Lycopodiastrum casuarinoides

Ethnobotanical Studies

Studies

Lycopodiastrum casuarinoides: An overview of their phytochemicals, biological activities, structure-activity relationship, biosynthetic pathway and (13)C NMR data.

Review Phytochemistry
Liu Y et al (2023).
Fitoterapia.
DOI:
10.1016/j.fitote.2022.105425
PubMed:
36608712

Entropy analysis and grey cluster analysis of multiple indexes of 5 kinds of genuine medicinal materials.

Zhou L, Jiang C and Lin Q (2022).
Sci Rep.
DOI:
10.1038/s41598-022-10509-0
PubMed:
35459282

Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity.

Summary

Researchers identified five new alkaloids and ten known analogues in Lycopodiastrum casuarinoides, a plant commonly used in traditional Chinese medicine to improve cognitive function. Spectroscopic techniques were used to determine the structures of the novel compounds and their absolute configurations. Only huperzine C showed moderate inhibitory activity against acetylcholinesterase, which is associated with Alzheimer's disease. The study highlights the potential of Lycopodiastrum casuarinoides as a source for developing new drugs to treat cognitive impairment.

NeurosciencePhytochemistry
Feng Z et al (2019).
Fitoterapia.
DOI:
10.1016/j.fitote.2019.104378
PubMed:
31676395

Leveraging plant exine capsules as pH-responsive delivery vehicles for hydrophobic nutraceutical encapsulation.

Wu D et al (2018).
Food Funct.
DOI:
10.1039/c8fo01665h
PubMed:
30280748

Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity.

Summary

Researchers have isolated four new alkaloids and ten known analogues from the whole plant of Lycopodiastrum casuarinoides. The new compounds' structures were determined using a variety of spectroscopic and chemical methods. Notably, compound 4 was a lycopodium alkaloidal glycoside never before reported. Four of the isolated compounds showed significant inhibitory activity against acetylcholinesterase, which is linked to Alzheimer's disease. The structure-activity relationships were discussed, potentially informing future treatments.

NeurosciencePhytochemistry
Zhang DB et al (2014).
Molecules.
DOI:
10.3390/molecules19079999
PubMed:
25014530