Gynostemma pentaphyllum

Ethnobotanical Studies

Clinical Trials

Gynostemma Pentaphyllum Increases Exercise Performance and Alters Mitochondrial Respiration and AMPK in Healthy Males.

Nayyar D et al (2023).
Nutrients.
DOI:
10.3390/nu15224721
PubMed:
38004115

Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial.

Park SH et al (2014).
Obesity (Silver Spring).
DOI:
10.1002/oby.20539
PubMed:
23804546

Studies

Use of Herbal Drugs in Cardiovascular Disease- A Review.

Summary

Researchers studied the use of phytochemicals from medicinal plants to prevent cardiovascular diseases, including lowering cholesterol and controlling diabetes. More research is needed to fully understand their effectiveness.

Cardiology
Kaur A and Kumar R (2024).
Curr Cardiol Rev.
DOI:
10.2174/011573403X323724240830075719
PubMed:
39229989

Network pharmacology, molecular docking, and molecular dynamics simulations shed light on the mechanism behind Gynostemma pentaphyllum's efficacy against osteosarcoma.

Zhang Y et al (2024).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000039454
PubMed:
39213234

New Sweet-Tasting Gypenosides from "Jiaogulan" (Gynostemma pentaphyllum) and Their Interactions with the Homology Model of Sweet Taste Receptors.

Zhang HX et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.4c03566
PubMed:
39105697

Genome-wide identification and characterization of the JAZ gene family in Gynostemma pentaphyllum reveals the COI1/JAZ/MYC2 complex potential involved in the regulation of the MeJA-induced gypenoside biosynthesis.

Genetics
Huang D et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108952
PubMed:
39043058

Metabolomics and molecular docking-directed anti-obesity study of the ethanol extract from Gynostemma pentaphyllum (Thunb.) Makino.

Summary

G. pentaphyllum is an herb with potential anti-obesity properties, but its mechanism is unclear. Research needed for insight into treating obesity and related conditions.

Obesity
Xu S et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118577
PubMed:
39019414

Label-free proteomic analysis reveals the hepatoprotective mechanism of gypenosides in liver injury rats.

Chen Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1417575
PubMed:
38994199

Network Pharmacology Analysis, Molecular Docking Integrated Experimental Verification Reveal the Mechanism of Gynostemma pentaphyllum in the Treatment of Type II Diabetes by Regulating the IRS1/PI3K/Akt Signaling Pathway.

Summary

Goldenroot (GP) has potential in treating type 2 diabetes mellitus (T2DM). GP contains 32 components and 326 potential targets related to T2DM, acting through insulin resistance signaling pathways. GP extracts increased glucose uptake and glycogen synthesis, suggesting a potential therapy for T2DM.

Diabetes
Yang S et al (2024).
Curr Issues Mol Biol.
DOI:
10.3390/cimb46060333
PubMed:
38921004

Gypenosides exert cardioprotective effects by promoting mitophagy and activating PI3K/Akt/GSK-3β/Mcl-1 signaling.

Summary

Study on Gypenosides (GYPs) in Thunb. Makino plant shows potential for anti-aging and treating age-related conditions like diabetes. GYPs preserve mitochondrial function and prevent heart failure. Important for cardiovascular health research.

Cardiology
Zheng Y et al (2024).
PeerJ.
DOI:
10.7717/peerj.17538
PubMed:
38912051

Neuroprotective effects of Gypenosides: A review on preclinical studies in neuropsychiatric disorders.

Summary

Gynostemma pentaphyllum gypenosides show promise in treating neuropsychiatric disorders. More research needed for clinical applications. Important for potential neuroprotective properties and improving human health.

Review Neuroscience
Liang G et al (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176766
PubMed:
38908668

Gypenoside A Protects Human Myocardial Cells from Ischemia/Reperfusion Injury via the circ_0010729/miR-370-3p/RUNX1 Axis.

Summary

Gypenoside A from Gynostemma pentaphyllum protects heart cells from ischemia/reperfusion injury by regulating circ_0010729/miR-370-3p/RUNX1 axis. Potential treatment for cardiovascular disease.

Cardiology
Ma H et al (2024).
Biochemistry (Mosc).
DOI:
10.1134/S000629792405016X
PubMed:
38880656

New natural protein tyrosine phosphatase 1B inhibitors from Gynostemma pentaphyllum.

Wang X et al (2024).
J Enzyme Inhib Med Chem.
DOI:
10.1080/14756366.2024.2360063
PubMed:
38873930

Single-cell transcriptome profiling reveals the spatiotemporal distribution of triterpenoid saponin biosynthesis and transposable element activity in Gynostemma pentaphyllum shoot apexes and leaves.

GeneticsPhytochemistry
Li R et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1394587
PubMed:
38779067

Gynostemma Pentaphyllum ameliorates CCl(4)-induced liver injury via PDK1/Bcl-2 pathway with comprehensive analysis of network pharmacology and transcriptomics.

Genetics
Hu L et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00942-w
PubMed:
38750545

The potential molecular mechanism underlying gypenoside amelioration of atherosclerosis in ApoE(-/-) mice: A multi-omics investigation.

Ju X et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e29164
PubMed:
38644881

Integrative metabolomic and transcriptomic analyses reveals the accumulation patterns of key metabolites associated with flavonoids and terpenoids of Gynostemma pentaphyllum (Thunb.) Makino.

Phytochemistry
Zhao X, Ge W and Miao Z (2024).
Sci Rep.
DOI:
10.1038/s41598-024-57716-5
PubMed:
38622163

Gynostemma pentaphyllum Hydrodistillate and Its Major Component Damulin B Promote Hair Growth-Inducing Properties In Vivo and In Vitro via the Wnt/β-Catenin Pathway in Dermal Papilla Cells.

Kovale L et al (2024).
Nutrients.
DOI:
10.3390/nu16070985
PubMed:
38613018

Genome-wide characterization of the bHLH gene family in Gynostemma pentaphyllum reveals its potential role in the regulation of gypenoside biosynthesis.

Genetics
Qin Y et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-04879-y
PubMed:
38509465

Gypenoside induces apoptosis by inhibiting the PI3K/AKT/mTOR pathway and enhances T-cell antitumor immunity by inhibiting PD-L1 in gastric cancer.

Summary

Gypenoside induces apoptosis in gastric cancer cells, inhibits PI3K/AKT/mTOR pathway, and reduces PD-L1 expression. Enhances antitumor immunity of T cells. Potential new therapeutic agent for immunotherapy in gastric cancer.

CancerGastroenterologyImmunology
Wu H et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1243353
PubMed:
38482051

Progress in Identification of UDP-Glycosyltransferases for Ginsenoside Biosynthesis.

Review
Yuan X et al (2024).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.3c00630
PubMed:
38449105

LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling.

Gu M et al (2024).
Chin Med.
DOI:
10.1186/s13020-024-00906-0
PubMed:
38439080

Critical review on anti-inflammation effects of saponins and their molecular mechanisms.

Summary

Saponins from plants and marine life show promise for anti-inflammatory therapies via molecular actions like NF-κB regulation. They shape the gut microbiome, impacting immune regulation and metabolic health, suggesting potential dietary interventions for chronic inflammation.

Review ImmunologyPhytochemistry
Wijesekara T, Luo J and Xu B (2024).
Phytother Res.
DOI:
10.1002/ptr.8164
PubMed:
38372176

Gypenoside XIII regulates lipid metabolism in HepG2 hepatocytes and ameliorates nonalcoholic steatohepatitis in mice.

Cheng SC et al (2024).
Kaohsiung J Med Sci.
DOI:
10.1002/kjm2.12795
PubMed:
38294255

Network Pharmacology Analysis and In Vitro Validation of the Active Ingredients and Potential Mechanisms of Gynostemma Pentaphyllum Against Esophageal Cancer.

Summary

Researchers investigated the potential anti-esophageal cancer effects of Gynostemma pentaphyllum Thunb. Makino. Understanding its active components and mechanisms can lead to improved treatment options for esophageal cancer.

Cancer
Guo J et al (2024).
Comb Chem High Throughput Screen.
DOI:
10.2174/0113862073280183240108113853
PubMed:
38243957

New dammarane-type triterpenoids from hydrolyzate of total Gynostemma pentaphyllum saponins with protein tyrosine phosphatase 1B inhibitory activity.

Summary

Researchers found that nine dammarane triterpenoids have significant inhibitory activity on protein tyrosine phosphatase 1B, indicating their potential as treatments for type 2 diabetes.

Phytochemistry
Tan D et al (2023).
J Enzyme Inhib Med Chem.
DOI:
10.1080/14756366.2023.2281263
PubMed:
37965892

Transcriptomics and metabolomics association analysis revealed the responses of Gynostemma pentaphyllum to cadmium.

Summary

seedlings of an important medicinal herb were exposed to cadmium (Cd) stress. They showed enhanced antioxidant activity and accumulation of certain metabolites. Genetic analysis identified key genes and metabolic pathways involved. Understanding this response mechanism can help develop varieties with low Cd accumulation.

Genetics
Zhou Y et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1265971
PubMed:
37877087

Identification of Meloidogyne species on traditional Chinese medicine plants in the Qinling mountain area of China and their aggressiveness to different medicinal herbs.

Pan S et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-01-23-0148-RE
PubMed:
37849284

The application of mixed stabilizing materials promotes the feasibility of the intercropping system of Gynostemma pentaphyllum/Helianthus annuus L. on arsenic contaminated soil.

Chen W et al (2023).
J Environ Manage.
DOI:
10.1016/j.jenvman.2023.119284
PubMed:
37839203

Production of Gypenoside XVII from Ginsenoside Rb1 by Enzymatic Transformation and Their Anti-Inflammatory Activity In Vitro and In Vivo.

Summary

Scientists cloned and expressed a gene encoding an enzyme that converts ginsenoside Rb1 into gypenoside XVII, a compound with improved anti-inflammatory activity. This method has potential for large-scale production of gypenoside XVII as a new anti-inflammatory drug.

Immunology
Zhou K et al (2023).
Molecules.
DOI:
10.3390/molecules28197001
PubMed:
37836844

Harder, better, faster, stronger? Retrospective chart review of adverse events of interactions between adaptogens and antidepressant drugs.

Summary

This study evaluated the prevalence and characteristics of adverse events associated with adaptogen-antidepressant interactions. Adaptogens were involved in 9% of adverse events. Clinicians should monitor these interactions due to the potential for clinically significant adverse events.

Neuroscience
Siwek M et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1271776
PubMed:
37829299

Protective effect of heat-processed Gynostemma pentaphyllum on high fat diet-induced glucose metabolic disorders mice.

Xie JB et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1215150
PubMed:
37822878

Bacoside a inhibits the growth of glioma by promoting apoptosis and autophagy in U251 and U87 cells.

Liu HY et al (2023).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-023-02724-x
PubMed:
37782380

Comparative Analysis of the Chloroplast Genome of Sicyos angulatus with Other Seven Species of Cucurbitaceae Family.

Genetics
Kousar M and Park J (2023).
Genes (Basel).
DOI:
10.3390/genes14091776
PubMed:
37761916

Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: A review.

Summary

Gynostemma pentaphyllum is a plant that can be used for medicine and tea. It contains flavonoids and saponins and has various positive effects, including lowering cholesterol, fighting cancer, protecting the heart and liver, as well as offering neuroprotection, antidiabetic, and anti-inflammatory benefits.

Review Phytochemistry
Xie P et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117186
PubMed:
37722515

The Content and Principle of the Rare Ginsenosides Produced from Gynostemma pentaphyllum after Heat Treatment.

Li XC et al (2023).
Molecules.
DOI:
10.3390/molecules28176415
PubMed:
37687242

Gynostemma pentaphyllum Makino extract induces hair growth and exhibits an anti-graying effect via multiple mechanisms.

Liu X et al (2023).
J Cosmet Dermatol.
DOI:
10.1111/jocd.15963
PubMed:
37649302

Chemical Constituents, Antioxidant, and α-Glucosidase Inhibitory Activities of Different Fermented Gynostemma Pentaphyllum Leaves and Untargeted Metabolomic Measurement of the Metabolite Variation.

Immunology
Zhang X et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12081505
PubMed:
37627500

Gypenoside XVII inhibits ox-LDL-induced macrophage inflammatory responses and promotes cholesterol efflux through activating the miR-182-5P/HDAC9 signaling pathway.

Immunology
Deng WY, Zhou CL and Zeng MY (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117070
PubMed:
37625608

Multi‑omics‑based analysis of the regulatory mechanism of gypenosides on bile acids in hypercholesterolemic mice.

Feng C et al (2023).
Exp Ther Med.
DOI:
10.3892/etm.2023.12136
PubMed:
37614436

Dammarane-type triterpenoid saponins isolated from Gynostemma pentaphyllum ameliorate liver fibrosis via agonizing PP2Cα and inhibiting deposition of extracellular matrix.

Summary

New gypenosides derived from Gynostemma pentaphyllum have potential as anti-fibrotic agents for treating chronic hepatic disorders, particularly hepatic fibrosis. Compound 5 shows promise in mitigating hepatic fibrosis in mice.

Phytochemistry
Liu Y et al (2023).
Chin J Nat Med.
DOI:
10.1016/S1875-5364(23)60395-4
PubMed:
37611978

Gypenosides suppress hepatocellular carcinoma cells by blocking cholesterol biosynthesis through inhibition of MVA pathway enzyme HMGCS1.

Xiao MY et al (2023).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2023.110674
PubMed:
37604220

Isolation and purification of high polar glycosides from aerial parts of Gynostemma pentaphyllum (Thunb.) Makino by linear gradient counter-current chromatography coupled with inner-recycling mode.

Phytochemistry
Sun X et al (2023).
J Sep Sci.
DOI:
10.1002/jssc.202300238
PubMed:
37548129

Gypenosides Synergistically Reduce the Extracellular Matrix of Hepatic Stellate Cells and Ameliorate Hepatic Fibrosis in Mice.

Li H et al (2023).
Molecules.
DOI:
10.3390/molecules28145448
PubMed:
37513321

NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease-like pathology in mice by targeting protein phosphatase magnesium-dependent 1A phosphatase.

Summary

Gynostemma pentaphyllum extract shows promise in reducing cognitive impairment in Alzheimer's disease. A specific compound from the extract, NPLC0393, targets a protein called PPM1A, reducing inflammation and tau hyperphosphorylation, and improving communication between microglia and neurons.

Neuroscience
Lv J et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7945
PubMed:
37434441

Gypenoside biotransformation into ginsenoside F2 by endophytic Aspergillus niger from Gynostemma pentaphyllum.

Zhang X et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2209823
PubMed:
37157839

Systematical characterization of gypenosides in Gynostemma pentaphyllum and the chemical composition variation of different origins.

Chen XB et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115328
PubMed:
37149947

Liver lipidomics analysis reveals the anti-obesity and lipid-lowering effects of gypnosides from heat-processed Gynostemma pentaphyllum in high-fat diet fed mice.

Summary

This study investigates how heat-processed G. pentaphyllum affects lipid metabolism in hyperlipidemic conditions, which is relevant for understanding its potential as a treatment option.

Obesity
Xie P et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154834
PubMed:
37094422

Gypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism.

Zhou T et al (2023).
PeerJ.
DOI:
10.7717/peerj.15225
PubMed:
37065701

A herbal product inhibits carbon tetrachloride-induced liver fibrosis by suppressing the epidermal growth factor receptor signaling pathway.

Qi J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116419
PubMed:
37003405

Effects of gypenoside L-containing Gynostemma pentaphyllum extract on fatigue and physical performance: A double-blind, placebo-controlled, randomized trial.

Ahn Y et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7801
PubMed:
36877124

Comparative Transcriptome Profiles of Human HaCaT Cells in Response to Gynostemma pentaphyllum Extracts Obtained Using Three Independent Methods by RNA Sequencing.

Genetics
Cho WK et al (2023).
Life (Basel).
DOI:
10.3390/life13020423
PubMed:
36836780

A comprehensive review on clinically proven medicinal plants in the treatment of overweight and obesity, with mechanistic insights.

Summary

This review examines how medicinal plants can help manage obesity, which is a growing global health problem associated with serious health conditions.

Review Obesity
Aziz MA et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e13493
PubMed:
36816319

Antioxidant and antibacterial activities of a polysaccharide produced by Chaetomium globosum CGMCC 6882.

Wang Z et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123628
PubMed:
36758762

Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway.

Li Y et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114319
PubMed:
36724639

Identification of Human UDP-Glucuronosyltransferase Involved in Gypensapogenin C Glucuronidation and Species Differences.

Chen J et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24021454
PubMed:
36674970

Diploid chromosome-level reference genome and population genomic analyses provide insights into Gypenoside biosynthesis and demographic evolution of Gynostemma pentaphyllum (Cucurbitaceae).

Genetics
Zhang X et al (2022).
Hortic Res.
DOI:
10.1093/hr/uhac231
PubMed:
36643751

Increasing brain glucose uptake by Gypenoside LXXV ameliorates cognitive deficits in a mouse model of diabetic Alzheimer's disease.

Summary

In a study, Gypenoside LXXV (GP-75), a natural plant compound, was administered to mice with Alzheimer's disease and diabetes. GP-75 improved cognitive function, glucose control, and insulin sensitivity in the mice. It also reduced beta-amyloid buildup in the brain and increased glucose uptake. The treatment worked by activating certain signaling pathways in the brain. These findings suggest that GP-75 has potential for treating cognitive impairment in humans with Alzheimer's and diabetes.

Neuroscience
Meng X et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7639
PubMed:
36325883

Effects of heat-processed Gynostemma pentaphyllum on high-fat diet-fed mice of obesity and functional analysis on network pharmacology and molecular docking strategy.

Obesity
Xie P et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115335
PubMed:
35513215

Network pharmacology analysis reveals neuroprotection of Gynostemma pentaphyllum (Thunb.) Makino in Alzheimer' disease.

Summary

Chinese medicinal herb Gynostemma Pentaphyllum (Thunb.) Makino (GpM) has been reported to ameliorate cognitive impairment in Alzheimer's disease (AD), but its neuroprotective mechanism remains unclear. Researchers aimed to investigate the targets and possible signaling pathways of GpM in the treatment of AD. GpM's anti-inflammatory, anti-oxidative stress, and anti-tumor properties make it a promising candidate for AD drug treatment.

Neuroscience
Wang J et al (2022).
BMC Complement Med Ther.
DOI:
10.1186/s12906-022-03534-z
PubMed:
35255879

Progress in the Medicinal Value, Bioactive Compounds, and Pharmacological Activities of Gynostemma pentaphyllum.

Review
Su C et al (2021).
Molecules.
DOI:
10.3390/molecules26206249
PubMed:
34684830

Mechanism of gypenosides of Gynostemma pentaphyllum inducing apoptosis of renal cell carcinoma by PI3K/AKT/mTOR pathway.

Liu H et al (2021).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.113907
PubMed:
33556477

Gynostemma Pentaphyllum Extract Ameliorates High-Fat Diet-Induced Obesity in C57BL/6N Mice by Upregulating SIRT1.

Obesity
Lee HS et al (2019).
Nutrients.
DOI:
10.3390/nu11102475
PubMed:
31618980

Herbal Medicine for Slowing Aging and Aging-associated Conditions: Efficacy, Mechanisms and Safety.

Review
Phu HT et al (2020).
Curr Vasc Pharmacol.
DOI:
10.2174/1570161117666190715121939
PubMed:
31418664

Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan).

Review Cancer
Li Y et al (2016).
Chin Med.
PubMed:
27708693