Lavandula angustifolia

Common Names: English lavender

Ethnobotanical Studies

Clinical Trials

The efficacy of oral Lavandula angustifolia Mill. essential oil on menopausal symptoms, serum lipid profile, and cortisol concentration in postmenopausal women: A triple-blind, randomized, controlled trial.

Study found that LEO reduced menopausal symptoms and cortisol levels, improving lipid profile in postmenopausal women. May be beneficial for managing menopausal symptoms.

Haramshahi M et al (2024).
Complement Ther Med.
PubMed:
38754638

Alleviating effect of lavender (Lavandula angustifolia) and its major components on postherpetic pain: a randomized blinded controlled trial.

Study evaluated inhalation of lavender oil and its components (linalool and linalyl acetate) on pain in PHN patients. Results could be helpful in managing severe pain and improving quality of life.

You J, Shin YK and Seol GH (2024).
BMC Complement Med Ther.
PubMed:
38267936

Lavender essential oil on postmenopausal women with insomnia: Double-blind randomized trial.

Researchers investigated if inhaling Lavandula angustifolia essential oil could improve sleep and menopausal symptoms in postmenopausal women with insomnia.

Dos Reis Lucena L et al (2021).
Complement Ther Med.
PubMed:
33905827

A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression.

Araj-Khodaei M et al (2020).
BMC Complement Med Ther.
PubMed:
32620104

Efficacy of inhaled Lavandula angustifolia Mill. Essential oil on sleep quality, quality of life and metabolic control in patients with diabetes mellitus type II and insomnia.

This study looked at whether inhaling lavender essential oil could help improve sleep for diabetic patients with insomnia.

Nasiri Lari Z et al (2020).
J Ethnopharmacol.
PubMed:
31931160

A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia.

This study examines the effectiveness of Lavender and Lemon Balm essential oils in managing agitation in older people with and without dementia in residential care facilities.

Watson K, Hatcher D and Good A (2019).
Complement Ther Med.
PubMed:
30670268

Studies

In vitro efficacy of lavender oil, otological gel and gentamicin to eradicate biofilm produced by Pseudomonas aeruginosa.

Mourão A et al (2024).
Vet Dermatol.
PubMed:
39210732

Burn Wound Healing Activity of Hydroxyethylcellulose Gels with Different Water Extracts Obtained from Various Medicinal Plants in Pseudomonas aeruginosa-Infected Rabbits.

Demyashkin G et al (2024).
Int J Mol Sci.
PubMed:
39201676

Nicoliella lavandulae sp. nov., a novel fructophilic Nicoliella species isolated from flowers of Lavandula angustifolia.

Alcántara C et al (2024).
Int J Syst Evol Microbiol.
PubMed:
39190463

Lavandula angustifolia Herb from Ukraine: Comparative Chemical Profile and in vitro Antioxidant Activity.

Mykhailenko O et al (2024).
Chem Biodivers.
PubMed:
39129131

Analysing the Antibacterial Synergistic Interactions of Romanian Lavender Essential Oils via Gas Chromatography-Mass Spectrometry: In Vitro and In Silico Approaches.

Bălașoiu Jigău RAC et al (2024).
Plants (Basel).
PubMed:
39124254

Short-term effect of reclaimed water irrigation on soil health, plant growth and the composition of soil microbial communities.

Mola M et al (2024).
Sci Total Environ.
PubMed:
39084118

Dose-dependent responses: a preliminary investigation into the olfactory effects of essential oil concentrations on canine behavior.

Haverbeke A et al (2024).
Vet Res Commun.
PubMed:
39066825

Comparative analysis of the differences in volatile organic components of three lavender essential oils in Ili region using sensory evaluation, GC-IMS and GC-MS techniques.

Lin Y et al (2024).
J Chromatogr A.
PubMed:
39059304

Comparative Study on the Chemical Composition and Biological Activities of the Essential Oils of Lavandula angustifolia and Lavandula x intermedia Cultivated in Lebanon.

Massoud RI et al (2024).
ACS Omega.
PubMed:
39035964

Efficacy of aromatherapy with Lavandula angustifolia oil on postoperative pain after cardiac surgery: A randomized clinical trial.

Summary

Aromatherapy with Lavandula angustifolia essential oil reduced postoperative pain in cardiac surgery patients. Promising for non-pharmacological pain management post-surgery.

Silva LCMA et al (2024).
Explore (NY).
PubMed:
39032323

Lavandula angustifolia Mill. inhibits high glucose and nicotine-induced Ca(2+) influx in microglia and neuron-like cells via two distinct mechanisms.

Summary

Study shows Lavandula angustifolia Mill. essential oil can reduce high glucose and nicotine-induced calcium influx in microglia and neurons, potentially mitigating smoking-related health issues in type 2 diabetes patients.

Kim YJ et al (2024).
Biomed Pharmacother.
PubMed:
38971009

Exploring the Antibacterial Potential of Lamiaceae Plant Extracts: Inhibition of Bacterial Growth, Adhesion, Invasion, and Biofilm Formation and Degradation in Pseudomonas aeruginosa PAO1.

Oalđe Pavlović M et al (2024).
Plants (Basel).
PubMed:
38931048

β-Cyclocitral from Lavandula angustifolia Mill. Exerts Anti-Aging Effects on Yeasts and Mammalian Cells via Telomere Protection, Antioxidative Stress, and Autophagy Activation.

Shan J et al (2024).
Antioxidants (Basel).
PubMed:
38929154

Anthelmintic effects of some medicinal plants on different life stages of Fasciola hepatica: Evidence on oxidative stress biomarkers, and DNA damage.

Allahyari M, Malekifard F and Yakhchali M (2024).
PLoS Negl Trop Dis.
PubMed:
38885188

Flower Power: An Overview on Chemistry and Biological Impact of Selected Essential Oils from Blossoms.

Review
Prosche S and Stappen I (2024).
Planta Med.
PubMed:
38843799

Water deprivation modifies the metabolic profile of lavender (Lavandula angustifolia Mill.) leaves.

Liao Z et al (2024).
Physiol Plant.
PubMed:
38802725

Phytochemical Composition and Antimicrobial Properties of New Lavandula angustifolia Ecotypes.

Summary

Study characterized ethanol extracts from leaves and flowers of two ecotypes of Mill plant. PL ecotype showed higher phytochemical content and antioxidant activity compared to KC ecotype. Extracts also showed antibacterial and antifungal properties. Ethanol extracts from PL ecotype may be more beneficial for industrial use.

Betlej I et al (2024).
Molecules.
PubMed:
38675563

Immunomodulatory Role of Rosmarinus officinalis L., Mentha x piperita L., and Lavandula angustifolia L. Essential Oils in Sheep Peripheral Blood Mononuclear Cells.

Ciliberti MG et al (2024).
Vet Sci.
PubMed:
38668424

Mitigating digestive disorders: Action mechanisms of Mediterranean herbal active compounds.

Review
Kmail A et al (2024).
Open Life Sci.
PubMed:
38645751

Volatiles from essential oils of three Lamiaceae plants repel the winged cotton aphid, disturb its feeding behavior and reduce its fecundity.

Zhang Y et al (2024).
Pest Manag Sci.
PubMed:
38624184

Effects of Seven Plant Essential Oils on the Growth, Development and Feeding Behavior of the Wingless Aphis gossypii Glover.

Wang X et al (2024).
Plants (Basel).
PubMed:
38611446

Development and characterization of a topical gel, containing lavender (Lavandula angustifolia) oil loaded solid lipid nanoparticles.

Fahimnia F, Nemattalab M and Hesari Z (2024).
BMC Complement Med Ther.
PubMed:
38589838

Cymbopogon winterianus (Java Citronella Plant): A Multi-Faceted Approach for Food Preservation, Insecticidal Effects, and Bread Application.

Rammal M et al (2024).
Foods.
PubMed:
38472916

Baseline symptom severity and efficacy of Silexan in patients with anxiety disorders: A symptom-based, patient-level analysis of randomized, placebo-controlled trials.

Summary

Silexan, an essential oil, is effective in treating anxiety disorders, especially in early stages. Baseline severity influences treatment outcome, with more severe symptoms showing greater improvement. Helpful for mild to moderate cases.

Dold M et al (2024).
Eur Psychiatry.
PubMed:
38425206

Application of Lavandula angustifolia Mill. Extracts for the Phytosynthesis of Silver Nanoparticles: Characterization and Biomedical Potential.

Șuică-Bunghez IR et al (2024).
Plants (Basel).
PubMed:
38337867

In Vitro anthelmintic efficacy of medicinal plant essential oils against Marshallagia marshalli: Evidence on oxidative/nitrosative stress biomarkers, DNA damage, and egg hatchability.

Ahmadzadeh Naghadeh Y, Malekifard F and Esmaeilnejad B (2024).
Vet Parasitol.
PubMed:
38286059

Medicinal herbs consumption in relation to cardiometabolic indices and coronary artery stenosis in participants undergoing coronary angiography: A cross-sectional study.

Arabi V et al (2024).
Phytother Res.
PubMed:
38233343

Short- and long-term effects of essential oils on swine spermatozoa during liquid phase refrigeration.

Troisio I et al (2024).
Sci Rep.
PubMed:
38168599

Transcriptome analyses reveal photosynthesis-related genes involved in photosynthetic regulation under low temperature stress in Lavandula angustifolia Mill.

Li L et al (2023).
Front Plant Sci.
PubMed:
38107014

Corrigendum: Transcriptome analyses reveal photosynthesis-related genes involved in photosynthetic regulation under low temperature stress in Lavandula angustifolia Mill.

Li L et al (2023).
Front Plant Sci.
PubMed:
38107011

Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia.

Rahimian Z et al (2023).
Biomed Res Int.
PubMed:
38089644

Effect of Lavandula angustifolia and Cananga odorata on decrease of blood pressure in high blood pressure volunteers: A randomized controlled trial.

Summary

Researchers evaluated the effectiveness and safety of sticker pads infused with lavender and ylang ylang oil in reducing blood pressure as an alternative treatment for hypertension.

Napavichayanun S et al (2023).
Explore (NY).
PubMed:
38087747

Genome-wide identification and expression of BAHD acyltransferase gene family shed novel insights into the regulation of linalyl acetate and lavandulyl acetate in lavender.

Zhang W et al (2023).
J Plant Physiol.
PubMed:
38064887

Potential of Biochar as a Peat Substitute in Growth Media for Lavandula angustifolia, Salvia rosmarinus and Fragaria × ananassa.

Iacomino G et al (2023).
Plants (Basel).
PubMed:
37960046

Sustainable Pest Management Using Novel Nanoemulsions of Honeysuckle and Patchouli Essential Oils against the West Nile Virus Vector, Culex pipiens, under Laboratory and Field Conditions.

Hikal WM et al (2023).
Plants (Basel).
PubMed:
37960039

Lavender and metformin effectively propagate progesterone levels in patients with polycystic ovary syndrome: A randomized, double-blind clinical trial.

Summary

Study evaluated the effects of lavender and metformin on PCOS patients. Findings can inform treatments for PCOS, a common hormonal disorder among women.

Simaei SR et al (2023).
Fitoterapia.
PubMed:
37931721

Lavandula angustifolia mill. (Lamiaceae) ethanol extract and its main constituents as promising agents for the treatment of metabolic disorders: chemical profile, in vitro biological studies, and molecular docking.

Tundis R et al (2023).
J Enzyme Inhib Med Chem.
PubMed:
37850338

Inhibitory potential of natural plant extracts against Escherichia coli strain isolated from diarrheic camel calves.

Bessalah S et al (2023).
Open Vet J.
PubMed:
37842111

Nanoemulsion of Lavandula angustifolia Essential Oil/Gold Nanoparticles: Antibacterial Effect against Multidrug-Resistant Wound-Causing Bacteria.

Summary

Researchers synthesized a novel nanosystem consisting of nano-essential oil and gold nanoparticles to promote wound healing and combat bacterial infection. The nanosystem showed potent antibacterial activity and accelerated wound closure, suggesting its potential in healthcare settings.

Fadel BA et al (2023).
Molecules.
PubMed:
37836831

Kokedama and essential oils had a relaxing psychophysiological effect on Taiwanese women during the COVID-19 pandemic.

Summary

Scientists designed an indoor nature activity using plants and essential oils to create a relaxing environment similar to forest bathing. This program promotes physical and mental health, especially during the COVID-19 pandemic.

Chung YH et al (2023).
Explore (NY).
PubMed:
37777433

Development of a Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for Characterizing Linalool Oral Pharmacokinetics in Humans.

Wang YH et al (2023).
Molecules.
PubMed:
37764231

The efficient activity of plant essential oils for inhibiting Botrytis cinerea and Penicillium expansum: Mechanistic insights into antifungal activity.

Summary

Certain plant essential oils, specifically those from Thymus vulgaris and Origanum vulgare, have been found to effectively inhibit the growth of Botrytis cinerea and Penicillium expansum. These oils cause structural and functional damage to the fungi, making them potential alternatives to synthetic fungicides.

Fincheira P et al (2023).
Microbiol Res.
PubMed:
37742453

Antimicrobial Properties and Assessment of the Content of Bioactive Compounds Lavandula angustifolia Mill. Cultivated in Southern Poland.

Summary

Lavender extracts from leaves and flowers were found to have antimicrobial properties and reduced bacterial and fungal growth. Leaves had more polyphenols and antioxidants, and chemical compositions varied, aiding in determining lavender's optimal use.

Betlej I et al (2023).
Molecules.
PubMed:
37687245

Lavender (Lavandula angustifolia) syrup as an adjunct to standard care in patients with mild to moderate COVID-19: An open-label, randomized, controlled clinical trial.

Summary

This study investigated the effectiveness of lavender syrup, alongside standard care, for patients with mild to moderate COVID-19 symptoms. Understanding its potential benefits can help scientists make informed decisions regarding treatment options for COVID-19 patients.

Qaraaty M et al (2023).
Avicenna J Phytomed.
PubMed:
37663382

Evaluation of the Antibacterial Activity of Gentamicin in Combination with Essential Oils Isolated from Different Cultivars and Morphological Parts of Lavender (Lavandula angustifolia Mill.) against Selected Bacterial Strains.

Adaszyńska-Skwirzyńska M et al (2023).
Molecules.
PubMed:
37570751

Evaluation of radioactivity levels and radiological hazards of some endemic plants used as medicine in Ankara, Turkey.

Güven A et al (2023).
Appl Radiat Isot.
PubMed:
37536028

Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis.

Summary

Study compares efficacy of essential oils (EOs) for treating anxiety, aiming to clarify discrepancies in previous research. Researchers analyze results of multiple RCTs to provide insights into potential benefits of EOs.

Meta-Analysis Neuroscience
Tan L et al (2023).
Front Public Health.
PubMed:
37325306

Improvements in the biochemical responses and Pb and Ni phytoremediation of lavender (Lavandula angustifolia L.) plants through Funneliformis mosseae inoculation.

Rasouli F et al (2023).
BMC Plant Biol.
PubMed:
37173650

Use of Lavandula angustifolia essential oil as a complementary therapy in adult health care: A scoping review.

Summary

Lavender essential oil has numerous beneficial properties like sedative, antidepressant, and antifungal effects. Researchers are studying its action mechanism to enhance patient well-being.

de Melo Alves Silva LC et al (2023).
Heliyon.
PubMed:
37153408

Lavandula x intermedia-A Bastard Lavender or a Plant of Many Values? Part II. Biological Activities and Applications of Lavandin.

Review
Pokajewicz K et al (2023).
Molecules.
PubMed:
37049749

Lavandula × intermedia-A Bastard Lavender or a Plant of Many Values? Part I. Biology and Chemical Composition of Lavandin.

Review
Pokajewicz K et al (2023).
Molecules.
PubMed:
37049706

Psychiatric manifestations of post-COVID-19 syndrome: the potential benefit of Silexan.

Summary

Silexan, an essential oil, may alleviate psychiatric symptoms in post-COVID-19 patients, including anxiety, depression, and sleep disturbances, thanks to its neurotrophic and anti-inflammatory properties. It is a safe and well-tolerated therapeutic option.

Review COVID-19
Kasper S et al (2023).
Int J Psychiatry Clin Pract.
PubMed:
37021969

Transfer of AgNPs' Anti-Biofilm Activity into the Nontoxic Polymer Matrix.

Mačák L et al (2023).
Polymers (Basel).
PubMed:
36904479

Development of Dairy Products Fortified with Plant Extracts: Antioxidant and Phenolic Content Characterization.

Kandyliari A et al (2023).
Antioxidants (Basel).
PubMed:
36830058

Efficacy of Silexan in patients with anxiety disorders: a meta-analysis of randomized, placebo-controlled trials.

Dold M et al (2023).
Eur Arch Psychiatry Clin Neurosci.
PubMed:
36717399

Botanical Ingredient Forensics: Detection of Attempts to Deceive Commonly Used Analytical Methods for Authenticating Herbal Dietary and Food Ingredients and Supplements.

Review
Gafner S et al (2023).
J Nat Prod.
PubMed:
36716213

Comparison between the Chemical Composition of Essential Oil from Commercial Products and Biocultivated Lavandula angustifolia Mill.

Todorova V et al (2023).
Int J Anal Chem.
PubMed:
36684478

Current Trends for Lavender (Lavandula angustifolia Mill.) Crops and Products with Emphasis on Essential Oil Quality.

Crișan I et al (2023).
Plants (Basel).
PubMed:
36679071

Insecticidal and Detoxification Enzyme Inhibition Activities of Essential Oils for the Control of Pulse Beetle, Callosobruchus maculatus (F.) and Callosobruchus chinensis (L.) (Coleoptera: Bruchidae).

Gupta H et al (2023).
Molecules.
PubMed:
36677552

Antinociceptive and anxiolytic-like effects of Lavandula angustifolia essential oil on rat models of orofacial pain.

Summary

Lavender oil has potential as a safer alternative for pain treatment. It shows analgesic and anxiolytic properties when inhaled, helping to relieve orofacial pain.

Lejeune VBP et al (2023).
J Appl Oral Sci.
PubMed:
36629536

The effects of Lavandula angustifolia essential oil on analgesic effects and percutaneous absorption of naproxen sodium gel; an in vivo and in vitro study.

Summary

Lavandula angustifolia essential oil (LAEO) increased the percutaneous absorption and analgesic effects of naproxen sodium topical gel, suggesting its potential as a permeation-enhancing agent.

Rostamkalaei SS et al (2023).
Clin Exp Pharmacol Physiol.
PubMed:
36573522

Binary Synergistic Combinations of Lavender and Fennel Essential Oils with Amoxicillin.

Karadağ AE et al (2023).
Planta Med.
PubMed:
35789993

Beneficial effects of Silexan on co-occurring depressive symptoms in patients with subthreshold anxiety and anxiety disorders: randomized, placebo-controlled trials revisited.

Meta-Analysis
Bartova L et al (2023).
Eur Arch Psychiatry Clin Neurosci.
PubMed:
35262795

Efficacy and tolerability of Lavandula angustifolia in treating patients with the diagnosis of depression: a systematic review of randomized controlled trials.

Review
Shamabadi A and Akhondzadeh S (2021).
J Complement Integr Med.
PubMed:
34420270

The antidepressant effects of lavender (Lavandula angustifolia Mill.): A systematic review and meta-analysis of randomized controlled clinical trials.

Meta-Analysis
Firoozeei TS et al (2021).
Complement Ther Med.
PubMed:
33549687

Lavender oil (Lavandula angustifolia) attenuates renal ischemia/reperfusion injury in rats through suppression of inflammation, oxidative stress and apoptosis.

Aboutaleb N et al (2019).
Biomed Pharmacother.
PubMed:
30453254

Lavender.

Review
(2022).
PubMed:
30000925

Exploring Pharmacological Mechanisms of Lavender (Lavandula angustifolia) Essential Oil on Central Nervous System Targets.

Summary

Lavender essential oil is used to alleviate stress and anxiety. Researchers evaluated its effects on the central nervous system and neurotoxicity. Lavender and its components bind to glutamate NMDA-receptors and the serotonin transporter but not the GABA-benzodiazepine receptor. Lavender did not enhance neurotoxic insult and improved cell viability. The study suggests that lavender may have pharmacological properties by modulating the NMDA receptor, SERT, and hydrogen peroxide-induced neurotoxicity.

López V et al (2017).
Front Pharmacol.
PubMed:
28579958

Adverse effects of herbal medicines: an overview of systematic reviews.

Review
Posadzki P, Watson LK and Ernst E (2013).
Clin Med (Lond).
PubMed:
23472485