Matricaria chamomilla

Ethnobotanical Studies

Clinical Trials

Putative Antidepressant Effect of Chamomile (Matricaria chamomilla L.) Oral Extract in Subjects with Comorbid Generalized Anxiety Disorder and Depression.

Amsterdam JD et al (2020).
J Altern Complement Med.
DOI:
10.1089/acm.2019.0252
PubMed:
31808709

Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial.

Mao JJ et al (2016).
Phytomedicine.
DOI:
10.1016/j.phymed.2016.10.012
PubMed:
27912875

Studies

Impact of NaCl stress on phytoconstituents and bioactivity of Matricaria chamomilla: a multi-analytical approach.

Shakir N et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-70672-4
PubMed:
39181928

German Chamomile (Matricaria chamomilla L.) Flower Extract, Its Amino Acid Preparations and 3D-Printed Dosage Forms: Phytochemical, Pharmacological, Technological, and Molecular Docking Study.

Phytochemistry
Koshovyi O et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25158292
PubMed:
39125862

Effects of chamomile (Matricaria chamomilla L.) on sleep: A systematic review and meta-analysis of clinical trials.

Meta-Analysis
Kazemi A et al (2024).
Complement Ther Med.
DOI:
10.1016/j.ctim.2024.103071
PubMed:
39106912

Farmers' knowledge in the Swiss canton Valais: cultural heritage with future significance for European veterinary medicine?

Holzner LA et al (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-024-00716-6
PubMed:
39103869

Anti-Inflammatory and Cancer-Preventive Potential of Chamomile (Matricaria chamomilla L.): A Comprehensive In Silico and In Vitro Study.

Summary

Study found chamomile tea may prevent cancer due to its anti-inflammatory properties. Worth investigating further for potential health benefits in cancer prevention.

CancerImmunology
Drif AI et al (2024).
Biomedicines.
DOI:
10.3390/biomedicines12071484
PubMed:
39062057

The effect of chamomile consumption on glycemic markers in humans and animals: a systematic review and meta-analysis.

Summary

Chamomile consumption with diabetes medications may improve blood sugar control. Conducted review and meta-analysis on human and animal studies. Useful info for diabetic patients and research labs.

Review Diabetes
Akhgarjand C et al (2023).
J Diabetes Metab Disord.
DOI:
10.1007/s40200-023-01345-8
PubMed:
38932814

GC-MS Combined with Fast GC E-Nose for the Analysis of Volatile Components of Chamomile (Matricaria chamomilla L.).

Lu J et al (2024).
Foods.
DOI:
10.3390/foods13121865
PubMed:
38928807

Variability of Chalcone Synthase in Chamomile Accessions (Matricaria chamomilla).

Novak M, Jovanovic D and Novak J (2024).
Planta Med.
DOI:
10.1055/a-2214-0940
PubMed:
38843793

Evaluation of the Therapeutical Effect of Matricaria Chamomilla Extract vs. Galantamine on Animal Model Memory and Behavior Using 18F-FDG PET/MRI.

Iacob R et al (2024).
Curr Issues Mol Biol.
DOI:
10.3390/cimb46050273
PubMed:
38785541

Osteoarthritis: Insights into Diagnosis, Pathophysiology, Therapeutic Avenues, and the Potential of Natural Extracts.

Review
Coppola C et al (2024).
Curr Issues Mol Biol.
DOI:
10.3390/cimb46050251
PubMed:
38785519

A new methodology for a rapid and high-throughput comparison of molecular profiles and biological activity of phytoextracts.

Caldeira V et al (2024).
Biotechnol Bioeng.
DOI:
10.1002/bit.28739
PubMed:
38760962

Impact of novel herbicide based on synthetic auxins and ALS inhibitor on weed control.

Grzanka M et al (2024).
Open Life Sci.
DOI:
10.1515/biol-2022-0868
PubMed:
38681726

Plant-Mediated Synthesis of Magnetite Nanoparticles with Matricaria chamomilla Aqueous Extract.

Paut A et al (2024).
Nanomaterials (Basel).
DOI:
10.3390/nano14080729
PubMed:
38668223

High-Quality Assembly and Analysis of the Complete Mitogenomes of German Chamomile (Matricaria recutita) and Roman Chamomile (Chamaemelum nobile).

Yang J et al (2024).
Genes (Basel).
DOI:
10.3390/genes15030301
PubMed:
38540360

Phytochemical, Technological, and Pharmacological Study on the Galenic Dry Extracts Prepared from German Chamomile (Matricaria chamomilla L.) Flowers.

Phytochemistry
Sepp J et al (2024).
Plants (Basel).
DOI:
10.3390/plants13030350
PubMed:
38337883

Elimination of detached Listeria monocytogenes from the biofilm on stainless steel surfaces during milk and cheese processing using natural plant extracts.

El-Sawy YNA et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-52394-9
PubMed:
38280925

Alternative Crops for the European Tobacco Industry: A Systematic Review.

Review
Mavroeidis A et al (2024).
Plants (Basel).
DOI:
10.3390/plants13020236
PubMed:
38256796

Essential Oil of Matricaria chamomilla Alleviate Psoriatic-Like Skin Inflammation by Inhibiting PI3K/Akt/mTOR and p38MAPK Signaling Pathway.

Summary

Researchers investigated the potential of German chamomile essential oil for treating skin inflammation. This study fills in the knowledge gap and offers a natural remedy option for dermatologists to consider.

ImmunologyPhytochemistry
Chen G et al (2024).
Clin Cosmet Investig Dermatol.
DOI:
10.2147/CCID.S445008
PubMed:
38222858

Chemoprofiling and antimicrobial activity of medicinal herbs used in the treatment of inflammatory bowel disease.

Summary

This study evaluated the antimicrobial activity of five herbs used to treat inflammatory bowel disease (IBD) in Saudi Arabia. The herbs showed good activity against E. coli and S. aureus, suggesting their potential as natural remedies for IBD.

AntimicrobialImmunology
Alshahrani A, Ali A and Abdelwahab SF (2023).
Cell Mol Biol (Noisy-le-grand).
DOI:
10.14715/cmb/2023.69.13.6
PubMed:
38158691

Antimicrobial effect of chamomile-containing over-the-counter ear and eye drops.

Summary

Chamomile eardrops and eye drops were tested for their antimicrobial effects on bacteria causing ear infections and conjunctivitis. Both drops showed significant reduction in bacterial growth, suggesting potential use as non-prescription treatments for these conditions.

Antimicrobial
Farsi S et al (2024).
J Investig Med.
DOI:
10.1177/10815589231223201
PubMed:
38142266

Establishment and validation of a callus tissue transformation system for German chamomile (Matricaria chamomilla L.).

Tai Y et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04680-3
PubMed:
38124039

Wild Edible Flowers of Western Himalayas: Nutritional Characterization, UHPLC-QTOF-IMS-Based Phytochemical Profiling, Antioxidant Properties, and In Vitro Bioaccessibility of Polyphenols.

ImmunologyPhytochemistry
Hegde AS et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c03861
PubMed:
37929082

Green synthesized silver nanoparticles using the plant-based reducing agent Matricaria chamomilla induce cell death in colorectal cancer cells.

Summary

Researchers used chamomile to synthesize silver nanoparticles (SNs) with anticancer properties, providing a safe and natural alternative to chemotherapy. This could potentially reduce side effects and offer a more affordable and eco-friendly treatment option for cancer.

CancerGastroenterology
Abdellatif AAH et al (2023).
Eur Rev Med Pharmacol Sci.
DOI:
10.26355/eurrev_202310_34191
PubMed:
37916381

Design and Development of a Topical Nanogel Formulation Comprising of a Unani Medicinal Agent for the Management of Pain.

Summary

Scientists developed a nanogel delivery system for chamomile oil to treat pain. In vitro and in vivo studies showed enhanced skin penetration, improved pain threshold, and reduced skin irritation, making it a promising treatment for migraines.

Pain
Sah A et al (2023).
Gels.
DOI:
10.3390/gels9100794
PubMed:
37888367

Therapeutic Potential of Green-Engineered ZnO Nanoparticles on Rotenone-Exposed D. melanogaster (Oregon R(+)): Unveiling Ameliorated Biochemical, Cellular, and Behavioral Parameters.

Shabir S et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12091679
PubMed:
37759981

Matricaria chamomilla Essential Oils: Repellency and Toxicity against Imported Fire Ants (Hymenoptera: Formicidae).

Shah FM et al (2023).
Molecules.
DOI:
10.3390/molecules28145584
PubMed:
37513455

Matricaria chamomilla essential oil-loaded hybrid electrospun nanofibers based on polycaprolactone/sulfonated chitosan/ZIF-8 nanoparticles for wound healing acceleration.

Phytochemistry
Nezhad-Mokhtari P et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.125718
PubMed:
37419259

Effect of chamomile (Matricaria chamomilla L.), linden (Tilia cordata Mill.), and green tea (Camellia sinensis L.) aqueous extract administration in the drinking water during pre-slaughter feed withdrawal period in broiler chickens.

Erener G et al (2023).
Trop Anim Health Prod.
DOI:
10.1007/s11250-023-03663-8
PubMed:
37382686

Estimation of the Controlled Release of Antioxidants from β-Cyclodextrin/Chamomile (Matricaria chamomilla L.) or Milk Thistle (Silybum marianum L.), Asteraceae, Hydrophilic Extract Complexes through the Fast and Cheap Spectrophotometric Technique.

Horablaga A et al (2023).
Plants (Basel).
DOI:
10.3390/plants12122352
PubMed:
37375976

Use of Multivariate Analysis to Unravel the Differences between Two Chamomile Varieties and Their Anticancer and Antioxidant Activities.

Summary

Two varieties of chamomile (Jordanian and European) were studied to measure the depth of variation in their bioactive flavonoids and phenolics. These plants, both belonging to the Asteraceae family, have been traditionally used in treating diseases. The study found significant distinctions in the secondary metabolites produced by the two varieties. By employing multivariate statistical analysis, researchers were able to determine the extent of this variation. This research provides valuable insights into the diversity within plant species and highlights the potential for the development of targeted therapeutic applications.

CancerImmunology
Atoum D et al (2023).
Plants (Basel).
DOI:
10.3390/plants12122297
PubMed:
37375922

Exploring the Potential of Supercritical Fluid Extraction of Matricaria chamomilla White Ray Florets as a Source of Bioactive (Cosmetic) Ingredients.

Pastare L et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12051092
PubMed:
37237958

In Vitro Anti-Inflammatory and Anticancer Evaluation of Mentha spicata L. and Matricaria chamomilla L. Essential Oils.

Summary

This study evaluated the anti-inflammatory and anticancer effects of pharma-grade essential oils, specifically spearmint and German chamomile. The oils were tested using enzyme assays and evaluated for their cytotoxic effects on various cell lines. The major components of the oils were identified, and their IC values were calculated. The essential oils were found to have no cytotoxic effects on healthy cells but increased apoptotic activity in cancer cells. Additionally, the oils showed selective inhibition of the COX-2 enzyme. These findings suggest a potential dual mode of action for the essential oils and warrant further investigation.

CancerImmunology
Biltekin SN et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c01501
PubMed:
37214687

Modulation of the bacterial virulence and resistance by well-known European medicinal herbs.

Křížkovská B et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116484
PubMed:
37044231

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre-clinical studies published from 2010 to 2020.

Summary

Researchers conducted a systematic review of scientific articles published between 2010 and 2020 that evaluated the anxiolytic, sedative, and/or hypnotic effects of flower extracts in pre-clinical animal models. They found that some flower extracts have an anxiolytic effect comparable to diazepam, but their therapeutic utility in anxiety disorders needs more investigation. The study compiled the characteristics of anxiety studies in animal models, evaluated locomotor activity, and the hypnotic effect of the extracts. The study revealed that matricaria chamomilla had a sedative effect, and 23 other flower plants had anxiolytic effects. However, more reliable behavioral tests and better experimental designs are needed to obtain more conclusive evidence with clinical significance.

Review Neuroscience
Meneses C et al (2023).
Phytother Res.
DOI:
10.1002/ptr.7830
PubMed:
37039741

Enhanced Bioactivity of Rosemary, Sage, Lavender, and Chamomile Essential Oils by Fractionation, Combination, and Emulsification.

Karaca N et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.2c07508
PubMed:
37008100

Drug Standardization through Pharmacognostic Approaches and Estimation of Anticancer Potential of Chamomile (Matricaria chamomilla L.) using Prostate-Cancer cell lines: An In-vitro Study.

Cancer
Khan N et al (2023).
J Cancer.
DOI:
10.7150/jca.77110
PubMed:
36860921

Essential Oils from Apiaceae, Asteraceae, Cupressaceae and Lamiaceae Families Grown in Serbia: Comparative Chemical Profiling with In Vitro Antioxidant Activity.

Phytochemistry
Gladikostić N et al (2023).
Plants (Basel).
DOI:
10.3390/plants12040745
PubMed:
36840093

The Potential of Medicinal Plants and Natural Products in the Treatment of Burns and Sunburn-A Review.

Review
Skowrońska W and Bazylko A (2023).
Pharmaceutics.
DOI:
10.3390/pharmaceutics15020633
PubMed:
36839954

The Therapeutic Wound Healing Bioactivities of Various Medicinal Plants.

Review
Albahri G et al (2023).
Life (Basel).
DOI:
10.3390/life13020317
PubMed:
36836674

Antibacterial Effect of Matricaria chamomilla L. Extract Against Enterococcus faecalis.

Kameri A et al (2023).
Clin Cosmet Investig Dent.
DOI:
10.2147/CCIDE.S399756
PubMed:
36820402

A phytotherapic blend immunity-6™ inhibits myeloid leukemic cells 2 activation involving purinergic signaling.

Bella YF et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.114263
PubMed:
36652732

Guaiazulene and related compounds: A review of current perspective on biomedical applications.

Review
Akram W et al (2023).
Life Sci.
DOI:
10.1016/j.lfs.2023.121389
PubMed:
36646376

[Effect of Matricaria chamomilla on stressed relatives of COVID-19 patients in andean communities of Peru].

COVID-19
Saldaña-Chafloque CF et al (2022).
Aten Primaria.
DOI:
10.1016/j.aprim.2022.102551
PubMed:
36641990

Chamomile: A Review of Its Traditional Uses, Chemical Constituents, Pharmacological Activities and Quality Control Studies.

Review
Dai YL et al (2022).
Molecules.
DOI:
10.3390/molecules28010133
PubMed:
36615326

Myrrh and Chamomile Flower Extract Inhibit Mediator Release from IgE-stimulated Mast-Cell-Like RBL-2H3 Cells.

Immunology
Altenbernd F et al (2022).
Plants (Basel).
DOI:
10.3390/plants11243422
PubMed:
36559534

Phytochemical Characterization of Chamomile (Matricaria recutita L.) Roots and Evaluation of Their Antioxidant and Antibacterial Potential.

Phytochemistry
Mailänder LK et al (2022).
Molecules.
DOI:
10.3390/molecules27238508
PubMed:
36500602

The Influence of Freeze-Dried Alcohol-Water Extracts from Common Yarrow (Achillea millefolium L.) and German Chamomile (Matricaria chamomilla L.) on the Properties of Elastomer Vulcanizates.

Aleksieiev A et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms232315048
PubMed:
36499374

Development of Silver nanoparticles green-formulated by ‎Matricaria chamomilla as novel chemotherapeutic nanoformulation for the treatment of oral squamous cell carcinoma‎.

Yang R et al (2022).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666221116101621
PubMed:
36397627

Matricaria chamomilla (Chamomile) Ameliorates Muscle Atrophy in Mice by Targeting Protein Catalytic Pathways, Myogenesis, and Mitochondrial Dysfunction.

Genetics
Park SH et al (2021).
Am J Chin Med.
DOI:
10.1142/S0192415X21500701
PubMed:
34247561

Polyherbal combination for wound healing: Matricaria chamomilla L. and Punica granatum L.

Niknam S et al (2021).
Daru.
DOI:
10.1007/s40199-021-00392-x
PubMed:
33966255

Chamomile.

Review
(2021).
PubMed:
30000867

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

Review
Jadoon S et al (2015).
Oxid Med Cell Longev.
DOI:
10.1155/2015/709628
PubMed:
26448818

A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.).

Review
McKay DL and Blumberg JB (2006).
Phytother Res.
PubMed:
16628544