Magnolia officinalis

Ethnobotanical Studies

Studies

Comprehensive exploration of a traditional Chinese medicinal plant of Magnolia officinalis based on high-coverage mass spectrometry and multidimensional chemical-biological analysis.

Wang WY et al (2024).
J Chromatogr B Analyt Technol Biomed Life Sci.
DOI:
10.1016/j.jchromb.2024.124290
PubMed:
39208603

Toxicological effects of Honokiol on zebrafish and its underlying mechanism.

Lin J et al (2024).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23789
PubMed:
39097765

Comparative Anti-Cancer and Anti-Inflammatory Activities of Essential Oils from the Bark and Flower of Magnolia officinalis Rehd. et Wils.

CancerImmunology
Hao KX et al (2024).
Foods.
DOI:
10.3390/foods13132074
PubMed:
38998580

Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review.

Summary

Researchers studied the effects of Magnolia officinalis on various health conditions. Active ingredients show potential for antibacterial, anti-tumor, anti-inflammatory, antioxidant, anti-aging, and anti-Alzheimer's effects. Promising for future treatments.

Review Neuroscience
Li N et al (2024).
Ageing Res Rev.
DOI:
10.1016/j.arr.2024.102398
PubMed:
38955265

Magterpenes A-C: Three Meroterpenoids with an Unprecedented 6/6/6/6/6 Polycyclic Skeleton Extracted from Magnolia officinalis Rehd. et Wils.

Sun J et al (2024).
J Org Chem.
DOI:
10.1021/acs.joc.4c00739
PubMed:
38837353

Magnolia Officinalis Alcohol Extract Alleviates the Intestinal Injury Induced by Polygala Tenuifolia Through Regulating the PI3K/AKT/NF-κB Signaling Pathway and Intestinal Flora.

GastroenterologyImmunology
Liu S et al (2024).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S461152
PubMed:
38799799

Extraction and Biological Activity of Lignanoids from Magnolia officinalis Rehder & E.H.Wilson Residual Waste Biomass Using Deep Eutectic Solvents.

Lu Y et al (2024).
Molecules.
DOI:
10.3390/molecules29102352
PubMed:
38792212

Semisynthesis and biological evaluation of novel honokiol thioethers against colon cancer cells HCT116 via inhibiting the transcription and expression of YAP protein.

Summary

Novel honokiol thioether 3k, derived from a traditional Chinese medicine, showed superior anticancer activity against colon cancer cells. Inhibits cell proliferation and induces cell death by directly inhibiting YAP protein expression. Could be a promising anticancer candidate.

CancerGastroenterology
Yang R et al (2024).
Bioorg Med Chem.
DOI:
10.1016/j.bmc.2024.117762
PubMed:
38759254

A network pharmacology-based method to explore the therapeutic effect of honokiol on diabetes with comorbid depression in mice.

Summary

Honokiol from Magnolia officinalis may help treat diabetes with depression by activating RXR/VDR heterodimer. This could restore autophagy balance and improve neuroplasticity in the hippocampus.

DiabetesNeuroscience
Sun H et al (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176642
PubMed:
38754538

Honokiol suppress the PD-L1 expression to improve anti-tumor immunity in lung cancer.

Summary

Honokiol from Magnolia officinalis inhibits lung cancer growth by targeting PD-L1, suppressing its expression, blocking PD-1/PD-L1 pathway, and enhancing anti-tumor immunity through T cell activation and infiltration. Important for improving lung cancer treatment.

Cancer
Luo L et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112098
PubMed:
38626551

Magnolia officinalis Rehder & E. Wilson ameliorates white adipogenesis by upregulating AMPK and SIRT1 in vitro and in vivo.

Park YJ et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e27600
PubMed:
38515723

Revealing receptor-ligand interactions of atypical antipsychotic drugs and screening anti-schizophrenia ingredients in Magnolia officinalis based on 5-HTR2A-SNAP-Tag/CMC and DRD2-SNAP-Tag/CMC models.

Summary

New models for studying interactions between antipsychotic drugs and key receptors in schizophrenia show promise for developing more effective treatments. High selectivity and stability suggest potential for screening new compounds.

Neuroscience
Gao C et al (2024).
J Chromatogr A.
DOI:
10.1016/j.chroma.2024.464784
PubMed:
38442497

Long COVID-19 gastrointestinal related disorders and traditional Chinese medicine: A network target-based approach.

Summary

Research reviewed nutraceuticals from Traditional Chinese Medicine for relieving Long COVID-19 gastrointestinal symptoms. Identified plants such as Cinnamomum cassia and Salvia miltiorrhiza show promise in reducing inflammation and oxidative stress. These natural remedies may offer multi-target therapeutic benefits for Long COVID-19 complications.

Review COVID-19
Mattioli LB et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8163
PubMed:
38421118

The natural compounds, Magnolol or Honokiol, promote adipose tissue browning and resist obesity through modulating PPARα/γ activity.

Summary

Magnolia officinalis extracts activate PPAR pathways, reduce NAFLD, promote adipose tissue browning, and combat obesity through enhanced energy expenditure and thermogenesis. Key role of FGF21 in liver-adipocyte communication.

Obesity
Chu Y et al (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176438
PubMed:
38402928

Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota.

Gastroenterology
Tuohongerbieke A et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17020153
PubMed:
38399368

Effect of Honokiol on culture time and survival of Alzheimer's disease iPSC-derived neurons.

Summary

Study tested honokiol on iPSC-derived neurons from an Alzheimer's patient to improve survival and culture time. Shows potential for therapeutic strategies in Alzheimer's disease research.

Neuroscience
Le DTT et al (2024).
Bioimpacts.
DOI:
10.34172/bi.2023.27652
PubMed:
38327632

Application and mechanisms of Sanhua Decoction in the treatment of cerebral ischemia-reperfusion injury.

Summary

Sanhua Decoction, a traditional Chinese medicinal formulation, shows potential in treating cerebral ischemia-reperfusion injury. It acts through antioxidant, anti-inflammatory, and neurotransmitter regulatory pathways to protect nerve cells and reduce cerebral edema. Studying its mechanisms can improve understanding and future clinical application.

Review Cardiology
Wang YK et al (2024).
World J Clin Cases.
DOI:
10.12998/wjcc.v12.i4.688
PubMed:
38322692

Honokiol targeting ankyrin repeat domain of TRPV4 ameliorates endothelial permeability in mice inflammatory bowel disease induced by DSS.

Immunology
Niu L et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117825
PubMed:
38296175

Chiral separation and bioactivities of six pairs of enantiomeric dilignans from Magnolia officinalis var. biloba.

Zang YD et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.113964
PubMed:
38184162

Inhibition of Ca(2+)-permeable TRPV3 and inflammatory cytokine release by honokiol and magnolol in human epidermal keratinocytes.

Immunology
Thi HD et al (2024).
Biochem Biophys Res Commun.
DOI:
10.1016/j.bbrc.2023.149332
PubMed:
38043155

Honokiol Attenuates Choroidal Neovascularization by Inhibiting the Hypoxia-Inducible Factor-α/Vascular Endothelial Growth Factor Axis via Nuclear Transcription Factor-Kappa B Activation.

Pan N et al (2024).
Curr Eye Res.
DOI:
10.1080/02713683.2023.2259634
PubMed:
37707827

Magnolia officinalis Bark Extract Prevents Enterocyte Death in a Colitis Mouse Model by Inhibiting ROS-Mediated Necroptosis.

Gastroenterology
Lee KI et al (2022).
Antioxidants (Basel).
DOI:
10.3390/antiox11122435
PubMed:
36552643

Magnolia officinalis and Its Honokiol and Magnolol Constituents Inhibit Human Norovirus Surrogates.

Kim H, Lim CY and Chung MS (2021).
Foodborne Pathog Dis.
DOI:
10.1089/fpd.2020.2805
PubMed:
32716659

Safety and Toxicology of Magnolol and Honokiol.

Review
Sarrica A et al (2018).
Planta Med.
DOI:
10.1055/a-0642-1966
PubMed:
29925102

Is there a potential of misuse for Magnolia officinalis compounds/metabolites?

Review
Schifano F et al (2017).
Hum Psychopharmacol.
DOI:
10.1002/hup.2595
PubMed:
28517911