Hypericum japonicum

Ethnobotanical Studies

1.

Gongcheng County, Guangxi, China

Uses: Liver cirrhosis, typhoid, hepatitis

DOI:: 10.1186/s13002-022-00544-6
PubMed:: 35729593

2.

Gelao ethnic minority, North Guizhou, China

Uses: Hemorrhoids

DOI:: 10.3389/fphar.2023.1217599
PubMed:: 37719846

Studies

1.

Discovery of PXR agonists from Hypericum japonicum: A class of novel nonaromatic acylphloroglucinol-terpenoid adducts.

Su H et al (2024).; Bioorg Chem.
DOI:: 10.1016/j.bioorg.2024.107354
PubMed:: 38599054

2.

Hypericum japonicum extract inhibited porcine epidemic diarrhea virus in vitro and in vivo.

Rao H et al (2023).; Front Pharmacol.
DOI:: 10.3389/fphar.2023.1112610
PubMed:: 37138845

3.

Hyjapones A-D, trimethylated acyphloroglucinol meroterpenoids from Hypericum japonicum thunb. With anti-inflammatory activity.

Immunology

Deng X et al (2022).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2022.113308
PubMed:: 35817204

4.

Betulinic acid prevents liver fibrosis by binding Lck and suppressing Lck in HSC activation and proliferation.

Zhao H et al (2022).; J Ethnopharmacol.
DOI:: 10.1016/j.jep.2022.115459
PubMed:: 35714879

5.

Discovery of acylphloroglucinol-based meroterpenoid enantiomers as KSHV inhibitors from Hypericum japonicum.

Hu L et al (2018).; RSC Adv.
DOI:: 10.1039/c8ra04073g
PubMed:: 35539193

6.

In vitro study of the antioxidant, antiproliferative, and anthelmintic properties of some medicinal plants of Kokrajhar district, India.

Cancer Immunology

Swargiary A, Roy MK and Verma AK (2021).; J Parasit Dis.
DOI:: 10.1007/s12639-021-01410-0
PubMed:: 34789998

7.

Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors.

Peng X et al (2021).; Fitoterapia.
DOI:: 10.1016/j.fitote.2021.104984
PubMed:: 34216691

8.

A Network Pharmacology Study of the Molecular Mechanisms of Hypericum japonicum in the Treatment of Cholestatic Hepatitis with Validation in an Alpha-Naphthylisothiocyanate (ANIT) Hepatotoxicity Rat Model.

Feng SL et al (2021).; Med Sci Monit.
DOI:: 10.12659/MSM.928402
PubMed:: 33657087

9.

An Integrated LC-ESI-MS(n) and High Resolution LC-ESI-QTOF Approach for the Identification of Phloroglucinols from Nepalese Hypericum japonicum.

Peron G et al (2020).; Molecules.
DOI:: 10.3390/molecules25245937
PubMed:: 33333871

10.

LC-MS(n) and HR-MS characterization of secondary metabolites from Hypericum japonicum Thunb. ex Murray from Nepalese Himalayan region and assessment of cytotoxic effect and inhibition of NF-κB and AP-1 transcription factors in vitro.

Peron G et al (2019).; J Pharm Biomed Anal.
DOI:: 10.1016/j.jpba.2019.06.042
PubMed:: 31288189

11.

Cytotoxic phenolic constituents from Hypericum japonicum.

Zhu W et al (2019).; Phytochemistry.
DOI:: 10.1016/j.phytochem.2019.04.012
PubMed:: 31071600

12.

Antibacterial Dimeric Acylphloroglucinols from Hypericum japonicum.

Li YP et al (2018).; J Nat Prod.
DOI:: 10.1021/acs.jnatprod.8b00017
PubMed:: 29667821

13.

Hypericum japonicum: a Double-Headed Sword to Combat Vector Control and Cancer.

Cancer

Puthur S et al (2018).; Appl Biochem Biotechnol.
DOI:: 10.1007/s12010-018-2713-7
PubMed:: 29476319

14.

Two New Bioactive α-Pyrones from Hypericum japonicum.

Hu L et al (2016).; Molecules.
DOI:: 10.3390/molecules21040515
PubMed:: 27104499

15.

Phenolic Derivatives from Hypericum japonicum.

Luo G et al (2015).; Nat Prod Commun.
PubMed:: 26882677

16.

Hypericum japonicum Thunb. ex Murray: phytochemistry, pharmacology, quality control and pharmacokinetics of an important herbal medicine.

Review Phytochemistry

Liu LS, Liu MH and He JY (2014).; Molecules.
DOI:: 10.3390/molecules190810733
PubMed:: 25061723

17.

A new bisxanthone from Hypericum japonicum.

Zhang WD et al (2007).; Fitoterapia.
PubMed:: 17067758

18.

Phloroglucinol derivatives from Hypericum japonicum.

Hu LH et al (2000).; Phytochemistry.
PubMed:: 10746884