Macleaya cordata

Common Names: plume poppy

Ethnobotanical Studies

Clinical Trials

Combination of plant phenolics and isoquinolinium alkaloids protects gingival fibroblast and improves post-extraction healing after lower third molar extraction.

This study examined the effects of a plant extract combination on reducing inflammation in gum cells and in patients who had oral surgery.

Chytilova K et al (2023).
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub.
DOI:
10.5507/bp.2021.055
PubMed:
34617520

Studies

The growth-promoting effect of water extract of Chuanminshen violaceum stem and leaf on broilers.

Liu H et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2024.104235
PubMed:
39241612

Dietary supplementation with Macleaya cordata extract alleviates intestinal injury in broiler chickens challenged with lipopolysaccharide by regulating gut microbiota and plasma metabolites.

Gastroenterology
Wang X et al (2024).
Front Immunol.
DOI:
10.3389/fimmu.2024.1414869
PubMed:
39100674

Effect of dietary supplementation with sanguinarine on meat quality and lipid metabolism of broilers.

Su Y et al (2024).
Poult Sci.
DOI:
10.1016/j.psj.2024.103925
PubMed:
38943809

Safety and efficacy of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® Extra) for suckling and weaned piglets and other growing Suidae (Phytobiotics Futterzusatzstoffe GmbH).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2024).
EFSA J.
DOI:
10.2903/j.efsa.2024.8793
PubMed:
38774115

Erratum: [Corrigendum] Macleaya cordata extracts exert antiviral effects in newborn mice with rotavirus‑induced diarrhea via inhibiting the JAK2/STAT3 signaling pathway.

Summary

Researchers investigated the effects of a new compound on cancer cells and found it inhibits tumor growth. Potential for new cancer treatment.

AntimicrobialImmunology
Jiang C et al (2024).
Exp Ther Med.
DOI:
10.3892/etm.2024.12531
PubMed:
38655038

Correction: Dong et al. Identification of the Trace Components in BopuzongJian and Macleaya cordata Extract Using LC-MS Combined with a Screening Method. Molecules 2021, 26, 3851.

Dong Z et al (2024).
Molecules.
DOI:
10.3390/molecules29061268
PubMed:
38543051

CRISPR/Cas9 revolutionizes Macleaya cordata breeding: a leap in sanguinarine biosynthesis.

Genetics
Sun M et al (2024).
Hortic Res.
DOI:
10.1093/hr/uhae024
PubMed:
38495029

Protective effect of Macleaya cordata isoquinoline alkaloids on lipopolysaccharide-induced liver injury in broilers.

Summary

Experiment: Studied if isoquinoline alkaloids from Macleaya cordata can protect broiler chickens from liver injury caused by lipopolysaccharide (LPS). Relevant for understanding potential benefits of IA supplementation in preventing liver damage.

Phytochemistry
Chen J et al (2023).
Anim Biosci.
DOI:
10.5713/ab.23.0267
PubMed:
37946426

Bacillus subtilis and Macleaya cordata extract regulate the rumen microbiota associated with enteric methane emission in dairy cows.

Summary

Feeding Bacillus subtilis (BS) and Macleaya cordata extract (MCE) to dairy cows increased dry matter intake and milk production, while reducing methane emissions. This study uses metagenomics to understand their impact on rumen methanogenesis.

Gastroenterology
Jia P et al (2023).
Microbiome.
DOI:
10.1186/s40168-023-01654-3
PubMed:
37858227

Microbiome-transcriptome analysis reveals that dietary supplementation with macleaya cordata extract alters multiple immune pathways with minimal impact on microbial structure.

Summary

Study investigated the effects of macleaya cordata extract (MCE) on the gut microbiota and host interactions in young goats. Results suggest MCE has potential as an antibiotic alternative.

Genetics
Wu J et al (2023).
Front Cell Infect Microbiol.
DOI:
10.3389/fcimb.2023.1264550
PubMed:
37842002

Effects of White Fish Meal Replaced by Low-Quality Brown Fish Meal with Compound Additives on Growth Performance and Intestinal Health of Juvenile American Eel (Anguilla rostrata).

Gastroenterology
Lu W et al (2023).
Animals (Basel).
DOI:
10.3390/ani13182873
PubMed:
37760273

Dietary Macleaya cordata extract supplementation improves the growth performance and gut health of broiler chickens with necrotic enteritis.

Gastroenterology
Song B et al (2023).
J Anim Sci Biotechnol.
DOI:
10.1186/s40104-023-00916-2
PubMed:
37674220

6-Methoxydihydrosanguinarine exhibits cytotoxicity and sensitizes TRAIL-induced apoptosis of hepatocellular carcinoma cells through ROS-mediated upregulation of DR5.

Wang LL et al (2023).
Med Oncol.
DOI:
10.1007/s12032-023-02129-z
PubMed:
37566135

Protopine Alleviates Dextran Sodium Sulfate-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Regulating Intestinal Microbiota.

Gastroenterology
Yue M et al (2023).
Molecules.
DOI:
10.3390/molecules28135277
PubMed:
37446938

Response and Tolerance of Macleaya cordata to Excess Zinc Based on Transcriptome and Proteome Patterns.

Genetics
Zhang H et al (2023).
Plants (Basel).
DOI:
10.3390/plants12122275
PubMed:
37375899

Safety and efficacy of a feed additive consisting of Macleaya cordata (Willd.) R. Br. extract and leaves (Sangrovit® extra) for all poultry species (excluding laying and breeding birds) (Phytobiotics Futterzusatzstoffe GmbH).

EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) et al (2023).
EFSA J.
DOI:
10.2903/j.efsa.2023.8052
PubMed:
37304353

Physiological and molecular response and tolerance of Macleaya cordata to lead toxicity.

Zhang H et al (2023).
BMC Genomics.
DOI:
10.1186/s12864-023-09378-2
PubMed:
37226137

Potential pharmacological mechanisms of four active compounds of Macleaya cordata extract against enteritis based on network pharmacology and molecular docking technology.

Yang P et al (2023).
Front Physiol.
DOI:
10.3389/fphys.2023.1175227
PubMed:
37200837

Determination of Some Isoquinoline Alkaloids in Extracts Obtained from Selected Plants of the Ranunculaceae, Papaveraceae and Fumarioideae Families by Liquid Chromatography and In Vitro and In Vivo Investigations of Their Cytotoxic Activity.

Phytochemistry
Misiurek J et al (2023).
Molecules.
DOI:
10.3390/molecules28083503
PubMed:
37110737

Sanguinarine inhibits melanoma invasion and migration by targeting the FAK/PI3K/AKT/mTOR signalling pathway.

Qi X et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2200787
PubMed:
37092313

Antibacterial activity and mechanism of sanguinarine against Staphylococcus aureus by interfering with the permeability of the cell wall and membrane and inducing bacterial ROS production.

Gu Y et al (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2023.1121082
PubMed:
37065245

Editorial: Phytotherapeutic alternatives in veterinary medicine, vol II.

Mestorino N and Reeve-Johnson L (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2023.1174494
PubMed:
37065242

Effects of Macleaya cordata extract supplementation on digestive parameters of ponies.

de Medeiros Ferreira JR et al (2023).
Arch Anim Nutr.
DOI:
10.1080/1745039X.2023.2187198
PubMed:
37020330

Sanguinarine Exhibits Antiviral Activity against Porcine Reproductive and Respiratory Syndrome Virus via Multisite Inhibition Mechanisms.

Antimicrobial
Ke Q et al (2023).
Viruses.
DOI:
10.3390/v15030688
PubMed:
36992397

Anti-Inflammatory Effects of Allocryptopine via the Target on the CX3CL1-CX3CR1 axis/GNB5/AKT/NF-κB/Apoptosis in Dextran Sulfate-Induced Mice.

Immunology
Yang Y et al (2023).
Biomedicines.
DOI:
10.3390/biomedicines11020464
PubMed:
36831001

Effects of Macleaya Cordata Extract on Performance, Nutrient Apparent Digestibilities, Milk Composition, and Plasma Metabolites of Dairy Goats.

Ling H et al (2023).
Animals (Basel).
DOI:
10.3390/ani13040566
PubMed:
36830352

Oxidative Stress Response and Metal Transport in Roots of Macleaya cordata Exposed to Lead and Zinc.

Zhang H et al (2023).
Plants (Basel).
DOI:
10.3390/plants12030516
PubMed:
36771604

Ethoxysanguinarine Induces Apoptosis, Inhibits Metastasis and Sensitizes cells to Docetaxel in Breast Cancer Cells through Inhibition of Hakai.

Cancer
Ma L et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202200284
PubMed:
36633334

Evaluating Ruminal and Small Intestinal Morphology and Microbiota Composition of Calves Fed a Macleaya cordata Extract Preparation.

Gastroenterology
Wickramasinghe J et al (2022).
Animals (Basel).
DOI:
10.3390/ani13010054
PubMed:
36611664

Administration of Samital® in children with oral mucositis: a feasibility study.

Massano D et al (2022).
Eur Rev Med Pharmacol Sci.
DOI:
10.26355/eurrev_202211_30393
PubMed:
36459038

Assessing Performance and Safety of Feeding a Standardized Macleaya cordata Extract to Calves.

Matulka RA et al (2022).
Animals (Basel).
DOI:
10.3390/ani12202875
PubMed:
36290259

Dietary supplementation of Macleaya cordata extract and Bacillus in combination improve laying performance by regulating reproductive hormones, intestinal microbiota and barrier function of laying hens.

Endocrinology
Wang F et al (2022).
J Anim Sci Biotechnol.
DOI:
10.1186/s40104-022-00766-4
PubMed:
36224643

Oregano Oil Combined with Macleaya Cordata Oral Solution Improves the Growth Performance and Immune Response of Broilers.

Zhang C et al (2022).
Animals (Basel).
DOI:
10.3390/ani12182480
PubMed:
36139338

Macleaya cordata extract improves the growth performance and intestinal health of American eels (Anguilla rostrata) farmed in intensive system.

Gastroenterology
Wang YL, Wu CY and Zhai SW (2022).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2120480
PubMed:
36067489

Impacts of Macleaya cordata on Productive Performance, Expression of Growth-Related Genes, Hematological, and Biochemical Parameters in Turkey.

Genetics
Manaa EA et al (2022).
Front Vet Sci.
DOI:
10.3389/fvets.2022.873951
PubMed:
35903127

Isoquinoline Alkaloid Contents in Macleaya cordata Extracts and Their Acetylcholinesterase and Butyrylcholinesterase Inhibition.

Summary

The study aimed to optimize a method for determining cholinesterase activity using high-performance liquid chromatography and then investigate the potential of isoquinoline alkaloids and plant extracts for inhibiting acetylcholinesterase and butyrylcholinesterase activity. The HPLC method successfully eliminated interference from certain alkaloids and allowed for identification of bioactive compounds in the plant extracts. Results showed high inhibition activity, particularly in sanguinarine and chelerythrine alkaloids and the May aerial plant extract. These extracts may be recommended for further in vivo testing to confirm cholinesterase inhibition activity.

NeurosciencePhytochemistry
Tuzimski T et al (2022).
Molecules.
DOI:
10.3390/molecules27113606
PubMed:
35684539

Nano-selenium and Macleaya cordata Extracts Improved Immune Function and Reduced Oxidative Damage of Sows and IUGR Piglets After Heat Stress of Sows in Late Gestation.

Li Y et al (2022).
Biol Trace Elem Res.
DOI:
10.1007/s12011-022-03103-y
PubMed:
35020160

The effect of Macleaya cordata extract on in vitro ruminal fermentation and methanogenesis.

Genetics
Zeng Z et al (2021).
Food Sci Nutr.
DOI:
10.1002/fsn3.2436
PubMed:
34401103

Medicinal plants of the genus Macleaya (Macleaya cordata, Macleaya microcarpa): A review of their phytochemistry, pharmacology, and toxicology.

Review Phytochemistry
Lin L et al (2018).
Phytother Res.
DOI:
10.1002/ptr.5952
PubMed:
29130543