Levisticum officinale

Common Names: garden lovage

Ethnobotanical Studies

Studies

Antioxidant Activities of Ethanolic Extracts Obtained from α-Pinene-Containing Plants and Their Use in Cosmetic Emulsions.

Immunology
Grzeszczak J et al (2024).
Antioxidants (Basel).
DOI:
10.3390/antiox13070811
PubMed:
39061880

Antioxidant Activity of Medicinal Herbs and Spices from Plants of the Lamiaceae, Apiaceae and Asteraceae Families: Chemometric Interpretation of the Data.

Immunology
Ulewicz-Magulska B and Wesolowski M (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12122039
PubMed:
38136159

Coumarins of Lovage Roots (Levisticum officinale W.D.J.Koch): LC-MS Profile, Quantification, and Stability during Postharvest Storage.

Olennikov DN et al (2022).
Metabolites.
DOI:
10.3390/metabo13010003
PubMed:
36676932

Treadmill running and Levisticum Officinale extract protect against LPS-induced memory deficits by modulating neurogenesis, neuroinflammation and oxidative stress.

Summary

Exercise and Levisticum officinale extract can protect against Alzheimer's disease by reducing neuroinflammation. In a study with male Wister rats, a week of treadmill running and/or treatment with Levisticum officinale extract for a week, followed by three weeks of treadmill running and/or treatment, improved spatial learning and memory, reduced levels of interleukin-6 and malondialdehyde, and increased superoxide dismutase activity and neurogenesis in the hippocampus. These results suggest that the antioxidant and anti-inflammatory properties of Levisticum officinale extract may help prevent or mitigate Alzheimer's disease.

GeneticsImmunologyNeuroscience
Amraie E et al (2022).
Metab Brain Dis.
DOI:
10.1007/s11011-022-01140-z
PubMed:
36478529

Profile of Selected Secondary Metabolites and Antioxidant Activity of Valerian and Lovage Grown in Organic and Low-Input Conventional System.

Średnicka-Tober D et al (2022).
Metabolites.
DOI:
10.3390/metabo12090835
PubMed:
36144239

Investigating the Antituberculosis Activity of Selected Commercial Essential Oils and Identification of Active Constituents Using a Biochemometrics Approach and In Silico Modeling.

Phytochemistry
Boussamba-Digombou KJ et al (2022).
Antibiotics (Basel).
DOI:
10.3390/antibiotics11070948
PubMed:
35884202

[The use of complex herbal supplements for the prevention and treatment of urinary tract infections. The analysis of active components].

Tsukanov AY, Matveev EV and Nurgalieva AI (2021).
Urologiia.
PubMed:
34967180

Influence of Elicitation and Drying Methods on Anti-Metabolic Syndrome, and Antimicrobial Properties of Extracts and Hydrolysates Obtained from Elicited Lovage (Levisticum officinale Koch).

Antimicrobial
Jakubczyk A, Złotek U and Rybczyńska-Tkaczyk K (2021).
Nutrients.
DOI:
10.3390/nu13124365
PubMed:
34959917

Green Synthesis of Silver Nanoparticles Using Natural Extracts with Proven Antioxidant Activity.

Flieger J et al (2021).
Molecules.
DOI:
10.3390/molecules26164986
PubMed:
34443574

Uncovering the multi-level response of Glycine max L. to the application of allelopathic biostimulant from Levisticum officinale Koch.

Szparaga A et al (2021).
Sci Rep.
DOI:
10.1038/s41598-021-94774-5
PubMed:
34321544

Assessing the Levisticum officinale Koch. essential oil as a novel preservative for stored chia seeds (Salvia hispanica L.) with emphasis on probable mechanism of action.

Phytochemistry
Deepika et al (2021).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-021-14985-1
PubMed:
34273074

The effect of Apium graveolens L., Levisticum officinale and Calendula officinalis L. on cell viability, membrane integrity, steroidogenesis, and intercellular communication in mice Leydig cells in vitro.

Genetics
Jambor T et al (2021).
Physiol Res.
PubMed:
34062080

Characterization and Antibacterial Activity of Phthalides from the Roots of the Medicinal Herb Levisticum officinale W.D.J. Koch.

Miran M et al (2020).
Iran J Pharm Res.
DOI:
10.22037/ijpr.2020.112583.13839
PubMed:
33224223

Neuroprotective effects of Levisticum officinale on LPS-induced spatial learning and memory impairments through neurotrophic, anti-inflammatory, and antioxidant properties.

Summary

Levisticum officinale extract (LOE) has anti-inflammatory, antioxidant, and anticholinesterase activities. In a study on rats, LOE was administered at doses of 100, 200, and 400 mg kg-1 for a week and continued for 3 more weeks with lipopolysaccharide (LPS) injection to induce neuroinflammation. LOE significantly attenuated LPS-induced spatial learning and memory deficits. LPS increased the mRNA expression level of interleukin-6 in the hippocampus, accompanied by decreased brain-derived neurotrophic factor (BDNF) mRNA expression levels. LPS also increased malondialdehyde levels, reduced antioxidant enzyme activities, and impaired neurogenesis. However, pre-treatment with LOE at a dose of 100 mg kg-1 significantly reversed LPS-induced changes and improved neurogenesis. LOE's beneficial effect on learning and memory is attributed to its anti-inflammatory, antioxidant activities, and ability to increase BDNF expression and neurogenesis.

ImmunologyNeuroscience
Amraie E, Pouraboli I and Rajaei Z (2020).
Food Funct.
DOI:
10.1039/d0fo01030h
PubMed:
32648872

Levisticum Officinale Extract Triggers Apoptosis and Down-Regulates ZNF703 Gene Expression in Breast Cancer Cell Lines.

Cancer
Mollashahee-Kohkan F et al (2019).
Rep Biochem Mol Biol.
PubMed:
31832434

The activity of Levisticum officinale W.D.J. Koch essential oil against multidrug-resistant Mycobacterium tuberclosis.

Phytochemistry
Miran M et al (2018).
Iran J Microbiol.
PubMed:
30873267

The hepatoprotective effects of aquatic extract of Levisticum officinale against paraquat hepatocyte toxicity.

Afarnegan H, Shahraki A and Shahraki J (2017).
Pak J Pharm Sci.
PubMed:
29188770

Antimycobacterial polyacetylenes from Levisticum officinale.

Schinkovitz A et al (2008).
Phytother Res.
DOI:
10.1002/ptr.2408
PubMed:
18350523