Morus nigra

Common Names: black mulberry

Ethnobotanical Studies

Studies

Black Mulberries (Morus nigra L.) Modulate Oxidative Stress and Beta-Amyloid-Induced Toxicity, Becoming a Potential Neuroprotective Functional Food.

Summary

The study shows that black mulberry extract is rich in antioxidants and has neuroprotective properties, potentially preventing neurodegenerative diseases. It also inhibits MAO-A enzyme and scavenges free radicals.

ImmunologyNeuroscience
Cásedas G et al (2024).
Foods.
DOI:
10.3390/foods13162577
PubMed:
39200504

Antidepressant-like and antioxidant effects of Morus nigra L. in rats subjected to the unpredictable chronic mild stress model.

Summary

Study shows Morus nigra leaf extract reduces depression-like behavior in stressed rats, possibly through antioxidant effects. Potential new treatment for depression.

ImmunologyNeuroscience
Merida BF et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2387253
PubMed:
39172975

Chemical Profile and Potential Application of Agri-food Waste Products for Counteracting Diabetes Induced Neuropathy in Rats.

Summary

Extracts from okra, mulberry, and pomegranate leaves and peel help diabetic rats by reducing blood glucose, inflammation, and restoring brain health. Promising for treating diabetic neuropathy.

Diabetes
El Souda SS et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202400843
PubMed:
39140441

Contribution of Extracellular Particles Isolated from Morus sp. (Mulberry) Fruit to Their Reported Protective Health Benefits: An In Vitro Study.

Garrett NR, Pink RC and Lawson C (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25116177
PubMed:
38892365

[Study on the total flavonoid content and antioxidant activity of Morus nigra Linn. from different origins in Xinjiang].

Summary

Scientists optimized a method to extract flavonoids from Morus nigra Linn. from different Xinjiang regions. This can help understand antioxidant properties and improve lab decisions.

ImmunologyPhytochemistry
Dawuti T et al (2024).
Wei Sheng Yan Jiu.
DOI:
10.19813/j.cnki.weishengyanjiu.2024.03.018
PubMed:
38839589

New molecular and macroscopic understandings of novel green chemicals based on Xanthan Gum and bio-surfactants for enhanced oil recovery.

Rezaei A et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-63244-z
PubMed:
38831003

Facilitation of infectious and non-infectious wound healing using Morus nigra fruit extract ointment: An in vitro and in vivo study.

Sharifee F et al (2024).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2024.112230
PubMed:
38744171

A Novel Strategy for Mixed Jam Evaluation: Apparent Indicator, Sensory, Metabolomic, and GC-IMS Analysis.

Maimaitiyiming R et al (2024).
Foods.
DOI:
10.3390/foods13071104
PubMed:
38611408

Specific Antimicrobial Activities Revealed by Comparative Evaluation of Selected Gemmotherapy Extracts.

Summary

Researchers tested various plant extracts for antimicrobial activity. Blackberry extract was most effective, olive extract showed strongest bactericidal results. These extracts could be potential antimicrobials to enhance antibiotic therapies and combat antimicrobial resistance.

Antimicrobial
Héjja M et al (2024).
Antibiotics (Basel).
DOI:
10.3390/antibiotics13020181
PubMed:
38391567

Colorimetric sensing of hydrogen peroxide using capped Morus nigra-sawdust deposited zinc oxide nanoparticles via Trigonella foenum extract.

Nishan U et al (2024).
Front Bioeng Biotechnol.
DOI:
10.3389/fbioe.2024.1338920
PubMed:
38390362

Combined pH ratiometry and fluorescence lectin-binding analysis (pH-FLBA) for microscopy-based analyses of biofilm pH and matrix carbohydrates.

Del Rey YC et al (2024).
Appl Environ Microbiol.
DOI:
10.1128/aem.02007-23
PubMed:
38265212

Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted treatment of hepatocellular carcinoma via the oral route.

Gao Q et al (2024).
J Nanobiotechnology.
DOI:
10.1186/s12951-023-02286-3
PubMed:
38169394

Effects of adding milk to fermented black mulberry (Morus nigra L.) juice on its antioxidant activity in C2C12 cells and changes in volatile flavor compounds during storage.

Immunology
Lv M et al (2023).
Food Chem X.
DOI:
10.1016/j.fochx.2023.101029
PubMed:
38144770

In Vitro Evaluation of Potentially Edible Brazilian Trees and Shrubs in Ruminant Nutrition.

de Morais JPG et al (2023).
Animals (Basel).
DOI:
10.3390/ani13233703
PubMed:
38067053

The effect of black mulberry (Morus nigra) consumption on cognition in patients with mild-to-moderate Alzheimer's dementia: A pilot feasibility study.

Summary

This study tested the effects of black mulberry on cognitive function in Alzheimer's disease (AD) patients. Those given black mulberry had improved cognitive scores, suggesting it may have potential benefits for AD.

Neuroscience
Güçer Öz Y et al (2023).
Geriatr Nurs.
DOI:
10.1016/j.gerinurse.2023.11.014
PubMed:
38052130

Combinational application of the natural products 1-deoxynojirimycin and morin ameliorates insulin resistance and lipid accumulation in prediabetic mice.

Ren X et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155106
PubMed:
37797432

Phytoconstituent Profiles Associated with Relevant Antioxidant Potential and Variable Nutritive Effects of the Olive, Sweet Almond, and Black Mulberry Gemmotherapy Extracts.

Immunology
Aleya A et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12091717
PubMed:
37760021

Black mulberry extract inhibits hepatic adipogenesis through AMPK/mTOR signaling pathway in T2DM mice.

Yao Y et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117216
PubMed:
37741475

Blackberries and Mulberries: Berries with Significant Health-Promoting Properties.

Review
Martins MS et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241512024
PubMed:
37569399

Estimation of Some Phytochemical Compounds and Antioxidant Properties of Leaves from Different Mulberry Varieties Grown in Syria.

Summary

This study compared the chemical and bioactive compounds in mulberry leaves grown in Syria. Different mulberry species varied in composition and antioxidant activity. Mulberry leaves hold potential for food supplements and medical applications.

ImmunologyPhytochemistry
Alidee T et al (2023).
Evid Based Complement Alternat Med.
DOI:
10.1155/2023/9929276
PubMed:
37547035

Morphometric analysis and roosting ecology of bat species Pteropus Medius in Mansehra, Khyber Pakhtunkhwa, Pakistan.

Rehbar B et al (2023).
Braz J Biol.
DOI:
10.1590/1519-6984.259039
PubMed:
37466508

Comprehensive structural analysis of polyphenols and their enzymatic inhibition activities and antioxidant capacity of black mulberry (Morus nigra L.).

Immunology
Huo J et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136605
PubMed:
37390741

Effect of Frost on the Different Metabolites of Two Mulberry (Morus nigra L. and Morus alba L.) Leaves.

Yang L et al (2023).
Molecules.
DOI:
10.3390/molecules28124718
PubMed:
37375273

Evaluation of the Anticancer Potential of Morus nigra and Ocimum basilicum Mixture against Different Cancer Cell Lines: An In Vitro Evaluation.

Cancer
Almutairi BO et al (2023).
Biomed Res Int.
DOI:
10.1155/2023/9337763
PubMed:
37124934

Dose-Dependent Dual Effect of Morus nigra L. Extract on Urinary Parameters of Hypertensive Rats.

Mariano LNB et al (2023).
Chem Biodivers.
DOI:
10.1002/cbdv.202300017
PubMed:
37071473

Polysaccharides extracted from mulberry fruits (Morus nigra L.): antioxidant effect of ameliorating H(2)O(2)-induced liver injury in HepG2 cells.

Immunology
Li X et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-03925-w
PubMed:
37046263

Comprehensive Analysis of Antioxidant and Hepatoprotective Properties of Morus nigra L.

Vukmirović S et al (2023).
Antioxidants (Basel).
DOI:
10.3390/antiox12020382
PubMed:
36829941

Comparative and phylogenetic analyses of the chloroplast genome reveal the taxonomy of the Morus genus.

Summary

In this study, the chloroplast genomes of 123 varieties of the mulberry plant were analyzed. The genomes were found to be around 159,000 bp in size and contained 125 genes. The study discovered that 87 of the varieties shared 14 common ancestors, indicating maternal inheritance. The study also identified six species of the mulberry plant and proposed a new classification system. This research is important for the classification, domestication, and breeding improvement of the economically important mulberry plant.

GeneticsNeuroscience
Zeng Q et al (2022).
Front Plant Sci.
DOI:
10.3389/fpls.2022.1047592
PubMed:
36507423

Hydroethanolic Extract of Morus nigra L. Leaves: A Dual PPAR-α/γ Agonist with Anti-Inflammatory Properties in Lipopolysaccharide-Stimulated RAW 264.7.

Immunology
Carneiro AA et al (2022).
Plants (Basel).
DOI:
10.3390/plants11223147
PubMed:
36432875

Comparative metabolite profiling of four polyphenol rich Morus leaves extracts in relation to their antibiofilm activity against Enterococcus faecalis.

Phytochemistry
Salem MA et al (2022).
Sci Rep.
DOI:
10.1038/s41598-022-24382-4
PubMed:
36424446

Plant lectins as versatile tools to fight coronavirus outbreaks.

Summary

Plant lectins could be used to combat COVID-19 pandemics by masking the non-glycosylated receptor binding domain of the virus and the corresponding region of the receptor. The ability of plant lectins to interact with the N- and O-glycans present on the spike proteins and their receptors have been analyzed, as well as the in vitro and in vivo anti-COVID-19 activity reported for them. Possible ways for delivery of lectins to block the spikes and/or their receptors are also discussed.

Review COVID-19
Simplicien M et al (2023).
Glycoconj J.
DOI:
10.1007/s10719-022-10094-4
PubMed:
36418811

First Report of Mulberry Rust Caused by Cerotelium fici on Morus nigra in Brazil.

Gonçalves MP et al (2022).
Plant Dis.
DOI:
10.1094/PDIS-11-22-2656-PDN
PubMed:
36410015

Herbal medicinal uses and their practices in human health care and livestock from district Haripur, Khyber Pakhtunkhwa, Pakistan.

Siddique Z et al (2022).
Vet Med Sci.
DOI:
10.1002/vms3.948
PubMed:
36173733

Black mulberry (Morus nigra) fruit extract alleviated AD-Like symptoms induced by toxic Aβ protein in transgenic Caenorhabditis elegans via insulin DAF-16 signaling pathway.

Wang E et al (2022).
Food Res Int.
DOI:
10.1016/j.foodres.2022.111696
PubMed:
36076399

Dose dependent anticonvulsant activity of Morus nigra in strychnine induced seizures model.

Summary

The study evaluated the anti-seizure activity of Morus nigra (black mulberry) in different doses. Groups of rats were given different doses of Morus nigra for 15 days prior to being administered strychnine. Results showed significant seizure protection, particularly in the 500mg/kg dose group, with delayed latency of seizures, decrease in frequency, and decreased duration of jerks. The anticonvulsant activity could be due to potentiation of both Gabaergic and glycinergic activities and the antioxidant activity of Morus nigra could serve as a non-pharmacological treatment for seizure management.

Neuroscience
Zehra T, Sarfaraz S and Ikram R (2021).
Pak J Pharm Sci.
PubMed:
35034877

In silico and in vivo protective effect of Morus nigra leaves on oxidative damage induced by iron overload.

Figueredo KC et al (2022).
Drug Chem Toxicol.
DOI:
10.1080/01480545.2021.1991946
PubMed:
34663156

Protective Effects of Morus nigra and Its Phytochemicals against Hepatotoxicity: A Review of Preclinical Studies.

Review Phytochemistry
Ghorbani A and Hooshmand S (2021).
Pharmacology.
DOI:
10.1159/000515032
PubMed:
33849010

Morus nigra L. extract prolongs survival of rats with hepatocellular carcinoma.

Hooshmand S et al (2021).
Phytother Res.
DOI:
10.1002/ptr.7056
PubMed:
33624311

Protective Role of Morus nigra Leaf Extracts against Murine Infection with Eimeria papillata.

Thagfan FA et al (2021).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207323666200903152811
PubMed:
32885749

The effects of morus nigra on the alveolar bone loss in experimentally-induced periodontitis.

Yildirim TT et al (2019).
Eur Oral Res.
DOI:
10.26650/eor.20190021
PubMed:
31579889

Pharmacological Properties of Morus nigra L. (Black Mulberry) as A Promising Nutraceutical Resource.

Review
Lim SH and Choi CI (2019).
Nutrients.
DOI:
10.3390/nu11020437
PubMed:
30791521

Anti-Inflammatory and Antioxidant Properties of Black Mulberry (Morus nigra L.) in a Model of LPS-Induced Sepsis.

Immunology
de Pádua Lúcio K et al (2018).
Oxid Med Cell Longev.
DOI:
10.1155/2018/5048031
PubMed:
30524657