Hibiscus sabdariffa

Common Names: roselle

Ethnobotanical Studies

Clinical Trials

Bioavailability of bioactive compounds in Hibiscus sabdariffa beverage as a potential anti-inflammatory.

In a clinical study, the absorption and metabolism of compounds in a Hibiscus sabdariffa drink were evaluated. Various organic acids and phenolic compounds were detected in the drink. Metabolites derived from these compounds may have anti-inflammatory effects, but further research is needed.

Arce-Reynoso A et al (2023).
Food Res Int.
PubMed:
37986526

Studies

Modulation of the Hyperglycemia Condition in Diabetic Lab Rats with Extracts of the Creole Jamaica Flower (Hibiscus sabdariffa L.) from the Morelia Region (Mexico).

Summary

Jamaica flower extracts from Morelia can lower blood glucose levels, improve lipid metabolism, and reduce insulin resistance in diabetic rats. They could be used as functional ingredients for managing diabetes.

Suárez-Diéguez T et al (2024).
Antioxidants (Basel).
PubMed:
39199254

An untargeted metabolomics approach applied to the study of the bioavailability and metabolism of three different bioactive plant extracts in human blood samples.

Villegas-Aguilar MDC et al (2024).
Food Funct.
PubMed:
39158031

Development of a scalable, high-anthocyanin and low-acidity natural red food colorant from Hibiscus sabdariffa L.

Li N, Simon JE and Wu Q (2024).
Food Chem.
PubMed:
39151341

Enhanced bacterial cellulose production by Komagataeibacter species and Hibiscus sabdariffa herbal tea.

Avcioglu NH et al (2024).
Int J Biol Macromol.
PubMed:
39084992

Microencapsulation of Hibiscus sabdariffa L. extract using porous starch and gum Arabic: Optimized process, characterization, stability, and simulated gastrointestinal conditions.

Leyva-López R et al (2024).
Int J Biol Macromol.
PubMed:
39084984

Formulation and characterization of nanocapsules loaded with roselle anthocyanins extract and enhancement of anthocyanins bioaccessibility.

Song W et al (2024).
Food Chem.
PubMed:
39018620

Wound healing effect of polydeoxyribonucleotide derived from Hibiscus sabdariffa callus via Nrf2 signaling in human keratinocytes.

Kim E et al (2024).
Biochem Biophys Res Commun.
PubMed:
38996695

Roselle (Hibiscus sabdariffa L.) extract as an adjunct to valsartan in patients with mild chronic kidney disease: A double-blind randomized controlled clinical trial.

Dehkhoda B et al (2024).
Avicenna J Phytomed.
PubMed:
38952776

Biologically Synthesized Gold Nanoparticles Mitigate Aluminum Chloride-Induced Nephrotoxicity via Downregulation of iNOX, LCN2 and IL-1β Genes.

Anadozie SO, Aduma AU and Adewale OB (2024).
Cell Biochem Biophys.
PubMed:
38907938

Safety classification of herbal medicine use among hypertensive patients: a systematic review and meta-analysis.

Choi D et al (2024).
Front Pharmacol.
PubMed:
38881876

Clinical effects of Hibiscus sabdariffa Linn. on obesity treatment: A systematic review and meta-analysis of randomized controlled trials.

Summary

Researchers investigated Hibiscus sabdariffa Linn. for treating obesity, which is linked to many chronic diseases. Results are inconclusive, but 60% of adults are overweight. Consider potential benefits and risks before using.

Dilokthornsakul P et al (2024).
Complement Ther Med.
PubMed:
38878905

Contamination, speciation, and health risk assessment of arsenic in leafy vegetables in Ambagarh Chowki (India).

Khute M et al (2024).
Anal Sci.
PubMed:
38847963

Attitude and Practice of Pharmacy Students Toward Traditional Herbal Medicines, Sudan.

Mahmoud EI, Yousif MA and Arbab AH (2024).
Integr Pharm Res Pract.
PubMed:
38827648

Photostability and photodynamic antimicrobial profile of dye extracts from four (4) plants: prospects for eco-friendly low-cost food disinfection and topical biomedical applications.

Summary

Dye extracts from natural plants were tested for photostability and antimicrobial activity against bacteria and viruses. Lawsonia inermis showed the highest photostability and antibacterial activity, while Curcuma longa was most effective against viruses. This research may have applications in disinfection and sanitation practices.

Majiya H, Adamu A and Galstyan A (2024).
Photochem Photobiol Sci.
PubMed:
38771468

Hibiscus Sabdariffa L. Extract as a Natural Additive in Food Packaging Biodegradable Films to Improve Antioxidant, Antimicrobial, and Physicochemical Properties.

Summary

Biodegradable films made from potato starch, PVOH, HS extract show antioxidant, antimicrobial properties. Suitable for food packaging, eco-friendly alternative to traditional materials.

Hernández-Hernández FA et al (2024).
Plant Foods Hum Nutr.
PubMed:
38761283

The protective effects of some herbs on mitigating HFD-induced obesity via enhancing biochemical indicators and fertility in female rats.

Summary

Study showed that diets enriched with fennel and coriander reduced obesity risks and improved fertility in obese female rats better than chia seeds and hibiscus. Consider plant-based diets for obesity prevention.

Abdoon ASS et al (2024).
Heliyon.
PubMed:
38726161

Dataset on the qualitative characteristics of roselle varieties (Hibiscus sabdariffa L.).

Caballero PC et al (2024).
Data Brief.
PubMed:
38725554

Nephroprotective Effect of Hibiscus Sabdariffa Leaf Flavonoid Extracts via KIM-1 and TGF-1β Signaling Pathways in Streptozotocin-Induced Rats.

Ajiboye BO et al (2024).
ACS Omega.
PubMed:
38708257

Roselle Calyx (Hibiscus Sabdariffa. L) Ethyl Acetate Fraction Lowering MDA, TNF-α and Reduce Hypercoagulability in Diabetic Model.

Summary

Study on ethyl acetate fraction of Hibiscus calyxes in diabetic rats showed decreased MDA and TNF-α levels, improved bleeding time, and platelet count. Suggests potential for managing diabetes-related complications, relevant for lab research.

Abdillah R et al (2024).
Pharmacology.
PubMed:
38583417

The utility of Hibiscus sabdariffa L. to prepare metal oxides NPs for clinical application on osteoporosis supported by theoretical study.

Al-Garawi ZS et al (2024).
Bioprocess Biosyst Eng.
PubMed:
38573334

Simultaneous effect of medicinal plants as natural photosensitizers and low-level laser on photodynamic inactivation.

Aghaebrahimi Z et al (2024).
Lasers Med Sci.
PubMed:
38538952

Biofabricated Green Synthesized Hibiscus Silver Nanoparticles Potentiate Antibacterial Activity and Cytotoxicity in Human Lung Cancer Cells.

Summary

Hibiscus sabdariffa plant extract was used to create stable silver nanoparticles with antibacterial, cytotoxic, and anti-inflammatory properties. Further research is needed to explore their potential as medicines.

Ahirwar B et al (2024).
Appl Biochem Biotechnol.
PubMed:
38483765

Antioxidant and anti-inflammatory effects of Boswellia dalzielii and Hibiscus sabdariffa extracts in alloxan-induced diabetic rats.

Summary

"BD and HS extracts reduce hyperglycemia and inflammation in diabetic rats by enhancing antioxidant levels and decreasing inflammatory markers. Potential as natural treatments for diabetes mellitus."

Hamadjida A et al (2024).
Metabol Open.
PubMed:
38455229

Research on optimization of spray drying conditions, characteristics of anthocyanins extracted from Hibiscus sabdariffa L. flower, and application to marshmallows.

Hoang NTN et al (2024).
Food Sci Nutr.
PubMed:
38455187

Natural Products in the Clinical Management of Metabolic Syndrome.

Tabatabaei-Malazy O, Lavari N and Abdollahi M (2024).
Handb Exp Pharmacol.
PubMed:
38418667

Targets and Effects of Common Biocompounds of Hibiscus sabdariffa (Delphinidin-3-Sambubiosid, Quercetin, and Hibiscus Acid) in Different Pathways of Human Cells According to a Bioinformatic Assay.

Zúñiga-Hernández SR et al (2024).
Nutrients.
PubMed:
38398890

Evaluation of Bioactive Effects of Five Plant Extracts with Different Phenolic Compositions against Different Therapeutic Targets.

Villegas-Aguilar MDC et al (2024).
Antioxidants (Basel).
PubMed:
38397815

Enhancing the Antioxidant Potential of Weissella confusa PP29 Probiotic Media through Incorporation of Hibiscus sabdariffa L. Anthocyanin Extract.

Simionescu N and Petrovici AR (2024).
Antioxidants (Basel).
PubMed:
38397763

In Vivo Diuretic Activity and Anti-Hypertensive Potential of Hibiscus sabdariffa Extract by Inhibition of Angiotensin-Converting Enzyme and Hypertension Precursor Enzymes.

Summary

The study found that extracts from the calyx of roselle have potential anti-hypertensive effects by inhibiting various enzymes and showing diuretic activity. This suggests roselle could be a source of beneficial compounds for hypertension treatment.

Sanou A et al (2024).
Foods.
PubMed:
38397511

Unique properties of titanium dioxide quantum dots assisted regulation of growth and biochemical parameters of Hibiscus sabdariffa plants.

Abdelhameed RE, Abdalla H and Ibrahim MA (2024).
BMC Plant Biol.
PubMed:
38365586

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults.

Lubis L et al (2024).
Biomed Rep.
PubMed:
38357241

Medicinal herbs, especially Hibiscus sabdariffa, inhibit oral pathogenic bacteria.

Takada K et al (2024).
J Oral Biosci.
PubMed:
38278302

First Report of Rhizoctonia solani AG-4 HG-I Causing Root and Basal Stem Rot on Roselle (Hibiscus sabdariffa) in Mexico.

Palemon-Alberto F et al (2024).
Plant Dis.
PubMed:
38268178

Determination of anthocyanins, organic acids, and phenolic acids in hibiscus market products using LC/UV/MS.

Summary

This study analyzed the chemical diversity of commercially available hibiscus products. It identified major compounds and variations in the market. These findings are important for quality control, authentication, and standardization of natural products.

Li N, Simon JE and Wu Q (2024).
J Food Sci.
PubMed:
38235990

Examination of Hibiscus sabdariffa's bioactive arsenal: pharmacological prospects and comprehensive insights into catalysing health and wellness through its therapeutic attributes-an exposition.

Bhandare SD and Malode SS (2024).
J Pharm Pharmacol.
PubMed:
38226899

An extract of Hibiscus sabdariffa improves short-term memory in rats with experimental diabetic hyperglycemia.

Summary

Scientists found that the calyxes of Hs contain anthocyanins that can regulate blood glucose levels in diabetic patients. Additionally, consuming Hs may potentially improve memory alterations caused by diabetes.

López-Pérez SJ, Ureña-Guerrero ME and Bañuelos-Pineda J (2024).
Nutr Neurosci.
PubMed:
38193451

Production of functional recombinant roseltide rT1 antimicrobial peptide in tobacco plants.

Summary

Scientists successfully produced functional recombinant roseltide rT1 peptide in tobacco plants, which has antimicrobial properties and therapeutic applications for inflammatory lung diseases. This provides a rapid and cost-effective method for producing this important antimicrobial peptide for use in the food and therapeutic industries.

Khalifeh-Kandy AS, Nayeri FD and Ahmadabadi M (2024).
J Biotechnol.
PubMed:
38181983

The Potential Role of Gossypetin in the Treatment of Diabetes Mellitus and Its Associated Complications: A Review.

Summary

Gossypetin, a flavonoid similar to quercetin, shows potential in treating type 2 diabetes and its complications. It has antioxidant, anti-inflammatory, and immunomodulatory properties that can protect organs from damage caused by diabetes.

Review Diabetes
Naidoo K and Khathi A (2023).
Int J Mol Sci.
PubMed:
38139436

The methanolic extract of Hibiscus sabdariffa downregulates the relative expression of Kiss1 gene in the hypothalamus of Wistar rats: A preliminary report.

Summary

Researchers studied the effects of a plant extract on gene expression in the rat hypothalamus. This extract may regulate a gene that controls the reproductive system, providing insights into its potential as a fertility regulator.

Okafor IA et al (2023).
Avicenna J Phytomed.
PubMed:
38106630

Comparative Study on the Chemical Profile, Antioxidant Activity, and Enzyme Inhibition Capacity of Red and White Hibiscus sabdariffa Variety Calyces.

Yagi S et al (2023).
ACS Omega.
PubMed:
38024777

Exploring the Health Benefits and Therapeutic Potential of Roselle (Hibiscus sabdariffa) in Human Studies: A Comprehensive Review.

Review
Almajid A et al (2023).
Cureus.
PubMed:
38024072

Evaluating the potential of Hibiscus sabdariffa beverage to address the prevalence of iron deficiency in sub-Saharan Africa.

Oyewole AO and Diosady LL (2023).
Lebensm Wiss Technol.
PubMed:
38022393

Integrated Action of Rhizobacteria with Aloe vera and Moringa Leaf Extracts Improves Defense Mechanisms in Hibiscus sabdariffa L. Cultivated in Saline Soil.

Bahgat AR et al (2023).
Plants (Basel).
PubMed:
37960041

Plant Extracts as Skin Care and Therapeutic Agents.

Review
Michalak M et al (2023).
Int J Mol Sci.
PubMed:
37895122

Advanced interactional characterization of the inhibitory effect of anthocyanin extract from Hibiscus sabdariffa L. on apple polyphenol oxidase.

Boldea LS et al (2023).
J Food Sci.
PubMed:
37872831

Novel Insight into the Cellular and Molecular Signalling Pathways on Cancer Preventing Effects of Hibiscus sabdariffa: A Review.

Summary

A review found that extracts from the HS plant contain phytochemicals with anti-cancer effects, such as reducing cancer cell growth and promoting cell death. These compounds also impact cellular signaling pathways involved in cancer prevention.

Review Cancer
Yasmin R et al (2023).
J Cancer Prev.
PubMed:
37830114

Anticancer effects of gossypetin from Hibiscus sabdariffa in oral squamous cell carcinoma.

Summary

Gossypetin, derived from Hibiscus sabdariffa L., has anti-inflammatory and antibacterial properties. This study explores its potential anticancer effects on oral squamous cell carcinoma. Important for finding new treatments for oral cancer.

Huang K et al (2023).
J Appl Oral Sci.
PubMed:
37820185

Alteration of the aortic vascular reactivity associated to excessive consumption of Hibiscus sabdariffa Linnaeus: Preliminary findings.

Manzano-Pech L et al (2023).
Heliyon.
PubMed:
37810051

Hibiscus Anthocyanins Extracts Induce Apoptosis by Activating AMP-Activated Protein Kinase in Human Colorectal Cancer Cells.

Summary

Hibiscus anthocyanin-rich extracts induce apoptosis in colorectal cancer cells by activating AMPK and Fas-mediated pathways, leading to caspase-3 cleavage and cell death. This highlights the potential of these extracts for cancer treatment.

Tsai MC et al (2023).
Nutrients.
PubMed:
37764756

Effect of Hibiscus sabdariffa L. on the Metabolism of Arachidonic Acid in the Isolated Kidney of a Rat Model of Metabolic Syndrome.

Pérez-Torres I et al (2023).
Int J Mol Sci.
PubMed:
37762512

Drying temperature affects the hypolipidemic, antioxidant, and antihypertensive potential of Hibiscus sabdariffa calyx in rats induced with L-NAME.

Summary

Different drying temperatures were applied to calyx, and the resulting extract showed potential as a treatment for hypertension and cardiovascular diseases.

Efosa JO, Omage K and Azeke MA (2023).
Toxicol Rep.
PubMed:
37719201

The Dipeptide Gly-Pro (GP), Derived from Hibiscus sabdariffa, Exhibits Potent Antifibrotic Effects by Regulating the TGF-β1-ATF4-Serine/Glycine Biosynthesis Pathway.

Kim H et al (2023).
Int J Mol Sci.
PubMed:
37686422

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases.

Summary

Various bioactive metabolites found in herbs such as Rosmarinus officinalis and Punica granatum have shown impressive angiotensin converting enzyme (ACE) inhibitory activity. These natural ACE inhibitors could be a potential treatment for hypertension, respiratory distress syndrome, and chronic kidney diseases, but more clinical trials are needed.

Review Cardiology
Khaled A et al (2023).
Phytother Res.
PubMed:
37675925

Impact of Processing and Physicochemical Parameter on Hibiscus sabdariffa Calyxes Biomolecules and Antioxidant Activity: From Powder Production to Reconstitution.

Summary

This review discusses the effects of different stabilization methods on the properties of a tropical plant powder, particularly its bioactive molecules and antioxidant activity. Factors such as drying techniques, powder production, and reconstitution media are explored to improve its nutritional quality.

M'be CU et al (2023).
Foods.
PubMed:
37627982

Fusarium solani infection disrupts metabolism during the germination of roselle (Hibiscus sabdariffa L.) seeds.

Tahmasebi A et al (2023).
Front Plant Sci.
PubMed:
37615017

Hibiscus sabdariffa Linn. Extract Increases the mRNA Expression of the Arcuate Nucleus Leptin Receptor and is Predicted in silico as an Anti-obesity Agent.

Summary

Leptin helps regulate body weight by increasing energy expenditure. It also promotes browning of fat cells. However, in obese individuals, the receptors for leptin and a key protein are decreased.

Kartinah NT et al (2023).
Curr Comput Aided Drug Des.
PubMed:
37608673

Inulin as prebiotic encapsulating agent for the production of spray-dried Hibiscus sabdariffa L. tea microcapsules.

Calliari CM et al (2023).
Nat Prod Res.
PubMed:
37585694

A study on the use of sorrel seed flour (Hibiscus sabdariffa) for improving functionality of wheat flour bread.

Ayo-Omogie HN et al (2023).
Heliyon.
PubMed:
37539265

In Vitro Antiprotozoal Activity of Hibiscus sabdariffa Extract against a Ciliate Causing High Mortalities in Turbot Aquaculture.

Carvalho A et al (2023).
Biology (Basel).
PubMed:
37508344

Hibiscus-cisplatin combination treatment decreases liver toxicity in rats while increasing toxicity in lung cancer cells via oxidative stress- apoptosis pathway.

Summary

Hibiscus extract reduces liver damage caused by anti-cancer drug cisplatin in rats and enhances its effectiveness in killing lung cancer cells.

Hamza AA et al (2023).
Biomed Pharmacother.
PubMed:
37450997

Comparative Analysis of Water Extracts from Roselle (Hibiscus sabdariffa L.) Plants and Callus Cells: Constituents, Effects on Human Skin Cells, and Transcriptome Profiles.

Cho WK et al (2023).
Int J Mol Sci.
PubMed:
37446030

Influence of particle size in supercritical carbon dioxide extraction of roselle (Hibiscus sabdariffa) on bioactive compound recovery, extraction rate, diffusivity, and solubility.

Putra NR et al (2023).
Sci Rep.
PubMed:
37407592

Green synthesis of CuO nanoparticles using Hibiscus sabdariffa L. extract to treat wastewater in Soba Sewage Treatment Plant, Sudan.

Almisbah SRE et al (2023).
Water Sci Technol.
PubMed:
37387430

Therapeutic Potential of Hibiscus sabdariffa Linn. in Attenuating Cardiovascular Risk Factors.

Summary

Roselle, a medicinal plant, has bioactive compounds with anti-hyperlipidemia, anti-hyperglycemia, and anti-hypertension effects. It may be a potential therapy for cardiovascular diseases.

Review Cardiology
Sapian S et al (2023).
Pharmaceuticals (Basel).
PubMed:
37375755

GC-MS Analysis, Antibacterial, and Anticancer Activities of Hibiscus sabdariffa L. Methanolic Extract: In Vitro and In Silico Studies.

Summary

A study was conducted to investigate the effectiveness of various extracts from three medicinal plants (A, B, and C) against pathogenic bacteria. The methanol extract from plant A exhibited the highest antibacterial efficacy against all tested bacteria, including multidrug-resistant strains. Additionally, a combination of plant A and a certain antibiotic showed promising results. Furthermore, plant A showed potential anticancer activity against colon cancer cells. Analysis confirmed the presence of bioactive components in the methanol extract. Molecular docking suggested that these components could inhibit the tested substances, offering potential applications in the treatment of infections and colon cancer. Overall, the methanol extract from plant A shows promise as a natural therapy for treating infections.

Sehim AE et al (2023).
Microorganisms.
PubMed:
37375103

Effect of Roselle Flower Extract (Hibiscus sabdariffa Linn.) on Reducing Steatosis and Steatohepatitis in Vitamin B12 Deficiency Rat Model.

Ujianti I et al (2023).
Medicina (Kaunas).
PubMed:
37374248

Induction of Systemic Resistance in Hibiscus sabdariffa Linn. to Control Root Rot and Wilt Diseases Using Biotic and Abiotic Inducers.

Ahmed HFA et al (2023).
Biology (Basel).
PubMed:
37372074

The Phytoestrogenic Effect of Hibiscus sabdariffa Involves Estrogen Receptor α in Ovariectomized Wistar Rats.

Summary

The researchers found that an extract from the calyxes of Hibiscus sabdariffa improves memory and may act as a phytoestrogen, providing a potential alternative to hormone replacement therapy.

Lorenzana-Martínez G et al (2023).
Plant Foods Hum Nutr.
PubMed:
37314593

Effect of the Combination of Hibiscus sabdariffa in Combination with Other Plant Extracts in the Prevention of Metabolic Syndrome: A Systematic Review and Meta-Analysis.

Review
García-Muñoz AM et al (2023).
Foods.
PubMed:
37297513

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins.

Summary

This review article examines the potential of medicinal plants and vitamins in the prevention and treatment of diabetes mellitus (DM). Current research suggests that certain phytochemicals in medicinal plants and vitamins C, D, and E may possess anti-hypoglycemic activities and improve the health of diabetes patients. However, more research is needed in this area.

Review Diabetes
Yedjou CG et al (2023).
Int J Mol Sci.
PubMed:
37240430

Application of structurally modified WPC in combination with maltodextrin for microencapsulation of Roselle (Hibiscus sabdariffa) extract as a natural colorant source for gummy candy.

Younesi M et al (2023).
Int J Biol Macromol.
PubMed:
37220850

Effect of Different Extraction Methods on Anthocyanin Content in Hibiscus sabdariffa L. and their Antiplatelet and Vasorelaxant Properties.

Martins DRDS et al (2023).
Plant Foods Hum Nutr.
PubMed:
37120677

Ultrasound application for the decontamination of roselle (Hibiscus sabdariffa L.) seeds: Influence on fungal inhibition and seed quality.

Tahmasebi A et al (2023).
Ultrason Sonochem.
PubMed:
37060710

Biosorption of bioactive compounds in bacterial nanocellulose: Mechanisms and physical-chemical properties.

de Andrade Arruda Fernandes I et al (2023).
Int J Biol Macromol.
PubMed:
37054855

Antioxidant and Antiradical Activities of Hibiscus sabdariffa L. Extracts Encapsulated in Calcium Alginate Spheres.

Bevan P et al (2023).
Polymers (Basel).
PubMed:
37050354

Optimization of the Extraction of Antioxidant Compounds from Roselle Hibiscus Calyxes (Hibiscus sabdariffa), as a Source of Nutraceutical Beverages.

Villalobos-Vega MJ et al (2023).
Molecules.
PubMed:
36985600

Synergistic Antibacterial Proficiency of Green Bioformulated Zinc Oxide Nanoparticles with Potential Fosfomycin Synergism against Nosocomial Bacterial Pathogens.

Almaary KS et al (2023).
Microorganisms.
PubMed:
36985218

Therapeutic effect of gossypetin against paraquat-induced testicular damage in male rats: a histological and biochemical study.

Mustafa S et al (2023).
Environ Sci Pollut Res Int.
PubMed:
36940025

Production of low-tannin Hibiscus sabdariffa tea through D-optimal design optimization of the preparation conditions and the catalytic action of new tannase.

Sayed Mostafa H et al (2023).
Food Chem X.
PubMed:
36845514

Antioxidant, Alpha-Glucosidase Inhibition Activities, In Silico Molecular Docking and Pharmacokinetics Study of Phenolic Compounds from Native Australian Fruits and Spices.

Ali A, Cottrell JJ and Dunshea FR (2023).
Antioxidants (Basel).
PubMed:
36829816

Advances in Molecular Regulation of Prostate Cancer Cells by Top Natural Products of Malaysia.

Review Cancer
Prieto JM and Hanafi MMM (2023).
Curr Issues Mol Biol.
PubMed:
36826044

Insight into Green Extraction for Roselle as a Source of Natural Red Pigments: A Review.

Review
Rizkiyah DN et al (2023).
Molecules.
PubMed:
36771003

Effect of Partial Meat Replacement by Hibiscus sabdariffa By-Product and Pleurotus djamor Powder on the Quality of Beef Patties.

Bermúdez R et al (2023).
Foods.
PubMed:
36673487

Synergistic Antibacterial Potential of Greenly Synthesized Silver Nanoparticles with Fosfomycin Against Some Nosocomial Bacterial Pathogens.

Aljeldah MM et al (2023).
Infect Drug Resist.
PubMed:
36636381

The Nephroprotective Effects of Hibiscus sabdariffa Leaf and Ellagic Acid in Vitro and in Vivo Models of Hyperuricemic Nephropathy.

Chen JH et al (2023).
J Agric Food Chem.
PubMed:
36562602

Serum Phospholipids Are Potential Therapeutic Targets of Aqueous Extracts of Roselle (Hibiscus sabdariffa) against Obesity and Insulin Resistance.

Summary

The study found that aqueous extracts from white and purple varieties of roselle prevented obesity and insulin resistance in rats on a high-fat/fructose diet. White roselle was more beneficial due to its high organic and phenolic acid content.

Rangel-García CA et al (2022).
Int J Environ Res Public Health.
PubMed:
36554419

Nutritionally Enriched Muffins from Roselle Calyx Extract Using Response Surface Methodology.

Marak S et al (2022).
Foods.
PubMed:
36553724

Hibiscus sabdariffa (Roselle) calyx: a systematic and meta-analytic review of memory-enhancing, anti-neuroinflammatory and antioxidative activities.

Summary

Researchers conducted preclinical investigations into the neuroprotective properties of Hibiscus sabdariffa (HSD) extract. The study examined how the extract improved memory function, reduced neuroinflammation and oxidative damage in the central nervous system. These findings could guide future research for areas such as Alzheimer's Disease.

Olasehinde TA et al (2023).
Inflammopharmacology.
PubMed:
36436183

Hibiscus sabdariffa L. polyphenolic-rich extract promotes muscle glucose uptake and inhibits intestinal glucose absorption with concomitant amelioration of Fe(2+) -induced hepatic oxidative injury.

Mohamed AI et al (2022).
J Food Biochem.
PubMed:
36259155

A novel green preparation of zinc oxide nanoparticles with Hibiscus sabdariffa L.: photocatalytic performance, evaluation of antioxidant and antibacterial activity.

Chemingui H et al (2024).
Environ Technol.
PubMed:
36170044

Kiss1 gene expression, sperm indices and testicular histopathology following the administration of Hibiscus sabdariffa in rats.

Okafor IA et al (2023).
JBRA Assist Reprod.
PubMed:
36098456

Anthocyanin: A Natural Dye Extracted from Hibiscus Sabdariffa (L.) for Textile and Dye Industries.

Sankaralingam B et al (2023).
Appl Biochem Biotechnol.
PubMed:
35304691

Hibiscus sabdariffa anthocyanins are potential modulators of estrogen receptor alpha activity with favourable toxicology: a computational analysis using molecular docking, ADME/Tox prediction, 2D/3D QSAR and molecular dynamics simulation.

Laskar YB, Mazumder PB and Talukdar AD (2023).
J Biomol Struct Dyn.
PubMed:
34854367

Efficacy of Hibiscus sabdariffa on Reducing Blood Pressure in Patients With Mild-to-Moderate Hypertension: A Systematic Review and Meta-Analysis of Published Randomized Controlled Trials.

Summary

Hibiscus sabdariffa significantly reduces blood pressure in patients with mild-to-moderate hypertension, but not in patients with metabolic syndrome or when compared to antihypertensive drugs. More research is needed for long-term efficacy.

Meta-Analysis Cardiology
Abdelmonem M et al (2022).
J Cardiovasc Pharmacol.
PubMed:
34694241

Mechanisms of Action of Nutritionally Rich Hibiscus sabdariffa's Therapeutic Uses in Major Common Chronic Diseases: A Literature Review.

Review
Amos A and Khiatah B (2022).
J Am Nutr Assoc.
PubMed:
33507846

Beneficial Effects of Natural Bioactive Compounds from Hibiscus sabdariffa L. on Obesity.

Review Obesity
Ojulari OV, Lee SG and Nam JO (2019).
Molecules.
PubMed:
30626104

Hibiscus.

Review
(2021).
PubMed:
30000942

Effect of sour tea (Hibiscus sabdariffa L.) on arterial hypertension: a systematic review and meta-analysis of randomized controlled trials.

Summary

This study examines the potential heart health benefits of Hibiscus sabdariffa beverages, commonly used to treat high blood pressure. The researchers analyzed existing trials to determine if there is solid evidence to support this claim.

Meta-Analysis Cardiology
Serban C et al (2015).
J Hypertens.
PubMed:
25875025

Hibiscus sabdariffa L. in the treatment of hypertension and hyperlipidemia: a comprehensive review of animal and human studies.

Review Cardiology
Hopkins AL et al (2013).
Fitoterapia.
PubMed:
23333908