Inonotus obliquus

Ethnobotanical Studies

Studies

Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds.

Han Z et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1426917
PubMed:
39234117

Physical radiation induced the yield of triterpenoids in hypha of Inonotus obliquus to increase.

Wang Y et al (2024).
J Microbiol Methods.
DOI:
10.1016/j.mimet.2024.107025
PubMed:
39218357

Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens.

Summary

Chaga mushroom extracts from birch species have moderate cytotoxic activity on various cancer cell lines. Extracts from certain species show stronger effects due to higher content of specific compounds. Chaga shows potential as a source of selective anticancer compounds.

Cancer
Raal A et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17081013
PubMed:
39204121

Macrofungal Extracts as a Source of Bioactive Compounds for Cosmetical Anti-Aging Therapy: A Comprehensive Review.

Review
Paterska M, Czerny B and Cielecka-Piontek J (2024).
Nutrients.
DOI:
10.3390/nu16162810
PubMed:
39203946

Impact of Incorporating Dried Chaga Mushroom (Inonotus obliquus) into Gluten-Free Bread on Its Antioxidant and Sensory Characteristics.

Immunology
Kobus Z et al (2024).
Molecules.
DOI:
10.3390/molecules29163801
PubMed:
39202879

A brief overview of the medicinal and nutraceutical importance of Inonotus obliquus (chaga) mushrooms.

Review
Camilleri E et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e35638
PubMed:
39170453

"But how true that is, I do not know": the influence of written sources on the medicinal use of fungi across the western borderlands of the former Soviet Union.

Prakofjewa J et al (2024).
IMA Fungus.
DOI:
10.1186/s43008-024-00156-7
PubMed:
39103962

Comparison of the Controlled Atmosphere Treatment for Submerged and Solid-State Fermentation of Inonotus obliquus.

Chen HJ et al (2024).
Foods.
DOI:
10.3390/foods13142275
PubMed:
39063359

Inonotus obliquus (Chaga) against HFD/STZ-induced glucolipid metabolism disorders and abnormal renal functions by regulating NOS-cGMP-PDE5 signaling pathway.

Feng Y et al (2024).
Chin J Nat Med.
DOI:
10.1016/S1875-5364(24)60571-6
PubMed:
39059831

Comparative Cytotoxicity Evaluation of Heat-Assisted vs Cold Water Extractions of Six Medicinal Fungi against Breast and Lung Cancer Cells.

Cancer
Ng MJ et al (2024).
Food Technol Biotechnol.
DOI:
10.17113/ftb.62.02.24.8424
PubMed:
39045305

A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus.

Review
Tee PYE et al (2024).
Fungal Biol Biotechnol.
DOI:
10.1186/s40694-024-00176-3
PubMed:
38987829

Effects of Chemical Modification on the Structure and Biological Activities of Polysaccharides Extracted from Inonotus Obliquus by Microwave.

Xie H et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400783
PubMed:
38888110

How lignocellulose degradation can promote the quality and function of dietary fiber from bamboo shoot residue by Inonotus obliquus fermentation.

Fang L et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139479
PubMed:
38696939

Structural characterization of the polysaccharide from the black crystal region of Inonotus obliquus and its effect on AsPC-1 and SW1990 pancreatic cancer cell apoptosis.

Summary

IOP1-1, a polysaccharide from Inonotus obliquus, inhibits pancreatic cancer cell growth and induces apoptosis through multiple pathways. Potential adjuvant for cancer treatment.

Cancer
Ding M et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.131891
PubMed:
38677687

Study of active components and mechanisms mediating the hypolipidemic effect of Inonotus obliquus polysaccharides.

Ding G et al (2024).
Food Sci Nutr.
DOI:
10.1002/fsn3.3964
PubMed:
38628208

The Effect of Green Extraction Technologies on the Chemical Composition of Medicinal Chaga Mushroom Extracts.

Lazić V et al (2024).
J Fungi (Basel).
DOI:
10.3390/jof10030225
PubMed:
38535233

Protective effect of Inonotus obliquus polysaccharide on MGO-induced nonenzymatic glycation fibroblasts.

Chen C et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e27458
PubMed:
38496906

Rapid screening and isolation of 5-lipoxygenase inhibitors in Inonotus obliquus and mechanism of action in the treatment of asthma.

Summary

Study developed a new method to efficiently screen and isolate potential active ingredients in Inonotus obliquus for treatment of asthma. Utilized UF mass spectrometry and molecular docking to identify inhibitors of 5-LOX, followed by isolation of betulin, lanosterol, and quercetin.

Asthma
Yun H et al (2024).
J Sep Sci.
DOI:
10.1002/jssc.202300647
PubMed:
38466162

Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity.

Summary

Inonotus obliquus polysaccharides AcF1 and AcF3 activate tumor-fighting functions in macrophages by triggering immune receptors TLR2 and TLR4, showing promise for cancer immunotherapy.

CancerImmunology
Wold CW et al (2024).
Commun Biol.
DOI:
10.1038/s42003-024-05853-y
PubMed:
38396285

Structural analysis of polysaccharide from Inonotus obliquus and investigate combined impact on the sex hormones, intestinal microbiota and metabolism in SPF male mice.

Gastroenterology
Hu B et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129686
PubMed:
38331071

Protective effect of Inonotus obliquus polysaccharide on mice infected with Neospora caninum.

Tang Z et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.129906
PubMed:
38309392

Synergistic Cytotoxicity of Extracts of Chaga Mushroom and Microalgae against Mammalian Cancer Cells In Vitro.

Summary

Chaga mushroom and microalgae extracts showed cytotoxicity against various cancer cell lines. Supercritical water and ethanol-based extracts were most effective, especially when combined. Potential for therapeutic use, but further in vivo studies needed.

Cancer
Wagle S, Lee JA and Rupasinghe HPV (2024).
Oxid Med Cell Longev.
DOI:
10.1155/2024/7944378
PubMed:
38268969

Research Progress on Application of Inonotus obliquus in Diabetic Kidney Disease.

Summary

Inonotus obliquus, a rare medicinal fungi, shows potential in treating diabetic kidney disease (DKD). This paper summarizes its biological activities, pharmacological effects, and latest progress in isolating metabolites for DKD treatment, providing valuable insights for potential application in DKD therapy.

Review Diabetes
Wang S et al (2023).
J Inflamm Res.
DOI:
10.2147/JIR.S431913
PubMed:
38161352

Microwave-Assisted Fabrication of Fugus-Based Biocarbons for Malachite Green and NO(2) Removal.

Bazan-Wozniak A et al (2023).
Materials (Basel).
DOI:
10.3390/ma16247553
PubMed:
38138695

Chaga mushroom: a super-fungus with countless facets and untapped potential.

Review
Fordjour E et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1273786
PubMed:
38116085

Comparative genomic analysis of Sanghuangporus sanghuang with other Hymenochaetaceae species.

Wang X et al (2023).
Braz J Microbiol.
DOI:
10.1007/s42770-023-01212-x
PubMed:
38099978

Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system.

Summary

Studying the potential link between an antidiabetic herb and Alzheimer's disease (AD), researchers tested the effects of raw polysaccharide (IOP) in AD mice. Results may provide insights for AD treatment.

Neuroscience
Wang S et al (2023).
Nutr Res Pract.
DOI:
10.4162/nrp.2023.17.6.1128
PubMed:
38053824

Chaga mushroom triterpenoids as adjuncts to minimally invasive cancer therapies: A review.

Summary

This study reviews the anti-cancer activity of triterpenoids from Chaga mushrooms. Promising results suggest triterpenoid supplementation could be a viable option in cancer treatment. Bioavailability challenges are also discussed.

Cancer
Plehn S, Wagle S and Rupasinghe HPV (2023).
Curr Res Toxicol.
DOI:
10.1016/j.crtox.2023.100137
PubMed:
38046279

I.obliquus sclerotia epidermis were different from internal tissues in compound composition, antioxidant activity and associated fungi.

Immunology
Zhang Y et al (2023).
FEMS Microbiol Lett.
DOI:
10.1093/femsle/fnad126
PubMed:
38017614

Inotodiol ameliorates the progression of osteoarthritis: An in vitro and in vivo study.

Qian W et al (2023).
Drug Res (Stuttg).
DOI:
10.1055/a-2176-4098
PubMed:
37935202

Preventive effects of inotodiol on polyinosinic-polycytidylic acid-induced inflammation in human dermal fibroblasts.

Summary

Inotodiol, a compound found in Chaga mushroom, has significant anti-inflammatory effects. It can suppress the inflammation induced by poly(I:C), which mimics double-strand RNA, in human dermal fibroblast cells. This suggests that inotodiol could be used as an effective anti-inflammatory agent in cosmetics.

Immunology
Won GW et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e20556
PubMed:
37886743

Inonotus obliquus polysaccharide are linear molecules that alter the abundance and composition of intestinal microbiota in Sprague Dawley rats.

Summary

Study investigated how a macromolecular polysaccharide affected intestinal flora in male and female rats. Results could help determine potential gender differences in gut health and guide future research in modulating intestinal flora for health benefits.

Gastroenterology
Liu S et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1231485
PubMed:
37841402

Microwave Heating for Synthesis of Carbonaceous Adsorbents for Removal of Toxic Organic and Inorganic Contaminants.

Bazan-Wozniak A et al (2023).
Molecules.
DOI:
10.3390/molecules28196825
PubMed:
37836668

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism.

You CL et al (2023).
Int J Biol Sci.
DOI:
10.7150/ijbs.84970
PubMed:
37781506

Integrated omic profiling of the medicinal mushroom Inonotus obliquus under submerged conditions.

Hao J et al (2023).
BMC Genomics.
DOI:
10.1186/s12864-023-09656-z
PubMed:
37726686

Antifungal Activity of Cadinane-type Sesquiterpenes from Eupatorium adenophorum against Wood-decaying Fungi.

Summary

The researchers studied Eupatorium adenophorum's antifungal properties against wood-decaying fungi. They found six cadinane-type sesquiterpinoids with high antifungal activity. You should care because this plant extract could be a potential natural antifungal agent for your lab.

Antimicrobial
Yan X et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202300879
PubMed:
37691010

Necessity of Different Lignocellulose on Exopolysaccharide Synthesis and Its Hypoglycemic Activity In Vitro of Inonotus obliquus.

Summary

Researchers found that certain plant materials, like cotton straw, significantly increased the production of polysaccharides with hypoglycemic activity by the fungus Inonotus obliquus, offering insight into ideal materials for polysaccharide synthesis.

Diabetes
Lu X et al (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-023-04716-2
PubMed:
37659052

Protective Effects of Lanostane Triterpenoids from Chaga Mushroom in Human Keratinocytes, HaCaT Cells, against Inflammatory and Oxidative Stresses.

Immunology
Park J et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241612803
PubMed:
37628993

Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo.

Summary

An extract from mixed medicinal mushroom mycelia was shown to reduce the accumulation of amyloid-β plaques and neuroinflammation in an Alzheimer's disease model. It improved cell viability, reduced oxidative damage, and improved memory function in mice. This suggests that the extract may have potential as a treatment for Alzheimer's disease.

Neuroscience
Jeong JH et al (2023).
Curr Issues Mol Biol.
DOI:
10.3390/cimb45080428
PubMed:
37623247

Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.

Review
Łysakowska P, Sobota A and Wirkijowska A (2023).
Molecules.
DOI:
10.3390/molecules28145393
PubMed:
37513265

Inonotsutriol E from Inonotus obliquus exhibits promising anti breast cancer activity via regulating the JAK2/STAT3 signaling pathway.

Summary

Scientists studied a fungus and found compounds that can kill tumor cells, especially in breast cancer. One compound, ITE, inhibits the growth and migration of breast cancer cells by blocking the JAK2/STAT3 signal axis. This study supports the use of this fungus in cancer treatment.

CancerImmunology
Shan P et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2023.106741
PubMed:
37480812

Comparison of Bioactive Secondary Metabolites and Cytotoxicity of Extracts from Inonotus obliquus Isolates from Different Host Species.

Sułkowska-Ziaja K et al (2023).
Molecules.
DOI:
10.3390/molecules28134907
PubMed:
37446570

Mushroom polysaccharides from Grifola frondosa (Dicks.) Gray and Inonotus obliquus (Fr.) Pilat ameliorated dextran sulfate sodium-induced colitis in mice by global modulation of systemic metabolism and the gut microbiota.

Gastroenterology
Sun R et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1172963
PubMed:
37351508

Lignin-degrading enzymes from a pathogenic canker-rot fungus Inonotus obliquus strain IO-B2.

Agnestisia R et al (2023).
AMB Express.
DOI:
10.1186/s13568-023-01566-3
PubMed:
37302091

[Antiviral activity of basidial fungus Inonotus obliquus aqueous extract against SARS-CоV-2 virus (Coronaviridae: Betacoronavirus: Sarbecovirus) in vivo in BALB/c mice model].

Antimicrobial
Shipovalov AV et al (2023).
Vopr Virusol.
DOI:
10.36233/0507-4088-168
PubMed:
37264850

Studies on the interaction mechanism between xanthine oxidase and osmundacetone: Molecular docking, multi-spectroscopy and dynamical simulation.

Song J et al (2023).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2023.122861
PubMed:
37209475

Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids.

Summary

Chaga mushroom extract inhibits bladder cancer cell growth, reduces stemness, and potentiates the effect of chemotherapy, offering potential as a natural supplement to improve treatment outcomes and reduce adverse effects.

Cancer
Abugomaa A et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1159516
PubMed:
37153767

In silico targeting of SARS-CoV-2 spike receptor-binding domain from different variants with chaga mushroom terpenoids.

COVID-19
Amin FG, Elfiky AA and Nassar AM (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2199084
PubMed:
37042960

Fungi as a source of bioactive molecules for the development of longevity medicines.

Review
Shevchuk Y, Kuypers K and Janssens GE (2023).
Ageing Res Rev.
DOI:
10.1016/j.arr.2023.101929
PubMed:
37031727

3,4-Dihydroxybenzalacetone Inhibits the Propagation of Hydrogen Peroxide-Induced Oxidative Effect via Secretory Components from SH-SY5Y Cells.

Ikemoto MJ et al (2023).
Biol Pharm Bull.
DOI:
10.1248/bpb.b22-00727
PubMed:
37005304

Structural diversity, fermentation production, bioactivities and applications of triterpenoids from several common medicinal fungi: Recent advances and future perspectives.

Review
Zhao P et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2023.105470
PubMed:
36914012

Renoprotective Impacts of Inonotus obliquus Ethanol-Ethyl Acetate Extract on Combined Streptozotocin and Unilateral Nephrectomy-Induced Diabetic Nephropathy in Mice.

Diabetes
Chiang KH et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24054443
PubMed:
36901874

Study on the hypolipidemic effect of Inonotus obliquus polysaccharide in hyperlipidemia rats based on the regulation of intestinal flora.

Gastroenterology
Lin F et al (2022).
Food Sci Nutr.
DOI:
10.1002/fsn3.3052
PubMed:
36655098

Microporous Biocarbons Derived from Inonotus obliquus Mushroom and Their Application in the Removal of Liquid and Gaseous Impurities.

Bazan-Wozniak A et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms232415788
PubMed:
36555430

Polysaccharide derived from Inonotus obliquus inhibits lipopolysaccharide-induced acute endometritis in mice.

Sun Y et al (2022).
Am J Transl Res.
PubMed:
36505332

Effect of Inonotus obliquus Extract Supplementation on Endurance Exercise and Energy-Consuming Processes through Lipid Transport in Mice.

Chen YM, Chiu WC and Chiu YS (2022).
Nutrients.
DOI:
10.3390/nu14235007
PubMed:
36501037

Neuroprotective effects of a new triterpenoid from edible mushroom on oxidative stress and apoptosis through the BDNF/TrkB/ERK/CREB and Nrf2 signaling pathway in vitro and in vivo.

Summary

Researchers identified 10 secondary metabolites from the edible mushroom Fr. Pilat, including a new lanostane triterpenoid. The neuroprotective function of all steroidal metabolites was investigated, and results showed that 2α-HI exhibited the most significant neuroprotective activity. The Nrf2 and BDNF/TrkB/ERK/CREB signaling pathway mediated the neuroprotective effects of 2α-HI against oxidative stress and apoptosis. The neuroprotection of 2α-HI was also verified in zebrafish. These findings suggest that Fr. Pilat could be a potential dietary supplement to ameliorate neurodegenerative diseases.

Neuroscience
Kou RW et al (2022).
Food Funct.
DOI:
10.1039/d2fo02854a
PubMed:
36321740

Reclamation of ginseng residues using two-stage fermentation and evaluation of their beneficial effects as dietary feed supplements for piglets.

Xiao D et al (2022).
Waste Manag.
DOI:
10.1016/j.wasman.2022.10.020
PubMed:
36308796

Anti-diabetic effects of Inonotus obliquus extract in high fat diet combined streptozotocin-induced type 2 diabetic mice.

Diabetes
Chen S et al (2022).
Nutr Hosp.
DOI:
10.20960/nh.03838
PubMed:
36173186

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application.

Review
Lu Y et al (2021).
Polymers (Basel).
DOI:
10.3390/polym13091441
PubMed:
33947037

Highly modified steroids from Inonotus obliquus.

Zou CX et al (2020).
Org Biomol Chem.
DOI:
10.1039/d0ob00474j
PubMed:
32400796

Inonotus obliquus polysaccharide ameliorates dextran sulphate sodium induced colitis involving modulation of Th1/Th2 and Th17/Treg balance.

Gastroenterology
Chen YF et al (2019).
Artif Cells Nanomed Biotechnol.
DOI:
10.1080/21691401.2019.1577877
PubMed:
30856346

Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B).

Cancer
Géry A et al (2018).
Integr Cancer Ther.
DOI:
10.1177/1534735418757912
PubMed:
29484963

Review on Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes): Realm of Medicinal Applications and Approaches on Estimating its Resource Potential.

Review
Balandaykin ME and Zmitrovich IV (2015).
Int J Med Mushrooms.
PubMed:
25746615