Mespilus germanica

Common Names: common medlar, medlar

Ethnobotanical Studies

Studies

Phenolic Contents, Antioxidant Activities, LCMS Profiles of Mespilus germanica Leaf Extract and Effects on mRNA Transcription Levels of Apoptotic, Autophagic, and Necrotic Genes in MCF7 and A549 Cancer Cell Lines.

Summary

Scientists studied the impact of Mespilus germanica leaf extract on cancer cells and healthy cells. Results show potential for cancer treatment without harming healthy cells.

CancerGeneticsImmunologyPhytochemistry
Görmez G et al (2024).
Cell Biochem Biophys.
DOI:
10.1007/s12013-024-01321-w
PubMed:
38850406

Acaricidal Efficacy of Thirty-Five Egyptian Plants Against the Camel Tick, Hyalomma Dromedarii.

Khater HF et al (2024).
Acta Parasitol.
DOI:
10.1007/s11686-024-00801-6
PubMed:
38671280

Phytochemistry, nutritional composition, health benefits and future prospects of Mespilus germanica L. (Medlar): A review.

Summary

Scientists studied the medlar plant for its nutritional value and potential benefits, including anti-diabetic and antioxidant properties. Medlar waste can be used to extract heavy metals from water. This research can help address sustainability issues in food production.

Review Phytochemistry
Nistor DI, Marc RA and Mureșan CC (2024).
Food Chem X.
DOI:
10.1016/j.fochx.2024.101334
PubMed:
38586220

The Possibility of Using Fruit-Bearing Plants of Temperate Climate in the Treatment and Prevention of Diabetes.

Summary

This review suggests that alternative fruit species such as Cornelian cherry, mulberry, bird cherry, and sour cherry have potential health benefits, including antidiabetic effects attributed to polyphenols. These fruits could be used in the treatment of diabetes and related complications.

Review Diabetes
Łysiak GP and Szot I (2023).
Life (Basel).
DOI:
10.3390/life13091795
PubMed:
37763199

Colleters in leaves of Mespilus germanica L. (Rosaceae): Micromorphology, histochemistry and fluorescence.

Kumachova TK et al (2023).
Micron.
DOI:
10.1016/j.micron.2023.103537
PubMed:
37690393

Changes in the Fruit Quality Parameters of Medlar Fruit (Mespilus germanica L.) after Heat Treatment, Storage, Freezing or Hoarfrost.

Mikulic-Petkovsek M et al (2023).
Foods.
DOI:
10.3390/foods12163077
PubMed:
37628075

Effects of Dietary Medlar (Mespilus germanica L.) Extract on Growth Performance, Innate Immune Characteristics, Antioxidant Status, and Responses to Crowding Stress in Rainbow Trout (Oncorhynchus mykiss).

Summary

Medlar extract (ME) supplementation improved growth, antioxidant and immune status, and reduced stress responses in rainbow trout under high stocking density conditions. ME can be used as a beneficial feed additive.

Immunology
Patra I et al (2023).
Aquac Nutr.
DOI:
10.1155/2023/7613330
PubMed:
37564114

Phenolic composition, antioxidant, and cytotoxic effects on HeLa and HepG2 cancer cell lines of Mespilus germanica grown in Turkey.

Summary

In this study, researchers examined the antioxidant and cytotoxic properties of flavonoids and phenolic acids found in Turkish medlar. Using advanced analysis techniques, they identified various compounds in leaf and fruit extracts. Notably, the fruit extract showed excellent antioxidant properties, while the leaf extract demonstrated strong cytotoxicity against cancer cells. These findings suggest that Turkish medlar could be a valuable natural source for developing anticancer and antioxidant agents in the food and pharmaceutical industries.

CancerImmunologyPhytochemistry
Yunusa UM and Ozturk Urek R (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2023.2230612
PubMed:
37395516

New insights on the adsorption of phenol red dyes from synthetic wastewater using activated carbon/Fe(2)(MoO(4))(3).

Nobakht A, Jafari D and Esfandyari M (2023).
Environ Monit Assess.
DOI:
10.1007/s10661-023-11178-w
PubMed:
37060479

Bioactive content and phenolic compounds of common medlar (Mespilus germanica L.) and Stern's medlar (M. canescens Phipps).

Phytochemistry
Sadeghinejad Z, Erfani-Moghadam J and Khadivi A (2022).
Food Sci Nutr.
DOI:
10.1002/fsn3.2814
PubMed:
35702277

Sex-Independent Cognition Improvement in Response to Kaempferol in the Model of Sporadic Alzheimer's Disease.

Summary

This study investigated the effect of the antioxidant Kaempferol (KMP) on a rat model of Alzheimer's disease (AD) induced by the injection of STZ. The researchers found that KMP improved spatial memory in both male and female rats, as well as increasing levels of certain antioxidants in the hippocampus. The study suggests that KMP may be beneficial in treating cognitive impairments associated with AD, and that these benefits are not influenced by gender.

Neuroscience
Babaei P, Eyvani K and Kouhestani S (2021).
Neurochem Res.
DOI:
10.1007/s11064-021-03289-y
PubMed:
33710535

Antibacterial, antibiofilm, and antiquorum sensing activities of phytosynthesized silver nanoparticles fabricated from Mespilus germanica extract against multidrug resistance of Klebsiella pneumoniae clinical strains.

Foroohimanjili F et al (2020).
J Basic Microbiol.
DOI:
10.1002/jobm.201900511
PubMed:
31994223

Polyunsaturated and Very-Long-Chain Fatty Acids Are Involved in the Adaptation of Maloideae (Rosaceae) to Combined Stress in the Mountains.

Voronkov AS et al (2020).
Chem Biodivers.
DOI:
10.1002/cbdv.201900588
PubMed:
31782898

Lipid Fatty Acids from the Pericarp of Cydonia oblonga Mill. and Mespilus germanica L. are Involved in Plant Adaptation to Altitudinal Zonality.

Ivanova TV et al (2019).
Dokl Biochem Biophys.
DOI:
10.1134/S1607672919030189
PubMed:
31367828

First Report of Erwinia amylovora on Crataegus monogyna and Pyrus pyraster in Bulgaria.

Bobev SG, Crepel C and Maes M (1998).
Plant Dis.
DOI:
10.1094/PDIS.1998.82.11.1283C
PubMed:
30845429

Flavonoids Fraction of Mespilus Germanica Alleviates Insulin Resistance in Metabolic Syndrome Model of Ovariectomized Rats via Reduction in Tumor Necrosis Factor-α.

CancerPhytochemistry
Kouhestani S, Zare S and Babaei P (2018).
J Menopausal Med.
DOI:
10.6118/jmm.2018.24.3.169
PubMed:
30671409

Characterization of chemical, molecular, thermal and rheological properties of medlar pectin extracted at optimum conditions as determined by Box-Behnken and ANFIS models.

Al-Amoudi RH et al (2019).
Food Chem.
DOI:
10.1016/j.foodchem.2018.07.211
PubMed:
30236728

Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia.

Summary

The study investigated the effects of kaempferol (Kmp) isolated from medlar leaves on cognitive deficit and biomarkers associated with Alzheimer's disease in rat models. Results showed that Kmp significantly improved spatial learning and memory and increased levels of antioxidant enzymes while decreasing markers of inflammation and oxidative stress. The study suggests that Kmp may be a potential neuroprotective agent against cognitive deficit in Alzheimer's disease.

ImmunologyNeuroscience
Kouhestani S, Jafari A and Babaei P (2018).
Neural Regen Res.
DOI:
10.4103/1673-5374.238714
PubMed:
30136699

The Determination of Blood Glucose Lowering and Metabolic Effects of Mespilus germanica L. Hydroacetonic Extract on Streptozocin-Induced Diabetic Balb/c Mice.

Diabetes
Shafiee F et al (2018).
Medicines (Basel).
DOI:
10.3390/medicines5010001
PubMed:
29301240

Enrichment of common carp (Cyprinus carpio) diet with medlar (Mespilus germanica) leaf extract: Effects on skin mucosal immunity and growth performance.

Hoseinifar SH et al (2017).
Fish Shellfish Immunol.
DOI:
10.1016/j.fsi.2017.06.023
PubMed:
28602735

Effect of five different stages of ripening on chemical compounds in medlar (Mespilus germanica L.).

Rop O et al (2010).
Molecules.
DOI:
10.3390/molecules16010074
PubMed:
21189456