Lycopodium clavatum

Common Names: common club moss, running clubmoss

Ethnobotanical Studies

Clinical Trials

Spore exines increase vitamin D clinical bioavailability by mucoadhesion and bile triggered release.

Diego-Taboada A et al (2022).
J Control Release.
DOI:
10.1016/j.jconrel.2022.08.017
PubMed:
35973473

Efficacy of individualized homeopathic medicines in intervening with the progression of pre-hypertension to hypertension: A double-blind, randomized, placebo-controlled trial.

Researchers investigated the impact of exercise on pre-hypertension progression. Exercise reduces the risk of developing hypertension and cardiovascular diseases. Important for preventive healthcare strategies.

Dutta S et al (2022).
Explore (NY).
DOI:
10.1016/j.explore.2021.05.007
PubMed:
34147344

Studies

Origin and Persistence of Lycopodium clavatum and Lycopodium annotinum (Lycopodiaceae) in Scots Pine Forests.

Rimgailė-Voicik R et al (2024).
Plants (Basel).
DOI:
10.3390/plants13152120
PubMed:
39124238

Stimulus triggered release of actives from composite microcapsules based on sporopollenin from Lycopodium clavatum.

Lecoeuche M et al (2024).
RSC Adv.
DOI:
10.1039/d4ra00236a
PubMed:
38549792

Isolation and Characterization of Novel Huperzine-Producing Endophytic Fungi from Lycopodiaceae Species.

Le TTM et al (2023).
J Fungi (Basel).
DOI:
10.3390/jof9121134
PubMed:
38132735

Individualized homeopathic medicines in the treatment of post-COVID-19 fatigue in adults: A single-blind, randomized, placebo-controlled trial.

Summary

This trial investigates the effectiveness of homeopathic medicines compared to placebos for treating post-COVID-19 fatigue in adults. Results could provide insights on managing this challenging condition.

COVID-19
Saha S et al (2023).
Complement Med Res.
DOI:
10.1159/000535279
PubMed:
38008074

A Case Report of Multiple Renal Calculi Treated With Individualized Homoeopathy.

Lamba P and Gupta AK (2023).
Altern Ther Health Med.
PubMed:
37883771

The apoptotic effect of the Lycopodium clavatum extracts on MCF-7 human breast cancer cells.

Summary

Lycopodium Clavatum (LC), an herb, was found to have cytotoxic and apoptotic effects on MCF-7 human breast cancer cells, indicating its potential as an anticancer agent. LC activates apoptosis-related proteins and shows promise as a natural compound for breast cancer treatment.

Cancer
Kucukbagriacik Y et al (2023).
Med Oncol.
DOI:
10.1007/s12032-023-02159-7
PubMed:
37658180

Natural sporopollenin microcapsules: biological evaluation and application in regulating hepatic toxicity of diclofenac sodium in vivo.

Meligi NM and Dyab AKF (2023).
Biomater Sci.
DOI:
10.1039/d3bm00638g
PubMed:
37522344

The first homosporous lycophyte genome revealed the association between the recent dynamic accumulation of LTR-RTs and genome size variation.

Genetics
Yu JG et al (2023).
Plant Mol Biol.
DOI:
10.1007/s11103-023-01366-0
PubMed:
37380791

Fabrication of Sacha Inchi Oil-Loaded Microcapsules Employing Natural-Templated Lycopodium clavatum Spores and Their Pressure-Stimuli Release Behavior.

Khann B et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c01698
PubMed:
37323417

Calcium carbonate-modified plant sporopollen capsule as an eco-friendly microvehicle for controlled release of pesticide.

Xiang S et al (2022).
Pest Manag Sci.
DOI:
10.1002/ps.7333
PubMed:
36550686

Neuroprotective Treatments for Digestive Forms of Chagas Disease in Experimental Models: A Systematic Review.

Summary

A systematic review was conducted to identify potential neuroprotective drugs for the digestive form of Chagas disease, which is currently treated ineffectively. Eight experimental studies on murine models were included, with most showing neuroprotective activity of the tested drugs (acetylsalicylic acid, cyclophosphamide, and Lycopodium clavatum 13c). However, further study on the mechanisms, safety, and immunogenicity of these drugs is needed. This study provides valuable insight for the development of improved treatments for Chagas disease.

Review Neuroscience
do Carmo Neto JR et al (2022).
Oxid Med Cell Longev.
DOI:
10.1155/2022/9397290
PubMed:
36199427

Pollen-derived microcapsules for aspirin microencapsulation: in vitro release and physico-chemical studies.

Mohammed AY et al (2022).
RSC Adv.
DOI:
10.1039/d2ra02888c
PubMed:
36043102

Amaryllidaceae, Lycopodiaceae Alkaloids and Coumarins-A Comparative Assessment of Safety and Pharmacological Activity.

Phytochemistry
Herbet M et al (2022).
J Clin Med.
DOI:
10.3390/jcm11154291
PubMed:
35893381

Biobased Spore Microcapsules for Asphalt Self-Healing.

Alpizar-Reyes E et al (2022).
ACS Appl Mater Interfaces.
DOI:
10.1021/acsami.2c07301
PubMed:
35772026

Bioactivity study and metabolic profiling of Colletotrichum alatae LCS1, an endophyte of club moss Lycopodium clavatum L.

Santra HK and Banerjee D (2022).
PLoS One.
DOI:
10.1371/journal.pone.0267302
PubMed:
35482744

Cytotoxic and nitric oxide inhibitory activities of triterpenoids from Lycopodium clavatum L.

Giang VH et al (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2021.2024824
PubMed:
34989301

Antiproliferative effects of combinational therapy of Lycopodium clavatum and quercetin in colon cancer cells.

Cancer
Banerjee A et al (2020).
J Basic Clin Physiol Pharmacol.
DOI:
10.1515/jbcpp-2019-0193
PubMed:
32396140

Serratane triterpenoids isolated from Lycopodium clavatum by bioactivity-guided fractionation attenuate the production of inflammatory mediators.

Immunology
Jo A, Een Kim C and Lee M (2020).
Bioorg Chem.
DOI:
10.1016/j.bioorg.2020.103632
PubMed:
32059153

Treatment with Lycopodium clavatum 200dH Intensifies Kidney and Liver Injury in Mice Infected with Toxoplasma gondii.

Pereira AV et al (2020).
Arch Immunol Ther Exp (Warsz).
DOI:
10.1007/s00005-020-00567-5
PubMed:
31965304

Identification and Analysis of Chemical Constituents and Rat Serum Metabolites in Lycopodium clavatum Using UPLC-Q-TOF/MS Combined with Multiple Data-Processing Approaches.

Li X et al (2019).
Evid Based Complement Alternat Med.
DOI:
10.1155/2019/5165029
PubMed:
31354854

Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication.

Summary

Scientists have been investigating the use of 3,4-diaminopyridine to reverse botulinum intoxication, but its narrow therapeutic window and poor pharmacokinetics have limited its use. To address these problems, researchers developed an oral delivery system using the exines from club moss spores. These microcapsules slowed the absorption of the drug, reduced seizures, and allowed for higher doses to be administered, which improved survival rates in mice with botulinum neurotoxin A intoxication. This new delivery platform could potentially have broad implications for the treatment of botulinum intoxication.

Neuroscience
Harris TL et al (2016).
Chem Commun (Camb).
DOI:
10.1039/c6cc00615a
PubMed:
26906286

Effect of homeopathic Lycopodium clavatum on memory functions and cerebral blood flow in memory-impaired rats.

Hanif K et al (2015).
Homeopathy.
DOI:
10.1016/j.homp.2014.08.003
PubMed:
25576268

Vascular architecture in shoots of early divergent vascular plants, Lycopodium clavatum and Lycopodium annotinum.

Gola EM, Jernstedt JA and Zagórska-Marek B (2007).
New Phytol.
DOI:
10.1111/j.1469-8137.2007.02050.x
PubMed:
17504461

Lycopodium clavatum.

FLEAGLE MM et al (1955).
Hahnemannian.
PubMed:
13277900