Kaempferia galanga

Common Names: galanga

Ethnobotanical Studies

Studies

Kaempferia galanga L. alleviates the expression of COX-2 and NF-kappaB-p65 in the oral mucosa ulcer of Wistar rats and exhibits no irritation toward the vascular membrane of chicken eggs and the skin of albino rabbits.

Immunology
Wahyuni IS et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e35827
PubMed:
39224366

Effect of Kencur (Kaempferia galanga L.) Ethanolic Extract Treatment on Cerebral Caspase-3 Expression in Traumatic Brain Injury Rat Models.

Summary

Kencur extract may help prevent cell death in traumatic brain injury by inhibiting caspase-3, potentially reducing oxidative stress and inflammation.

Neuroscience
Suryo AP et al (2024).
Malays J Med Sci.
DOI:
10.21315/mjms2024.31.2.5
PubMed:
38694581

Synthesis of molecularly imprinted polymer with a methacrylate derivative monomer for the isolation of ethyl p-methoxycinnamate as an active compound from Kaempferia galanga L. extracts.

Ariani MD et al (2024).
RSC Adv.
DOI:
10.1039/d4ra01018c
PubMed:
38665502

Dual action effects of ethyl-p-methoxycinnamate against dengue virus infection and inflammation via NF-κB pathway suppression.

Immunology
Tarasuk M et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-60070-1
PubMed:
38654034

Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract.

Wahyuni IS et al (2024).
Pharmaceutics.
DOI:
10.3390/pharmaceutics16030421
PubMed:
38543315

Ethyl cinnamate suppresses tumor growth through anti-angiogenesis by attenuating VEGFR2 signal pathway in colorectal cancer.

Summary

Kaempferia galanga Linn. herb has anti-tumor potential due to ethyl cinnamate (EC) content. Its anti-angiogenic and tumor suppression effects require further research.

CancerGastroenterology
Wang S et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117913
PubMed:
38360380

In-silico molecular docking and molecular dynamic simulation of γ-elemene and caryophyllene identified from the essential oil of Kaempferia galanga L. against biofilm forming proteins, CrtM and SarA of Staphylococcus aureus.

Phytochemistry
Sharma V et al (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2024.2310773
PubMed:
38321959

Potent anti-angiogenic component in Kaempferia galanga L. and its mechanism of action.

Huang W et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117811
PubMed:
38286156

Antimicrobial and Antiproliferative Effects of Zingiberaceae Oils: A Natural Solution for Oral Health.

Summary

This study evaluated the antibacterial and antiproliferative activity of essential oils from four Zingiberaceae species for oral care. Curcuma xanthorrhiza and Curcuma mangga oils showed strong antibacterial properties, suggesting they could be used as natural alternatives in oral care products. Further research is needed to explore their therapeutic potential.

AntimicrobialCancer
Amil MA et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202301836
PubMed:
38253795

Anti-inflammatory and wound healing effects of mouth gel containing kaempulchraol K from Kaempferia galanga rhizomes.

Summary

Researchers investigated the healing properties of Kaempferia galanga L., a medicinal plant traditionally used in Thailand for inflammation and wounds. Understanding its effectiveness could benefit lab decisions regarding potential treatments.

Immunology
Pathan N, Iadnut A and Tewtrakul S (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117762
PubMed:
38219883

Kaempferol attenuates carbon tetrachloride (CCl(4))-induced hepatic fibrosis by promoting ASIC1a degradation and suppression of the ASIC1a-mediated ERS.

Cao R et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155125
PubMed:
37820466

The dissolution of p-methoxycinnamic acid-β-cyclodextrin inclusion complex produced with microwave irradiation.

Isadiartuti D et al (2023).
J Public Health Afr.
DOI:
10.4081/jphia.2023.2500
PubMed:
37492546

Effects of atmospheric dust particles on common medicinal plants in an industrial area of West Bengal, India.

Majee CK, Ali SY and Padhy PK (2023).
Environ Monit Assess.
DOI:
10.1007/s10661-023-11573-3
PubMed:
37477710

Kaempferia galanga L. extract and its main component, ethyl p-methoxycinnamate, inhibit the proliferation of Ehrlich ascites tumor cells by suppressing TFAM expression.

Summary

In this study, researchers explored the mechanism behind the anti-cancer effects of L. rhizome extracts (KGEs). They found that KGEs inhibit the proliferation of Ehrlich ascites tumor cells by impacting cell cycle progression. The main component of KGEs, ethyl-methoxycinnamate (EMC), also displayed anti-proliferative effects. Additionally, EMC affected the expression of key proteins involved in cell cycle regulation, such as cyclin D1 and p21. Importantly, the study demonstrated that EMC and KGEs can suppress the growth of ascites fluid in mice with EATC. These findings provide valuable insights into the potential therapeutic applications of KGEs and EMC in cancer treatment.

Cancer
Sasaki Y et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e17588
PubMed:
37408910

Preclinical evaluation of antimalarial activity of CPF-1 formulation as an alternative choice for the treatment of malaria.

Chaniad P et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-03973-2
PubMed:
37143036

Evaluation of Larvicidal Activity of Kaempferia galanga Extracts Against Aedes aegypti Larvae.

Anwar R et al (2022).
Pak J Biol Sci.
DOI:
10.3923/pjbs.2022.1040.1046
PubMed:
36978271

An in vitro analysis on the antioxidant and anti-diabetic properties of Kaempferia galanga rhizome using different solvent systems.

Diabetes
Vishaka S, Sridevi G and Selvaraj J (2022).
J Adv Pharm Technol Res.
DOI:
10.4103/japtr.japtr_189_22
PubMed:
36798576

Kaempferide ameliorates cisplatin-induced nephrotoxicity via inhibiting oxidative stress and inducing autophagy.

Shao YF et al (2023).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-023-01051-4
PubMed:
36658427

Novel ethyl p-methoxy cinnamate rich Kaempferia galanga (L.) essential oil and its pharmacological applications: special emphasis on anticholinesterase, anti-tyrosinase, α-amylase inhibitory, and genotoxic efficiencies.

Phytochemistry
Begum T et al (2023).
PeerJ.
DOI:
10.7717/peerj.14606
PubMed:
36643622

Insecticidal and Feeding Deterrent Effects of Kaempferia galanga L. and Amomum subulatum on Pieris rapae L. Larva.

Pham HH et al (2022).
Pak J Biol Sci.
DOI:
10.3923/pjbs.2022.971.977
PubMed:
36591927

Ultraviolet Radiation Protective and Anti-Inflammatory Effects of Kaempferia galanga L. Rhizome Oil and Microemulsion: Formulation, Characterization, and Hydrogel Preparation.

Immunology
Chittasupho C et al (2022).
Gels.
DOI:
10.3390/gels8100639
PubMed:
36286140

Anti-Inflammatory Activity and Wound Healing Effect of Kaempferia galanga L. Rhizome on the Chemical-Induced Oral Mucosal Ulcer in Wistar Rats.

Immunology
Wahyuni IS et al (2022).
J Inflamm Res.
DOI:
10.2147/JIR.S359042
PubMed:
35422649

Mitigative capacity of Kaempferia galanga L. and kaempferol on heterocyclic amines and advanced glycation end products in roasted beef patties and related mechanistic analysis by density functional theory.

Xue C et al (2022).
Food Chem.
DOI:
10.1016/j.foodchem.2022.132660
PubMed:
35306240

Derivatives of Cinnamic Acid Esters and Terpenic Diversity in Volatiles of Thirty-Six Sand Ginger (Kaempferia galanga L.) Accessions of Eastern India Revealing Quality Chemovars.

Singh S et al (2022).
Molecules.
DOI:
10.3390/molecules27031116
PubMed:
35164381

Wound healing properties of pharmaceutical gel containing isopimarane diterpene isolated from Kaempferia galanga L.

Phytochemistry
Sudsai T, Tungcharoen P and Tewtrakul S (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115052
PubMed:
35101569

Isopimarane-type diterpenoids from the rhizomes of Kaempferia galanga L. and their biological activities.

Wisetsai A et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2021.1989681
PubMed:
34636702

Anti-inflammatory effect of isopimarane diterpenoids from Kaempferia galanga.

Immunology
Tungcharoen P et al (2020).
Phytother Res.
DOI:
10.1002/ptr.6549
PubMed:
31755164

Complete Chloroplast Genome Sequences of Kaempferia Galanga and Kaempferia Elegans: Molecular Structures and Comparative Analysis.

Genetics
Li DM, Zhao CY and Liu XF (2019).
Molecules.
DOI:
10.3390/molecules24030474
PubMed:
30699955

Antinociceptive activity of the methanolic extract of Kaempferia galanga Linn. in experimental animals.

Pain
Ridtitid W et al (2008).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2008.04.002
PubMed:
18486374