Marsilea minuta, a plant used in traditional Indian medicine for insomnia and mental disorders, contains the compound marsiline, known for its sedative and anticonvulsant properties. Researchers extracted Marsilea minuta ethanol to study its antidepressant effects, standardizing for marsiline content at 1.15%. The study aimed to investigate the potential antidepressant activity of the extract. This research adds to the growing body of literature supporting the use of natural remedies in mental healthcare. Further research is needed to determine the extent of its clinical benefits.