Hypericum androsaemum

Common Names: sweet-amber, tutsan

Ethnobotanical Studies

Studies

Cytotoxic and apoptotic effects of Hypericum androsaemum on prostate adenocarcinoma (PC-3) and hepatocellular carcinoma (Hep G2) cell lines with identification of secondary metabolites by LC-HRMS.

Yazici Bektaş N et al (2021).
Turk J Chem.
DOI:
10.3906/kim-2104-17
PubMed:
34849072

The water extract of tutsan (Hypericum androsaemum L.) red berries exerts antidepressive-like effects and in vivo antioxidant activity in a mouse model of post-stroke depression.

Summary

Hypericum androsaemum L., also known as tutsan, is a plant commonly grown for its ornamental value and has been used in traditional Portuguese and Spanish medicine to treat depression. In this study, researchers tested the water extract of its red berries (WE) in a mouse model of post-stroke depression. They found that the highest dose of WE significantly reduced depression symptoms and increased endogenous antioxidant defenses in the mouse brain. The study identified four bioactive compounds in WE, including shikimic acid and chlorogenic acid. This is the first study to demonstrate the protective effects of WE in post-stroke depression in vivo, which suggests that tutsan may have potential as an alternative treatment for depression.

CardiologyNeuroscience
Nabavi SM et al (2018).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2018.01.073
PubMed:
29353203

Molecular architectures of benzoic acid-specific type III polyketide synthases.

Stewart C Jr et al (2017).
Acta Crystallogr D Struct Biol.
DOI:
10.1107/S2059798317016618
PubMed:
29199980

Polar extracts from the berry-like fruits of Hypericum androsaemum L. as a promising ingredient in skin care formulations.

Antognoni F et al (2017).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2016.11.029
PubMed:
27864112

Benzophenone Synthase and Chalcone Synthase Accumulate in the Mesophyll of Hypericum perforatum Leaves at Different Developmental Stages.

Belkheir AK et al (2016).
Front Plant Sci.
DOI:
10.3389/fpls.2016.00921
PubMed:
27446151

Pharmacological screening of Hypericum androsaemum extracts for antioxidant, anti-lipid peroxidation, antiglycation and cytotoxicity activity.

Saddiqe Z et al (2016).
Pak J Pharm Sci.
PubMed:
27087068

Polar Constituents and Biological Activity of the Berry-Like Fruits from Hypericum androsaemum L.

Caprioli G et al (2016).
Front Plant Sci.
DOI:
10.3389/fpls.2016.00232
PubMed:
26973675

Water extracts of tree Hypericum sps. protect DNA from oxidative and alkylating damage and enhance DNA repair in colon cells.

Genetics
Ramos AA et al (2013).
Food Chem Toxicol.
DOI:
10.1016/j.fct.2012.09.014
PubMed:
23000446

Polycyclic polyprenylated acylphloroglucinols and cytotoxic constituents of Hypericum androsaemum.

Wang K et al (2012).
Chem Biodivers.
DOI:
10.1002/cbdv.201100154
PubMed:
22700239

Hypericum androsaemum water extract inhibits proliferation in human colorectal cancer cells through effects on MAP kinases and PI3K/Akt pathway.

Cancer
Xavier CP et al (2012).
Food Funct.
DOI:
10.1039/c2fo10226a
PubMed:
22596086

In vitro protective effect of Hypericum androsaemum extract against oxygen and nitrogen reactive species.

Almeida IF et al (2009).
Basic Clin Pharmacol Toxicol.
DOI:
10.1111/j.1742-7843.2009.00458.x
PubMed:
19614890

Hypericum androsaemum infusion increases tert-butyl hydroperoxide-induced mice hepatotoxicity in vivo.

Valentão P et al (2004).
J Ethnopharmacol.
PubMed:
15325741

Protective activity of Hypericum androsaemum infusion against tert-butyl hydroperoxide-induced oxidative damage in isolated rat hepatocytes.

Valentão P et al (2004).
J Ethnopharmacol.
PubMed:
15099852

Benzoic acid biosynthesis in cell cultures of Hypericum androsaemum.

Abd El-Mawla AM and Beerhues L (2002).
Planta.
PubMed:
11882941