Marrubium vulgare

Common Names: horehound

Ethnobotanical Studies

Studies

Phytogenic effects of Marrubium vulgare on the growth performance of weaned piglets: biochemical parameters and liquid chromatographic-electrospray ionization-mass spectrometric profile of plant and animal serum.

da Silva AC et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13799
PubMed:
39113580

Biological Activity of Horehound (Marrubium vulgare L.) Herb Grown in Poland and Its Phytochemical Composition.

Summary

Horehound extract contains antioxidants and antimicrobial compounds, showing potential for pharmaceutical and cosmetic applications. Its chemical composition and biological properties offer protective benefits for skin cells and antimicrobial activity against various pathogens.

Phytochemistry
Michalak M et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17060780
PubMed:
38931446

Neuroprotective Effect of Marrubium vulgare Extract in Scopolamine-Induced Cognitive Impairment in Rats: Behavioral and Biochemical Approaches.

Summary

The study found that the extract improved memory in rats by preserving cholinergic function, increasing NA levels, and restoring pCREB expression. It may have neuroprotective effects through modulation of cholinergic function and NA neurotransmission.

Neuroscience
Lazarova M et al (2024).
Biology (Basel).
DOI:
10.3390/biology13060426
PubMed:
38927306

Development of Biologically Active Phytosynthesized Silver Nanoparticles Using Marrubium vulgare L. Extracts: Applications and Cytotoxicity Studies.

Lupuliasa AI et al (2024).
Nanomaterials (Basel).
DOI:
10.3390/nano14100895
PubMed:
38786851

Chemical Investigation and Antinociceptive Activity Evaluation of Marrubium Vulgare L. Aqueous Extract.

Aitbaba A et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400228
PubMed:
38613448

Marrubium vulgare Extract Improves Spatial Working Memory and Oxidative Stress Damage in Scopolamine-Treated Rats.

Summary

Researchers studied the potential benefits of Marrubium vulgare, or 'white horehound,' on Alzheimer's disease. Results suggest it may protect against neuronal loss, oxidative stress, and improve short-term memory. Promising for future treatments.

Immunology
Lazarova MI et al (2024).
J Alzheimers Dis.
DOI:
10.3233/JAD-231011
PubMed:
38489175

Efficacy and tolerability of SEDIFLÙ in treating dry or productive cough in the pediatric population (SEPEDIA): A pilot, randomized, double-blind, placebo-controlled, multicenter clinical trial.

Núñez C et al (2024).
Clin Pediatr (Phila).
DOI:
10.1177/00099228241228074
PubMed:
38323572

Biochemical and pharmaceutical traits of Marrubium vulgare L. plants treated with plant growth-promoting bacteria and elevated CO(2).

AbdElgawad H et al (2023).
3 Biotech.
DOI:
10.1007/s13205-023-03836-0
PubMed:
37997597

Insight into biological activities of chemically characterized extract from Marrubium vulgare L. in vitro, in vivo and in silico approaches.

Gourich AA et al (2023).
Front Chem.
DOI:
10.3389/fchem.2023.1238346
PubMed:
37663139

Evaluation of pharmaceutical compounds at vegetative and reproductive growth stages of Marrubium vulgare, a medicinal plant to cleanse the body.

Aeineh M, Najafian S and Hosseinifarahi M (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2245116
PubMed:
37599619

Effect of honey bee forage plants in Tunisia on diversity and antibacterial potential of lactic acid bacteria and bifidobacteria from Apis mellifera intermissa and its products.

Ben-Miled H et al (2023).
Arch Microbiol.
DOI:
10.1007/s00203-023-03630-9
PubMed:
37480514

Diversity of Medicinal Plants Used by the Local Communities of the Coastal Plateau of Safi Province (Morocco).

Lemhadri A et al (2023).
Front Biosci (Schol Ed).
DOI:
10.31083/j.fbs1501001
PubMed:
36959109

Chemical Profile and Cytotoxicity Evaluation of Aerial Parts of Marrubium vulgare L. From Different Locations in Turkey.

Demiroz Akbulut T et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202201188
PubMed:
36929733

The Application of Ultrasonic Waves and Microwaves to Improve Antihyperglycaemic and Antimicrobial Activities of Marrubium vulgare Extracts.

Antimicrobial
Gavarić A et al (2022).
Antibiotics (Basel).
DOI:
10.3390/antibiotics11111475
PubMed:
36358130

Tunisian Horehound (Marrubium vulgare) Aqueous Extract Improves Treatment of Bleomycin-Induced Lung Fibrosis in Rat.

Abidi A et al (2022).
Dose Response.
DOI:
10.1177/15593258221119300
PubMed:
36003317

Neurobehavioral and Biochemical Evidences in Support of Protective Effect of Marrubiin (Furan Labdane Diterpene) from Marrubium vulgare Linn. and Its Extracts after Traumatic Brain Injury in Experimental Mice.

Summary

Traumatic brain injuries (TBI) can cause severe health problems. Researchers have found that the plant Linn. and its compound marrubiin have potential neuroprotective effects. In this study, marrubiin and hydroalcoholic extracts of the plant were used to test their effectiveness on TBI. The samples showed significant improvements in neurological severity score, oxidative stress parameters, and neurotransmitter levels. The study suggests that the plant extract could be beneficial in the treatment of TBI due to the presence of marrubiin and other secondary metabolites.

NeurosciencePhytochemistry
Nidhi et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/4457973
PubMed:
35656476

Supercritical CO(2) extraction of Marrubium vulgare: intensification of marrubiin.

Gavarić A et al (2021).
RSC Adv.
DOI:
10.1039/d0ra10253a
PubMed:
35423440

GC-MS Analysis, Heavy Metals, Biological, and Toxicological Evaluation of Reseda muricata and Marrubium vulgare Methanol Extracts.

Ullah R and Alqahtani AS (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/2284328
PubMed:
35356243

Ointment-Based Combination of Dittrichia viscosa L. and Marrubium vulgare L. Accelerate Burn Wound Healing.

Mssillou I et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15030289
PubMed:
35337087

Variation of the Chemical Composition of Essential Oils and Total Phenols Content in Natural Populations of Marrubium vulgare L.

Phytochemistry
Guedri Mkaddem M et al (2022).
Plants (Basel).
DOI:
10.3390/plants11050612
PubMed:
35270084

Evaluation of Marrubium vulgare Growing Wild in Tunisia for Its Potential as a Dietary Supplement.

Rezgui M et al (2021).
Foods.
DOI:
10.3390/foods10112864
PubMed:
34829146

Ethnobotanical survey about medicinal plants used in traditional treatment of insomnia, asthenia, and oral and gum infections in the region Fez-Meknes, Morocco.

Ethnobotany
Beniaich G et al (2022).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-021-14439-8
PubMed:
34031820

Chemical Characterization of Marrubium vulgare Volatiles from Serbia.

Aćimović M et al (2021).
Plants (Basel).
DOI:
10.3390/plants10030600
PubMed:
33806732

Novel potent natural peroxidases inhibitors with in vitro assays, inhibition mechanism and molecular docking of phenolic compounds and alkaloids.

Phytochemistry
Benarous K et al (2021).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2020.1808073
PubMed:
32799732

An Insight into a Blockbuster Phytomedicine; Marrubium vulgare L. Herb. More of a Myth than a Reality?

Review
Rodríguez Villanueva J and Martín Esteban J (2016).
Phytother Res.
DOI:
10.1002/ptr.5661
PubMed:
27271209

Chromatographic Fingerprint Analysis of Marrubiin in Marrubium vulgare L. via HPTLC Technique.

Yousefi K et al (2016).
Adv Pharm Bull.
DOI:
10.15171/apb.2016.019
PubMed:
27123428

[Marrubium vulgare].

CAVANNA D and PIRONA M (1950).
Boll Chim Farm.
PubMed:
14772340