A traditional Mexican remedy, known for its anticancer properties, has been found to contain cadinane-type sesquiterpenes like 7-hydroxy-3,4-dihydrocadalene, which have shown cytotoxic effects. However, the exact mechanism of action and regulation of these agents on tumor cells remains unknown. In this study, the cytotoxic activity and mechanism of action of 7-hydroxy-3,4-dihydrocadalene and two semi-synthetic cadinanes derivatives were investigated for the first time on breast cancer cells. This research aims to shed light on the potential of these compounds in fighting breast cancer.
In this study, researchers investigated the effects of natural products from a medicinal plant called on brain damage induced by kainic acid. They administered methanolic and acetonic extracts and quercetin at different doses to male Wistar rats and found that the natural products protected against the hyperexcitability underlying the damage caused by kainic acid-induced seizures. The group treated with natural products had decreased seizure severity and increased seizure latency compared to the control group. They also found that the natural products had antioxidant effects that protected against reactive oxygen species (ROS) and modulation of antioxidant enzyme activity. These findings suggest that organic extracts and quercetin from may have potential as anticonvulsant agents.
Researchers investigated the impact of natural products on two neurotransmitters, dopamine and 5-hydroxyindole acetic acid (5-HIAA), in the brains of infected models. The study’s methods involved infecting specific types of mice with a virus and then treating them with varying concentrations of the natural products. The researchers then measured the levels of DA and 5-HIAA in the mice's brains. The study showed that some natural products had a positive effect on these neurotransmitters, which may have implications for neurological disorders that involve imbalances in these chemicals. However, further research is necessary to confirm these findings.