Common Names: cream narcissus
Scientists isolated and identified 19 alkaloids from Narcissus tazetta bulbs, with (+)-Narciclasine showing strong immunosuppressive activity on human T cells. It also reduced liver damage in an autoimmune hepatitis mouse model. This research could lead to new treatments for autoimmune diseases.
Researchers investigated the immunopharmacological effects of pseudolycorine chloride (PLY), a constituent of L. var. Roem with antitumor and antiviral activities. They found that PLY significantly increased the production of cytokines and chemokines, indicating its potential in modulating the immune response. This study sheds light on the potential medical uses of PLY as an immunomodulator.
A new plant lectin called NTL-125 from Narcissus tazetta bulb has been identified as an effective inhibitor of SARS-CoV-2 replication. The lectin has been shown in in silico docking studies to prevent the virus from attaching to the cellular entryway, hACE2 receptor, by binding strongly to the viral Spike RBD protein. Mutant variants of the protein also showed stronger affinity to NTL-125 than hACE2. This natural antiviral compound may serve as an important therapeutic for COVID-19 management despite the virus's tendency to mutate.