Momordica charantia

Common Names: balsam pear, balsampear

Ethnobotanical Studies

Clinical Trials

Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus.

Study investigated the effectiveness and safety of bitter melon as an additional treatment for type 2 diabetes. Results can inform diabetes management strategies.

Kim SK et al (2020).
Complement Ther Med.
DOI:
10.1016/j.ctim.2020.102524
PubMed:
32951763

Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus.

In a clinical trial, patients with type 2 diabetes who took Momordica charantia saw improvements in glycemic control, insulin secretion, and insulin sensitivity. This suggests that M. charantia could be a beneficial treatment for diabetes.

Cortez-Navarrete M et al (2018).
J Med Food.
DOI:
10.1089/jmf.2017.0114
PubMed:
29431598

Studies

Innovative treatments for obesity and NAFLD: A bibliometric study on antioxidants, herbs, phytochemicals, and natural compounds.

Summary

Scientists analyzed research trends on antioxidants, herbs, and natural compounds for obesity and NAFLD. China, Korea, and USA are main contributors. Key compounds include resveratrol, curcumin, and quercetin. Study provides valuable insights for future research on obesity and NAFLD treatments.

Review Obesity
Pezzino S et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e35498
PubMed:
39220898

'Candidatus Phytoplasma vignae', assigning a species description to a long-known phytoplasma occurring in northern Australia.

Rodrigues Jardim B et al (2024).
Int J Syst Evol Microbiol.
DOI:
10.1099/ijsem.0.006502
PubMed:
39190596

Antioxidant activities, dietary nutrients, and yield potential of bitter gourd (Momordica charantia L.) lines in diverse growing environments.

Immunology
Jat GS et al (2024).
Front Nutr.
DOI:
10.3389/fnut.2024.1393476
PubMed:
39166126

Investigation of the cardioprotective effects of Momordica charantia in the isoproterenol-induced myocardial infarction model in rats.

Summary

Study tested Momordica charantia on rats with induced heart attacks to see if it had protective effects. MC was found to have antioxidant and anti-inflammatory properties, potentially beneficial for treating MI.

Cardiology
Karadeniz B and Beyazcicek O (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.117274
PubMed:
39116781

Momordica charantia L.-derived exosome-like nanovesicles stabilize p62 expression to ameliorate doxorubicin cardiotoxicity.

Ye C et al (2024).
J Nanobiotechnology.
DOI:
10.1186/s12951-024-02705-z
PubMed:
39095755

The double-layer emulsions loaded with bitter melon (Momordica charantia L.) seed oil protect against dextran sulfate sodium-induced ulcerative colitis in mice.

Gastroenterology
Ma Y et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.134279
PubMed:
39084441

The effects of bitter melon (Momordica charantia) on anthropometric indices in adults: A systematic review and meta-analysis of randomized controlled trials.

Review
Zou Y et al (2024).
Prostaglandins Other Lipid Mediat.
DOI:
10.1016/j.prostaglandins.2024.106877
PubMed:
39079610

Effect of conventional and novel techniques on extraction yield, chemical characterisation and biological activities of proteins from bitter gourd (Momordica charantia).

Noore S et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139516
PubMed:
39053391

The activities of suaveolol and other compounds from Hyptis suaveolens and Momordica charantia against the aetiological agents of African trypanosomiasis, leishmaniasis and malaria.

Oaikhena EE et al (2024).
Exp Parasitol.
DOI:
10.1016/j.exppara.2024.108807
PubMed:
39043327

Comparative transcriptomics analysis of tolerant and sensitive genotypes reveals genes involved in the response to cold stress in bitter gourd (Momordica charantia L.).

Genetics
Ning Y et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-58754-9
PubMed:
39019887

Histopathological and Toxicological Studies on Zebra Fish Using White-Fruited and Green-Fruited Varieties of Momordica charantia.

Xavier J et al (2024).
Scientifica (Cairo).
DOI:
10.1155/2024/4689625
PubMed:
38938544

Phytochemical Study of the Anthelminthic Potential of Guadeloupean Plant Biodiversity.

Summary

Researchers investigated the anthelmintic potential of plant extracts on gastrointestinal parasites in ruminants. Plants with high polyphenolic content were tested for their effectiveness against Rudolphi. This study aims to find alternative treatments for parasite infections in animals.

Phytochemistry
Cabald T et al (2024).
Pharmaceuticals (Basel).
DOI:
10.3390/ph17060774
PubMed:
38931441

Bitter melon extract mitigates heterocyclic aromatic amine formation in chicken thigh meat.

Gumus D et al (2024).
Food Sci Nutr.
DOI:
10.1002/fsn3.4085
PubMed:
38873469

Momordica charantia Is a Novel Host of 'Candidatus Phytoplasma malaysianum'-Related Strains Associated with Bitter Melon Stem Fasciation Disease in China.

Bottner-Parker K et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-05-24-0971-PDN
PubMed:
38861468

Network Pharmacology and Experimental Study of Momordicine I and Momordicine II from Bitter Melon Saponins in Inhibiting Fat Accumulation.

Phytochemistry
Huang ST et al (2024).
Biomed Environ Sci.
DOI:
10.3967/bes2024.058
PubMed:
38843926

Applying Network Pharmacology and Molecular Docking in the Screening for Molecular Mechanisms of Ampalaya (Momordica charantia L.) and Banaba (Lagerstroemia speciosa L.) against Type 2 Diabetes Mellitus.

Summary

Philippines validated herbal medicines (MC) and (LS) have synergistic effects in managing Type 2 diabetes. Mechanisms of compounds in these herbs can inform treatment strategies and potentially reduce the cost of conventional medications.

Diabetes
Rivera RG Jr et al (2024).
Acta Med Philipp.
DOI:
10.47895/amp.vi0.7351
PubMed:
38812760

Effects of Momordica charantia L. supplementation on glycemic control and lipid profile in type 2 diabetes mellitus patients: A systematic review and meta-analysis of randomized controlled trials.

Summary

The study reviewed L. () for managing type 2 diabetes. Results show it improves glycemic indexes and lipid profile in patients. Important for T2DM treatment.

Diabetes
Zhang X et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e31126
PubMed:
38784554

Antitussive, Expectorant and Antipyretic Effect of the Ethanolic Extract of the Leaves of Momordica charantia L.

Ribeiro T et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400072
PubMed:
38780224

Momordica charantia Bioactive Components: Hypoglycemic and Hypolipidemic Benefits Through Gut Health Modulation.

Summary

MC from the Cucurbitaceae family has hypoglycemic and hypolipidemic properties due to bioactive compounds. Studies show regulatory effects on glycolipid metabolism. Review highlights its components and potential as a nutrient supplement.

DiabetesGastroenterology
Xiao X et al (2024).
J Med Food.
DOI:
10.1089/jmf.2024.k.0037
PubMed:
38770678

Splenic Elemental Composition of Breast Cancer-Suffering Rats Supplemented with Pomegranate Seed Oil and Bitter Melon Extract.

Cancer
Białek M et al (2024).
Molecules.
DOI:
10.3390/molecules29091942
PubMed:
38731433

Pharmacotherapeutic Potential of Bitter Gourd (Momordica charantia) in Age-related Neurological Diseases.

Review
Adarmanabadi SMHH et al (2024).
J Integr Neurosci.
DOI:
10.31083/j.jin2304086
PubMed:
38682220

Extraction, structures, biological effects and potential mechanisms of Momordica charantia polysaccharides: A review.

Review
Hu Z et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.131498
PubMed:
38614167

Anthelmintic screening of Bangladeshi medicinal plants and related phytochemicals using in vitro and in silico methods: An ethnobotanical perspective.

Summary

Researchers studied medicinal plants used by indigenous communities in Bangladesh for helminth infections. Discovering phytochemicals with anthelmintic activity could lead to new drugs to combat drug-resistant helminthiases in underdeveloped regions.

Ethnobotany
Khairuzzaman M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118132
PubMed:
38565411

A phage-displayed disulfide constrained peptide discovery platform yields novel human plasma protein binders.

Gao X et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0299804
PubMed:
38547072

Momordica charantia fruit reduces plasma fructosamine whereas stems and leaves increase plasma insulin in adult mildly diabetic obese Göttingen Minipigs.

Summary

Study compared blood glucose-lowering effects of Bitter gourd fruit and stems-leaves in diabetic obese pigs. Results may provide insight into physiological mechanisms and potential for human diabetes management.

DiabetesObesity
Koopmans SJ et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0298163
PubMed:
38498469

Potential locus W and candidate gene McPRR2 associated with pericarp pigment accumulation in bitter gourd (Momordica charantia L.) revealed via BSA-seq analysis.

Summary

Researchers identified gene McPRR2 as key in regulating bitter gourd pericarp color. Its overexpression in tomato increases chlorophyll content, enhancing green color. This study offers valuable insights for genetic improvement in breeding programs.

Genetics
Guo J et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108515
PubMed:
38484681

Study the yield and quality of bitter gourd fruit (Momordica charantia) in inoculation with two species of mycorrhizal fungi and phosphorus fertilizer under different irrigation regimes.

Dolatmand-Shahri N et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108479
PubMed:
38461752

Determination of the volatile chemical profile of Momordica charantia (bitter melon) leaf and fruit by GC-MS.

Ferreira Almeida N et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2325595
PubMed:
38440938

Extraction methods, multiple biological activities, and related mechanisms of Momordica charantia polysaccharide: A review.

Review
Liu J et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.130473
PubMed:
38423437

Immunomodulatory Role of Plants and Their Constituents on the Management of Metabolic Disorders: An Evidence-Based Review.

Summary

Plant-derived bioactive compounds show promise in improving metabolic and immune functions in patients with metabolic disorders. This review highlights the therapeutic potential of phytochemical formulations in alleviating conditions like obesity and diabetes. Further research and clinical trials are needed for validation.

Review Immunology
Febriyanti RM, Levita J and Diantini A (2024).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S442566
PubMed:
38415194

Different particle sizes of Momordica charantia leaf powder modify the rheological and textural properties of corn starch-based 3D food printing ink.

Fan M et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e24915
PubMed:
38370168

In vitro and In vivo Determination of Biological Activities of Bitter Gourd (Momordica charantia L.) Peel, Flesh and Seeds.

Hussain A et al (2024).
Plant Foods Hum Nutr.
DOI:
10.1007/s11130-024-01153-2
PubMed:
38358638

Anti-diabetic drug discovery using the bioactive compounds of Momordica charantia by molecular docking and molecular dynamics analysis.

Summary

Researchers conducted virtual screenings and molecular dynamics investigations to discover natural inhibitors of α-amylase and α-glucosidases for diabetes management. Rutin from the MC plant exhibited the highest binding affinity and could potentially be an effective therapeutic agent for diabetes. Further research is needed to validate its efficacy.

Diabetes
Choudhury AA et al (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2024.2313156
PubMed:
38334124

High-quality Momordica balsamina genome elucidates its potential use in improving stress resilience and therapeutic properties of bitter gourd.

Genetics
Vinay ND et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1258042
PubMed:
38333042

Synergistic effects of Momordica charantia, Nigella sativa, and Anethum graveolens on metabolic syndrome targets: In vitro enzyme inhibition and in silico analyses.

Chavan RS et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e24907
PubMed:
38304787

The metabolic effect of Momordica charantia cannot be determined based on the available clinical evidence: a systematic review and meta-analysis of randomized clinical trials.

Laczkó-Zöld E et al (2024).
Front Nutr.
DOI:
10.3389/fnut.2023.1200801
PubMed:
38274207

In vitro assessment of Momordica charantia/Hypericum perforatum oils loaded PCL/Collagen fibers: Novel scaffold for tissue engineering.

Ediz EF et al (2024).
J Appl Biomater Funct Mater.
DOI:
10.1177/22808000231221067
PubMed:
38217369

Exploring the mechanism of action bitter melon in the treatment of breast cancer by network pharmacology.

Summary

Bitter melon inhibits breast cancer cell growth, but the exact process is unknown. Understanding the mechanism could lead to potential treatments for BRCA.

Cancer
Panchal K et al (2023).
World J Exp Med.
DOI:
10.5493/wjem.v13.i5.142
PubMed:
38173546

Evaluation of the impact of polypeptide-p on diabetic rats upon its cloning, expression, and secretion in Saccharomyces boulardii.

Summary

Researchers evaluated the effectiveness of a recombinant protein from Momordica charantia on diabetic rats. They cloned the optimized gene sequence into a probiotic yeast and fed it to diabetic rats, resulting in a significant reduction in blood glucose levels. This study suggests a potential safe plant-based supplement for diabetes.

Diabetes
Yamchi A et al (2023).
Arch Microbiol.
DOI:
10.1007/s00203-023-03773-9
PubMed:
38142245

Saponins from Momordica charantia exert hypoglycemic effect in diabetic mice by multiple pathways.

Summary

Saponins from L. were tested on diabetic mice. Results: MCS reduced glucose levels, improved antioxidant capacity, decreased lipid levels, and repaired pancreatic cells. Implications: MCS has potential as an antidiabetic treatment.

DiabetesPhytochemistry
Deng Y et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3682
PubMed:
38107145

Medicinal plants used for management of diabetes and hypertension in Ghana.

Summary

This study investigated medicinal plants used by herbalists in Ghana for managing diabetes and hypertension. 39 species of plants were identified, 18 for hypertension, 12 for diabetes, and 9 for both. Some of these plants have potential therapeutic benefits, but clinical studies are needed for confirmation.

CardiologyDiabetes
Asafo-Agyei T et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22977
PubMed:
38076168

Efficacy of different organic and inorganic nutrient sources on the growth and yield of bitter gourd (Momordica charantia L.).

Ghimire S, Poudel Chhetri B and Shrestha J (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22135
PubMed:
38074878

Investigating the multitargeted anti-diabetic potential of cucurbitane-type triterpenoid from Momordica charantia: an LC-MS, docking-based MM\GBSA and MD simulation study.

Summary

A cucurbitane-type triterpene exhibited anti-diabetic properties, showing favorable binding energy, stability, pharmacokinetic, and toxicity properties. It has potential as an anti-diabetic drug candidate, but further research is needed.

Diabetes
Famuyiwa SO et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2291174
PubMed:
38069604

Residue analysis and dietary risk assessment of abamectin in fresh corn, bitter melon, and Fritillaria.

Luo X et al (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5779
PubMed:
38050189

Plant regeneration from embryogenic callus-derived from immature leaves of Momordica charantia L.

Stevenson Naïtchédé LH et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22122
PubMed:
38045192

The neuroprotective potential of turmeric rhizome and bitter melon on aspartame-induced spatial memory impairment in rats.

Summary

Turmeric and bitter melon extracts improved memory and protected the brain in rats exposed to aspartame, suggesting their antioxidant properties could prevent memory problems caused by aspartame.

Neuroscience
Suswidiantoro V et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21693
PubMed:
38027700

Momordica anti-HIV protein MAP30 abrogates the Epstein-Barr virus nuclear antigen 1 dependent functions in host cells.

Huang WH et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e21486
PubMed:
38027600

Antibacterial and phytotoxicological properties assessment of Momordica charantia extract-based ZnO nanoparticles.

Doğaroğlu ZG et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.13176
PubMed:
38012056

Effect of melatonin foliar sprays on morphophysiological attributes, fruit yield and quality of Momordica charantia L. under salinity stress.

Sheikhalipour M et al (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.108194
PubMed:
37992418

McAPRR2: The Key Regulator of Domesticated Pericarp Color in Bitter Gourd.

Tian S et al (2023).
Plants (Basel).
DOI:
10.3390/plants12203585
PubMed:
37896048

A point mutation in MC06g1112 encoding FLOWERING LOCUS T decreases the first flower node in bitter gourd (Momordica charantia L.).

Zhong J et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1153208
PubMed:
37881613

Protective effects and mechanisms of Momordica charantia polysaccharide on early-stage diabetic retinopathy in type 1 diabetes.

Summary

This study found that Momordica charantia polysaccharide (MCP) can potentially prevent and alleviate diabetes mellitus (DM) and diabetic retinopathy (DR) by improving body weight, inflammation, and apoptosis in retinal tissues. MCP may be a promising medication for DM and a natural medicine for DR.

Diabetes
Liu J et al (2023).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2023.115726
PubMed:
37862973

Genetic Diversity and Population Structure Analyses in Bitter Gourd (Momordica charantia L.) Based on Agro-Morphological and Microsatellite Markers.

Mallikarjuna KN et al (2023).
Plants (Basel).
DOI:
10.3390/plants12193512
PubMed:
37836252

Integrated Secondary Metabolomic and Antioxidant Ability Analysis Reveals the Accumulation Patterns of Metabolites in Momordica charantia L. of Different Cultivars.

Immunology
Zhang Y et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241914495
PubMed:
37833943

Metabolome revealed the potential mechanism of Fusarium wilt resistance in bitter gourd (Momordica charantia) based on liquid chromatography with mass spectrometry.

Phytochemistry
Guan F et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-07-23-1371-RE
PubMed:
37814516

Positive Outcome in Catastrophic Momordica charantia-Associated Herb-Induced Liver Injury: A Tale of Two Cities - From Gonaives, Haiti to New York City.

Kwentoh I et al (2023).
Cureus.
DOI:
10.7759/cureus.46597
PubMed:
37808602

The Impact of the Soil Survival of the Pathogen of Fusarium Wilt on Soil Nutrient Cycling Mediated by Microorganisms.

Yan X et al (2023).
Microorganisms.
DOI:
10.3390/microorganisms11092207
PubMed:
37764051

Transcriptomic Analysis of the Response of Susceptible and Resistant Bitter Melon (Momordica charantia L.) to Powdery Mildew Infection Revealing Complex Resistance via Multiple Signaling Pathways.

Chen X et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241814262
PubMed:
37762563

In Vitro Cercaricidal Activity, Acute Toxicity, and GC/MS Analysis of Some Selected Ghanaian Medicinal Plants.

Osei-Mensah B et al (2023).
J Parasitol Res.
DOI:
10.1155/2023/4589424
PubMed:
37745984

Momordica charantia-Derived Extracellular Vesicles Provide Antioxidant Protection in Ulcerative Colitis.

Summary

Plant-derived extracellular vesicles (MCEVs) from - with antioxidant properties were studied. MCEVs showed potential in preventing and treating ulcerative colitis by regulating oxidation and inflammation. This research suggests MCEVs could be used as drugs for ulcerative colitis.

GastroenterologyImmunology
Wang F et al (2023).
Molecules.
DOI:
10.3390/molecules28176182
PubMed:
37687011

Selected phytochemicals of Momordica charantia L. as potential anti-DENV-2 through the docking, DFT and molecular dynamic simulation.

Huq AKMM et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2251069
PubMed:
37676311

Coumarin regulated redox homeostasis to facilitate phytoremediation of saline and alkaline soils by bitter gourd (Momordica charantia L.).

Iram K et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-29360-5
PubMed:
37620696

Bioactive polysaccharides from Momordica charantia as functional ingredients: a review of their extraction, bioactivities, structural-activity relationships, and application prospects.

Review
Zheng J et al (2023).
Crit Rev Food Sci Nutr.
DOI:
10.1080/10408398.2023.2248246
PubMed:
37599638

Momordica charantia enhances tendon healing in rats: An experimental study.

Erdoğan F et al (2023).
Cells Tissues Organs.
DOI:
10.1159/000533644
PubMed:
37586334

Glycation Inhibition of Bovine Serum Albumin by Extracts of Momordica charantia L. using Spectroscopic and Computational Methods.

Oso B, Agboola O and Olaoye I (2023).
Avicenna J Med Biotechnol.
DOI:
10.18502/ajmb.v15i3.12928
PubMed:
37538235

Momordica charantia saponins administration in low-protein-high-carbohydrate diet improves growth, blood biochemical, intestinal health and microflora composition of juvenile common carp (Cyprinus carpio).

GastroenterologyPhytochemistry
Fan Z et al (2023).
Fish Shellfish Immunol.
DOI:
10.1016/j.fsi.2023.108980
PubMed:
37532068

Momordica charantia phytoconstituents can inhibit human T-lymphotropic virus type-1 (HTLV-1) infectivity in vitro and in vivo.

Ahmadi Ghezeldasht S et al (2023).
J Neurovirol.
DOI:
10.1007/s13365-023-01160-0
PubMed:
37531001

Momordica charantia seed proteins - Purification, biochemical characterization of a class II α-mannosidase isoenzyme and its interaction with the lectin and protein body membrane.

Vutharadhi S, Ranganatha KS and Nadimpalli SK (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.126022
PubMed:
37506790

The Microemulsion with Solubilization of the Ethanolic Extract of the Leaves of Melão-de-São-Caetano (Momordica charantia) and Antibacterial Action.

de Brito AMQ et al (2023).
J Funct Biomater.
DOI:
10.3390/jfb14070359
PubMed:
37504854

Application of a generative adversarial network for multi-featured fermentation data synthesis and artificial neural network (ANN) modeling of bitter gourd-grape beverage production.

Gbashi S et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-38322-3
PubMed:
37474706

Effects of the Inclusion of Dietary Bitter Gourd (Momordica charantia) on the Performance and Carcass Characteristics of Pigs: Potential Application in the Feed Chain.

Guan X et al (2023).
Animals (Basel).
DOI:
10.3390/ani13132159
PubMed:
37443956

Trace Elemental and Heavy Metal Levels in Frequently Consumed Local Vegetables of Three Chronic Kidney Disease-Prevalent Villages.

Murthy GN and Yadav PBS (2023).
Biol Trace Elem Res.
DOI:
10.1007/s12011-023-03761-6
PubMed:
37428412

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2.

Summary

Bitter melon proteins can inhibit SARS-CoV-2 replication and have potential for COVID-19 treatment, according to new research. Two specific proteins from bitter melon, MAP30 and Momordin, showed strong inhibition of the virus in lung cells without damaging the cells. This discovery could lead to the development of effective treatments for COVID-19.

COVID-19
Watts NR et al (2023).
PLoS One.
DOI:
10.1371/journal.pone.0286370
PubMed:
37384752

Promising roles of Zingiber officinale roscoe, Curcuma longa L., and Momordica charantia L. as immunity modulators against COVID-19: A bibliometric analysis.

Summary

Study examines therapeutic potential of antioxidant, anti-inflammatory, immune-stimulating plants against SARS-CoV-2. India leads research, proposes herbal blend for COVID-19 treatment and prevention.

COVID-19
Sheikh HI et al (2023).
J Agric Food Res.
DOI:
10.1016/j.jafr.2023.100680
PubMed:
37346755

Green-synthesized nanoparticles of the polyherbal extract attenuate the necrosis of pancreatic β-cell in a streptozotocin-induced diabetic model.

Diabetes
Hasan Chowdhury MA et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e16137
PubMed:
37251822

The Management of Diabetes Mellitus Using Medicinal Plants and Vitamins.

Summary

This review article examines the potential of medicinal plants and vitamins in the prevention and treatment of diabetes mellitus (DM). Current research suggests that certain phytochemicals in medicinal plants and vitamins C, D, and E may possess anti-hypoglycemic activities and improve the health of diabetes patients. However, more research is needed in this area.

Review Diabetes
Yedjou CG et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24109085
PubMed:
37240430

The Role of Bitter Melon in Breast and Gynecological Cancer Prevention and Therapy.

Summary

Bitter melon, a widely used plant-based treatment, has potent antitumor effects against various cancers. Surprisingly, there is no review on its role in breast and gynecological cancer prevention and therapy. Our comprehensive literature review addresses this gap and highlights the promising anticancer effects of bitter melon on breast, ovarian, and cervical cancer cells. This research provides valuable insights and suggests directions for future studies in this field.

Review Cancer
Psilopatis I et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24108918
PubMed:
37240264

Impact of ultrasonication and blanching as a pre-treatment on quality parameter of dried and rehydrated bitter gourd.

Walawalkar AK, Poosarla VG and Shivshetty N (2023).
Food Sci Technol Int.
DOI:
10.1177/10820132231177324
PubMed:
37218153

Seedling nanopriming with selenium-chitosan nanoparticles mitigates the adverse effects of salt stress by inducing multiple defence pathways in bitter melon plants.

Sheikhalipour M et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.124923
PubMed:
37211072

Optimization of Magnetic and Paper-Based Molecularly Imprinted Polymers for Selective Extraction of Charantin in Momordica charantia.

Nuchtavorn N et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24097870
PubMed:
37175576

Role of Fenugreek, Cinnamon, Curcuma longa, Berberine and Momordica charantia in Type 2 Diabetes Mellitus Treatment: A Review.

Summary

This review explores the hypoglycemic activity of five medicinal plants (fenugreek, cinnamon, berberine, etc.) for treating type 2 diabetes. It summarizes mechanisms of action and supporting evidence.

Review Diabetes
Cortez-Navarrete M, Pérez-Rubio KG and Escobedo-Gutiérrez MJ (2023).
Pharmaceuticals (Basel).
DOI:
10.3390/ph16040515
PubMed:
37111272

Integration of microRNA and mRNA analyses depicts the potential roles of Momordica charantia saponin administration in insulin resistance of juvenile common carp (Cyprinus carpio) fed with a high-starch diet.

GeneticsPhytochemistry
Fan Z et al (2023).
Front Mol Biosci.
DOI:
10.3389/fmolb.2023.1054949
PubMed:
37091861

The effect of carboxymethyl cellulose and β-cyclodextrin as debittering agents on bitterness and physicochemical properties of bitter gourd extract.

Phytochemistry
Tran CTH et al (2023).
J Food Sci Technol.
DOI:
10.1007/s13197-023-05693-4
PubMed:
37033307

Momordica charantia (bitter melon) efficacy and safety on glucose metabolism in Korean prediabetes participants: a 12-week, randomized clinical study.

Kim B et al (2022).
Food Sci Biotechnol.
DOI:
10.1007/s10068-022-01214-9
PubMed:
37009042

Isolation of Momordica charantia seed lectin and glycosidases from the protein bodies: Lectin-glycosidase (β-hexosaminidase) protein body membrane interaction reveals possible physiological function of the lectin.

Vutharadhi S and Nadimpalli SK (2023).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2023.107663
PubMed:
36989986

Seed Transmission of Begomoviruses: A Potential Threat for Bitter Gourd Cultivation.

Gomathi Devi R et al (2023).
Plants (Basel).
DOI:
10.3390/plants12061396
PubMed:
36987084

Ethnopharmacological Value and Biological Activities via Antioxidant and Anti-Protein Denaturation Activity of Morinda lucida Benth and Momordica charantia L. Leaves Extracts from Benin.

Immunology
Dah-Nouvlessounon D et al (2023).
Plants (Basel).
DOI:
10.3390/plants12061228
PubMed:
36986917

Understanding the Combined Effects of High Glucose Induced Hyper-Osmotic Stress and Oxygen Tension in the Progression of Tumourigenesis: From Mechanism to Anti-Cancer Therapeutics.

Cancer
G GK et al (2023).
Cells.
DOI:
10.3390/cells12060825
PubMed:
36980166

Fine-mapping and candidate gene analysis of the Mcgy1 locus responsible for gynoecy in bitter gourd (Momordica spp.).

Zhong J et al (2023).
Theor Appl Genet.
DOI:
10.1007/s00122-023-04314-0
PubMed:
36952023

Molecular mapping of genomic regions and identification of possible candidate genes associated with gynoecious sex expression in bitter gourd.

Genetics
N D V et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1071648
PubMed:
36938036

The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease.

Summary

Type 2 diabetes (T2DM) and Alzheimer's disease (AD) share similar characteristics and common therapy options, including bioactive compounds found in fruits and vegetables. Bitter melon, a plant utilized for its glucose-lowering effects, has received recognition for its beneficial effects in treating T2DM and related metabolic conditions. Pre-clinical studies have identified multiple mechanisms by which bitter melon's bioactive components may be effective in reducing hyperglycemia and blocking the formation of amyloid plaques in AD. Further studies are necessary to establish its clinical efficacy in treating metabolic and neurodegenerative disorders.

Review Neuroscience
Richter E et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24054643
PubMed:
36902074

Role of PGPR and silver nanoparticles on the physiology of Momordica charantia L. irrigated with polluted water comprising high Fe and Mn.

Tariq S and Bano A (2023).
Int J Phytoremediation.
DOI:
10.1080/15226514.2023.2180288
PubMed:
36823757

Interaction of sugar stabilised silver nanoparticles with Momordica charantia seed lectin, a type II ribosome inactivating protein.

Kenoth R et al (2023).
Glycoconj J.
DOI:
10.1007/s10719-023-10107-w
PubMed:
36800135

Comparison study of Beninese and Chinese herbal medicines in treating COVID-19.

Summary

Researchers have observed a worldwide increase in the use of natural remedies, including Chinese herbal medicine and local plants, in response to COVID-19. This alternative approach to traditional medicine aims to strengthen immunity and prevent the spread of the disease. While the broader implications of these remedies and their effectiveness in treating COVID-19 remain unclear, these findings suggest the need for further exploration of alternative therapeutic solutions.

COVID-19
Houeze EA et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116172
PubMed:
36773790

Recombinant anti-HIV MAP30, a ribosome inactivating protein: against plant virus and bacteriophage.

Amirzadeh N et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-29365-7
PubMed:
36747030

Pd nanoparticles stabilized by bitter gourd polysaccharide with peroxidase properties for H(2)O(2) detection.

Li R et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123513
PubMed:
36739057

New insights into the bioactive polysaccharides, proteins, and triterpenoids isolated from bitter melon (Momordica charantia) and their relevance for nutraceutical and food application: A review.

Review
Bora AFM et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.123173
PubMed:
36642359

Effects of dietary wild bitter melon (Momordica charantia var. abbreviate Ser.) extract on glucose and lipid metabolism in HFD/STZ-induced type 2 diabetic rats.

Diabetes
Sun K et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116154
PubMed:
36634725

Variation of Mineral Composition in Different Fruit Parts of Bitter Gourd (Momordica charantia L.).

Singla D et al (2023).
Biol Trace Elem Res.
DOI:
10.1007/s12011-022-03546-3
PubMed:
36626030

Green Fabrication, Characterization of Zinc Oxide Nanoparticles Using Plant Extract of Momordica charantia and Curcuma zedoaria and Their Antibacterial and Antioxidant Activities.

Immunology
Ihsan M et al (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-022-04309-5
PubMed:
36622631

Attitudes, knowledge and practices of traditional snakebite healers in Nepal: implications for prevention and control of snakebite.

Pandey DP et al (2023).
Trans R Soc Trop Med Hyg.
DOI:
10.1093/trstmh/trac104
PubMed:
36366978

Ribosome-inactivating Protein MAP30 Isolated from Momordica Charantia L. Induces Apoptosis in Hepatocellular Carcinoma Cells.

Zhou Y et al (2024).
Recent Pat Anticancer Drug Discov.
DOI:
10.2174/1574892818666221103114649
PubMed:
36330636

Antiproliferative efficacy of the antioxidant bioactive compounds of defatted seeds of Azadirachta indica and Momordica charantia against the regulatory function of tumor suppressor gene inducing oral carcinoma.

CancerGeneticsImmunology
Sharma Y et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2022.2083015
PubMed:
35674735

Momordica charantia L.-Diabetes-Related Bioactivities, Quality Control, and Safety Considerations.

Review Diabetes
Çiçek SS et al (2022).
Front Pharmacol.
DOI:
10.3389/fphar.2022.904643
PubMed:
35656300

Drying kinetics and economic analysis of bitter gourd flakes drying inside hybrid greenhouse dryer.

Ahmad A, Prakash O and Kumar A (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-021-17044-x
PubMed:
34757557

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases.

Review Immunology
Bortolotti M, Mercatelli D and Polito L (2019).
Front Pharmacol.
DOI:
10.3389/fphar.2019.00486
PubMed:
31139079

Recent Advances in Momordica charantia: Functional Components and Biological Activities.

Review
Jia S et al (2017).
Int J Mol Sci.
DOI:
10.3390/ijms18122555
PubMed:
29182587