Houttuynia cordata

Common Names: chameleon

Ethnobotanical Studies

Studies

Extraction, purification, structural features, and pharmacological properties of polysaccharides from Houttuynia cordata: A review.

Review
Liu J et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.135230
PubMed:
39218180

Mechanism of Jizhi syrup's prevention and treatment of acute bronchitis based on LPS-iNOS inflammatory mediators' signalling pathway.

Immunology
Han M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118708
PubMed:
39197804

Isolation of an α-glucosidase Inhibitor from Houttuynia cordata Thunb. and Its In vitro and In vivo Hypoglycemic Bioactivity.

Summary

Researchers isolated neochlorogenic acid from Houttuynia cordata Thunb., showing potential as a natural α-glucosidase inhibitor to lower blood glucose levels. This study lays the groundwork for developing new hypoglycemic treatments.

Diabetes
Cao P et al (2024).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-024-01217-3
PubMed:
39133356

Sodium Houttuyfonate Prevents Seizures and Neuronal Cell Loss by Maintaining Glutamatergic System Stability in Male Rats with Kainic Acid-Induced Seizures.

Summary

SH (sodium houttuyfonate) showed antiseizure & neuroprotective effects in a rat model. It prevented glutamate level increase and altered glutamatergic system, similar to carbamazepine. Important potential alternative treatment for seizures.

Neuroscience
Chang Y, Chen YJ and Wang SJ (2024).
Biomedicines.
DOI:
10.3390/biomedicines12061312
PubMed:
38927519

iTRAQ-based proteomic analysis reveals the effect of ribosomal proteins on essential-oil accumulation in Houttuynia cordata Thunb.

Guo D et al (2024).
PeerJ.
DOI:
10.7717/peerj.17519
PubMed:
38903882

Exploring the immunological mechanism of Houttuynia cordata in the treatment of colorectal cancer through combined network pharmacology and experimental validation.

Summary

Study identified active components of Houttuynia cordata for CRC treatment. Quercetin and kaempferol target genes IL1B, MMP9, CXCL8, and IL6, inhibiting cell growth and promoting apoptosis. Potential for immunomodulation in CRC treatment.

CancerGastroenterology
Li Y et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
DOI:
10.1007/s00210-024-03203-7
PubMed:
38888753

Effects of three kinds of Chinese herbs on growth performance, oocysts output and gut microbiota in growing lambs with coccidiosis.

Gastroenterology
He Y et al (2024).
Folia Parasitol (Praha).
DOI:
10.14411/fp.2024.009
PubMed:
38813809

Effects and mechanism of Qingke Pingchuan granules against influenza virus infection.

He L et al (2024).
Arch Virol.
DOI:
10.1007/s00705-024-06053-z
PubMed:
38807015

Quality evaluation and identification of Houttuynia cordata bleached with sodium metabisulfite based on whole spectrum metabolomics.

Zhao D et al (2024).
Food Chem X.
DOI:
10.1016/j.fochx.2024.101463
PubMed:
38798794

Inhibition of LPS-Induced Skin Inflammatory Response and Barrier Damage via MAPK/NF-κB Signaling Pathway by Houttuynia cordata Thunb Fermentation Broth.

Immunology
Song Z et al (2024).
Foods.
DOI:
10.3390/foods13101470
PubMed:
38790770

A Single Latent Plant Growth-Promoting Endophyte BH46 Enhances Houttuynia cordata Thunb. Yield and Quality.

Wang XT et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c08177
PubMed:
38753758

Cadmium phytoremediation potential of Houttuynia cordata: Insights from growth, uptake, and rhizosphere mechanisms.

Zhang Q et al (2024).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2024.116417
PubMed:
38701655

Study on the Mechanism of Competing Endogenous Network of 'Scutellaria barbata D.Don-Houttuynia cordata- Radix Scutellariae' in the Treatment of NSCLC based on Bioinformatics, Molecular Dynamics and Experimental Verification.

Wu L et al (2024).
Curr Comput Aided Drug Des.
DOI:
10.2174/0115734099288771240419110716
PubMed:
38685811

Inhalation of 2, 4-di-tert-butylphenol-Loaded micelles suppresses respiratory syncytial virus infection in mice.

Guo M et al (2024).
Antiviral Res.
DOI:
10.1016/j.antiviral.2024.105880
PubMed:
38608838

Acetylation of the polysaccharide from Houttuynia cordata rhizome and their α-glucosidase inhibition mechanism.

He M et al (2024).
J Food Sci.
DOI:
10.1111/1750-3841.17000
PubMed:
38602052

Quality and production enhancement of fish mint, Houttuynia cordata Thunb., cultivated in a hydroponic planting system with designed plant growth-promoting additives.

Loo YC et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e28755
PubMed:
38586372

Surface ligand modified silver nanoparticles-based SERS sensing platform for ultrasensitive detection of the pesticide thiram in green tea leaves: roles of coating agents in sensing performance.

Linh DT et al (2024).
RSC Adv.
DOI:
10.1039/d4ra00048j
PubMed:
38528918

Determination of higenamine in common natural spices by ultrahigh-performance liquid chromatography-tandem mass spectrometry.

Phytochemistry
Du J et al (2024).
Drug Test Anal.
DOI:
10.1002/dta.3672
PubMed:
38440922

Response surface methodology for aqueous two-phase system extraction: An unprecedented approach for the specific flavonoid-rich extraction of Houttuynia cordata Thunb. leaves towards acne treatment.

Summary

Thunb. leaves have valuable pharmacological effects, extracted using ATPS and ultrasonic extraction. Useful for antibacterial, anti-inflammatory, and antioxidant properties in traditional medicine.

DermatologyPhytochemistry
Nguyen MH et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e25245
PubMed:
38420455

Physical impediment to sodium houttuyfonate conversely reinforces β-glucan exposure stimulated innate immune response to Candida albicans.

Wang Q et al (2024).
Med Mycol.
DOI:
10.1093/mmy/myae014
PubMed:
38389246

Evaluating the efficacy of hymexazol in controlling Globisporangium spinosum, the newly identified pathogen causing root rot in Houttuynia cordata.

Zhou X et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-10-23-2165-RE
PubMed:
38386301

Qingfei xieding prescription ameliorates mitochondrial DNA-initiated inflammation in bleomycin-induced pulmonary fibrosis through activating autophagy.

GeneticsImmunology
Wang Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117820
PubMed:
38286157

Evaluating Antioxidant Performance, Biosafety, and Antimicrobial Efficacy of Houttuynia cordata Extract and Microwave-Assisted Synthesis of Biogenic Silver Nano-Antibiotics.

Summary

Chinese herbal extract used to synthesize silver nanoparticles (HCE-AgNPs) exhibited improved antioxidant and antibacterial effects, making it a potential solution for healthcare-associated infections.

AntimicrobialImmunology
Moorthy K et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox13010032
PubMed:
38247457

Endophytic Pseudomonas fluorescens promotes changes in the phenotype and secondary metabolite profile of Houttuynia cordata Thunb.

Wang K et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-52070-y
PubMed:
38243055

Study on medicinal food plants in the Gaoligongshan Biosphere Reserve, the richest biocultural diversity center in China.

Cheng Z et al (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-023-00638-9
PubMed:
38225656

Phenolic changes in a combined herbal extract of Lithospermum erythrorhizon, Houttuynia cordata, and Spirodela polyrhiza and alleviation of DNCB-induced atopic dermatitis in BALB/c mice.

DermatologyPhytochemistry
Choi GY et al (2023).
Food Sci Biotechnol.
DOI:
10.1007/s10068-023-01329-7
PubMed:
38186620

Photoresponsive 'chemo-free' phytotherapy: formulation development for the treatment of triple-negative breast cancer.

Summary

Scientists developed a chemo-free treatment strategy for triple-negative breast cancer (TNBC) using a nanophytosomal system and phyto-photo dual treatment. Experiment showed promising anti-TNBC activity, suppression of mitochondrial potential, and induction of caspase-3 activity, indicating potential effectiveness and safety of this approach.

Cancer
Maheshwari N and Sharma MC (2024).
Nanomedicine (Lond).
DOI:
10.2217/nnm-2023-0231
PubMed:
38179960

A magnetic beads-based ligand fishing method Coupled with UHPLC-QTOF MS for screening and identification of α-glucosidase inhibitors from Houttuynia cordata Thunb.

Zhu P et al (2023).
Talanta.
DOI:
10.1016/j.talanta.2023.125583
PubMed:
38141464

An in-silico approach to identify bioactive phytochemicals from Houttuynia cordata Thunb. As potential inhibitors of human glutathione reductase.

Sangeet S and Khan A (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2294181
PubMed:
38109166

Houttuynia cordata thunb. alleviates inflammatory bowel disease by modulating intestinal microenvironment: a research review.

Summary

This article explores the potential mechanisms by which Houttuynia cordata thunb., a traditional Chinese plant, and its active ingredients alleviate IBD by regulating the intestinal microenvironment. It also discusses the safety of this plant and its potential for further research in IBD treatment.

Review GastroenterologyImmunology
Wang S et al (2023).
Front Immunol.
DOI:
10.3389/fimmu.2023.1306375
PubMed:
38077358

Houttuynia Cordata Thunb.: A comprehensive review of traditional applications, phytochemistry, pharmacology and safety.

Summary

Houttuynia Cordata Thunb. is a plant with volatile oils, flavonoids, polysaccharides, and alkaloids. It has various health benefits and can be used in medicine.

Review Phytochemistry
Wei P et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155195
PubMed:
37956635

Identifying the Potential of miRNAs in Houttuynia cordata-Derived Exosome-Like Nanoparticles Against Respiratory RNA Viruses.

Genetics
Zhu H et al (2023).
Int J Nanomedicine.
DOI:
10.2147/IJN.S425173
PubMed:
37901360

Bacteriocin-Producing Enterococcus faecium OV3-6 as a Bio-Preservative Agent to Produce Fermented Houttuynia cordata Thunb. Beverages: A Preliminary Study.

Choeisoongnern T et al (2023).
Foods.
DOI:
10.3390/foods12193520
PubMed:
37835173

Hydroalcoholic root extracts of Houttuynia cordata (Thunb.) standardized by UPLC-Q-TOF-MS/MS promotes apoptosis in human hepatocarcinoma cell HepG2 via GSK-3β/β-catenin/PDL-1 axis.

Sarkar S et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105684
PubMed:
37751799

Afzelin protects against doxorubicin-induced cardiotoxicity by promoting the AMPKα/SIRT1 signaling pathway.

Sun Y et al (2023).
Toxicol Appl Pharmacol.
DOI:
10.1016/j.taap.2023.116687
PubMed:
37703929

RP-HPLC-Based Flavonoid Profiling Accompanied with Multivariate Analysis: An Efficient Approach for Quality Assessment of Houttuynia cordata Thunb Leaves and Their Commercial Products.

Summary

This study developed an HPLC method to analyze flavonoids in medicinal plants, assessing their quality. Principal component and cluster analysis were used to evaluate similarity and variance. This methodology will aid in quantification and quality control of samples. Future studies will examine environmental factors' impact on flavonoid content.

Phytochemistry
Nguyen MH et al (2023).
Molecules.
DOI:
10.3390/molecules28176378
PubMed:
37687204

Regioselective Claisen-Schmidt Adduct of 2-Undecanone from Houttuynia cordata Thunb as Insecticide/Repellent against Solenopsis invicta and Repositioning Plant Fungicides against Colletotrichum fragariae.

Kurmanbayeva A et al (2023).
Molecules.
DOI:
10.3390/molecules28166100
PubMed:
37630353

Houttuynia cordata Thunb. Hexane fraction induces MDA-MB-231 cell apoptosis via caspases, ER stress, cell cycle arrest and attenuated Akt/ERK signaling.

Inthi P et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e18755
PubMed:
37576204

Sodium houttuyfonate plays a protective role in the asthmatic airway by alleviating the NLRP3-related pyroptosis and Th1/Th2 immune imbalance.

Summary

Houttuynia cordata is a herbal compound from China with anti-inflammatory, antiviral, and antioxidant properties. It can potentially help in asthma treatment by targeting NLRP3 inflammasome.

Asthma
Li M et al (2023).
Mol Immunol.
DOI:
10.1016/j.molimm.2023.06.013
PubMed:
37413910

Targeting calcium signaling by inositol trisphosphate receptors: A novel mechanism for the anti-asthmatic effects of Houttuynia cordata.

Summary

Houttuynia cordata, a traditional Chinese herb, may help treat asthma by modulating intracellular calcium signaling and reducing airway remodeling.

Asthma
Huang AS et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114935
PubMed:
37245337

Analysis of target organs of Houttuynia cordata: A study on the anti-inflammatory effect of upper respiratory system.

Immunology
Ho TY et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116687
PubMed:
37244408

Anti-cancer Effect and Active Phytochemicals of Houttuynia cordata Thunb. against Human Breast Cancer Cells.

Cancer
Inthi P et al (2023).
Asian Pac J Cancer Prev.
DOI:
10.31557/APJCP.2023.24.4.1265
PubMed:
37116149

Sodium New Houttuyfonate Effectively Improves Phagocytosis And Inhibits the Excessive Release of Inflammatory Factors By Repressing TLR4/NF-Кb Pathway in Macrophages.

Immunology
He X et al (2023).
Curr Pharm Biotechnol.
DOI:
10.2174/1389201024666230418163100
PubMed:
37070797

Deciphering Houttuynia cordata extract as electron shuttles with anti-COVID-19 activity and its performance in microbial fuel cells.

Summary

Researchers investigated traditional herbal medicines for potential antiviral compounds, focusing on electron shuttle-like structures. They assessed their use in bioenergy extraction and anti-COVID-19 applications, with significant implications for natural antiviral medication development.

COVID-19
Lin CK et al (2023).
J Taiwan Inst Chem Eng.
DOI:
10.1016/j.jtice.2023.104838
PubMed:
37051508

Impact of Matrix Species and Mass Spectrometry on Matrix Effects in Multi-Residue Pesticide Analysis Based on QuEChERS-LC-MS.

Zhang S et al (2023).
Foods.
DOI:
10.3390/foods12061226
PubMed:
36981154

Study on the Mechanism of Qing-Fei-Shen-Shi Decoction on Asthma Based on Integrated 16S rRNA Sequencing and Untargeted Metabolomics.

Summary

QFSS, a Chinese herbal formula, showed promising results in treating asthma in mice by regulating gut microbiota and metabolism. Potential mechanism for further research.

AsthmaGenetics
Hu H et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/1456844
PubMed:
36846048

Aerial part of Houttuynia cordata reverses memory impairment by regulating amyloid beta accumulation and neuroinflammation in Alzheimer's disease model.

Summary

An herbal medicine, Houttuyniae Herba (HH), traditionally used to treat various ailments, has been found to protect neurons and regulate dysfunction in Alzheimer's disease (AD) models. Administered to transgenic mice, HH reduced amyloid-β accumulation and improved memory impairment. In vitro, HH inhibited amyloid-β aggregation and increased alpha-secretase expression. With anti-neuroinflammatory effects, HH reduced glial activation and increased synaptophysin expression. HH may be a promising herbal drug for AD patients in need of multiple improvements.

ImmunologyNeuroscience
Ju IG et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7781
PubMed:
36814130

In vitro nephrotoxicity and quantitative UPLC-MS analysis of three aristololactams in Houttuynia cordata.

Xu Z et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115289
PubMed:
36812795

Antioxidant activity and interactions between whey protein and polysaccharides from different parts of Houttuynia cordata.

Liu X et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1020328
PubMed:
36761222

Antimicrobial mechanism of semi-bionic extracts of three traditional medicinal plants-Rheum palmatum L., Scutellaria baicalensis Georgi, and Houttuynia cordata Thunb-That can be used as antibiotic alternatives.

AntimicrobialGenetics
Jiang H et al (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2022.1083223
PubMed:
36713859

The sodium new houttuyfonate suppresses NSCLC via activating pyroptosis through TCONS-14036/miR-1228-5p/PRKCDBP pathway.

Jiang R et al (2023).
Cell Prolif.
DOI:
10.1111/cpr.13402
PubMed:
36696967

The Mechanism of Houttuynia cordata Embryotoxicity Was Explored in Combination with an Experimental Model and Network Pharmacology.

Liu Y et al (2023).
Toxins (Basel).
DOI:
10.3390/toxins15010073
PubMed:
36668893

Herbal medicines exhibit a high affinity for ACE2 in treating COVID-19.

Summary

Many herbal medicines, including Lianhua Qingwen capsules and Houttuynia cordata, have shown promise in treating COVID-19 by targeting the angiotensin converting enzyme 2 (ACE2) receptor which allows the virus to enter host cells. This study summarizes a range of herbal formulas, single herbs, and active ingredients that exhibit a high affinity for ACE2 and warrant further investigation. Such research could lead to the discovery of new drugs to fight COVID-19.

COVID-19
Zhang B and Qi F (2023).
Biosci Trends.
DOI:
10.5582/bst.2022.01534
PubMed:
36596560

Sodium houttuyfonate derived from Houttuynia cordata Thunb improves intestinal malfunction via maintaining gut microflora stability in Candida albicans overgrowth aggravated ulcerative colitis.

Gastroenterology
Cheng T et al (2023).
Food Funct.
DOI:
10.1039/d2fo02369e
PubMed:
36594429

Protective Effects of Fermented Houttuynia cordata Against UVA and H(2)O(2)-Induced Oxidative Stress in Human Skin Keratinocytes.

Kwon N et al (2022).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-022-04241-8
PubMed:
36495375

A dispersive solid-phase extraction method for the determination of Aristolochic acids in Houttuynia cordata based on MIL-101(Fe): An analytes-oriented adsorbent selection design.

Immunology
Cheng R et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2022.135074
PubMed:
36493489

2-Undecanone alleviates asthma by inhibiting NF-κB pathway.

Summary

2-Undecanone can reduce airway inflammation and remodeling in asthma. It decreases inflammatory cells, cytokines, and inhibits NF-κB pathway, showing potential as a treatment.

Asthma
Song G et al (2023).
Biochem Cell Biol.
DOI:
10.1139/bcb-2022-0185
PubMed:
36480816

The synergistic effect and mechanisms of flavonoids and polysaccharides from Houttuynia cordata on H1N1-induced pneumonia in mice.

Phytochemistry
Ling L et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115761
PubMed:
36309113

Pharmacological Effects of Houttuynia cordata Thunb (H. cordata): A Comprehensive Review.

Review
Rafiq S et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15091079
PubMed:
36145299

Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID-19: A review.

Summary

Scientists have identified 93 potential drug candidates from natural products such as medicinal plants and herbs that could effectively inhibit the coronavirus, including COVID-19. These candidates include pure compounds like Blancoxanthone and herbacetin, and extracts from plants like Artemisia annua and Tinospora cordifolia. The study suggests that natural products can be used as a source for potential drug discovery against COVID-19 and other respiratory viruses, including SARS and MERS-CoV. This provides a promising avenue for future research to develop effective treatments for the ongoing pandemic.

Review COVID-19
Adhikari B et al (2021).
Phytother Res.
DOI:
10.1002/ptr.6893
PubMed:
33037698

Flavonoids from Houttuynia cordata attenuate H1N1-induced acute lung injury in mice via inhibition of influenza virus and Toll-like receptor signalling.

Phytochemistry
Ling LJ et al (2020).
Phytomedicine.
DOI:
10.1016/j.phymed.2019.153150
PubMed:
31958713

Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review.

Review Immunology
Shingnaisui K et al (2018).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2018.03.038
PubMed:
29605674