Ilex pubescens

Ethnobotanical Studies

Studies

Jin-Xin-Kang alleviates heart failure by mitigating mitochondrial dysfunction through the Calcineurin/Dynamin-Related Protein 1 signaling pathway.

Summary

JXK, a traditional Chinese herbal formula, effectively treats chronic heart failure (CHF) with seven medicinal herbs. While its clinical efficacy is proven, the specific mechanisms remain unknown. Further research is needed for potential cardiac treatment advancements.

Cardiology
Lin L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118685
PubMed:
39127116

Integrated network pharmacology and metabolomics reveal vascular protective effects of Ilex pubescens on thromboangiitis obliterans.

Chen J et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155720
PubMed:
38763010

Chemical and activity investigation on metabolites from the endophytic fungus Penicillium macrosclerotiorum isolated from Ilex pubescens Hook. et Arn.

Chen J, Tao Z and Yang S (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2337111
PubMed:
38646779

A first insight into the genomic background of Ilex pubescens (Aquifoliaceae) by flow cytometry and genome survey sequencing.

Genetics
Zhou P et al (2023).
BMC Genomics.
DOI:
10.1186/s12864-023-09359-5
PubMed:
37208610

Pharmacokinetic and tissue distribution study of six saponins in the rat after oral administration of Ilex pubescens extract using a validated simultaneous UPLC-qTOF-MS/MS assay.

Phytochemistry
Chen B et al (2023).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2023.115431
PubMed:
37148697

Bioassay guided isolation of caffeoylquinic acids from the leaves of Ilex pubescens Hook. et Arn. and investigation of their anti-influenza mechanism.

Wang F et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116322
PubMed:
36868436

Triterpenoid saponins of Ilex pubescens against TNF-α induced inflammation and apoptosis in human umbilical vein endothelial cells via autophagy pathway.

ImmunologyPhytochemistry
Yan X et al (2022).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgac074
PubMed:
36206186

Absorption characteristics of ilexgenin A and ilexsaponin B1 in human umbilical vein endothelial cells after administration of the total triterpenoid saponins from Ilex pubescens.

Phytochemistry
Qiu J et al (2022).
Biomed Chromatogr.
DOI:
10.1002/bmc.5438
PubMed:
35778366

Triterpenoid saponins from Ilex pubescens promote blood circulation in blood stasis syndrome by regulating sphingolipid metabolism and the PI3K/AKT/eNOS signaling pathway.

Phytochemistry
Chen J et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154242
PubMed:
35728385

Uncovering the molecular mechanisms of Ilex pubescens against myocardial ischemia-reperfusion injury using network pharmacology analysis and experimental pharmacology.

Cardiology
Zheng Y et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114611
PubMed:
34537280

Oleuropein Attenuates Lipopolysaccharide-Induced Acute Kidney Injury In Vitro and In Vivo by Regulating Toll-Like Receptor 4 Dimerization.

Cui Y et al (2021).
Front Pharmacol.
DOI:
10.3389/fphar.2021.617314
PubMed:
33841147

Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.

Cardiology
Cheng Y et al (2021).
Theranostics.
DOI:
10.7150/thno.48436
PubMed:
33391509