Lagenaria siceraria

Common Names: birdhouse gourd, bottle gourd, calabash, dipper gourd, Hercules club gourd, Italian edible gourd

Ethnobotanical Studies

Studies

The de novo assembly and characterization of the complete mitochondrial genome of bottle gourd (Lagenaria siceraria) reveals the presence of homologous conformations produced by repeat-mediated recombination.

Genetics
Qin N et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1416913
PubMed:
39188545

Prophylactic impacts of Lagenaria siceraria against cardiomyopathy induced by doxorubicin in a rat model.

Summary

Researchers studied the potential of resveratrol to protect against doxorubicin-induced heart damage in cancer treatment. Result: resveratrol showed promise as a protective agent. Important for improving cancer treatment outcomes.

Cardiology
Almohmadi NH et al (2024).
Open Vet J.
DOI:
10.5455/OVJ.2024.v14.i7.16
PubMed:
39175975

Investigating the Reactive Reinforcement Ability of Maleic Anhydride-Modified Cellulose Nanocrystals via In-Situ Emulsion Polymerization.

Meda RS et al (2024).
ACS Omega.
DOI:
10.1021/acsomega.3c07849
PubMed:
39130565

A Transcriptomic Analysis of Bottle Gourd-Type Rootstock Roots Identifies Novel Transcription Factors Responsive to Low Root Zone Temperature Stress.

Liu J et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25158288
PubMed:
39125858

Combined BSA-Seq and RNA-Seq to Identify Potential Genes Regulating Fruit Size in Bottle Gourd (Lagenaria siceraria L.).

Genetics
Fang H et al (2024).
Plants (Basel).
DOI:
10.3390/plants13152154
PubMed:
39124272

Exogenous Sodium Nitroprusside Alleviates Drought Stress in Lagenaria siceraria.

Zhang X et al (2024).
Plants (Basel).
DOI:
10.3390/plants13141972
PubMed:
39065499

Ocimum basilicum and Lagenaria siceraria Loaded Lignin Nanoparticles as Versatile Antioxidant, Immune Modulatory, Anti-Efflux, and Antimicrobial Agents for Combating Multidrug-Resistant Bacteria and Fungi.

Summary

Lignin nanoparticles show strong antimicrobial and antifungal activity, lower efflux pump gene expression, and improve blood and organ parameters in rats. They can be used for drug delivery and treating Salmonella and fungal infections.

AntimicrobialImmunology
El-Samahy LA et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13070865
PubMed:
39061933

Nutritional Variation on Sequentially Harvested Shoots and Fruits of Lagenaria siceraria Landraces.

Buthelezi LG et al (2024).
Plants (Basel).
DOI:
10.3390/plants13111475
PubMed:
38891284

A Comprehensive Perception of Biological Control Potential of Endophytes and Quality Refinement of Lagenaria siceraria.

Rehan N et al (2024).
Curr Microbiol.
DOI:
10.1007/s00284-024-03706-9
PubMed:
38771325

Archaeobotanical evidence supports indigenous cucurbit long-term use in the Mesoamerican Neotropics.

Domic AI et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-60723-1
PubMed:
38740801

A green and economic approach to synthesize magnetic Lagenaria siceraria biochar (γ-Fe(2)O(3)-LSB) for methylene blue removal from aqueous solution.

Mishra A et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-33477-6
PubMed:
38696013

Chitosan-Loaded Lagenaria siceraria and Thymus vulgaris Potentiate Antibacterial, Antioxidant, and Immunomodulatory Activities against Extensive Drug-Resistant Pseudomonas aeruginosa and Vancomycin-Resistant Staphylococcus aureus: In Vitro and In Vivo Approaches.

Immunology
Taha SM et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13040428
PubMed:
38671876

Detection of typical indigenous gut bacteria related to kanpyo Lagenaria siceraria var. hispida powder in murine caecum and human faecal cultures.

Gastroenterology
Yamamoto M et al (2024).
3 Biotech.
DOI:
10.1007/s13205-024-03960-5
PubMed:
38524237

Genomic and pangenomic analyses provide insights into the population history and genomic diversification of bottle gourd.

Zhao X et al (2024).
New Phytol.
DOI:
10.1111/nph.19673
PubMed:
38503725

Trace metals translocation from soil to plants: Health risk assessment via consumption of vegetables in the urban sprawl of a developing country.

Haque KS et al (2024).
Food Chem Toxicol.
DOI:
10.1016/j.fct.2024.114580
PubMed:
38467293

Foodborne Disease Outbreaks Caused by Biotoxins in Yantai City: A 10-Year Spatiotemporal Monitoring Study.

Dong F et al (2023).
Foodborne Pathog Dis.
DOI:
10.1089/fpd.2023.0112
PubMed:
38112728

Transcriptome and Metabolome Analyses Reveal That Jasmonic Acids May Facilitate the Infection of Cucumber Green Mottle Mosaic Virus in Bottle Gourd.

Genetics
Li Z et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242316566
PubMed:
38068889

Investigating Mineral Accumulation and Seed Vigor Potential in Bottle Gourd (Lagenaria siceraria) through Crossbreeding Timing.

Malik A et al (2023).
Plants (Basel).
DOI:
10.3390/plants12233998
PubMed:
38068633

Cucumber grafting on indigenous cucurbit landraces confers salt tolerance and improves fruit yield by enhancing morpho-physio-biochemical and ionic attributes.

Abbas F et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-48947-z
PubMed:
38066051

Comparative Evaluation of Volatile Organic Compounds in Two Bottle Gourd Accessions with Distinct Fruit Shapes.

Zia B et al (2023).
Foods.
DOI:
10.3390/foods12213921
PubMed:
37959039

First Report of Cucurbit aphid-borne yellows virus infecting five cucurbits in India.

Verma R, Verma A and Tripathi S (2023).
Plant Dis.
DOI:
10.1094/PDIS-09-23-1719-PDN
PubMed:
37883637

Alleviation of salinity stress in zinc oxide nanoparticle-treated Lagenaria siceraria L. by modulation of physiochemical attributes, enzymatic and non-enzymatic antioxidative system.

Javeed A, Ahmed S and Sardar R (2023).
Funct Plant Biol.
DOI:
10.1071/FP23069
PubMed:
37875018

Cucurbitacins B, E and I Concentrations and Relationship with Drought Tolerance in Bottle Gourd [Lagenaria siceraria (Molina) Standl.].

Mkhize P, Shimelis H and Mashilo J (2023).
Plants (Basel).
DOI:
10.3390/plants12193492
PubMed:
37836232

Correction to: Tramadol Biological Effects: 4: Effective Therapeutic Efficacy of Lagenaria siceraria Preparation (Gamal & Aref1) and Melatonin on Cell Biological, Histochemical, and Histopathological Changes in the Kidney of Tramadol-Induced Male Mice.

(2023).
Microsc Microanal.
DOI:
10.1093/micmic/ozac056
PubMed:
37749718

Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis.

Xu D et al (2023).
Biochem Pharmacol.
DOI:
10.1016/j.bcp.2023.115810
PubMed:
37717690

Safety and antidiabetic activity of Lagenaria siceraria (Molina) Standl. juice in streptozotocin -induced diabetic rats.

Summary

Researchers investigated the potential antidiabetic effects and toxicity of Lagenaria siceraria (Molina) Standl. Juice. This has implications for developing affordable and safer dietary alternatives for diabetes management in India.

Diabetes
Das MJ et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117111
PubMed:
37673199

A 'green' adsorbent: effect of chemical modification of biosorbents on the adsorption of methylene blue and malachite green.

Franceschini SB et al (2023).
An Acad Bras Cienc.
DOI:
10.1590/0001-3765202320210124
PubMed:
37586007

Utilization of bottle gourd (Lagenaria siceraria (Mol.) Standl.) pomace for the preparation of instant kheer (dessert) mix.

Abrol GS et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e18533
PubMed:
37576206

Effect of citric acid on phytoextraction potential of Cucurbita pepo, Lagenaria siceraria, and Raphanus sativus plants exposed to multi-metal stress.

Ibrahim EA et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-40233-2
PubMed:
37567950

In silico studies on the phytochemical components of Lagenaria siceraria targeting aromatase receptors against breast cancer.

Summary

This study investigated the potential use of natural compounds against breast cancer. Five substances showed higher binding affinity than a commonly used treatment, Tamoxifen.

CancerPhytochemistry
Samajdar S and Mondal P (2023).
In Silico Pharmacol.
DOI:
10.1007/s40203-023-00155-3
PubMed:
37525849

Comprehensive analyses of microtubule-associated protein MAP65 family genes in Cucurbitaceae and CsaMAP65s expression profiles in cucumber.

Genetics
Liang M et al (2023).
J Appl Genet.
DOI:
10.1007/s13353-023-00761-z
PubMed:
37219731

In vivo antimalarial activity of the 80% methanolic crude fruit extract of Lagenaria siceraria (Molina) Standl. against Plasmodium berghei infected mice.

Habte G, Tamiru S and Eyasu K (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e15453
PubMed:
37151678

Genome-wide characterization and expression analysis of the MLO gene family sheds light on powdery mildew resistance in Lagenaria siceraria.

Genetics
Wang J et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e14624
PubMed:
37025859

Comparative Analysis of Traditional Oriental Herbal Fruits as Potential Sources of Polyphenols and Minerals for Nutritional Supplements.

Quesada-Granados JJ et al (2023).
Molecules.
DOI:
10.3390/molecules28062682
PubMed:
36985653

Forward genetic studies reveal LsAPRR2 as a key gene in regulating the green color of pericarp in bottle gourd (Lagenaria siceraria).

Huo Y et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1130669
PubMed:
36875578

Insight into the bZIP gene family in Lagenaria siceraria: Genome and transcriptome analysis to understand gene diversification in Cucurbitaceae and the roles of LsbZIP gene expression and function under cold stress.

Genetics
Wang J et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2022.1128007
PubMed:
36874919

How Does Lagenaria siceraria (Bottle Gourd) Metabolome Compare to Cucumis sativus (Cucumber) F. Cucurbitaceae? A Multiplex Approach of HR-UPLC/MS/MS and GC/MS Using Molecular Networking and Chemometrics.

El-Akad RH, El-Din MGS and Farag MA (2023).
Foods.
DOI:
10.3390/foods12040771
PubMed:
36832849

Variation in Shoot, Peduncle and Fruit Growth of Lagenaria siceraria Landraces.

Buthelezi LG et al (2023).
Plants (Basel).
DOI:
10.3390/plants12030532
PubMed:
36771617

Rootstocks Comparison in Grafted Watermelon under Water Deficit: Effects on the Fruit Quality and Yield.

Morales C et al (2023).
Plants (Basel).
DOI:
10.3390/plants12030509
PubMed:
36771594

Identification of Bottle Gourd (Lagenaria siceraria) OVATE Family Genes and Functional Characterization of LsOVATE1.

Genetics
Feng Z et al (2022).
Biomolecules.
DOI:
10.3390/biom13010085
PubMed:
36671470

Novel detection method to rapidly quantify toxic cucurbitacin in Lagenaria siceraria (bottle gourd).

Saurabh CK, Ghosh SK and Sanyal B (2023).
J Food Sci Technol.
DOI:
10.1007/s13197-022-05600-3
PubMed:
36618033

Effect of Leaf Trichomes in Different Species of Cucurbitaceae on Attachment Ability of the Melon Ladybird Beetle Chnootriba elaterii.

Saitta V et al (2022).
Insects.
DOI:
10.3390/insects13121123
PubMed:
36555032

Tendril Anatomy: A Tool for Correct Identification among Cucurbitaceous Taxa.

Abbas N et al (2022).
Plants (Basel).
DOI:
10.3390/plants11233273
PubMed:
36501313

Solubility enhancement of extract of Lagenaria siceraria by development of Phospholipon® 90 H modulated phospholipid complex employing Box-Behnken design.

Rarokar NR et al (2022).
Ann Pharm Fr.
DOI:
10.1016/j.pharma.2022.11.007
PubMed:
36375530

Scions impact biomass allocation and root enzymatic activity of rootstocks in grafted melon and watermelon plants.

Sallaku G et al (2022).
Front Plant Sci.
DOI:
10.3389/fpls.2022.949086
PubMed:
36247619

Preparation and sulfate modified of Lagenaria siceraria (Molina) Standl polysaccharide and its immune-enhancing adjuvant activity.

Wusiman A et al (2022).
Poult Sci.
DOI:
10.1016/j.psj.2022.102112
PubMed:
36067576

Combining LC-MS/MS profiles with network pharmacology to predict molecular mechanisms of the hyperlipidemic activity of Lagenaria siceraria stand.

Banerjee S et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115633
PubMed:
36031104

Seasonal Variations in Bioaccumulation and Translocation of Toxic Heavy Metals in the Dominant Vegetables of East Kolkata Wetlands: a Case Study with Suggestive Ecorestorative Strategies.

Agarwal S et al (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-022-04057-6
PubMed:
35852756

Morpho-Agronomic Evaluation of Lagenaria siceraria Landraces and Their F(1) Populations.

Nkosi LS, Ntuli NR and Mavengahama S (2022).
Plants (Basel).
DOI:
10.3390/plants11121558
PubMed:
35736709

Extraction and Characterization of Microcrystalline Cellulose from Lagenaria siceraria Fruit Pedicles.

Asif M et al (2022).
Polymers (Basel).
DOI:
10.3390/polym14091867
PubMed:
35567035

Lagenaria siceraria and it's bioactive constituents in carbonic anhydrase inhibition: A bioactivity guided LC-MS/MS approach.

Chanda J et al (2021).
Phytochem Anal.
DOI:
10.1002/pca.2975
PubMed:
32683785

Medicinal Plants in the Treatment of Obsessive-Compulsive Disorder: A Review.

Summary

This study investigated the potential effectiveness of an herbal remedy called ashwagandha root extract in treating OCD. They conducted a double-blind, randomized, placebo-controlled trial with 60 participants over 12 weeks. The group taking the ashwagandha extract showed significant reduction in OCD symptoms compared to the placebo group. The researchers conclude that ashwagandha may be a promising herbal remedy for OCD treatment. However, more research is needed to confirm these findings and determine the long-term safety and effectiveness.

Review Neuroscience
Talaei A, Forouzanfar F and Akhondzadeh S (2021).
Curr Drug Discov Technol.
DOI:
10.2174/1570163816666191011105050
PubMed:
31660838

Lagenaria siceraria - synthesised ZnO NPs - a valuable green route to control the malaria vector Anopheles stephensi.

Vellore Nagarajan K and Vijayarangan DR (2019).
IET Nanobiotechnol.
DOI:
10.1049/iet-nbt.2018.5011
PubMed:
31051447

Radioprotective potential of Lagenaria siceraria extract against radiation-induced gastrointestinal injury.

Gastroenterology
Sharma D, Goel HC and Chauhan S (2016).
Appl Physiol Nutr Metab.
PubMed:
27863208

Biotechnology and pharmacological evaluation of Indian vegetable crop Lagenaria siceraria: an overview.

Review
Roopan SM et al (2016).
Appl Microbiol Biotechnol.
DOI:
10.1007/s00253-015-7190-0
PubMed:
26637422

Proteomic analysis of mature Lagenaria siceraria seed.

Kumari N, Tajmul M and Yadav S (2015).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-015-1532-3
PubMed:
25672325

Free radical scavenging potential of Lagenaria siceraria (Molina) Standl fruits extract.

Mayakrishnan V et al (2013).
Asian Pac J Trop Med.
DOI:
10.1016/S1995-7645(12)60195-3
PubMed:
23317881