Study identified 113 compounds in plant extract, evaluated drug-likeness and potential targets. Hub proteins identified, high binding affinity in molecular docking. Further research needed for natural drug development.
Jivanti, an Ayurvedic herb, has traditional medicinal uses for respiratory disorders, inflammation, and snake bites. It contains potent compounds with antidiabetic, antimicrobial, and antioxidant properties. This review explores its distribution, ethnobotanical use, and therapeutic properties.
Researchers investigated the mechanism by which the medicinal plant Jivanti increases breast milk production. Dopamine D2 receptor (D2R) activation inhibits lactotroph cell prolactin synthesis. In-silico analysis of phytocompounds from Jivanti identified campesterol and β-sitosterol as having high binding affinity (-10.1 and -10.0 kcal/mol) with D2R and stable interaction for prolactin release, which may increase breast milk production. Campesterol had good solubility and absorption characteristics, making it a candidate medication for boosting breast milk production. Jivanti has traditionally been consumed by nursing mothers to improve breast milk production.