Central Europe
- PubMed:
- 36616265
Common Names: savin
Certain Cupressaceae species have active antiarrhythmic components, providing potential for preventing cardiac arrhythmias and reducing sudden cardiac death. Importance lies in developing new, effective and safe treatments.
This study shows that cupressuflavone (CUP), a bioflavonoid found in Abhal plants, has neuroprotective effects on brain ischemia/reperfusion (IR) injury in rats. CUP reduces neurological deficits, inflammation, and oxidative stress, potentially making it a promising treatment for stroke.
The study found beneficial compounds in roots and leaves of a plant used in Chinese medicine, with potential for medicinal purposes. The findings emphasize the importance of understanding chemical differences in plant tissues for effective utilization.
The aerial parts of a plant species contain bioflavonoids, including cupressuflavone (CPF), a biflavonoid with various biological activities. To improve the bioavailability of CPF, three self-emulsifying drug delivery systems (SEDDS) were prepared and administered via the intranasal route to rats. Formulations B and C decreased the locomotor activity and balance of rats, with formula C at an intranasal dose of 5 mg/kg having the strongest effect. This study suggests that nose-to-brain drug delivery may be an effective method for treating neurological disorders.