Hedyotis diffusa

Ethnobotanical Studies

Studies

The immunotherapy mechanism of Hedyotis Diffusae Herba in treating liver cancer: a study based on network pharmacology, bioinformatics, and experimental validation.

Summary

Study evaluates Hedyotis diffusa Willd (HDW) in treating liver cancer through network pharmacology and experimental validation. HDW inhibits proliferation, promotes apoptosis, targets IL6 and TNF, and may activate key pathways. Provides promising treatment strategy for liver cancer.

Cancer
Zheng Q, Wu X and Peng S (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03312-3
PubMed:
39093467

Molecular mechanism of the treatment of lung adenocarcinoma by Hedyotis Diffusa: an integrative study with real-world clinical data and experimental validation.

Wang S et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1355531
PubMed:
38903989

Can Chinese herbal medicine offer feasible solutions for newly diagnosed esophageal cancer patients with malnutrition? a multi-institutional real-world study.

Summary

Study on CHM use in EC patients with malnutrition in Taiwan. CHM commonly used but long-term impact unclear. Important for patient prognosis and treatment decisions.

Cancer
Lu YC et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1364318
PubMed:
38855746

Network pharmacology prediction and experiment validation of anti-liver cancer activity of Curcumae Rhizoma and Hedyotis diffusa Willd.

Summary

Study found CR-HDW has potential anti-liver cancer properties with specific mechanisms. Relevant for identifying potential new treatments for liver cancer.

Cancer
Tie S et al (2024).
Ann Med Surg (Lond).
DOI:
10.1097/MS9.0000000000002074
PubMed:
38846818

Network pharmacology and experimental verification to explore the effect of Hedyotis diffusa on Alzheimer's disease.

Summary

Researchers identified active compounds in Hedyotis diffusa for Alzheimer's disease treatment using network pharmacology and molecular docking. Results suggest HD may inhibit Aβ, suppress AChE activity, and reduce oxidative stress. Care about potential new treatment options for AD.

Neuroscience
Chen J et al (2024).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14558
PubMed:
38828741

The Populations of Two Differently Medicine-Used Plants of Hedyotis diffusa and Hedyotis corymbosa Shoot-Assembling Rich Bacterial and Fungal Communities with Varied Compositions but Conserved Structures.

Bai Y et al (2024).
Curr Microbiol.
DOI:
10.1007/s00284-024-03726-5
PubMed:
38801460

Hedyotis diffusa Willd inhibits inflammation and oxidative stress to protect against chronic prostatitis via the NRF2/ARE signaling pathway.

Immunology
Mo J, Xia K and Wu C (2024).
Environ Toxicol.
DOI:
10.1002/tox.24298
PubMed:
38738704

Hedyotis diffusa Willd and Astragalus membranaceus May Exert Anti-colon Cancer Effects by Affecting AKTI Expression, as Determined by Network Pharmacology and Molecular Docking.

Summary

Using network pharmacology, researchers found that HDW and AM have potential anticancer properties against colon cancer. This information can guide treatment decisions for colon cancer patients.

CancerGastroenterology
Ren J et al (2024).
Curr Comput Aided Drug Des.
DOI:
10.2174/0115734099282388240405055003
PubMed:
38638040

Synergistic action of Hedyotis diffusa Willd and Andrographis paniculata in Nasopharyngeal Carcinoma: Downregulating AKT1 and upregulating VEGFA to curb tumorigenesis.

Ye C et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.111866
PubMed:
38603854

Network pharmacology, bioinformatics, and experimental validation to identify the role of Hedyotis diffusa willd against gastric cancer through the activation of the endoplasmic reticulum stress.

CancerGastroenterology
Ou L, Li M and Hou Y (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e28833
PubMed:
38576568

Identification of Hedyotis diffusa Willd-specific mRNA-miRNA-lncRNA network in rheumatoid arthritis based on network pharmacology, bioinformatics analysis, and experimental verification.

Summary

Tossers studied potential benefits of Hedyotis diffusa Willd on rheumatoid arthritis using gene analysis and experimental verification to target MMP9, finding its regulatory impact on RA progression. Implications for future traditional Chinese medicine research on RA.

ArthritisGenetics
Jiang J et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-56880-y
PubMed:
38491124

Network pharmacology and experimental verification study on the mechanism of Hedyotis diffusa Willd in treating colorectal cancer.

Summary

Study assessed Hedyotis diffusa Willd effects on CRC using network pharmacology & experimental validation. Identified potential targets, key genes, pathways, & validated anti-CRC effects in vitro. Important for developing new CRC treatments.

CancerGastroenterology
Yuan X et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03024-8
PubMed:
38446216

Asperuloside alleviates cyclophosphamide-induced myelosuppression by promoting AMPK/mTOR pathway-mediated autophagy.

Che H et al (2024).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23641
PubMed:
38348709

Molecular Targets and Mechanisms of Hedyotis diffusa Willd. for Esophageal Adenocarcinoma Treatment Based on Network Pharmacology and Weighted Gene Co-expression Network Analysis.

Genetics
Zhuang Y et al (2024).
Curr Drug Targets.
DOI:
10.2174/0113894501265851240102101122
PubMed:
38213161

Exploring inhibitory components of Hedyotis diffusa on androgen receptor through molecular docking and molecular dynamics simulations.

Endocrinology
Xiang J, Li Z and Liu Q (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000036637
PubMed:
38206742

Network-based pharmacology-based research on the effect and mechanism of the Hedyotis diffusa-Scutellaria Barbata pair in the treatment of hepatocellular carcinoma.

Hou C et al (2024).
Sci Rep.
DOI:
10.1038/s41598-023-50696-y
PubMed:
38200019

Asperulosidic Acid Ameliorates Renal Interstitial Fibrosis via Removing Indoxyl Sulfate by Up-Regulating Organic Anion Transporters in a Unilateral Ureteral Obstruction Mice Model.

Wang J et al (2023).
Molecules.
DOI:
10.3390/molecules28237690
PubMed:
38067420

Toxicity study of compound granules of Hedyotis diffusa: Acute toxicity and long-term toxicity.

Chen DH et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117434
PubMed:
37992881

Seventeen undescribed iridoid derivatives with anti-inflammatory effects from Hedyotis diffusa and their structure-activity relationships.

Immunology
Qin LF et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113904
PubMed:
37926152

Kaempferol promotes non-small cell lung cancer cell autophagy via restricting Met pathway.

Summary

Kaempferol, extracted from Hedyotis diffusa, has been found to have anti-cancer effects on non-small cell lung cancer cells. Further research is needed to understand the underlying mechanisms.

Cancer
Wang R et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155090
PubMed:
37738907

Hedyotis Diffusa-Scutellaria Barbata inhibits Breast Cancer Ethyl Acetate Fraction from Hedyotis Diffusa Plus Scutellaria Barbata inhibits the Progression of Breast Cancer via Targeting LMO1 and AKT/Mtor Signaling Pathway.

Summary

Scutellaria barbata and Hedyotis diffusa herb pair (SH) has anticancer effects in various cancers, including breast cancer, but the precise mechanism is unknown.

Cancer
Li Z et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666230913105858
PubMed:
37711008

Effect of heat-clearing and dampness-eliminating Chinese medicine for high-risk cervical cancer papillomavirus infection: a systematic review and meta-analysis of randomized controlled trials.

Summary

A study conducted a comprehensive review to evaluate the effectiveness and safety of heat-clearing and dampness-eliminating Chinese medicine (HDCM) for high-risk cervical HPV-infected patients. This information is important for making informed decisions about treating cervical HPV infections using HDCM.

Cancer
Huang S et al (2023).
Front Med (Lausanne).
DOI:
10.3389/fmed.2023.1022030
PubMed:
37692777

Hedyotis diffusa-Sculellaria barbata (HD-SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis.

Summary

Combination of Hedyotis diffusa and Scutellaria barbata inhibits colorectal cancer through downregulation of hsa_circ_0039933, a molecule that promotes cancer progression via the Wnt signaling pathway.

CancerGastroenterology
Zhu D, Yuan S and Chen C (2023).
Sci Rep.
DOI:
10.1038/s41598-023-40393-1
PubMed:
37587207

Evaluation of therapeutic mechanism of Hedyotis diffusa Willd (HDW)‒Scutellaria barbata (SB) in clear cell renal cell carcinoma via single-cell RNA sequencing and network pharmacology.

Genetics
Bai Y et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666230731155309
PubMed:
37526191

Analysis of the cluster efficacy and prescription characteristics of traditional Chinese medicine intervention for non-small cell lung cancer based on a clustering algorithm.

Cancer
Hong M et al (2023).
Technol Health Care.
DOI:
10.3233/THC-220644
PubMed:
36970924

Network pharmacology and experimental validation to identify the potential mechanism of Hedyotis diffusa Willd against rheumatoid arthritis.

Arthritis
Deng H et al (2023).
Sci Rep.
DOI:
10.1038/s41598-022-25579-3
PubMed:
36697436

Network Pharmacology Analysis and Experimental Verification on Antiangiogenesis Mechanism of Hedyotis diffusa Willd in Liver Cancer.

CancerGenetics
Wu H et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/1416841
PubMed:
36647454

Hedyotis diffusa alleviate aflatoxin B1-induced liver injury in ducks by mediating Nrf2 signaling pathway.

Wang P et al (2023).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2022.114339
PubMed:
36508825

The association between mortality and use of Chinese herbal medicine among incident stage IV esophageal cancer patients: A retrospective cohort study with core herbs exploration.

Cancer
Chen SL et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.1018281
PubMed:
36278218

Novel Antiviral Efficacy of Hedyotis diffusa and Artemisia capillaris Extracts against Dengue Virus, Japanese Encephalitis Virus, and Zika Virus Infection and Immunoregulatory Cytokine Signatures.

AntimicrobialImmunology
Mao ZQ, Minakawa N and Moi ML (2022).
Plants (Basel).
DOI:
10.3390/plants11192589
PubMed:
36235456

An anticomplement homogeneous polysaccharide from Hedyotis diffusa attenuates lipopolysaccharide-induced acute lung injury and inhibits neutrophil extracellular trap formation.

Zhang J et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154453
PubMed:
36116199

Hedyotis diffusa injection induces ferroptosis via the Bax/Bcl2/VDAC2/3 axis in lung adenocarcinoma.

Huang F et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154319
PubMed:
35853302

Anti-Alzheimer's disease active components screened out and identified from Hedyotis diffusa combining bioaffinity ultrafiltration LC-MS with acetylcholinesterase.

Summary

Researchers investigated the effects of different chemical extract fractions of Hedyotis diffusa on amyloid-beta aggregation, a key process in AD development. They found that the fractions significantly inhibited amyloid-beta aggregation and showed potential as promising sources for AD treatment. The study highlights the importance of exploring traditional remedies in finding new treatments for complex diseases like AD.

Neuroscience
Li J et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115460
PubMed:
35714878

Dose-dependent effects of Hedyotis diffusa extract on the pharmacokinetics of tamoxifen, 4-hydroxytamoxifen, and N-desmethyltamoxifen.

Cheng YY et al (2022).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2021.112466
PubMed:
34839255

Hedyotis diffusa Willd. Suppresses Hepatocellular Carcinoma via Downregulating AKT/mTOR Pathways.

Huang L et al (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/5210152
PubMed:
34527062

Hedyotis diffusa plus Scutellaria barbata Suppress the Growth of Non-Small-Cell Lung Cancer via NLRP3/NF-κB/MAPK Signaling Pathways.

Cancer
Lv YX et al (2021).
Evid Based Complement Alternat Med.
DOI:
10.1155/2021/6666499
PubMed:
34239588

Differentiation of Hedyotis diffusa and Common Adulterants Based on Chloroplast Genome Sequencing and DNA Barcoding Markers.

Genetics
Yik MH et al (2021).
Plants (Basel).
DOI:
10.3390/plants10010161
PubMed:
33467716

The effectiveness of Hedyotis diffusa Willd extract in a mouse model of experimental autoimmune prostatitis.

Wazir J et al (2021).
Andrologia.
DOI:
10.1111/and.13913
PubMed:
33236398