Lonicera japonica

Common Names: Chinese honeysuckle, Japanese honeysuckle

Ethnobotanical Studies

Studies

Intricate microbe-plant-metabolic remodeling mediated by intercropping enhances the quality of Panax quinquefolius L.

Duan W et al (2024).
Physiol Plant.
DOI:
10.1111/ppl.14499
PubMed:
39221485

Lonicera Japonica Caulis Ameliorates LPS and TNF-α-Induced HT-29 Cell Injury by Inhibiting the MAPK/ERK/JNK/p38 Pathway.

Immunology
Lu HX et al (2024).
Biomed Environ Sci.
DOI:
10.3967/bes2024.091
PubMed:
39198246

Study on Optimization of Liquid Fermentation Medium and Antitumor Activity of the Mycelium on Phyllopora lonicerae.

Summary

Researchers optimized the fermentation medium of a parasitic fungus for increased mycelium production. Extracted components showed potential as an anticancer agent in functional foods, offering valuable support for further development.

Cancer
Liu M et al (2024).
J Microbiol Biotechnol.
DOI:
10.4014/jmb.2405.05004
PubMed:
39187449

Major specialized natural products from the endangered plant Heptacodium miconioides, potential medicinal uses and insights into its longstanding unresolved systematic classification.

Zhao ZY et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114259
PubMed:
39186996

Evaluating the impact of ecological factors on the quality and habitat distribution of Lonicera japonica Flos using HPLC and the MaxEnt model.

Cheng J et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1397939
PubMed:
39166244

Exogenous melatonin alleviates sodium chloride stress and increases vegetative growth in Lonicera japonica seedlings via gene regulation.

Genetics
Song C et al (2024).
BMC Plant Biol.
DOI:
10.1186/s12870-024-05506-6
PubMed:
39164652

Regulation of gene expression in the secondary metabolic synthesis pathway of Lonicera japonica Flos by yeast polysaccharides.

Genetics
Gu XP et al (2024).
Physiol Mol Biol Plants.
DOI:
10.1007/s12298-024-01482-1
PubMed:
39100882

Global lysine succinylation analysis unveils post-translational regulation effect on phenylpropanoid metabolism remodeling during Lonicera japonica flower development.

Chen Y et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108978
PubMed:
39084169

Lonicera japonica Thunb. Ethanol Extract Exerts a Protective Effect on Normal Human Gastric Epithelial Cells by Modulating the Activity of Tumor-Necrosis-Factor-α-Induced Inflammatory Cyclooxygenase 2/Prostaglandin E2 and Matrix Metalloproteinase 9.

CancerGastroenterologyImmunology
Hsieh HL et al (2024).
Curr Issues Mol Biol.
DOI:
10.3390/cimb46070433
PubMed:
39057074

Inhibitory effect of Lonicera japonica flos on Streptococcus mutans biofilm and mechanism exploration through metabolomic and transcriptomic analyses.

Wang L et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1435503
PubMed:
39027105

The Essential Oils Obtained from (Lonicerae japonicae Flos) Flower Buds Could Affect the Deposition of Sunflower Oil under Common High Temperature Conditions and the Traditional Frying Process in Maye.

Qu M, Liu Y and Wang D (2024).
J Oleo Sci.
DOI:
10.5650/jos.ess23242
PubMed:
39019619

Comparative study on chemical constituents of different medicinal parts of Lonicera japonica Thunb. Based on LC-MS combined with multivariate statistical analysis.

Zhang X et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e31722
PubMed:
38975169

Variation of mesophyll conductance mediated by nitrogen form is related to changes in cell wall property and chloroplast number.

Cao Y et al (2024).
Hortic Res.
DOI:
10.1093/hr/uhae112
PubMed:
38919556

Virtual Screening of Inhibitors of Streptococcus mutans Biofilm from Lonicera japonica flos and Activity Validation.

Liu P et al (2024).
ACS Med Chem Lett.
DOI:
10.1021/acsmedchemlett.4c00051
PubMed:
38894900

First Report of Leaf Spot Disease on Lonicera japonica Caused by Nigrospora oryzae in China.

Chen X et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-01-24-0190-PDN
PubMed:
38861465

[Content of secondary metabolites and antioxidant activities of Lonicera japonica flowers at different developmental stages from Shandong province].

Immunology
Kou YN et al (2024).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20240129.101
PubMed:
38812166

Coping with alpine habitats: genomic insights into the adaptation strategies of Triplostegia glandulifera (Caprifoliaceae).

Zhang J et al (2024).
Hortic Res.
DOI:
10.1093/hr/uhae077
PubMed:
38779140

The protective effect of Lonicera japonica Thunb. against lipopolysaccharide-induced acute lung injury in mice: Modulation of inflammation, oxidative stress, and ferroptosis.

Immunology
Xiong L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118333
PubMed:
38750986

Network pharmacology combined with an experimental validation study to reveal the effect and mechanism of Lonicera japonica Thunb. extracts against immunomodulation.

Wang W et al (2024).
J Food Sci.
DOI:
10.1111/1750-3841.17074
PubMed:
38745368

Pharmacological Activities of Lonicerae japonicae flos and Its Derivative-"Chrysoeriol" in Skin Diseases.

Review
Law SK et al (2024).
Molecules.
DOI:
10.3390/molecules29091972
PubMed:
38731465

Effects of Lonicera japonica Extract with Different Contents of Chlorogenic Acid on Lactation Performance, Serum Parameters, and Rumen Fermentation in Heat-Stressed Holstein High-Yielding Dairy Cows.

Ma F et al (2024).
Animals (Basel).
DOI:
10.3390/ani14081252
PubMed:
38672400

Optimization of the fermentation process and antioxidant activity of mixed lactic acid bacteria for honeysuckle beverage.

Immunology
Ran J et al (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1364448
PubMed:
38633692

Research and application progress of microbial β-mannanases: a mini-review.

Review
Wang P et al (2024).
World J Microbiol Biotechnol.
DOI:
10.1007/s11274-024-03985-1
PubMed:
38630389

Correction: Lonicera japonica Thunb. as a promising antibacterial agent for Bacillus cereus ATCC14579 based on network pharmacology, metabolomics, and in vitro experiments.

Xu N et al (2024).
RSC Adv.
DOI:
10.1039/d4ra90032d
PubMed:
38595710

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial.

Wu Y et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1162883
PubMed:
38549665

Identification of toxic Gelsemium elegans in processed food and honey based on real-time PCR analysis.

Wang G et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114188
PubMed:
38519193

Research Progress of Natural Product Photosensitizers in Photodynamic Therapy.

Zhou X et al (2024).
Planta Med.
DOI:
10.1055/a-2257-9194
PubMed:
38423033

Quantitative analysis of the quality constituents of Lonicera japonica Thunberg based on Raman spectroscopy.

Zeng Q et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.138513
PubMed:
38277933

Seasonal dynamics of phyllosphere epiphytic microbial communities of medicinal plants in farmland environment.

He C et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1328586
PubMed:
38239215

Biochar reduces the cadmium content of Panax quinquefolium L. by improving rhizosphere microecology.

Chen X et al (2024).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2024.170005
PubMed:
38232852

Ameliorating Effects of Graphene Oxide on Cadmium Accumulation and Eco-Physiological Characteristics in a Greening Hyperaccumulator (Lonicera japonica Thunb.).

Liu Z et al (2023).
Plants (Basel).
DOI:
10.3390/plants13010019
PubMed:
38202327

Quality evaluation of Lonicerae Japonicae Flos from different origins based on high-performance liquid chromatography (HPLC) fingerprinting and multicomponent quantitative analysis combined with chemical pattern recognition.

Phytochemistry
Zhang J et al (2024).
Phytochem Anal.
DOI:
10.1002/pca.3319
PubMed:
38185766

Lonicera japonica protects Pelodiscus sinensis by inhibiting the biofilm formation of Aeromonas hydrophila.

Huo LC et al (2024).
Appl Microbiol Biotechnol.
DOI:
10.1007/s00253-023-12910-9
PubMed:
38183487

Chinese herbal compound for multidrug-resistant or extensively drug-resistant bacterial pneumonia: a meta-analysis and trial sequential analysis with association rule mining to identify core herb combinations.

Zhao S et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1282538
PubMed:
38174222

Improvement in gravel-mulched land soil nutrient and bacterial community diversity with Lonicera japonica.

Wang X et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1225503
PubMed:
38130947

Lonicera japonica Thunb extract ameliorates lipopolysaccharide-induced acute lung injury associated with luteolin-mediated suppression of NF-κB signaling pathway.

Summary

This study examined the protective effects of Lonicera japonica Thunb (LJT) extract on acute lung injury caused by inflammation. Results suggest that LJT extract, particularly its active ingredient luteolin, may have potential therapeutic benefits.

Immunology
Jia Q et al (2023).
J Inflamm (Lond).
DOI:
10.1186/s12950-023-00372-9
PubMed:
38115057

Lonicerin promotes wound healing in diabetic rats by enhancing blood vessel regeneration through Sirt1-mediated autophagy.

Summary

Tossers investigated LCR, a compound found in plants, for treating diabetic wounds. They found it promotes autophagy and activates SIRT signaling, reducing inflammation and oxidative stress, enhancing cell survival and angiogenesis. LCR shows potential as a therapeutic agent for diabetic wounds.

Diabetes
Lin Z et al (2023).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-023-01193-5
PubMed:
38066346

First Report of Cercospora Leaf Spot Caused by Cercospora cf. flagellaris on Lonicera japonica Thunb. in Henan, China.

Wen Y et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-09-23-1865-PDN
PubMed:
37981571

Lonicerae Japonicae Caulis: a review of its research progress of active metabolites and pharmacological effects.

Review
Cao YX et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1277283
PubMed:
37954842

Discovery of the covalent SARS-CoV-2 M(pro) inhibitors from antiviral herbs via integrating target-based high-throughput screening and chemoproteomic approaches.

Summary

Lonicera japonica Flos extract contains gallic acid and quercetin, potent inhibitors of a coronavirus protein, offering a practical method to discover antiviral compounds from herbal medicines.

AntimicrobialCOVID-19
Zhang YN et al (2023).
J Med Virol.
DOI:
10.1002/jmv.29208
PubMed:
37947293

Plant Extracts as Skin Care and Therapeutic Agents.

Review
Michalak M et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242015444
PubMed:
37895122

Structurally diverse indole alkaloids with cytotoxicity from Lonicera Japonica-associated endophytic fungus Penicillium ochrochloron YT2022-65.

Phytochemistry
Liu X, Li R and Zhou X (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2272778
PubMed:
37867305

Antidepressant effects of 70% ethanolic extract of Lonicerae japonicae flos and it contained chlorogenic acid via upregulation of BDNF-TrkB pathway in the hippocampus of mice.

Summary

Lonicera japonica flos (LJF) extract and chlorogenic acid (CGA) show significant antidepressant effects, correlating with CGA content. LJF-70% ethanolic extract and CGA improve depressive behavior, upregulate BDNF-TrkB pathway, restore hippocampal neurons, and protect the liver.

Neuroscience
Qin L et al (2023).
Brain Res Bull.
DOI:
10.1016/j.brainresbull.2023.110796
PubMed:
37863440

Vertical flow constructed wetlands as green facades and gardens for on-site greywater treatment in buildings: Two-year mesocosm study on removal performance.

Stefanatou A et al (2023).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.167362
PubMed:
37769734

Qishen granule attenuates doxorubicin-induced cardiotoxicity by protecting mitochondrial function and reducing oxidative stress through regulation of Sirtuin3.

Immunology
Zhang J et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117134
PubMed:
37714227

Qualitative identification of lonicerae japonicae flos in traditional chinese medicine using metabarcoding combined with specific mini-barcodes.

Gao Y et al (2023).
Mol Biol Rep.
DOI:
10.1007/s11033-023-08739-0
PubMed:
37658933

Integrated metabolic profiling and transcriptome analysis of Lonicera japonica flowers for chlorogenic acid, luteolin and endogenous hormone syntheses.

Summary

Study investigates the regulation of secondary metabolites in Lonicera japonica during flower development. Results show decrease in chlorogenic acid and luteolin content, down-regulation of crucial enzymes, and identification of transcription factor families involved in biosynthesis. Hormone biosynthesis, signaling pathways, and flowering process also analyzed.

EndocrinologyGenetics
Guan R et al (2023).
Gene.
DOI:
10.1016/j.gene.2023.147739
PubMed:
37633535

Combinatorial transcriptomics and metabolomics analysis reveals the effects of the harvesting stages on the accumulation of phenylpropanoid metabolites in Lonicera japonica.

Genetics
Ran Z et al (2023).
Funct Plant Biol.
DOI:
10.1071/FP23033
PubMed:
37607828

Smartphone-based electrochemical sensor for cost-effective, rapid and on site detection of chlorogenic acid in herbs using biomass-derived hierarchically porous carbon synthesized by a soft-hard dual template method.

Jiang W et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137165
PubMed:
37598652

Inhibitory effect of Lonicera japonica-derived exosomal miR2911 on human papilloma virus.

Chi Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116969
PubMed:
37516391

Caffeoylquinic acids isolated from Lonicera japonica Thunb. as TAK1 inhibitors protects against LPS plus IFN-γ-stimulated inflammation by interacting with KEAP1-regulated NRF2 activation.

Immunology
Ge L et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115038
PubMed:
37418981

LjaFGD: Lonicera japonica functional genomics database.

Xiao Q et al (2021).
J Integr Plant Biol.
DOI:
10.1111/jipb.13112
PubMed:
33982879

Lonicera japonica Thunb.: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine.

Review Phytochemistry
Shang X et al (2011).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2011.08.016
PubMed:
21864666