Common Names: common St. John's wort, common St. Johnswort, Klamath weed, Klamathweed, St. John's wort, St. Johnswort
This study examined the effects of homeopathic Hypericum on postoperative pain in patients undergoing lumbar spine surgery. While no significant differences were found, patients taking Hypericum showed lower analgesic consumption. Further research on this topic is needed.
Scientists sequenced the genome of St. John's wort to identify cells responsible for producing antidepressant compound hyperforin. They discovered key enzymes and pathways, advancing understanding of plant metabolism for potential future applications.
Researchers studied the potential of HPL to improve gut microbiota and alleviate depression symptoms. Understanding this mechanism may lead to novel treatment options for depression.
Plant-derived hypericin was not detectable in peritoneal tissue, making fluorescence-guided laparoscopy (FGL) ineffective in detecting peritoneal metastasis in gastric cancer staging. More research needed to optimize hypericin concentrations for FGL effectiveness.
Tossers investigated GLP and HP for their anti-inflammatory and antioxidant effects on ovarian tissue in rats with PCOS. Results could help understand and potentially treat inflammation-related aspects of PCOS.
Study investigates hyperoside from Hypericum perforatum for antidepressant effects. Results will help understand effectiveness for depression treatment.
Researchers studied hyperforin's effects on VCI, finding it to have neuroprotective potential. Understanding its molecular mechanisms could lead to new therapeutic approaches for cognitive impairment.
Four new compounds were found in St. John's wort. Compounds 1-4 have unique structures and may offer potential for treating hypoglycemia by inhibiting glycogen synthase kinase 3 expression in liver cells.
Photosensitizers from plant extracts were effective in inactivating bacteria, showing potential for antimicrobial photodynamic therapy to combat antimicrobial resistance. The extracts generate singlet oxygen efficiently, with chlorophyll and hypericin as major chromophores. Irradiation with blue light led to significant reduction in bacteria.
Hyperoside, found in Hypericum perforatum L., has potential anti-prostate cancer effects. This study examines its mechanisms in vitro and in vivo.
This study investigated the effectiveness and safety of Shugan Jieyu capsules in treating depression in epilepsy patients. Currently, there are no guidelines for depression treatment in epilepsy patients. It is important because antidepressants may worsen seizures.
The study found that an apolar supercritical CO extract of St. John's wort showed better effects against Alzheimer's disease (AD) compared to other extracts. It improved food intake, body weight, and reduced soluble and insoluble Aβ, suggesting it could be a recommended treatment for mild cognitive impairment or early AD.
St. John's wort shows promise in treating neurodegenerative diseases due to its anti-inflammatory and antioxidant properties, as well as its ability to regulate neurotransmitter systems. Animal studies have shown improved cognitive performance and nerve cell survival. More research is needed for clinical applications.
New compounds and known compounds obtained from an endophyte isolated from [unnamed source]. Structures confirmed through spectroscopic analyses and molecular docking. Compounds 1 and 3 show anti-neuroinflammatory activity in microglial cells. Potential for treatment of neuroinflammatory-related diseases.
This study investigated the effects of olive oil extract on colorectal cancer cells and bone marrow-derived stem cells. Results showed reduced cell migration and colony formation, suggesting potential therapeutic benefits against colorectal cancer.
Scientists have found that natural deep eutectic solvents (NADES) can effectively extract botanical ingredients. NADES are safe, eco-friendly, and versatile, but analyzing the extracted compounds is challenging due to their low concentration in the thick NADES solution.
This study examines the effects of combined plant extracts rich in flavonoids on cytokine levels in stressed rats. The extracts, Antistress I and Antistress II, showed potential in reducing pro-inflammatory cytokines (TNF-α and IL-6) and increasing anti-inflammatory cytokine (IL-10) levels. The combinations were more effective than individual extracts.
This study reviewed herbal medicines and phytochemicals for treating ADHD in children. It offers an updated analysis to aid in making informed decisions for pediatric ADHD treatment.
The study evaluated the effectiveness of and extracts in treating mild to moderate depression. Traditional Iranian medicine uses dried flowers for mental disorder therapy.
Tossers identified HpAP2 genes to study their functions in plant development, hormonal response, and stress. Findings can aid in understanding how these genes affect plant growth and survival.
Plant-derived bioactive compounds, such as vitamin C, polyphenols, curcumin, and resveratrol, have antioxidant and neuroprotective properties, suggesting potential for treating oxidative stress-related diseases like MDD, ASD, ADHD, and neurodegenerative disorders. Additional clinical research is needed to confirm their therapeutic benefits.
Shugan Jieyu Capsule (SJC) is a Chinese medicine compound that uses Hypericum perforatum and Acanthopanacis Senticosi. It is currently used to treat depression, but how it works is not fully understood. Further research is needed to determine the mechanism of action. Understanding this could lead to improved treatment options and potentially help more people in the future.
This study notes that patients can suffer harm from using conventional and complementary medicines together. However, this harm can be avoided. The researchers emphasize the importance of healthcare professionals educating patients about safe practices when using CMs alongside conventional medicine.
Researchers encapsulated an extract into nanophytosomes and tested its effectiveness in treating neuropathic pain caused by nerve damage.
Psychiatric symptoms emerged post-Moderna mRNA vaccination in a patient, effectively treated with St. John's wort. Hypericin in the herb may sensitize post-vaccine administration, highlighting implications for self-medication in mild depression.
A review of 41 studies found that adaptogens, particularly St. John's Wort and saffron, may be effective non-pharmacological strategies for depression. The studies suggest that adaptogens reduce allostatic load via the regulation of BDNF. However, there is limited research on combining adaptogens with physical exercise. The review provides support for the use of St. John's Wort and saffron in depression treatment and highlights the need for more research on the efficacy of other adaptogens and the combination of herbal extracts and resistance training.
Psychiatric symptoms like depression, anxiety, and insomnia are common in epilepsy patients and affect their quality of life. Available antiepileptic drugs do little to alleviate these symptoms, and there's insufficient evidence on existing drugs. This study tested the efficacy of Shugan Jieyu capsule (SJC), a traditional herbal medicine containing and , in treating psychiatric symptoms in epilepsy patients. The study showed that SJC offered significant relief from psychiatric symptoms, making it a potentially viable treatment option for these patients.
A study investigated whether a medicinal plant, HP L., and its nanoemulsion could protect the brain from harmful effects of the chemotherapeutic agent, Cisplatin. HP.NE was tested on rats and showed that it improved motor activity and memory, increased antioxidant defense, reduced inflammation, and lowered brain levels of harmful molecules. HP.NE was found to be more effective at lessening oxidative stress, inflammation, and apoptosis in brain tissue than HP L. alone. These findings suggest that HP L. and its nanoemulsion could be useful in reducing neurotoxicity induced by chemotherapy.
Hyperoside, found in Hypericum perforatum and Crataegus pinnatifida, has potential to treat obesity and metabolic diseases, but more research is needed.
Research has revealed potential herbal medicines for treating mild mood disorders, but with unclear active components. The microbiota-gut-brain axis offers new avenues for treatment and prevention of mood disorders.
St. John's wort is a plant with bioactive compounds that have been found to have therapeutic effects on psychiatric and mood disorders such as PTSD, ADHD, OCD, and anxiety. This review study discusses the role of St. John's wort in modulating depression, with respect to changes in neurotransmitter levels in the brain. The study concludes that changes in neurotransmitter levels in depression are complex and that St. John's wort can have inconsistent effects on them. Future studies should focus on studying glutamate and acetylcholine as important neurotransmitters to understand in depression, and on the dualistic modulation of cholinergic signaling induced by St. John's wort.
Pre-clinical studies have shown that St. John's Wort has a positive effect on cognitive performance in healthy and stress-impaired rodents, making it a potential cognitive-enhancing agent.