Inula japonica

Ethnobotanical Studies

Studies

Characterization of Sesquiterpene Dimers from the Flowers of Inula japonica and the Structural Revisions of Related Compounds.

Niu Z et al (2024).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.4c00269
PubMed:
38982404

Inulae Flos has Anti-Depressive Effects by Suppressing Neuroinflammation and Recovering Dysfunction of HPA-axis.

Summary

Inulae Flos (IF) alleviates depression by reducing neuroinflammation and restoring HPA-axis function in vitro and in vivo studies. Potential new therapy for depression.

Neuroscience
Kim JS et al (2024).
Mol Neurobiol.
DOI:
10.1007/s12035-024-04094-8
PubMed:
38457106

Integrated Pharmaco-Bioinformatics Approaches and Experimental Verification To Explore the Effect of Britanin on Nonalcoholic Fatty Liver Disease.

Dou C et al (2024).
ACS Omega.
DOI:
10.1021/acsomega.3c08968
PubMed:
38405493

Anti-Fibrosis Effect of Panax ginseng and Inula japonica Formula in Human Pulmonary Fibroblasts.

Jung Y et al (2024).
Nutrients.
DOI:
10.3390/nu16020319
PubMed:
38276557

Identification of diverse sesquiterpenoids with anti-fibrotic potential from Inula japonica Thunb.

Peng Y et al (2023).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2023.107084
PubMed:
38176376

Corrigendum to "Essential oils from Inula japonica and Angelicae dahuricae enhance sensitivity of MCF-7/ADR breast cancer cells to doxorubicin via multiple mechanisms" [J. Ethnopharmacol. 180 (2016) 18-27].

Cancer
Wu M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117496
PubMed:
38008656

Ethanol Extracts from the Aerial Parts of Inula japonica and Potentilla chinensis Alleviate Airway Inflammation in Mice That Inhaled Particulate Matter 10 and Diesel Particulate Matter.

Immunology
Jung SH et al (2023).
Nutrients.
DOI:
10.3390/nu15214599
PubMed:
37960252

Britanin inhibits titanium wear particle‑induced osteolysis and osteoclastogenesis.

Kim JA et al (2023).
Mol Med Rep.
DOI:
10.3892/mmr.2023.13092
PubMed:
37732549

Essential oil from Inula japonica Thunb. And its phenolic constituents ameliorate pulmonary injury and fibrosis in bleomycin-treated mice.

Summary

Inula japonica essential oil (EOI) is used in Chinese medicine for lung diseases. This study investigates EOI's impact and mechanism on pulmonary injury and fibrosis, crucial for potential therapeutic applications.

Phytochemistry
Wei F et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117169
PubMed:
37704119

Chemical constituents from the flowers of Inula japonica and their anti-inflammatory activity.

Summary

Scientists investigated the therapeutic properties of Inula japonica flowers in traditional Chinese medicine for treating cough, asthma, and phlegm and found potential benefits worth considering for further research in the lab.

Immunology
Li J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117052
PubMed:
37597674

Genetic deletion or pharmacological inhibition of soluble epoxide hydrolase attenuated particulate matter 2.5 exposure mediated lung injury.

Zhang J et al (2023).
J Hazard Mater.
DOI:
10.1016/j.jhazmat.2023.131890
PubMed:
37406527

A polysaccharide from Inula japonica showing in vivo antitumor activity by interacting with TLR-4, PD-1, and VEGF.

Summary

Researchers have purified a polysaccharide (IJP70-1) from Inula japonica flowers, a traditional medicinal plant. IJP70-1, with a molecular weight of 1.019 × 10 Da, has a unique structure composed of various sugar units. Studies using zebrafish models showed that IJP70-1 has promising antitumor activity. Interestingly, this activity is not due to direct toxicity, but rather through activating the immune system and inhibiting angiogenesis by interacting with specific proteins. These findings suggest that IJP70-1 has the potential to be developed into an effective anticancer agent.

Cancer
Wang X et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.125555
PubMed:
37364807

Eupatin, a Flavonoid, Inhibits Coronavirus 3CL Protease and Replication.

Summary

Eupatin, found in flowers, inhibits coronavirus protease and replication. It reduces plaque formation, viral protein, and RNA levels, showing potential as a remedy for coronavirus disease.

COVID-19Phytochemistry
Park YI et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24119211
PubMed:
37298159

Nitrogen Deposition Effects on Invasive and Native Plant Competition: Implications for Future Invasions.

Guo X et al (2023).
Ecotoxicol Environ Saf.
DOI:
10.1016/j.ecoenv.2023.115029
PubMed:
37216867

Effects of salt stress on interspecific competition between an invasive alien plant Oenothera biennis and three native species.

Guo X et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1144511
PubMed:
37025129

Inhibition effect of 1-acetoxy-6α-(2-methylbutyryl)eriolanolide toward soluble epoxide hydrolase: Multispectral analysis, molecular dynamics simulation, biochemical, and in vitro cell-based studies.

Zhang J et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123911
PubMed:
36878397

Inula japonica ameliorated the inflammation and oxidative stress in LPS-induced acute lung injury through the MAPK/NF-κB and Keap1/Nrf2 signalling pathways.

Immunology
Zhang M et al (2023).
J Pharm Pharmacol.
DOI:
10.1093/jpp/rgac084
PubMed:
36617177

Total flavonoids of Inula japonica alleviated the inflammatory response and oxidative stress in LPS-induced acute lung injury via inhibiting the sEH activity: Insights from lipid metabolomics.

ImmunologyPhytochemistry
Zhang J et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154380
PubMed:
36150346

A Botanical Mixture Consisting of Inula japonica and Potentilla chinensis Relieves Obesity via the AMPK Signaling Pathway in 3T3-L1 Adipocytes and HFD-Fed Obese Mice.

Obesity
Lee SY et al (2022).
Nutrients.
DOI:
10.3390/nu14183685
PubMed:
36145056

Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury.

Immunology
Zhang J et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154377
PubMed:
36116200

Study on inhibition of Britannin on triple-negative breast carcinoma through degrading ZEB1 proteins.

Lu H et al (2022).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154291
PubMed:
35839735

Antimelanogenic activity of patuletin from Inula japonica flowers in B16F10 melanoma cells and zebrafish embryos.

Lee IS and Kim JH (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2021.1983812
PubMed:
34933629

Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase.

Zhao WY et al (2020).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2020.104065
PubMed:
32663670

Bioactive sesquiterpenoids and sesquiterpenoid glucosides from the flowers of Inula japonica.

Yu ZP et al (2019).
Fitoterapia.
DOI:
10.1016/j.fitote.2019.104292
PubMed:
31398451

Inula Japonica Thunb. Flower Ethanol Extract Improves Obesity and Exercise Endurance in Mice Fed A High-Fat Diet.

Obesity
Park SH et al (2018).
Nutrients.
DOI:
10.3390/nu11010017
PubMed:
30577560