Lobelia cardinalis

Common Names: cardinalflower

Ethnobotanical Studies

Studies

A Plant Model of α-Synucleinopathy: Expression of α-Synuclein A53T Variant in Hairy Root Cultures Leads to Proteostatic Stress and Dysregulation of Iron Metabolism.

Kurepa J et al (2024).
Appl Biosci (Basel).
DOI:
10.3390/applbiosci3020016
PubMed:
38835931

Target-directed evolution of novel modulators of the dopamine transporter in Lobelia cardinalis hairy root cultures.

Summary

Researchers identified lobinaline N-oxide, a water-soluble derivative of lobinaline, an atypical dopamine transporter (DAT) inhibitor lead from Lobelia cardinalis, through "target-directed evolution" of mutant L. cardinalis cell population expressing human DAT. Lobinaline N-oxide showed promising therapeutic potential to treat Substance Use Disorder (SUD) as it prolonged dopamine peak amplitudes in the ventral striatum and produced complex changes in post-peak dopamine clearance. Target-directed evolution of plant cells has been proved useful for lead optimization in drug development.

Neuroscience
Rogers DT et al (2021).
J Biotechnol.
DOI:
10.1016/j.jbiotec.2021.10.001
PubMed:
34648893

Microfluidic capillary zone electrophoresis mass spectrometry analysis of alkaloids in Lobelia cardinalis transgenic and mutant plant cell cultures.

Phytochemistry
Kelley ZD et al (2019).
Electrophoresis.
DOI:
10.1002/elps.201900220
PubMed:
31475363

The rhizosphere of aquatic plants is a habitat for cable bacteria.

Scholz VV et al (2019).
FEMS Microbiol Ecol.
DOI:
10.1093/femsec/fiz062
PubMed:
31054245

Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells.

Brown DP et al (2016).
J Biotechnol.
DOI:
10.1016/j.jbiotec.2016.09.007
PubMed:
27637316

Pollen limitation and its influence on natural selection through seed set.

Bartkowska MP and Johnston MO (2015).
J Evol Biol.
DOI:
10.1111/jeb.12741
PubMed:
26310698

Development of polymorphic microsatellite markers for Indian tobacco, Lobelia inflata (Campanulaceae)(1.).

Hughes PW et al (2014).
Appl Plant Sci.
DOI:
10.3732/apps.1300096
PubMed:
25202618

The sexual neighborhood through time: competition and facilitation for pollination in Lobelia cardinalis.

Bartkowska MP and Johnston MO (2014).
Ecology.
PubMed:
24933810

Differences in the structure of anthocyanins from the two amphibious plants, Lobelia cardinalis and Nesaea crassicaulis.

Vodopivec BM et al (2013).
Nat Prod Res.
DOI:
10.1080/14786419.2012.688046
PubMed:
22694738

Pollinators cause stronger selection than herbivores on floral traits in Lobelia cardinalis (Lobeliaceae).

Bartkowska MP and Johnston MO (2012).
New Phytol.
DOI:
10.1111/j.1469-8137.2011.04013.x
PubMed:
22225567

[Paper chromatographic separation of the alkaloids of Lobelia inflata from lobinaline, the main alkaloid of Lobelia cardinalis].

Phytochemistry
KACZMAREK F and STEINEGGER E (1959).
Pharm Acta Helv.
PubMed:
14408314

[Paper chromatographic analysis of the hybrid of Lobelia cardinalis var. cardinalis X Lobelia syphilitica var. syphilitica and comparison with the parent plants].

STEINEGGER E and KACZMAREK F (1958).
J Pharm Belg.
PubMed:
13642247