Nardostachys jatamansi, also known as muskroot, has been used in traditional medicine for heart diseases. It has shown anxiolytic, sedative, and antihypertensive properties.
Nardostachys jatamansi DC. roots & rhizomes treat Parkinson's disease; Nardosinone, main active component, shows potential for PD treatment. Important for PD research & treatment development.
This review article summarizes the traditional uses, phytochemistry, and pharmacological activities of Nardostachys jatamansi. It also discusses procedures for variety improvement, protection, and utilization, highlighting potential prospects for this plant.
This review provides updated information on thirteen medicinal plants prioritized by the Indian government. It covers traditional uses, phytochemistry, pharmacology, quality control, and conservation status. Useful for understanding their importance and developing conservation strategies.
Combining levodopa with traditional Chinese medicine (NJ) can effectively alleviate Parkinson's disease (PD) symptoms, offering a potential holistic treatment option.
Chinese herbal extracts show promise in the treatment of Alzheimer's disease by improving memory and reducing inflammation. These extracts have potential for early AD treatment due to their fewer adverse effects and ease of consumption.
The plant Nardostachys jatamansi is commonly used in traditional medicine to treat epilepsy and cardiovascular issues. Its underground parts are specifically used for this purpose.
Researchers optimized microwave-assisted extraction (MAE) parameters for extracting secondary metabolites from the medicinal herb (D. Don) DC. They used a Box Behkhen Design (BBD) to optimize microwave power, temperature, and time of irradiation. Compared to conventional methods, MAE significantly increased extract yield, as well as the total phenolic content and total flavonoid content (TFC). Gas chromatography-mass spectrometry (GC-MS) analysis confirmed higher concentrations of various sesquiterpenes and steroidal compounds in the optimized extract. The optimized extract also showed improved anti-Alzheimer's potential. Thus, MAE could provide a successful and more environmentally friendly way to extract secondary metabolites from this valuable medicinal herb.
Jatamansinol, a compound extracted from Nardostachys jatamansi used in traditional medicine, has been found to protect against Tau-induced neurotoxicity in a Drosophila model of Alzheimer's Disease (AD). The study investigated the effects of jatamansinol on lifespan, learning and memory, oxidative stress, and cholinesterase activities in tauopathy flies. Results showed that jatamansinol treatment extended lifespan, improved locomotor activity, enhanced learning and memory, and reduced Tau protein levels while boosting antioxidant enzyme activities and inhibiting cholinesterase activities in Tau-induced AD models. These findings suggest jatamansinol could be a potential therapeutic drug candidate for AD.
Sleep disorders are prevalent and pharmacological treatments often have side effects. Researchers suggest exploring natural plant-based sources as a safe and effective alternative. A rhizome commonly used for insomnia and mental conditions in Indian medicine is a promising candidate.
A study analyzed the effect of jatamansinol, an active compound in an essential Indian Ayurvedic plant, on neuroprotection against Alzheimer's disease (AD) in a Drosophila AD model. Flies supplemented with jatamansinol showed extended lifespan, enhanced learning and memory, improved locomotor abilities, reduced Aβ protein levels, and prevented oxidative stress-induced eye degeneration and cholinesterase activities. Jatamansinol showed neuroprotective effects against Aβ protein-induced neurotoxicity in the AD model, suggesting its therapeutic potential against AD.
This study looked at the effects of Nardostachys jatamansi, a traditional Chinese medicine, on the gut microbiota of rats with Parkinson's disease. The researchers found that the extract improved behavior and reversed increased levels of proinflammatory cytokines and protein aggregation in the colon and striatum, indicating a potential neuroprotective effect. They also discovered a decrease in gut microbiota diversity and abundance in the PD model, and the extract increased the relative abundance of certain beneficial bacteria while reversing the increase of harmful ones. This study provides a basis for combining traditional and modern medicine to treat PD.
This study looks at a plant called D.Don DC, which has traditionally been used to treat neurological disorders, and its potential as a drug candidate for Alzheimer's disease (AD). Using computational drug discovery techniques, the study found that certain pyranocoumarins from the plant, such as dihydrojatamansin and jatamansinol, could be potential drug candidates for AD. The study also found that dihydrojatamansin inhibits acetylcholinesterase, while jatamansinol inhibits other AD therapeutic targets. These findings could lead to new treatments for AD.