Gynura japonica

Ethnobotanical Studies

1.

Gongcheng County, Guangxi, China

Uses: Stop bleeding, promote tissue regeneration, metrorrhagia, set a broken bone

DOI:: 10.1186/s13002-022-00544-6
PubMed:: 35729593

Studies

1.

Exposure to Gynura japonica (Thunb.) Juel plants induces hepatoxicity in rats and Buffalo rat liver cells.

Wen C et al (2024).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2024.118692
PubMed:: 39151710

2.

Endophytic fungus from Gynura japonica: phytochemical screening, biological activities, and characterisation of its bioactive compound.

Riga R et al (2024).; Nat Prod Res.
DOI:: 10.1080/14786419.2024.2332947
PubMed:: 38529767

3.

The complete chloroplast genome of Gynura japonica and its phylogenetic implications.

Genetics

Li M et al (2022).; Mitochondrial DNA B Resour.
DOI:: 10.1080/23802359.2022.2102443
PubMed:: 35923637

4.

Pyrrolizidine Alkaloid-Induced Hepatotoxicity Associated with the Formation of Reactive Metabolite-Derived Pyrrole-Protein Adducts.

Ma J et al (2021).; Toxins (Basel).
DOI:: 10.3390/toxins13100723
PubMed:: 34679016

5.

Characterization of natural herbal medicines by thin-layer chromatography combined with laser ablation-assisted direct analysis in real-time mass spectrometry.

Chen Y et al (2021).; J Chromatogr A.
DOI:: 10.1016/j.chroma.2021.462461
PubMed:: 34438305

6.

Gynura japonica: A new host of Apple stem grooving virus and Chrysanthemum virus B in China.

Lai Y et al (2021).; Plant Dis.
DOI:: 10.1094/PDIS-11-20-2512-PDN
PubMed:: 33908792

7.

Blood microRNA Signatures Serve as Potential Diagnostic Biomarkers for Hepatic Sinusoidal Obstruction Syndrome Caused by Gynura japonica Containing Pyrrolizidine Alkaloids.

Genetics Phytochemistry

Wang X et al (2021).; Front Pharmacol.
DOI:: 10.3389/fphar.2021.627126
PubMed:: 33679405

8.

Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China.

Review Phytochemistry

Zhu L et al (2021).; Acta Pharmacol Sin.
DOI:: 10.1038/s41401-020-00553-9
PubMed:: 33154553

9.

Rapid identification and determination of pyrrolizidine alkaloids in herbal and food samples via direct analysis in real-time mass spectrometry.

Chen Y et al (2021).; Food Chem.
DOI:: 10.1016/j.foodchem.2020.127472
PubMed:: 32721831

10.

Seneciphylline, a main pyrrolizidine alkaloid in Gynura japonica, induces hepatotoxicity in mice and primary hepatocytes via activating mitochondria-mediated apoptosis.

Wang W et al (2020).; J Appl Toxicol.
DOI:: 10.1002/jat.4004
PubMed:: 32618019

11.

The long persistence of pyrrolizidine alkaloid-derived pyrrole-protein adducts in vivo: Kinetic study following multiple exposures of a pyrrolizidine alkaloid containing extract of Gynura japonica.

Chen Y et al (2020).; Toxicol Lett.
DOI:: 10.1016/j.toxlet.2020.01.021
PubMed:: 31982501

12.

Comparative analysis of toxic components in different medicinal parts of Gynura japonica and its toxicity assessment on mice.

Xiong A et al (2019).; Phytomedicine.
DOI:: 10.1016/j.phymed.2018.06.015
PubMed:: 30668385

13.

Mass-spectrometry-directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in Gynura japonica.

Fang L et al (2014).; J Sep Sci.
DOI:: 10.1002/jssc.201400314
PubMed:: 24840731

14.

Anti-platelet aggregation and chemical constituents from the rhizome of Gynura japonica.

Lin WY et al (2003).; Planta Med.
PubMed:: 14531028