Ilex rotunda

Common Names: Kurogane holly

Ethnobotanical Studies

Studies

Main active components of Ilex rotunda Thunb. protect against ulcerative colitis by restoring the intestinal mucosal barrier and modulating the cytokine-cytokine interaction pathways.

Summary

Study identified and analyzed the main active components and mechanism of Ilex rotunda in treating ulcerative colitis, providing potential insights for its use in gastrointestinal diseases.

GastroenterologyImmunology
Li Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116961
PubMed:
37541404

Pedunculoside inhibits epithelial-mesenchymal transition and overcomes Gefitinib-resistant non-small cell lung cancer through regulating MAPK and Nrf2 pathways.

Summary

Researchers investigated the potential of Pedunculoside (PE) in treating non-small cell lung cancer (NSCLC) and its resistance to Gefitinib, a common therapy. PE, derived from Ilex rotunda Thunb., has demonstrated anti-inflammatory, lipid-lowering, and anti-tumor effects. The study aimed to understand the therapeutic effect and underlying mechanisms of PE. This research is significant as it may provide insights into new treatment options for NSCLC and combating Gefitinib resistance.

CancerImmunology
Fan Q et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154884
PubMed:
37209605

Relationship between the amount of black carbon particles deposited on the leaf surface and leaf surface traits in nine urban greening tree species.

Ohta A et al (2023).
Int J Phytoremediation.
DOI:
10.1080/15226514.2023.2204148
PubMed:
37148212

Analysis of Antioxidant Constituents from Ilex rotunda and Evaluation of Their Blood-Brain Barrier Permeability.

Summary

A study investigated the antioxidant composition of Thunb., a plant commonly used for medicinal purposes. Twig extracts showed the best potential for antioxidant capacity, and the -butanol fraction had the highest antioxidant effect. Eight marker compounds were isolated, and their structures determined. One compound (4,5-dicaffeoylquinic acid) showed significant antioxidant activity and penetrated the blood-brain barrier. This compound could be used as a potential therapeutic candidate for central nervous system drug discovery.

Neuroscience
Kim CK et al (2022).
Antioxidants (Basel).
DOI:
10.3390/antiox11101989
PubMed:
36290712

A systematic review: Botany, phytochemistry, traditional uses, pharmacology, toxicology, quality control and pharmacokinetics of Ilex rotunda Thunb.

Review Phytochemistry
Zeng W et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115419
PubMed:
35781006

Ilex rotunda Thunb Protects Against Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Restoring the Intestinal Mucosal Barrier and Modulating the Oncostatin M/Oncostatin M Receptor Pathway.

Gastroenterology
Li Y et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.819826
PubMed:
35645824

Absolute bioavailability, dose proportionality, and tissue distribution of rotundic acid in rats based on validated LC-QqQ-MS/MS method.

Shang H et al (2022).
J Pharm Anal.
DOI:
10.1016/j.jpha.2021.03.008
PubMed:
35582394

Seasonal variations in the amount of black carbon particles deposited on the leaf surfaces of nine Japanese urban greening tree species and their related factors.

Takahashi K et al (2023).
Int J Phytoremediation.
DOI:
10.1080/15226514.2022.2072808
PubMed:
35549775

Characterization and phylogenetic analysis of the complete chloroplast genome of Ilex rotunda, traditional Chinese medicine plant.

Genetics
Chen H et al (2021).
Mitochondrial DNA B Resour.
DOI:
10.1080/23802359.2021.1967804
PubMed:
34514128

Extract of Ilex rotunda Thunb alleviates experimental colitis-associated cancer via suppressing inflammation-induced miR-31-5p/YAP overexpression.

Immunology
Chen G et al (2019).
Phytomedicine.
DOI:
10.1016/j.phymed.2019.152941
PubMed:
31100679

ISOLATION OF GLYCOSIDES FROM THE BARKS OF ILEX ROTUNDA BY HIGH-SPEED COUNTER-CURRENT CHROMATOGRAPHY.

Phytochemistry
Wang C et al (2014).
J Liq Chromatogr Relat Technol.
PubMed:
25132792