Helicteres angustifolia

Ethnobotanical Studies

Studies

Bioactivity-guided fractionation of Helicteres angustifolia L. extract and its molecular evidence for tumor suppression.

Summary

The 40% ethanol fraction (EF40) of the root extract possesses attractive anticancer properties with no toxicity to normal cells. EF40 reduces the expression of Nrf2, a protein found in many cancers, leading to the accumulation of reactive oxygen species (ROS) that cause cell cycle arrest and apoptosis. EF40 also inhibits NSCLC cell migration by downregulating MMPs and hnRNP-K. Mouse studies showed significant suppression of tumor growth and lung metastasis. EF40 could be a potential natural anti-NSCLC drug that requires further attention for its mechanisms and clinical applications.

Cancer
Li K et al (2023).
Front Cell Dev Biol.
DOI:
10.3389/fcell.2023.1157172
PubMed:
37427379

Metabolic stimulation-elicited transcriptional responses and biosynthesis of acylated triterpenoids precursors in the medicinal plant Helicteres angustifolia.

Huang Y et al (2022).
BMC Plant Biol.
DOI:
10.1186/s12870-022-03429-8
PubMed:
35216551

Experimental evidence and mechanism of action of some popular neuro-nutraceutical herbs.

Review
Kumar A et al (2021).
Neurochem Int.
DOI:
10.1016/j.neuint.2021.105124
PubMed:
34245808

Corrigendum to "Antiviral activity of methyl helicterate isolated from Helicteres angustifolia (Sterculiaceae) against hepatitis B virus" [Antiviral Res. 100 (2013) 373-381].

Antimicrobial
Huang Q et al (2021).
Antiviral Res.
DOI:
10.1016/j.antiviral.2021.105017
PubMed:
33485675

Methyl helicterilate ameliorates alcohol-induced hepatic fibrosis by modulating TGF-β1/Smads pathway and mitochondria-dependent pathway.

Wen S et al (2019).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2019.105759
PubMed:
31325729

Anti-Stress and Glial Differentiation Effects of a Novel Combination of Cucurbitacin B and Withanone (CucWi-N): Experimental Evidence.

Garg S, Kaul SC and Wadhwa R (2018).
Ann Neurosci.
DOI:
10.1159/000490693
PubMed:
31000958

Methyl Helicterate Inhibits Hepatic Stellate Cell Activation Through Modulation of Apoptosis and Autophagy.

Zhang XL et al (2018).
Cell Physiol Biochem.
DOI:
10.1159/000495390
PubMed:
30466104

Characterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7.

Immunology
Sun S et al (2019).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2018.10.039
PubMed:
30396084

[Study on Triterpenoids from Helicteres angustifolia by High-Speed Countercurrent Chromatography].

Phytochemistry
Su D et al (2016).
Zhong Yao Cai.
PubMed:
30133191

Purification and analysis of the composition and antioxidant activity of polysaccharides from Helicteres angustifolia L.

Liu Q et al (2018).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2017.10.095
PubMed:
29051093

Anti-Complementary Components of Helicteres angustifolia.

Yin X et al (2016).
Molecules.
PubMed:
27834928

Glucose consumption and alpha-glucosidase inhibitory activities of aqueous root extract of Helicteres angustifolia.

Hu XS et al (2016).
Eur Rev Med Pharmacol Sci.
PubMed:
27097967

Cytotoxic triterpenoids from the root bark of Helicteres angustifolia.

Pan MH et al (2008).
Chem Biodivers.
DOI:
10.1002/cbdv.200890053
PubMed:
18421748