Mentha spicata

Common Names: bush mint, spearmint

Ethnobotanical Studies

Clinical Trials

Evaluation of the effectiveness of Berberis integerrima Bunge root extract combined with spearmint essential oil in the treatment of acne vulgaris: A randomized controlled clinical trial.

Researchers tested a combination of B. integerrima root extract and spearmint essential oil for treating acne vulgaris. Both ingredients have antimicrobial, antioxidant, and anti-inflammatory properties. This study evaluates their clinical effectiveness.

Saeidi S et al (2024).
J Cosmet Dermatol.
DOI:
10.1111/jocd.16291
PubMed:
38545754

Volatile Terpenes and Brain Function: Investigation of the Cognitive and Mood Effects of Mentha × Piperita L. Essential Oil with In Vitro Properties Relevant to Central Nervous System Function.

Essential oils from various plants in the Lamiaceae sub-family Nepetoideae have been shown to have cognitive and mood effects possibly related to their effects on neurotransmitters. Researchers conducted a double-blind, placebo-controlled study to assess the cognitive and mood effects of peppermint essential oil, which showed promising in vitro properties. The study involved 24 participants who consumed single doses of encapsulated placebo and peppermint essential oil. The highest dose of essential oil improved performance on the demanding Rapid Visual Information Processing task and attenuated fatigue, compared to the placebo. Peppermint oil also showed cholinergic inhibitory, calcium regulatory, and GABA/nicotinic receptor binding properties. Future studies should examine higher doses of peppermint essential oil.

Kennedy D et al (2018).
Nutrients.
DOI:
10.3390/nu10081029
PubMed:
30087294

Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial.

Grant P et al (2010).
Phytother Res.
DOI:
10.1002/ptr.2900
PubMed:
19585478

Studies

Systematic metabolic engineering for improved synthesis of perillic acid in Candida tropicalis.

Yang H et al (2024).
Appl Microbiol Biotechnol.
DOI:
10.1007/s00253-024-13279-z
PubMed:
39190181

Effect of the molar mass of chitosan and film casting solvents on the properties of chitosan films loaded with Mentha spicata essential oil for potential application as wound dressing.

Phytochemistry
Gana FZ et al (2024).
J Biomater Sci Polym Ed.
DOI:
10.1080/09205063.2024.2390752
PubMed:
39167543

Insulin-Mimetic Activity of Herbal Extracts Identified with Large-Scale Total Internal Reflection Fluorescence Microscopy.

Neuhauser C et al (2024).
Nutrients.
DOI:
10.3390/nu16142182
PubMed:
39064624

Innovative Analogs of Unpasteurized Kombucha Beverages: Comparative Analysis of Mint/Nettle Kombuchas, Considering Their Health-Promoting Effect, Polyphenolic Compounds and Chemical Composition.

Pawluś P and Kolniak-Ostek J (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25147572
PubMed:
39062813

Comprehensive Modulation of Secondary Metabolites in Terpenoid-Accumulating Mentha spicata L. via UV Radiation.

Crestani G et al (2024).
Plants (Basel).
DOI:
10.3390/plants13131746
PubMed:
38999586

Effects of Gold Nanoparticles on Mentha spicata L., Soil Microbiota, and Human Health Risks: Impact of Exposure Routes.

Gastroenterology
Peshkova A et al (2024).
Nanomaterials (Basel).
DOI:
10.3390/nano14110955
PubMed:
38869580

Herbal oral care products for the prevention of ventilator-associated pneumonia: A systematic review and network meta-analysis of randomised trials.

Meta-Analysis
Li S, Huang Y and Xie H (2024).
PLoS One.
DOI:
10.1371/journal.pone.0304583
PubMed:
38848351

Attitude and Practice of Pharmacy Students Toward Traditional Herbal Medicines, Sudan.

Mahmoud EI, Yousif MA and Arbab AH (2024).
Integr Pharm Res Pract.
DOI:
10.2147/IPRP.S465056
PubMed:
38827648

Chemical Characterization of the Essential Oil Compositions of Mentha spicata and M. longifolia ssp. cyprica from the Mediterranean Basin and Multivariate Statistical Analyses.

Phytochemistry
İsfendiyaroğlu H et al (2024).
Molecules.
DOI:
10.3390/molecules29091970
PubMed:
38731461

Mentha spp. essential oils: toxicity to Alphitobius diaperinus, activity against poultry pathogenic bacteria, and Beauveria bassiana compatibility.

Gebauer S et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-33484-7
PubMed:
38693455

Herbal Spices as Food and Medicine: Microscopic Authentication of Commercial Herbal Spices.

Khan A et al (2024).
Plants (Basel).
DOI:
10.3390/plants13081067
PubMed:
38674476

Efficient production of (S)-limonene and geraniol in Saccharomyces cerevisiae through the utilization of an Erg20 mutant with enhanced GPP accumulation capability.

Bernard A et al (2024).
Metab Eng.
DOI:
10.1016/j.ymben.2024.04.003
PubMed:
38631459

Investigating the effectiveness of iron nanoparticles synthesized by green synthesis method in chemoradiotherapy of colon cancer.

Summary

Nanoparticles, specifically Fe nanoparticles made from Mentha spicata extract, show great potential for targeted colon cancer treatment with reduced side effects. Further clinical trials needed.

CancerGastroenterology
Nejad FS et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e28343
PubMed:
38560153

Visible-Light-Driven Mentha spicata L.-Mediated Ag-Doped Bi(2)Zr(2)O(7) Nanocomposite for Enhanced Degradation of Organic Pollutants, Electrochemical Sensing, and Antibacterial Applications.

Pompapathi K et al (2024).
ACS Environ Au.
DOI:
10.1021/acsenvironau.3c00057
PubMed:
38525021

Dietary agents in the prevention of radiation-induced nausea and vomiting (RINV): review addressing the scientific observations, benefits, lacunae and future direction.

Review
Palatty PL et al (2024).
Int J Radiat Biol.
DOI:
10.1080/09553002.2024.2309899
PubMed:
38506659

Mentha piperita silver nanoparticle-loaded hydrocolloid film for enhanced diabetic wound healing in rats.

Summary

Silver nanoparticles in gel improves wound healing in diabetic rats. Bioactive compounds from high altitude plants may have potential for wound healing. Useful for lab research.

Diabetes
Aftab R et al (2024).
J Wound Care.
DOI:
10.12968/jowc.2024.33.Sup3a.xlviii
PubMed:
38457268

Chemical composition and toxicity of Moroccan mentha spicata and Artemisia absinthium essential oils against Pthorimaea operculella, the potato moth.

Mahboub F et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2320740
PubMed:
38403974

Chemical composition and toxicity of commercial Mentha spicata and Eucalyptus citriodora essential oils on Culex quinquefasciatus and non-target insects.

Unni PS et al (2024).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-024-32249-6
PubMed:
38393552

A survey into the utilization of probiotics and medicinal plants among individuals afflicted with gastrointestinal disorders in healthcare institutions in Saïda, Algeria.

Tazi LA et al (2024).
Libyan J Med.
DOI:
10.1080/19932820.2024.2317492
PubMed:
38369815

Morphological and genetic evidence suggest gene flow among native and naturalized mint species.

Genetics
Olofsson JK et al (2024).
Am J Bot.
DOI:
10.1002/ajb2.16280
PubMed:
38334273

Prevalence and Antimicrobial Characteristics of Escherichia coli in Selected Vegetables and Herbs in Bangkok, Thailand.

Summary

This study found that raw vegetables and herbs in Bangkok have a high prevalence of Escherichia coli and are resistant to multiple antibiotics, which may contribute to foodborne illnesses.

Antimicrobial
Datta S et al (2024).
J Food Prot.
DOI:
10.1016/j.jfp.2024.100229
PubMed:
38246524

Examining the varied concentrations of Mentha spicata and Ocimum basilicum affect the synthesis of AgNPs that restrict the development of bacteria.

Qaeed MA et al (2024).
Saudi J Biol Sci.
DOI:
10.1016/j.sjbs.2023.103899
PubMed:
38125734

Steps to achieve carvone-rich spearmint (Mentha spicata L.) essential oil: a case study on the use of different distillation methods.

Phytochemistry
Moradi-Sadr J, Ebadi MT and Ayyari M (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1292224
PubMed:
38107005

Simultaneous quantification of Two Neonicotinoids using QuERChERS-LC-MS/MS in Moroccan Spearmint (Mentha Spicata.L): Qualimetry of the method by Uncertainty estimation using Generalized Pivotal Quantities approach and Monte Carlo simulation.

Aaziz H et al (2023).
J AOAC Int.
DOI:
10.1093/jaoacint/qsad136
PubMed:
38070149

Mechanistic Approach on Melatonin-Induced Hormesis of Photosystem II Function in the Medicinal Plant Mentha spicata.

Moustakas M et al (2023).
Plants (Basel).
DOI:
10.3390/plants12234025
PubMed:
38068660

Modeling purple basil, sage, spearmint, and sweet basil responses to daily light integral and mean daily temperature.

Walters KJ, Tarr S and Lopez RG (2023).
PLoS One.
DOI:
10.1371/journal.pone.0294905
PubMed:
38032962

[Production of limonene and its derivative in Saccharomyces cerevisiae via metabolic engineering].

Huang Y et al (2023).
Sheng Wu Gong Cheng Xue Bao.
DOI:
10.13345/j.cjb.230181
PubMed:
38013190

Study on Antioxidant Activity of Spearmint Essential Oil and Pure Dew.

Summary

Researchers evaluated the antioxidant capacity of spearmint essential oil and dew. 1% spearmint oil had the strongest antioxidant effect (50.94% superoxide scavenging, 90.11% hydroxyl scavenging), while 100% dew had moderate effects (47.65% superoxide scavenging, 45.60% hydroxyl scavenging). This is relevant for developing spearmint truffle and oil.

ImmunologyPhytochemistry
Han L et al (2023).
Stud Health Technol Inform.
DOI:
10.3233/SHTI230824
PubMed:
38007725

Effects of Harvest Time and Hydrodistillation Time on Yield, Composition, and Antioxidant Activity of Mint Essential Oil.

Summary

This study found that harvesting spearmint at 9 a.m. and distilling it for 60 minutes resulted in the highest menthol content and antioxidant activity. It suggests that sun exposure and longer distillation times decrease menthol content and alter the chemical composition.

ImmunologyPhytochemistry
Marques SPPM et al (2023).
Molecules.
DOI:
10.3390/molecules28227583
PubMed:
38005307

Promising Larvicidal Effects of Nanoliposomes Containing Carvone and Mentha spicata and Tanacetum balsamita Essential Oils Against Anopheles stephensi.

Sanei-Dehkordi A et al (2023).
Acta Parasitol.
DOI:
10.1007/s11686-023-00735-5
PubMed:
37979013

Efficacy of a Spearmint (Mentha spicata L.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma.

Amato R et al (2023).
Transl Vis Sci Technol.
DOI:
10.1167/tvst.12.11.6
PubMed:
37917085

Enhancement of the anti-microbial activity of Mentha spicata essential oil on storage by glycerosomes.

Summary

Researchers prepared glycerosomes of an essential oil (EO) to improve its stability and solubility. The optimized EO-loaded glycerosomes showed sustained release and enhanced antibacterial effects, making them a potential solution for food and clinical industries.

AntimicrobialPhytochemistry
Taheri SL and Varshosaz J (2023).
Food Sci Biotechnol.
DOI:
10.1007/s10068-023-01301-5
PubMed:
37860731

Use of medicinal plants during COVID-19 pandemic in Brazil.

Summary

Study finds 40.2% of participants in a Brazilian city use medicinal plants, primarily for anxiety. Females, non-whites, and lower-educated with higher income and comorbidities were more likely to use. No reported use for treating COVID-19.

COVID-19
da Silva AM et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-43673-y
PubMed:
37783716

Anti-oomycete activities from essential oils and their major compounds on Phytophthora infestans.

Deweer C, Sahmer K and Muchembled J (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-29270-6
PubMed:
37779122

Synergistic effect of a Bi(2)Zr(2)O(7) and hydroxyapatite composite: organic pollutant remediation, antibacterial and electrochemical sensing applications.

Pompapathi K et al (2023).
RSC Adv.
DOI:
10.1039/d3ra05222b
PubMed:
37753401

Growth, oil and physiological parameters of three mint species grown under saline stress levels.

Kumar D et al (2023).
Physiol Mol Biol Plants.
DOI:
10.1007/s12298-023-01337-1
PubMed:
37649882

Activity of volatiles induced by microbes and natural plants stifled the growth of Pythium aphanidermatum - the damping off in Tomato.

Thangaraj P et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04351-3
PubMed:
37563742

Exploring the antibacterial potential of plant extracts and essential oils against Bacillus thermophilus in beet sugar for enhanced sucrose retention: a comparative assessment and implications.

Yousef MM et al (2023).
Front Microbiol.
DOI:
10.3389/fmicb.2023.1219823
PubMed:
37547698

Evaluating the Effect of pH, Temperature and Concentration on Antioxidant and Antibacterial Potential of Spectroscopically, Spectrophotometrically and Microscopically Characterized Mentha Spicata Capped Silver Nanoparticles.

Summary

This study fabricated silver nanoparticles using Mentha spicata and found they have significant antibacterial and antioxidant properties. They are stable at various pH and temperatures.

Immunology
Tanveer T et al (2023).
J Fluoresc.
DOI:
10.1007/s10895-023-03322-z
PubMed:
37523138

Essential Oils and Their Components Control Behaviour of Yellow Mealworm (Tenebrio molitor) Larvae.

Bumbulytė G, Būdienė J and Būda V (2023).
Insects.
DOI:
10.3390/insects14070636
PubMed:
37504642

Shelf-life improvement of raw milk using ethanolic extracts of selected medicinal plants (Moringa stenopetale, Artemesia anua and MenthaSpicata).

Matewos Orcho A et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e17659
PubMed:
37449135

Author Correction: Prediction of essential oil content in spearmint (Mentha spicata) via near-infrared hyperspectral imaging and chemometrics.

Phytochemistry
Van Haute S et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-36583-6
PubMed:
37296160

In Vitro Anti-Inflammatory and Anticancer Evaluation of Mentha spicata L. and Matricaria chamomilla L. Essential Oils.

Summary

This study evaluated the anti-inflammatory and anticancer effects of pharma-grade essential oils, specifically spearmint and German chamomile. The oils were tested using enzyme assays and evaluated for their cytotoxic effects on various cell lines. The major components of the oils were identified, and their IC values were calculated. The essential oils were found to have no cytotoxic effects on healthy cells but increased apoptotic activity in cancer cells. Additionally, the oils showed selective inhibition of the COX-2 enzyme. These findings suggest a potential dual mode of action for the essential oils and warrant further investigation.

CancerImmunology
Biltekin SN et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c01501
PubMed:
37214687

Biochemical basis for the formation of organ-specific volatile blends in mint.

Lange BM et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1125065
PubMed:
37123862

l-carvone decreases breast cancer cells adhesion, migration, and invasion by suppressing FAK activation.

Cancer
Lima LTF et al (2023).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2023.110480
PubMed:
37059214

Green nanotechnology advances: green manufacturing of zinc nanoparticles, characterization, and foliar application on wheat and antibacterial characteristics using Mentha spicata (mint) and Ocimum basilicum (basil) leaf extracts.

Doğaroğlu ZG et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-26827-3
PubMed:
37039921

Health risk assessment and bioaccumulation of potentially toxic metals from water, soil, and forages near coal mines of district Chakwal, Punjab, Pakistan.

Zainab N et al (2023).
Environ Geochem Health.
DOI:
10.1007/s10653-023-01531-w
PubMed:
37029254

Phytochemical Composition and Bioactive Potential of Melissa officinalis L., Salvia officinalis L. and Mentha spicata L. Extracts.

Phytochemistry
Silva BN et al (2023).
Foods.
DOI:
10.3390/foods12050947
PubMed:
36900464

Bio-Converted Spirulina for Nutraceutical Chewing Candy Formulations Rich in L-Glutamic and Gamma-Aminobutyric Acids.

Bartkiene E et al (2023).
Microorganisms.
DOI:
10.3390/microorganisms11020441
PubMed:
36838408

Inhibitory Activity of Essential Oils of Mentha spicata and Eucalyptus globulus on Biofilms of Streptococcus mutans in an In Vitro Model.

Phytochemistry
Landeo-Villanueva GE et al (2023).
Antibiotics (Basel).
DOI:
10.3390/antibiotics12020369
PubMed:
36830281

Development of Dairy Products Fortified with Plant Extracts: Antioxidant and Phenolic Content Characterization.

Phytochemistry
Kandyliari A et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12020500
PubMed:
36830058

The effect of irrigation with treated and untreated wastewater on the yield and chemical composition of essential oil of Mentha spicata L. and Rosmarinus officinalis L.

Phytochemistry
Asadzadeh M, Ghavam M and Mirzaei R (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-25398-7
PubMed:
36715796

Combined impact of lemongrass and spearmint herbs on performance, serum metabolites, liver enzymes, and meat quality of broiler.

Rahman MA et al (2022).
J Adv Vet Anim Res.
DOI:
10.5455/javar.2022.i640
PubMed:
36714510

Medicinal plants used by rural communities in the arid zone of Viesca and Parras Coahuila in northeast Mexico.

Torres-León C et al (2023).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2022.11.003
PubMed:
36685306

Green-engineered synthesis of Bi(2)Zr(2)O(7) NPs: excellent performance on electrochemical sensor and sunlight-driven photocatalytic studies.

Kurlla P et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-022-24760-5
PubMed:
36602731

Acute and Rapid Response of Melissa officinalis and Mentha spicata to Saline Reclaimed Water in Terms of Water Relations, Hormones, Amino Acids and Plant Oxylipins.

Endocrinology
Gómez-Bellot MJ et al (2022).
Plants (Basel).
DOI:
10.3390/plants11243427
PubMed:
36559540

Bioactive Profile of Distilled Solid By-Products of Rosemary, Greek Sage and Spearmint as Affected by Distillation Methods.

Christaki S et al (2022).
Molecules.
DOI:
10.3390/molecules27249058
PubMed:
36558189

Impact of Foliar Application of Amino Acids on Essential Oil Content, Odor Profile, and Flavonoid Content of Different Mint Varieties in Field Conditions.

Phytochemistry
Velička A et al (2022).
Plants (Basel).
DOI:
10.3390/plants11212938
PubMed:
36365392

Mitigation of salinity impact in spearmint plants through the application of engineered chitosan-melatonin nanoparticles.

Gohari G et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2022.10.175
PubMed:
36283550

Phytochemical screening, cytotoxicity assessment and evaluation of in vitro antiplasmodial and in vivo antimalarial activities of Mentha spicata L. methanolic leaf extract.

Phytochemistry
Chatterjee A et al (2022).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2022.115636
PubMed:
35998785

δ(18)O compound-specific stable isotope assessment: An advanced analytical strategy for sophisticated adulterations detection in essential oils - Application to spearmint, cinnamon, and bitter almond essential oils authentication.

Phytochemistry
Cuchet A et al (2023).
Talanta.
DOI:
10.1016/j.talanta.2022.123801
PubMed:
35969926

Medicinal Uses, Phytochemistry, Pharmacology, and Toxicology of Mentha spicata.

Review Phytochemistry
El Menyiy N et al (2022).
Evid Based Complement Alternat Med.
DOI:
10.1155/2022/7990508
PubMed:
35463088

Chemical Compounds Emitted from Mentha spicata Repel Aromia bungii Females.

Cao D et al (2022).
Insects.
DOI:
10.3390/insects13030244
PubMed:
35323540

A Revised Phylogeny of the Mentha spicata Clade Reveals Cryptic Species.

Heylen OCG et al (2021).
Plants (Basel).
DOI:
10.3390/plants10040819
PubMed:
33924227

The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review.

Review Endocrinology
Ashkar F et al (2020).
Biomol Concepts.
DOI:
10.1515/bmc-2020-0005
PubMed:
32229652

Adverse effects of herbal medicines: an overview of systematic reviews.

Review
Posadzki P, Watson LK and Ernst E (2013).
Clin Med (Lond).
PubMed:
23472485