Inula helenium

Common Names: elecampane inula

Ethnobotanical Studies

Clinical Trials

Efficacy and safety of the syrup "KalobaTUSS®" as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial.

Carnevali I et al (2021).
BMC Pediatr.
DOI:
10.1186/s12887-020-02490-2
PubMed:
33430841

Studies

Targeted isolation of dimeric sesquiterpene lactones and sesquiterpene derivatives from the roots of Inula helenium.

Han JS et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114258
PubMed:
39182534

Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation.

Summary

Alantolactone from Inula helenium kills lung cancer cells through ferroptosis by degrading FTH1 protein. Shows promise as a targeted anticancer treatment.

Cancer
Huang Y et al (2024).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14560
PubMed:
39175059

Inula helenium extract and lidocaine-loaded electrospun wound dressings for managing skin wounds pain and their healing: An in vitro and in vivo study.

Summary

Scientists developed nanofiber dressings loaded with extract and lidocaine to promote wound healing and reduce pain. In vitro and rat model studies showed slow drug release, antioxidant, anti-inflammatory effects, reduced bacterial infiltration, and significant wound closure. These dressings also decreased pain sensitivity and inflammation in animals.

Pain
Wang H et al (2024).
J Biomater Appl.
DOI:
10.1177/08853282241265920
PubMed:
39042854

Determination of prebiotic activity and probiotic encapsulation ability of inulin type fructans obtained from Inula helenium roots.

Meral HD et al (2024).
J Food Sci.
DOI:
10.1111/1750-3841.17261
PubMed:
39042555

Microwave-assisted extraction optimization of sesquiterpene lactones from Inula helenium roots: A sustainable approach to reduce energy consumption and carbon footprint.

Özcan FŞ et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3775
PubMed:
38268885

Effectiveness and tolerance of multicorrective topical treatment for infraorbital dark circles and puffiness.

Rajabi-Estarabadi A et al (2023).
J Cosmet Dermatol.
DOI:
10.1111/jocd.16122
PubMed:
38112168

Isoalantolactone Suppresses Glycolysis and Resensitizes Cisplatin-Based Chemotherapy in Cisplatin-Resistant Ovarian Cancer Cells.

Summary

Isoalantolactone, a compound found in Herba Inulae, can inhibit glycolysis in cisplatin-resistant ovarian cancer cells and sensitize them to cisplatin-induced apoptosis. It also suppresses tumor growth in cisplatin-resistant tumors, offering a potential treatment for overcoming drug resistance in ovarian cancer.

CancerEndocrinology
Chun J et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241512397
PubMed:
37569773

Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.

Summary

Isoalantolactone (LAT) found in Elecampane can alleviate symptoms of depression in mice, showing potential as an alternative treatment for the condition.

GastroenterologyNeuroscience
Wang S et al (2023).
Psychopharmacology (Berl).
DOI:
10.1007/s00213-023-06413-8
PubMed:
37400661

Isoalantolactone mediates the degradation of BCR-ABL protein in imatinib-resistant CML cells by down-regulating survivin.

Yin SS et al (2023).
Cell Cycle.
DOI:
10.1080/15384101.2023.2209963
PubMed:
37202916

The Sesquiterpene Lactone-Rich Fraction of Inula helenium L. Enhances the Antitumor Effect of Anti-PD-1 Antibody in Colorectal Cancer: Integrative Phytochemical, Transcriptomic, and Experimental Analyses.

CancerPhytochemistry
Chun J et al (2023).
Cancers (Basel).
DOI:
10.3390/cancers15030653
PubMed:
36765611

Alantolactone inhibits oesophageal adenocarcinoma cells through nuclear factor erythroid 2-related factor 2-mediated reactive oxygen species increment.

Chen J et al (2023).
Basic Clin Pharmacol Toxicol.
DOI:
10.1111/bcpt.13824
PubMed:
36507595

Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway.

Cancer
Hu Y et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154528
PubMed:
36343549

Mongolian medicine in treating type 2 diabetes mellitus combined with nonalcoholic fatty liver disease via FXR/LXR-mediated P2X7R/NLRP3/NF-κB pathway activation.

Review DiabetesImmunology
Bao S et al (2022).
Chin Herb Med.
DOI:
10.1016/j.chmed.2022.06.003
PubMed:
36118003

In vitro evaluation of the effects of methanolic plant extracts on the embryonation rate of Ascaridia galli eggs.

Poulopoulou I et al (2022).
Vet Res Commun.
DOI:
10.1007/s11259-022-09958-9
PubMed:
35727416

Biological Activities and Chemical Profile of Gentiana asclepiadea and Inula helenium Ethanolic Extracts.

Buza V et al (2022).
Molecules.
DOI:
10.3390/molecules27113560
PubMed:
35684497

Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways.

Cancer
Yang C et al (2020).
Genes Dis.
DOI:
10.1016/j.gendis.2020.07.014
PubMed:
35224161

Systematic exploration of the potential material basis and molecular mechanism of the Mongolian medicine Nutmeg-5 in improving cardiac remodeling after myocardial infarction.

Cardiology
Liu T et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2021.114847
PubMed:
34800647

Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage.

Genetics
Nder AE et al (2021).
J Tradit Chin Med.
PubMed:
33825410

Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways.

Immunology
Dang X et al (2020).
Respir Res.
DOI:
10.1186/s12931-020-01358-4
PubMed:
32321531

Effect of remained stem height on yield, quality of Inula helenium I. and on soil water content.

Ma L et al (2018).
Saudi J Biol Sci.
DOI:
10.1016/j.sjbs.2017.10.016
PubMed:
30174524

Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway.

Cancer
Cui L et al (2018).
Arch Pharm Res.
DOI:
10.1007/s12272-017-0990-2
PubMed:
29214600

Microwave-assisted Extraction of Alantolactone and Isoalantolactone from Inula helenium.

Zhao YM et al (2015).
Indian J Pharm Sci.
PubMed:
25767328

Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica.

Phytochemistry
Li Y et al (2012).
Z Naturforsch C J Biosci.
PubMed:
23016276