Hydrastis canadensis

Common Names: goldenseal

Ethnobotanical Studies

Studies

Nanocarrier optimization: Encapsulating Hydrastis canadensis in chitosan nanoparticles for enhanced antibacterial and dye degradation performance.

Revathi S et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133316
PubMed:
38908618

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.).

Gao Y et al (2024).
Molecules.
DOI:
10.3390/molecules29030556
PubMed:
38338301

Non-targeted chemical analysis of consumer botanical products labeled as blue cohosh (Caulophyllum thalictroides), goldenseal (Hydrastis canadensis), or yohimbe bark (Pausinystalia yohimbe) by NMR and MS.

Summary

This study analyzed botanical dietary supplements using NMR and mass spectrometry to assess product quality and authenticity. Outliers were identified, and known constituents helped determine product authenticity. NMR and MS data provided similar and complementary results.

Phytochemistry
Quiroz-Delfi GO et al (2023).
Anal Bioanal Chem.
DOI:
10.1007/s00216-023-05004-y
PubMed:
37910202

Facile extraction of berberine from different plants, separation, and identification by thin-layer chromatography, high-performance liquid chromatography, and biological evaluation against Leishmaniosis.

Phytochemistry
Alam SD et al (2023).
J Sep Sci.
DOI:
10.1002/jssc.202300582
PubMed:
37675810

In Silico Analysis of the Effect of Hydrastis canadensis on Controlling Breast Cancer.

Summary

Researchers studied the effects of Hydrastis Canadensis (Goldenseal) on hormone-independent breast cancer using computational techniques. Canadaline and Riboflavin were found to effectively interact with target proteins, making Hydrastis Canadensis a potential treatment for hormone-independent and some hormone-dependent breast cancers.

Cancer
Vyshnavi Am H et al (2023).
Medicina (Kaunas).
DOI:
10.3390/medicina59081412
PubMed:
37629702

Interactions between complementary medicines and drugs used in primary care and oral COVID-19 antiviral drugs.

Summary

This study notes that patients can suffer harm from using conventional and complementary medicines together. However, this harm can be avoided. The researchers emphasize the importance of healthcare professionals educating patients about safe practices when using CMs alongside conventional medicine.

AntimicrobialCOVID-19
Hunter J and Harnett JE (2023).
Aust J Gen Pract.
DOI:
10.31128/AJGP-12-22-6631
PubMed:
37291812

Evaluation of Therapeutic Potential of Selected Plant-Derived Homeopathic Medicines for their Action against Cervical Cancer.

Cancer
Singh T et al (2023).
Homeopathy.
DOI:
10.1055/s-0042-1756436
PubMed:
36858077

Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO-1 pathway.

Summary

This study explored the potential neuroprotective effects of berberine (BBR) against Alzheimer's disease (AD) in vitro. Researchers established an apoptotic model in HT22 cells induced by Aβ and treated them with BBR. Results showed that BBR improved cell viability, inhibited Aβ-induced apoptosis and intracellular ROS levels, and intensified the activity of Nrf2/HO-1 antioxidants in HT22 cells. It also restrained the mitochondrial pathway of cellular apoptosis by decreasing the rate of p-p65/p65, cytochrome C, and cleaved caspase-3. This led the researchers to conclude that BBR provides neuroprotectiveness by alleviating oxidative stress and inhibiting the mitochondrial pathway of cellular apoptosis.

Neuroscience
Zhang RL et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2022.106210
PubMed:
36724611

Interactions between natural products and cancer treatments: underlying mechanisms and clinical importance.

Review Cancer
Chan WJ et al (2023).
Cancer Chemother Pharmacol.
DOI:
10.1007/s00280-023-04504-z
PubMed:
36707434

Hydrastis Canadensis in Uterine Troubles.

Barron RB et al (1888).
Atlanta Med Surg J (1884).
PubMed:
35827543

Effects of Dietary Inclusion of Dry Hydrastis canadensis on Laying Performance, Egg Quality, Serum Biochemical Parameters and Cecal Microbiota in Laying Hens.

Gastroenterology
Tzeng TJ et al (2021).
Animals (Basel).
DOI:
10.3390/ani11051381
PubMed:
34067964

Is it safe to consume traditional medicinal plants during pregnancy?

Review
Bernstein N et al (2021).
Phytother Res.
DOI:
10.1002/ptr.6935
PubMed:
33164294

Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues.

Review
Mandal SK et al (2020).
Pharmacol Res.
DOI:
10.1016/j.phrs.2020.105085
PubMed:
32683037

Effects of Hydrastis Canadensis, Commiphora Habessinica, Phytolacca Americana, and Echinacea Purpurea on Bacterial Growth.

Corn J et al (2021).
Altern Ther Health Med.
PubMed:
32619202

Goldenseal.

Review
(2021).
PubMed:
30000926

Hydrastis Canadensis.

(1891).
Hospital (Lond 1886).
PubMed:
29834493

Berberine and Its Role in Chronic Disease.

Review
Cicero AF and Baggioni A (2016).
Adv Exp Med Biol.
PubMed:
27671811

Effects of root isoquinoline alkaloids from Hydrastis canadensis on Fusarium oxysporum isolated from Hydrastis root tissue.

Phytochemistry
Tims Mc and Batista C (2007).
J Chem Ecol.
PubMed:
17549565

Berberine.

(2000).
Altern Med Rev.
PubMed:
10767672