C et al (2024).
Nutrients.
PubMed:
39064727

Effect of Gymnema sylvestre Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion.

Zuñiga LY, González-Ortiz M and Martínez-Abundis E (2017).
J Med Food.
PubMed:
28459647

Studies

Cross-relationship between COVID-19 infection and anti-obesity products efficacy and incidence of side effects: A cross-sectional study.

Summary

Study in Alexandria, Egypt showed pandemic led to increased obesity and AOP intake. Examined AOP efficacy/safety and impact on COVID-19 severity. Important for COVID-19 treatment strategies and public health interventions.

El-Mezayen NS et al (2024).
PLoS One.
PubMed:
39173063

In vitro and in silico assessment of antidiabetic and antioxidant potencies of secondary metabolites from Gymnema sylvestre.

Summary

Study on Gymnema sylvestre found bioactive compounds with antioxidant properties and potential to inhibit key enzymes related to managing postprandial hyperglycemia in type 2 diabetes.

Nganso Ditchou YO et al (2024).
Biomed Pharmacother.
PubMed:
38941896

Correction to: Novel gurmarin-like peptides from Gymnema sylvestre and their interactions with the sweet taste receptor T1R2/T1R3.

(2024).
Chem Senses.
PubMed:
38903042

Phytofabrication of biocompatible zinc oxide nanoparticle using Gymnema sylvestre and its potent in vitro antibacterial, antibiofilm, and cytotoxicity against human breast cancer cells (MDA-MB-231).

Summary

Green-synthesized ZnONPs from Gymnema sylvestre exhibit antibacterial, antibiofilm, and cytotoxic properties against breast cancer cells. These nanoparticles show promise as drug carriers for cancer therapy and biofilm-related infections.

Kavipriya R and Ramasubburayan R (2024).
Bioprocess Biosyst Eng.
PubMed:
38819452

Exploring Acute Liver Damage: Slimming Health Foods and CYP3A4 Induction.

Adachi M et al (2024).
Yonago Acta Med.
PubMed:
38803590

Exploring non-cytotoxic, antioxidant, and anti-inflammatory properties of selenium nanoparticles synthesized from Gymnema sylvestre and Cinnamon cassia extracts for herbal nanomedicine.

Bi Bi S et al (2024).
Microb Pathog.
PubMed:
38734323

Novel gurmarin-like peptides from Gymnema sylvestre and their interactions with the sweet taste receptor T1R2/T1R3.

Maaroufi H et al (2024).
Chem Senses.
PubMed:
38695158

Herbal Nanoformulations for Diabetes: Mechanisms, Formulations, and Clinical Impact.

Summary

Scientists developed innovative herbal nanoformulations for diabetes treatment, leveraging nanotechnology for improved efficacy and bioavailability. This research offers promising solutions for better managing diabetes worldwide.

Sunita M et al (2024).
Curr Diabetes Rev.
PubMed:
38500279

Characterization of phenylalanine ammonia lyase and revealing flavonoid biosynthesis in Gymnema sylvestre R. Br through transcriptomic approach.

Summary

Researchers identified genes involved in flavonoid biosynthesis in Gymnema sylvestre through RNA extraction, sequencing, and in silico protein modeling. This information can enhance understanding of medicinal properties and potential applications of this plant.

Kalariya KA, Mevada RR and Das M (2024).
J Genet Eng Biotechnol.
PubMed:
38494263

Polyherbal extract improves glycometabolic control in alloxan-induced diabetic rats via down-regulating the MAPK/JNK pathway, modulating Nrf-2/Keap-1 expression, and stimulating insulin signaling.

Summary

The researchers looked at a mix of plants to see if it has antioxidant and antidiabetic effects in a diabetes model. This information may be useful for managing diabetes and exploring natural remedies.

Aslam B et al (2024).
Iran J Basic Med Sci.
PubMed:
38234664

Identification of Potential Plant-Derived Pancreatic Beta-Cell-Directed Agents Using New Custom-Designed Screening Method: Gymnema sylvestre as an Example.

Review
Al-Romaiyan A, Persaud SJ and Jones PM (2023).
Molecules.
PubMed:
38202777

Comparative effectiveness of biorational pesticides for management of Phenacoccus solenopsis Tinsley and Paracoccus marginatus Williams & Granara de Willink in Gymnema sylvestre (Retz.) R.Br. ex Sm.

Kadanakuppe Thammayya S et al (2023).
Heliyon.
PubMed:
38187271

Combined Inositols, α-Lactalbumin, Gymnema Sylvestre and Zinc Improve the Lipid Metabolic Profile of Patients with Type 2 Diabetes Mellitus: A Randomized Clinical Trial.

Summary

Supplementing with myo-inositol, d-chiro-inositol, α-lactalbumin, Gymnema sylvestre, and zinc improved lipid profiles in T2DM patients without therapy modification, reducing cholesterol and LDL levels after 3 months and maintaining improvement after 6 months with weight reduction. (34 words)

Nani A et al (2023).
J Clin Med.
PubMed:
38137721

Unlocking the anti-diabetic potential of Gymnema sylvestre, Trigonella foenum-graecum, and their combination thereof: An in-vivo evaluation.

Summary

This study found that extracts from two plants improved blood glucose levels, insulin secretion, and restored serum parameters in diabetic rabbits. These plants may have potential as an alternative treatment for diabetes.

Kashif M et al (2023).
Food Sci Nutr.
PubMed:
38107140

Computer-aided identification of Mycobacterium tuberculosis resuscitation-promoting factor B (RpfB) inhibitors from Gymnema sylvestre natural products.

Shah M et al (2023).
Front Pharmacol.
PubMed:
38094882

Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part II: A systematic review in animals.

Rayo-Morales R et al (2023).
Heliyon.
PubMed:
37860570

Suppression of sweet taste-related responses by plant-derived bioactive compounds and eating. Part I: A systematic review in humans.

Rayo-Morales R et al (2023).
Heliyon.
PubMed:
37817998

Diet Plus Inositols, α-Lactalbumin and Gymnema sylvestre: The Successful Combo to Restore Body Weight and Metabolic Profile in Obese and Dysmetabolic Patients.

Summary

This study compared the effects of diet alone and diet with myo-inositol, d-chiro-inositol, α-lactalbumin, and in obese dysmetabolic patients. The treated group showed greater improvements in metabolic parameters, suggesting that this supplement combination could enhance the effects of dietary programs.

Basciani S et al (2023).
Nutrients.
PubMed:
37513560

Biotechnological approaches for the production of gymnemic acid from Gymnema sylvestre R. Br.

Review
Al-Khayri JM et al (2023).
Appl Microbiol Biotechnol.
PubMed:
37266583

Gymnema Sylvestre Supplementation Restores Normoglycemia, Corrects Dyslipidemia, and Transcriptionally Modulates Pancreatic and Hepatic Gene Expression in Alloxan-Induced Hyperglycemic Rats.

Muzaffar H et al (2023).
Metabolites.
PubMed:
37110174

Greater efficiency of polyherbal drug encapsulated biosynthesized chitosan nano-biopolymer on diabetes and its complications.

Revathi G et al (2023).
Int J Biol Macromol.
PubMed:
37060982

Estimation of genetic diversity and population genetic structure in Gymnema sylvestre (Retz.) R. Br. ex Schult. populations using DAMD and ISSR markers.

Vaishnav K et al (2023).
J Genet Eng Biotechnol.
PubMed:
37022506

Potential use of bio functionalized nanoparticles to attenuate triple negative breast cancer (MDA-MB-231 cells).

Santhoshkumar M et al (2023).
Bioprocess Biosyst Eng.
PubMed:
36977929

Can Polyherbal Medicine be used for the Treatment of Diabetes? - A Review of Historical Classics, Research Evidence and Current Prevention Programs.

Brahma S et al (2023).
Curr Diabetes Rev.
PubMed:
36918778

Cytotoxicity Study of Gold Nanoparticle Synthesis Using Aloe vera, Honey, and Gymnema sylvestre Leaf Extract.

Malik S et al (2023).
ACS Omega.
PubMed:
36844542

Anti-inflammatory and antioxidant activities of Gymnema Sylvestre extract rescue acute respiratory distress syndrome in rats via modulating the NF-κB/MAPK pathway.

Jangam A et al (2023).
Inflammopharmacology.
PubMed:
36662401

The effects of Gymnema Sylvestre supplementation on lipid profile, glycemic control, blood pressure, and anthropometric indices in adults: A systematic review and meta-analysis.

Summary

Gymnema Sylvestre (GS) supplementation may improve cardiovascular risk factors including lipid profile, glycemic control, blood pressure, and anthropometric indices, according to a study. However, more research is needed due to limitations in study quality and heterogeneity.

Meta-Analysis CardiologyDiabetes
Zamani M et al (2023).
Phytother Res.
PubMed:
36580574

Antimicrobial action of four herbal plants over mixed-species biofilms of Candida albicans with four different microorganisms.

Domingues N et al (2022).
Aust Endod J.
PubMed:
36057926

The effect of Gymnema sylvestre supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis.

Summary

This study reviewed 10 studies and found that Gymnema sylvestre supplementation can effectively improve glycemic control and lower lipid levels in patients with type-2 diabetes.

Meta-Analysis Diabetes
Devangan S et al (2021).
Phytother Res.
PubMed:
34467577

Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review.

Summary

Scientists have identified 93 potential drug candidates from natural products such as medicinal plants and herbs that could effectively inhibit the coronavirus, including COVID-19. These candidates include pure compounds like Blancoxanthone and herbacetin, and extracts from plants like Artemisia annua and Tinospora cordifolia. The study suggests that natural products can be used as a source for potential drug discovery against COVID-19 and other respiratory viruses, including SARS and MERS-CoV. This provides a promising avenue for future research to develop effective treatments for the ongoing pandemic.

Review COVID-19
Adhikari B et al (2021).
Phytother Res.
PubMed:
33037698

Enzymes inhibitors from natural sources with antidiabetic activity: A review.

Review Diabetes
Alam F et al (2019).
Phytother Res.
PubMed:
30417583

An Overview of Herbal Products and Secondary Metabolites Used for Management of Type Two Diabetes.

Review Diabetes
Ota A and Ulrih NP (2017).
Front Pharmacol.
PubMed:
28729836

Adverse effects of herbal medicines: an overview of systematic reviews.

Review
Posadzki P, Watson LK and Ernst E (2013).
Clin Med (Lond).
PubMed:
23472485