Morinda citrifolia

Common Names: Indian mulberry

Ethnobotanical Studies

Clinical Trials

Fermented Carica papaya and Morinda citrifolia as Perspective Food Supplements for the Treatment of Post-COVID Symptoms: Randomized Placebo-Controlled Clinical Laboratory Study.

Fermented food supplements improved clinical symptoms, reduced inflammation, and increased immune function in COVID-19 patients, according to a study with 188 participants. The findings suggest that fermented tropical fruits may effectively decrease post-COVID symptoms through immune-modulating, redox balancing, and pro-energy mechanisms.

Kharaeva Z et al (2022).
Nutrients.
DOI:
10.3390/nu14112203
PubMed:
35684003

Studies

Effect of temperature regulation on microbial community, volatile flavours, amino acid profiles, and iridoid glycosides during noni (Morinda citrifolia L.) fruit fermentation.

Phytochemistry
Zhang C et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.140966
PubMed:
39197244

Insight into the changes in active metabolite profiles of noni (Morinda citrifolia L.) fruit subjected to different drying treatments.

Su C et al (2024).
Food Res Int.
DOI:
10.1016/j.foodres.2024.114858
PubMed:
39160054

Olfactory sensory neuron population expansions influence projection neuron adaptation and enhance odour tracking.

Summary

Researchers studied how Drosophila sechellia evolved specialized olfactory pathways for detecting noni fruit. Increased sensory neuron populations lead to stronger tracking behavior, but not increased sensitivity. Understanding these mechanisms can help explain species-specific behavior in response to environmental cues.

Neuroscience
Takagi S et al (2024).
Nat Commun.
DOI:
10.1038/s41467-024-50808-w
PubMed:
39147786

Morinda citrifolia Essential Oil: A Plant Resistance Biostimulant and a Sustainable Alternative for Controlling Phytopathogens and Insect Pests.

Phytochemistry
Dias BL et al (2024).
Biology (Basel).
DOI:
10.3390/biology13070479
PubMed:
39056674

A simple and sensitive high-performance liquid chromatographic method combined with fluorescence detection for bioanalysis of scopoletin in rat plasma: Application to a pharmacokinetic study.

Kim T, Han DG and Yoon IS (2024).
Biomed Chromatogr.
DOI:
10.1002/bmc.5959
PubMed:
39039810

Morinda citrifolia protective effects on paclitaxel-induced testis parenchyma toxicity: An experimental study.

Genc S et al (2024).
Reprod Toxicol.
DOI:
10.1016/j.reprotox.2024.108611
PubMed:
38782144

Noni (Morinda citrifolia) leaf extract incorporated methylcellulose active films: A sustainable strategy for browning inhibition in apple slice packaging.

Eelager MP et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.132270
PubMed:
38734347

Microencapsulation of noni fruit extract using gum arabic and maltodextrin - Optimization, stability and efficiency.

Nguyen CT et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.132217
PubMed:
38729491

Noni enhances the anticancer activity of cyclophosphamide and suppresses myelotoxicity and hepatotoxicity in tumor-bearing mice.

Summary

Noni juice may prevent cancer by stopping harmful chemicals from damaging DNA. In a study, noni juice was found to have anti-tumor effects when used with a chemotherapy drug.

Cancer
Ali M et al (2024).
J Cancer Res Clin Oncol.
DOI:
10.1007/s00432-024-05734-1
PubMed:
38662247

Multiple metabolite profiles uncover remarkable bioactive compounds and metabolic characteristics of noni fruit (Morinda citrifolia L.) at various stages of ripeness.

Su C et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139357
PubMed:
38631202

Acute and Subchronic Toxicological Study of the Cocktail Extract from Curcuma xanthorrhiza Roxb, Phyllanthus niruri L. and Morinda citrifolia L.

Rosidah I et al (2024).
J Toxicol.
DOI:
10.1155/2024/9445226
PubMed:
38571743

Modulation of Gut Microbiota, and Morphometry, Blood Profiles and performance of Broiler Chickens Supplemented with Piper aduncum, Morinda citrifolia, and Artocarpus altilis leaves Ethanolic Extracts.

Gastroenterology
Paredes-López DM et al (2024).
Front Vet Sci.
DOI:
10.3389/fvets.2024.1286152
PubMed:
38511194

Morinda citrifolia leaf assisted synthesis of ZnO decorated Ag bio-nanocomposites for in-vitro cytotoxicity, antimicrobial and anticancer applications.

Summary

MCL extract used to make ZnO nanoparticles and ZnO/Ag nanocomposites. ZnO/Ag NCs show strong antimicrobial activity against nosocomial bacteria and higher toxicity towards lung cancer cells compared to normal cells. Useful for developing antimicrobial and anticancer materials.

AntimicrobialCancer
Venkatraman G et al (2024).
Bioprocess Biosyst Eng.
DOI:
10.1007/s00449-024-02995-5
PubMed:
38509421

Comparative evaluation of the effect of ultrasonic and rotary agitation of herbal irrigating solutions on smear layer: A SEM study.

Chavate PR, Ponnappa KC and Nanjappa AS (2024).
J Conserv Dent Endod.
DOI:
10.4103/JCDE.JCDE_277_23
PubMed:
38463471

Morinda citrifolia fruit extract enhances the resistance of Penaeus vannamei to Vibrio parahaemolyticus infection.

Moh JHZ et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-56173-4
PubMed:
38454039

Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells.

Summary

Morindone, a compound from Morinda citrifolia, shows promise as a potential anticancer agent for colorectal cancer with mutated TP53 and KRAS genes, exhibiting anti-proliferative and pro-apoptotic effects through multiple mechanisms.

CancerGastroenterology
Chee CW, Mohd Hashim N and Nor Rashid N (2024).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2024.110928
PubMed:
38423379

Anticancer and chemopreventive potential of Morinda citrifolia L. bioactive compounds: A comprehensive update.

Summary

Noni fruit, known for its traditional medicinal use, may possess anti-cancer properties. Studies have found that Noni extracts can induce cell death, halt cell division, hinder blood vessel growth, and impact the immune system. Further research is required to confirm these findings and assess Noni's potential as a cancer treatment.

Review Cancer
Kitic D et al (2024).
Phytother Res.
DOI:
10.1002/ptr.8137
PubMed:
38358681

Analysis of Positional Preference in Drosophila Using Multibeam Activity Monitors.

Porter MT, Roman G and Vecsey CG (2024).
Cold Spring Harb Protoc.
DOI:
10.1101/pdb.prot108181
PubMed:
38336393

Constituent analysis, laxative activity, and toxicological evaluation of methanol extract of noni fruit (Morinda citrifolia L., Rubiaceae).

Huo X et al (2023).
Food Chem X.
DOI:
10.1016/j.fochx.2023.100925
PubMed:
38144717

Alkaline lignins from Morinda citrifolia leaves are potential immunomodulatory, antitumor, and antimicrobial agents.

Summary

This study investigated the immunomodulatory, antitumor, and antimicrobial activities of lignin from Morinda citrifolia leaves. The results suggest that this lignin can activate immune cells, produce anti-inflammatory factors, and inhibit tumor and microbial growth. It has potential for developing biomedical and pharmaceutical products.

AntimicrobialCancerImmunology
Cruz Filho IJ et al (2023).
An Acad Bras Cienc.
DOI:
10.1590/0001-3765202320221026
PubMed:
38055562

Evaluation of Physical Properties of Denture Base Resins Containing Silver Nanoparticles of Aloe barbadensis Miller, Morinda citrifolia, and Boesenbergia rotunda and Its Anti-microbial Effect: An In Vitro Study.

Summary

Adding plant extract silver nanoparticles to PMMA denture bases increased flexural strength and hardness, with finger root extract showing the highest antimicrobial activity against Candida albicans. This suggests that AgNPs can enhance denture base properties. (40 words)

Antimicrobial
Kaul S et al (2023).
Cureus.
DOI:
10.7759/cureus.48260
PubMed:
38054116

The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

Shahrajabian MH and Sun W (2023).
Curr HIV Res.
DOI:
10.2174/011570162X271199231128092621
PubMed:
38047360

Effect of Plant-Based Mouthwash (Morinda citrifolia and Ocimum sanctum) on TNF-α, IL-α, IL-β, IL-2, and IL-6 in Gingival Crevicular Fluid and Plaque Scores of Patients Undergoing Fixed Orthodontic Treatment.

Summary

Two plant-based mouthwashes (MC and OS) used with toothbrushing and fluoride toothpaste reduced plaque and inflammatory biomarkers (TNF-α, IL-α, IL-β) better than traditional mouthwash.

Immunology
Kamran MA et al (2023).
Medicina (Kaunas).
DOI:
10.3390/medicina59111968
PubMed:
38004017

Green synthesis, characterization, antibacterial, and antifungal activity of copper oxide nanoparticles derived from Morinda citrifolia leaf extract.

Summary

The researchers synthesized copper oxide nanoparticles using Morinda citrifolia leaf extract. The nanoparticles were stable and had strong antibacterial and antifungal activity. They suggest that these nanoparticles could be used in biomedicine.

Antimicrobial
Priya M et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-46002-5
PubMed:
37914791

Effect of Morinda citrifolia fruit powder on physiological and productive performance of Cavia porcellus.

Paredes-López DM et al (2023).
Front Vet Sci.
DOI:
10.3389/fvets.2023.1134138
PubMed:
37901108

Effects of Noni (Morinda citrifolia L.) Fruit Extract Supplemented in Cashmere Goats with a High-Concentrate Diet on Growth Performance, Ruminal and Colonic Fermentation and SARA.

Zhang Q et al (2023).
Animals (Basel).
DOI:
10.3390/ani13203275
PubMed:
37893999

Potential of pharmaceutical formulation based on Morinda citrifolia extract for the treatment of schistosomiasis.

Gomes da Silva B et al (2023).
Exp Parasitol.
DOI:
10.1016/j.exppara.2023.108617
PubMed:
37844753

Chronic supplementation of noni in diabetic type 1-STZ rats: effects on glycemic levels, kidney toxicity and exercise performance.

Summary

Chronic noni fruit juice supplementation improved exercise performance and blood glucose control in rats with diabetes, but also caused kidney damage. Care should be taken when considering noni for clinical use.

Diabetes
de Oliveira Fernandes D et al (2023).
Diabetol Metab Syndr.
DOI:
10.1186/s13098-023-01171-1
PubMed:
37794521

Sensory neuron population expansion enhances odour tracking through relaxed projection neuron adaptation.

Summary

Researchers compared the olfactory sensory neuron (OSN) populations of two species and found that the one with larger expansions performed better in odor plume-tracking assays, highlighting the significance of sensory neuron expansions in species-specific behavior.

Neuroscience
Takagi S et al (2023).
bioRxiv.
DOI:
10.1101/2023.09.15.556782
PubMed:
37745467

Insight into the effects of different ripeness levels on the quality and flavor chemistry of Noni fruit (Morinda citrifolia L.).

Chen X et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.137408
PubMed:
37716147

Green synthesis of silver nanoparticles using Morinda citrifolia Linn leaf extract and its antioxidant, antibacterial and anticancer potential.

Summary

Nanomedicine is a promising approach for treating both infectious and non-infectious diseases, potentially revolutionizing medicine.

CancerImmunology
Datkhile KD et al (2023).
Pharm Nanotechnol.
DOI:
10.2174/2211738511666230913095001
PubMed:
37711107

RNA Sequencing and Bioinformatics Analysis Reveals the Downregulation of DNA Replication Genes by Morindone in Colorectal Cancer Cells.

Summary

Morindone, a natural compound, shows promise as a treatment for colorectal cancer (CRC). It downregulates genes involved in DNA replication and cell development. GINS2 is identified as a potential target. Validation confirms these findings. Consider using morindone for CRC treatment.

CancerGastroenterologyGenetics
Chee CW et al (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-023-04690-9
PubMed:
37642925

UHPLC-QQQ-MS and RP-HPLC Detection of Bioactive Alizarin and Scopoletin Metabolites from Morinda citrifolia Root Extracts and Their Antitubercular, Antibacterial, and Antioxidant Activities.

Summary

Root extracts were found to have strong antitubercular, antibacterial, and antioxidant properties. The extracts contain various compounds with potential biomedical applications.

Immunology
Sam-Ang P et al (2023).
ACS Omega.
DOI:
10.1021/acsomega.3c03656
PubMed:
37599981

Molecular dynamics study of stigmasterol and beta-sitosterol of Morinda citrifolia L. towards α-amylase and α-glucosidase.

Lolok N et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2243519
PubMed:
37539686

Phenytoin's Pharmacological Interactions with Medicinal Herbs: A Review.

Review
Taleb MH et al (2023).
Pharmazie.
DOI:
10.1691/ph.2023.3546
PubMed:
37537774

Pharmacoinformatics-Based Approach for Uncovering the Quorum-Quenching Activity of Phytocompounds against the Oral Pathogen, Streptococcus mutans.

Marimuthu SCV et al (2023).
Molecules.
DOI:
10.3390/molecules28145514
PubMed:
37513386

Characterizations of microRNAs involved in the molecular mechanisms underlying the therapeutic effects of noni (Morinda citrifolia L.) fruit juice on hyperuricemia in mice.

Liu Y et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1121734
PubMed:
37426193

Neuroprotective Effect of Morinda citrifolia on Behavioural and Biochemical Deficits in PTZ-induced Kindled Mice.

Summary

Researchers used a chronic epileptic mouse model to better understand epilepsy and search for new anti-epileptic drugs. They repeatedly delivered sub-convulsive stimuli, causing massive convulsions. They also looked at the effects of Morinda citrifolia (Noni) extracts, which have been used in Ayurvedic medicine to treat various ailments and were recently shown to help protect mice from memory loss caused by amyloid beta. This study could lead to new treatments for epilepsy and other neurological conditions.

Neuroscience
Ali M et al (2023).
Infect Disord Drug Targets.
DOI:
10.2174/1871526523666230605160222
PubMed:
37282657

Genetic variation in disease resistance in Drosophila spp. is mitigated in Drosophila sechellia by specialization to a toxic host.

O'Malley L et al (2023).
Sci Rep.
DOI:
10.1038/s41598-023-34976-1
PubMed:
37179396

First Report of Root rot Caused by Mucor circinelloides on Fructus forsythiae in Hubei China.

Zhou Y et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-02-23-0339-PDN
PubMed:
37172975

Potential peptidyl arginine deiminase type 4 inhibitors from Morinda citrifolia: a structure-based drug design approach.

Roy Chowdhury D et al (2023).
In Silico Pharmacol.
DOI:
10.1007/s40203-023-00147-3
PubMed:
37153695

An In Vitro Evaluation of Morinda citrifolia and Ocimum sanctum as Potential Storage Media to Maintain Cell Viability for Avulsed Teeth Using Collagenase Dispase Assay.

Vijaykumar Sagare S et al (2023).
Cureus.
DOI:
10.7759/cureus.36837
PubMed:
37123786

Effectiveness of Morinda Citrofolia, Sapindus Mukorossi, and Curcumin used in curry spice, to the radicular canal irrigant in improving bond integrity of glass fiber post.

AlGhamdi AS et al (2023).
Photodiagnosis Photodyn Ther.
DOI:
10.1016/j.pdpdt.2023.103526
PubMed:
36996965

A survey on the potential contribution of Reunion Island dye plant species diversity to the market demand for bioactive plant-based dyes and pigments.

Andriamanantena M et al (2023).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-023-00580-w
PubMed:
36964580

Anti-inflammatory Effect of a Combination of Cannabidiol and Morinda citrifolia Extract on Lipopolysaccharide-stimulated RAW264 Macrophages.

Immunology
Tanikawa T et al (2023).
In Vivo.
DOI:
10.21873/invivo.13117
PubMed:
36881078

Production of anthraquinones from cell and organ cultures of Morinda species.

Review
Murthy HN et al (2023).
Appl Microbiol Biotechnol.
DOI:
10.1007/s00253-023-12440-4
PubMed:
36847855

Advances in Molecular Regulation of Prostate Cancer Cells by Top Natural Products of Malaysia.

Review Cancer
Prieto JM and Hanafi MMM (2023).
Curr Issues Mol Biol.
DOI:
10.3390/cimb45020099
PubMed:
36826044

[Chemical constituents from fruits of Morinda citrifolia and their inhibitory effects on proliferation of synoviocytes in vitro].

Shen ZY et al (2023).
Zhongguo Zhong Yao Za Zhi.
DOI:
10.19540/j.cnki.cjcmm.20220421.203
PubMed:
36725263

Computational assessment of chemicals from Morinda citrifolia as potential inhibitors of B-Raf kinase in hepatocellular carcinoma treatment.

Ugwah-Oguejiofor CJ et al (2023).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2023.2172459
PubMed:
36709454

Variation in physicochemical properties and bioactivities of Morinda citrifolia L. (Noni) polysaccharides at different stages of maturity.

Phytochemistry
Cai J et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2022.1094906
PubMed:
36687691

Dietary Polysaccharide-Rich Extract from Noni (Morinda citrifolia L.) Fruit Modified Ruminal Fermentation, Ruminal Bacterial Community and Nutrient Digestion in Cashmere Goats.

Zhang Q et al (2023).
Animals (Basel).
DOI:
10.3390/ani13020221
PubMed:
36670760

Taste adaptations associated with host specialization in the specialist Drosophila sechellia.

Reisenman CE et al (2023).
J Exp Biol.
DOI:
10.1242/jeb.244641
PubMed:
36637369

Efficacy and Safety of Morinda citrifolia L. (Noni) as a Potential Anticancer Agent.

Review Cancer
Chanthira Kumar H et al (2022).
Integr Cancer Ther.
DOI:
10.1177/15347354221132848
PubMed:
36448674

Bisabolane-type sesquiterpenoids with potential anti-inflammatory and anti-HIV activities from the stems and leaves of Morinda citrifolia.

Immunology
Zhao YY et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2112577
PubMed:
35975763

Genotoxicity Comparison between Morinda citrifolia Fruit and Seed Substances.

Shin S et al (2022).
Foods.
DOI:
10.3390/foods11121773
PubMed:
35741971

Evaluation of morinda citrifolia ethanolic extract versus morinda citrifolia fresh fruit juice for tissue response and systemic toxicity in animal model.

Teja KV et al (2021).
Indian J Dent Res.
DOI:
10.4103/ijdr.IJDR_436_19
PubMed:
35645066

Toxicological effects of the Morinda citrifolia L. fruit extract on maternal reproduction and fetal development in rats.

Genetics
Leal-Silva T et al (2023).
Drug Chem Toxicol.
DOI:
10.1080/01480545.2022.2070197
PubMed:
35502509

Extraction, derivatization, and antioxidant activity of Morinda citrifolia polysaccharide.

Zhou S and Huang G (2022).
Chem Biol Drug Des.
DOI:
10.1111/cbdd.14023
PubMed:
35092172

Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function.

Dermatology
Kim SH, Seong GS and Choung SY (2020).
Nutrients.
DOI:
10.3390/nu12010249
PubMed:
31963703

Adverse effects of herbal medicines: an overview of systematic reviews.

Review
Posadzki P, Watson LK and Ernst E (2013).
Clin Med (Lond).
PubMed:
23472485

Morinda citrifolia (Noni): a literature review and recent advances in Noni research.

Review
Wang MY et al (2002).
Acta Pharmacol Sin.
PubMed:
12466051