Nelumbo nucifera

Common Names: sacred lotus

Ethnobotanical Studies

Studies

Unintentionally-produced persistent organic pollutants in the aquatic environment contaminated from historical chlor-alkali production.

Huang Z et al (2024).
Environ Pollut.
DOI:
10.1016/j.envpol.2024.124882
PubMed:
39241952

Preparation, structural characterization, and biological activities of lotus polysaccharides: A review.

Review
Liu H et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.135191
PubMed:
39216588

Lotus (Nelumbo nucifera G.) seed starch: Understanding the impact of physical modification sequence (ultrasonication and HMT) on properties and in vitro digestibility.

Chandak A et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.135032
PubMed:
39182880

Quercetin and its derivatives from lotus (Nelumbo nucifera) seedpod extract combat radioresistance by suppressing ACSL4.

Nguyen PA et al (2024).
Biofactors.
DOI:
10.1002/biof.2118
PubMed:
39167022

Therapeutic potential of Nelumbo nucifera Linn. in systemic lupus erythematosus: Network pharmacology and molecular modeling insights.

Dermatology
Jaiswal S et al (2024).
Lupus.
DOI:
10.1177/09612033241273074
PubMed:
39135520

Dosage sensitivity shapes balanced expression and gene longevity of homoeologs after whole-genome duplications in angiosperms.

Genetics
Shi T et al (2024).
Plant Cell.
DOI:
10.1093/plcell/koae227
PubMed:
39121058

The peels of sacred Lotus (Nelumbo nucifera) rhizomes suppress allergic reactions by inhibiting the A23187-induced degranulation in rat basophilic leukemia (RBL2H3) cells.

Summary

Researchers isolated ten compounds from sacred lotus rhizome peels and found three, stigmasterol glucoside, oleanolic acid, and pinoresinol, effectively inhibited allergic reactions without harming cells. The findings suggest potential use for affordable anti-allergic treatments.

Cancer
Ashour A et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.106153
PubMed:
39089597

Genome-wide identification of the Q-type C2H2 zinc finger protein gene family and expression analysis under abiotic stress in lotus (Nelumbo nucifera G.).

Summary

Researchers investigated Q-type C2H2 zinc finger proteins in lotus plants, crucial for growth and stress responses. Understanding these proteins can help improve lotus growth and resilience to environmental stress.

Genetics
Liu H et al (2024).
BMC Genomics.
DOI:
10.1186/s12864-024-10546-1
PubMed:
38943098

Mixture of Rhodiola rosea and Nelumbo nucifera Extracts Ameliorates Sleep Quality of Adults with Sleep Disturbance.

Kim Y et al (2024).
Nutrients.
DOI:
10.3390/nu16121867
PubMed:
38931222

Nelumbo nucifera flower extract incorporated alginate/polyvinyl alcohol films as a sustainable pH indicator for active food packaging applications.

Radoor S et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133170
PubMed:
38880445

Liensinine diperchlorate and artemisitene synergistically attenuate breast cancer progression through suppressing PI3K-AKT signaling and their efficiency in breast cancer patient-derived organoids.

Summary

LIN and ATT, compounds from lotus and Artemisia, synergistically inhibit breast cancer cell growth and invasion by enhancing apoptosis and suppressing PI3K-AKT signaling. Promising potential for BC therapy.

Cancer
Lin X et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116871
PubMed:
38861856

Assessment of phytodiversity and phytoremediation potential of plants in the vicinity of a thermal power plant.

Pandey A et al (2024).
Int J Phytoremediation.
DOI:
10.1080/15226514.2024.2358377
PubMed:
38832563

Evaluation and validation of suitable reference genes for quantitative real-time PCR analysis in lotus (Nelumbo nucifera Gaertn.).

Genetics
Wang B et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-61806-9
PubMed:
38740848

Examining starch metabolism in lotus roots (Nelumbo nucifera Gaertn.) during post-harvest storage at different temperatures.

Gong X et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2024.139494
PubMed:
38723566

Advances in the pharmacological effects and mechanisms of Nelumbo nucifera Gaertn. extract Nuciferine.

Review
Ren X et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118262
PubMed:
38670406

Flavor Chemical Research on Different Bee Pollen Varieties Using Fast E-Nose and E-Tongue Technology.

Liu C et al (2024).
Foods.
DOI:
10.3390/foods13071022
PubMed:
38611329

Enhancing the therapeutic potential of isoliensinine for hypertension through PEG-PLGA nanoparticle delivery: A comprehensive in vivo and in vitro study.

Summary

Scientists developed PEG-PLGA nanoparticles loaded with isoliensinine to improve its antihypertensive efficacy. This could lead to better treatment options for hypertension, a common and damaging chronic disease.

Cardiology
Yao M et al (2024).
Biomed Pharmacother.
DOI:
10.1016/j.biopha.2024.116541
PubMed:
38565063

Hypoglycemic activity in vivo and in vitro of the Lotus (Nelumbo nucifera Gaertn.) seed skin (testa) phenolic-rich extracts.

Summary

Study showed lotus seed skin phenolic-rich extract (LSSE) decreased blood glucose levels and α-glucosidase activity in mice. LSSE has potential as a natural hypoglycemic functional food.

DiabetesPhytochemistry
Xu H, Wang C and Gong L (2024).
Food Chem X.
DOI:
10.1016/j.fochx.2024.101282
PubMed:
38550890

Neferine Pretreatment Attenuates Isoproterenol-Induced Cardiac Injury Through Modulation of Oxidative Stress, Inflammation, and Apoptosis in Rats.

Summary

Neferine, derived from lotus seeds, protects against heart damage in rats induced with heart attacks. It improves cardiac function, lipid profiles, and reduces inflammation and apoptosis through various signaling pathways. Neferine shows promising medicinal effects for cardiovascular health.

CardiologyImmunology
Sun X et al (2024).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-024-04917-3
PubMed:
38526658

Southern blight of water lily: The first host record of Agroathelia rolfsii on Nelumbo nucifera discovered in Florida, USA.

Urbina H et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-01-24-0020-PDN
PubMed:
38514444

First Report of Neofusicoccum parvum Causing Seedpod Blight on Lotus (Nelumbo nucifera) in China.

Yan X et al (2024).
Plant Dis.
DOI:
10.1094/PDIS-11-23-2423-PDN
PubMed:
38506908

Structurally Diverse Bisbenzylisoquinoline Alkaloids with Antiadipogenic Activity through PPARγ Downregulation from the Embryo of Nelumbo nucifera Seeds.

Summary

Unknown compounds isolated from seeds' embryos have antiadipogenic effects by downregulating key receptors. Configurations in alkaloids enhance activity. Potential for antiobesity treatments with further research.

Phytochemistry
Zhang P et al (2024).
J Nat Prod.
DOI:
10.1021/acs.jnatprod.3c01290
PubMed:
38483204

Synergistic effect of Panax ginseng, Polygonatum cyrtonema, Epiphyllum oxypetalum, Nelumbo nucifera and Osmanthus fragrans extracts on skin aging regulation. From in silico predictions to in vitro outcome.

Feng C et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e26131
PubMed:
38449662

Determination of higenamine in common natural spices by ultrahigh-performance liquid chromatography-tandem mass spectrometry.

Phytochemistry
Du J et al (2024).
Drug Test Anal.
DOI:
10.1002/dta.3672
PubMed:
38440922

Nelumbo nucifera leaves extract ameliorated scopolamine-induced cognition impairment via enhanced adult hippocampus neurogenesis.

Summary

N. nucifera leaf extracts and Q3G improved cognition and reduced apoptosis in scopolamine-induced cognitive impairment by regulating the BDNF signaling pathway and promoting neurogenesis in the hippocampus. Important for lab decisions.

Neuroscience
Lee YJ et al (2024).
Environ Toxicol.
DOI:
10.1002/tox.24175
PubMed:
38351887

AN UPDATED REVIEW ON NELUMBO NUCIFERA GAERTN: CHEMICAL COMPOSITION, NUTRITIONAL VALUE AND PHARMACOLOGICAL ACTIVITIES.

Sahu B et al (2024).
Chem Biodivers.
DOI:
10.1002/cbdv.202301493
PubMed:
38327030

Evaluation of the inhibitory potential of bioactive compounds against SARS-CoV-2 by in silico approach.

Summary

Researchers investigated the antiviral potential of bioactive compounds from medicinal plants to treat COVID-19. Compounds from Sphaeranthus indicus, Lantana camara, and Nelumbo nucifera showed inhibitory effects against SARS-CoV-2 in molecular docking studies. Consider these natural compounds for potential treatment.

COVID-19
Rani JMS et al (2024).
J Mol Model.
DOI:
10.1007/s00894-024-05858-8
PubMed:
38321299

Unveiling the Potential of Nelumbo nucifera-Derived Liensinine to Target The Myostatin Protein and to Counteract Muscle Atrophy.

Zheng Y et al (2024).
J Agric Food Chem.
DOI:
10.1021/acs.jafc.3c09002
PubMed:
38258624

The CYP80A and CYP80G Are Involved in the Biosynthesis of Benzylisoquinoline Alkaloids in the Sacred Lotus (Nelumbo nucifera).

Phytochemistry
Hao C et al (2024).
Int J Mol Sci.
DOI:
10.3390/ijms25020702
PubMed:
38255776

Evaluation of the Susceptibility of Lotus Seeds (Nelumbo nucifera Gaertn.) to Aspergillus flavus Infection and Aflatoxin Contamination.

Elamin A, Sultana S and Sakuda S (2024).
Toxins (Basel).
DOI:
10.3390/toxins16010029
PubMed:
38251245

Response surface methodology based development of an optimized polyherbal formulation and evaluation of its anti-diabetic and anti-obesity potential in high-fat diet-induced obese mice.

Summary

Researchers created a mix of edible seeds to test its effect on diabetes and obesity in mice. The results could potentially help develop a new treatment for these conditions.

DiabetesObesity
Tanisha, Venkategowda S and Majumdar M (2023).
J Tradit Complement Med.
DOI:
10.1016/j.jtcme.2023.07.002
PubMed:
38223811

In-silico evaluation of natural alkaloids against the main protease and spike glycoprotein as potential therapeutic agents for SARS-CoV-2.

Summary

Scientists studied 102 alkaloids and found six from the lotus plant that can potentially treat COVID-19 by targeting the spike protein and protease of SARS-CoV-2, aiding drug discovery with minimal side effects.

COVID-19Phytochemistry
Shah M et al (2024).
PLoS One.
DOI:
10.1371/journal.pone.0294769
PubMed:
38175855

Nelumbo nucifera synthesized selenium nanoparticles modulate the immune-antioxidants, biochemical indices, and pro/anti-inflammatory cytokines pathways in Oreochromis niloticus infected with Aeromonas veronii.

Immunology
Ibrahim RE et al (2023).
Fish Shellfish Immunol.
DOI:
10.1016/j.fsi.2023.109287
PubMed:
38092091

Exfoliation and physico-chemical characterization of novel bioplasticizers from Nelumbo nucifera leaf for biofilm application.

Divakaran D et al (2023).
Heliyon.
DOI:
10.1016/j.heliyon.2023.e22550
PubMed:
38076077

Exploring Major Flavonoid Phytochemicals from Nelumbo nucifera Gaertn. as Potential Skin Anti-Aging Agents: In Silico and In Vitro Evaluations.

Phytochemistry
Nutho B and Tungmunnithum D (2023).
Int J Mol Sci.
DOI:
10.3390/ijms242316571
PubMed:
38068894

Skin-Whitening Effect of a Callus Extract of Nelumbo nucifera Isolate Haman.

Moon SH et al (2023).
Plants (Basel).
DOI:
10.3390/plants12233923
PubMed:
38068559

Functional keystone taxa promote N and P removal of the constructed wetland to mitigate agricultural nonpoint source pollution.

Fan H et al (2023).
Sci Total Environ.
DOI:
10.1016/j.scitotenv.2023.169155
PubMed:
38065493

Exploring domestication pattern in lotus: insights from dispensable genome assembly.

Summary

Researchers collected lotus accessions and analyzed their genomes to study the domestication process. They identified genes involved in specific developmental processes and found metabolic pathways specific to each subgroup. This research provides valuable information for future lotus genomic studies and understanding domestication.

Genetics
Qi H et al (2023).
Front Plant Sci.
DOI:
10.3389/fpls.2023.1294033
PubMed:
38034573

Comparison of fresh and browning lotus roots (Nelumbo nucifera Gaertn.) on modulating cholesterol metabolism via decreasing hepatic cholesterol deposition and increasing fecal bile acid excretion.

Li J et al (2023).
Curr Res Food Sci.
DOI:
10.1016/j.crfs.2023.100630
PubMed:
38021260

NnWOX1-1, NnWOX4-3, and NnWOX5-1 of lotus (Nelumbo nucifera Gaertn)promote root formation and enhance stress tolerance in transgenic Arabidopsis thaliana.

Quan L et al (2023).
BMC Genomics.
DOI:
10.1186/s12864-023-09772-w
PubMed:
38017402

Mitophagy suppression by miquelianin-rich lotus leaves extract induces "beiging" of white fat via AMPK/DRP1-PINK1/PARKIN signaling axis.

Wang Z et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.13143
PubMed:
37991930

Liensinine and neferine exert neuroprotective effects via the autophagy pathway in transgenic Caenorhabditis elegans.

Summary

Liensinine and neferine, found in Nelumbo nucifera, inhibit acetylcholinesterase and cross the blood-brain barrier. They hold promise for treating Alzheimer's disease.

Neuroscience
Wu MC et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04183-6
PubMed:
37891552

Modifications of native lotus (Nelumbo nucifera G.) rhizome starch and its overall characterization: A review.

Review
Dhull SB et al (2023).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2023.127543
PubMed:
37866555

Potential Implications of Hyperoside on Oxidative Stress-Induced Human Diseases: A Comprehensive Review.

Summary

Hyperoside is a natural compound found in many plants. It has many beneficial effects, including anti-inflammatory, antidepressant, and antioxidant properties. This review provides a summary of its characteristics, potential uses, and effectiveness, helping in the development of new drugs and maximizing its potential.

Review Immunology
Wang K et al (2023).
J Inflamm Res.
DOI:
10.2147/JIR.S418222
PubMed:
37854313

Nuciferine Inhibits Oral Squamous Cell Carcinoma Partially through Suppressing the STAT3 Signaling Pathway.

Immunology
Xie JR, Chen XJ and Zhou G (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241914532
PubMed:
37833979

Molecular docking Study of Nuciferine as a Tyrosinase Inhibitor and Its Therapeutic Potential for Hyperpigmentation.

Veerichetty V and Saravanabavan I (2023).
Genomics Inform.
DOI:
10.5808/gi.23054
PubMed:
37813639

Genome-Wide Analysis of WUSCHEL-Related Homeobox Gene Family in Sacred Lotus (Nelumbo nucifera).

Genetics
Chen GZ et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms241814216
PubMed:
37762519

Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis.

Jiang P et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.110914
PubMed:
37734199

Enhanced adsorption of Congo red from urea/calcium chloride co-modified biochar: Performance, mechanisms and toxicity assessment.

Liu Z et al (2023).
Bioresour Technol.
DOI:
10.1016/j.biortech.2023.129783
PubMed:
37722546

Isoliensinine Attenuates Renal Fibrosis and Inhibits TGF-β1/Smad2/3 Signaling Pathway in Spontaneously Hypertensive Rats.

Yao M et al (2023).
Drug Des Devel Ther.
DOI:
10.2147/DDDT.S414179
PubMed:
37701045

Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families.

Panklai T et al (2023).
Molecules.
DOI:
10.3390/molecules28155821
PubMed:
37570790

Biomimetics in Botanical Gardens-Educational Trails and Guided Tours.

Speck O and Speck T (2023).
Biomimetics (Basel).
DOI:
10.3390/biomimetics8030303
PubMed:
37504191

A review on extraction, composition, structure, and biological activities of polysaccharides from different parts of Nelumbo nucifera.

Review
Kakar MU et al (2023).
Food Sci Nutr.
DOI:
10.1002/fsn3.3376
PubMed:
37457175

Overexpression of Geranyl Diphosphate Synthase 1 (NnGGPPS1) From Nelumbo nucifera Enhances Carotenoid and Chlorophyll Content and Biomass.

Dong C et al (2023).
Gene.
DOI:
10.1016/j.gene.2023.147645
PubMed:
37453723

Neferine protected cardiomyocytes against hypoxia/oxygenation injury through SIRT1/Nrf2/HO-1 signaling.

Lu C et al (2023).
J Biochem Mol Toxicol.
DOI:
10.1002/jbt.23398
PubMed:
37421224

Liensinine pretreatment reduces inflammation, oxidative stress, apoptosis, and autophagy to alleviate sepsis acute kidney injury.

Immunology
Zhang W et al (2023).
Int Immunopharmacol.
DOI:
10.1016/j.intimp.2023.110563
PubMed:
37392573

Transcription factor NnMYB5 controls petal color by regulating GLUTATHIONE S-TRANSFERASE2 in Nelumbo nucifera.

Liu J et al (2023).
Plant Physiol.
DOI:
10.1093/plphys/kiad363
PubMed:
37348874

Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases.

Immunology
Zhao T et al (2023).
Pharmacol Res.
DOI:
10.1016/j.phrs.2023.106820
PubMed:
37315822

Neferine attenuates development of testosterone-induced benign prostatic hyperplasia in mice by regulating androgen and TGF-β/Smad signaling pathways.

Summary

Neferine, an alkaloid, reduces prostate cell proliferation in mice with BPH. It inhibits growth and ROS production in human prostate cells, suggesting it as a potential treatment for BPH.

Endocrinology
Liu CM et al (2023).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2023.05.004
PubMed:
37293563

Substrate specificity of polyphenol oxidase and its selectivity towards polyphenols: Unlocking the browning mechanism of fresh lotus root (Nelumbo nucifera Gaertn.).

Phytochemistry
Li J et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136392
PubMed:
37244194

The antioxidant capacity and nutrient composition characteristics of lotus (Nelumbo nucifera Gaertn.) seed juice and their relationship with color at different storage temperatures.

Immunology
Zhang Y et al (2023).
Food Chem X.
DOI:
10.1016/j.fochx.2023.100669
PubMed:
37168721

Bisbenzylisoquinoline alkaloids from Plumula Nelumbinis inhibit vascular smooth muscle cells migration and proliferation by regulating the ORAI2/Akt pathway.

Phytochemistry
Feng X et al (2023).
Phytochemistry.
DOI:
10.1016/j.phytochem.2023.113700
PubMed:
37119920

Melatonin-induced myeloblastosis viral oncogene homologs alleviate fresh-cut lotus root browning during storage by attenuating flavonoid biosynthesis and reactive oxygen species.

Phytochemistry
Zhang C et al (2023).
J Sci Food Agric.
DOI:
10.1002/jsfa.12619
PubMed:
37046375

The modulation effect of lotus (Nelumbo nucifera Gaertn.) seeds oligosaccharides with different structures on intestinal flora and action mode of growth effects on Bifidobacterium in vivo and in vitro.

Gastroenterology
Ma X et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.136057
PubMed:
37011571

Corrigendum to "Recent advances on bioactive compounds, biosynthesis mechanism, and physiological functions of Nelumbo nucifera" [Food Chem. 412 (2023) 135581].

Zhao X et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.135968
PubMed:
36996654

Responses of soil phosphorus cycling and bioavailability to plant invasion in river-lake ecotones.

Yan Z et al (2023).
Ecol Appl.
DOI:
10.1002/eap.2843
PubMed:
36922375

Recent advances on bioactive compounds, biosynthesis mechanism, and physiological functions of Nelumbo nucifera.

Review
Zhao X et al (2023).
Food Chem.
DOI:
10.1016/j.foodchem.2023.135581
PubMed:
36731239

Comprehensive Analysis for GRF Transcription Factors in Sacred Lotus (Nelumbo nucifera).

Review
Chen GZ et al (2022).
Int J Mol Sci.
DOI:
10.3390/ijms23126673
PubMed:
35743113

Lotus (Nelumbo nucifera Gaertn.) and Its Bioactive Phytocompounds: A Tribute to Cancer Prevention and Intervention.

Review Cancer
Bishayee A et al (2022).
Cancers (Basel).
DOI:
10.3390/cancers14030529
PubMed:
35158798

An updated review on pharmacological properties of neferine-A bisbenzylisoquinoline alkaloid from Nelumbo nucifera.

Review Phytochemistry
Bharathi Priya L et al (2021).
J Food Biochem.
DOI:
10.1111/jfbc.13986
PubMed:
34779018

Nuciferine from Nelumbo nucifera Gaertn. attenuates isoproterenol-induced myocardial infarction in Wistar rats.

Cardiology
HarishKumar R and Selvaraj CI (2022).
Biotechnol Appl Biochem.
DOI:
10.1002/bab.2194
PubMed:
33998037

Anticariogenic activity of Nelumbo nucifera leaf extract in oral healthcare.

Lee HE, Han MS and Nam SH (2019).
Technol Health Care.
DOI:
10.3233/THC-191732
PubMed:
31127738

A Comprehensive Review on Chemical Profiling of Nelumbo Nucifera: Potential for Drug Development.

Review
Sharma BR et al (2017).
Phytother Res.
DOI:
10.1002/ptr.5732
PubMed:
27667670

Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity.

Review
Jadoon S et al (2015).
Oxid Med Cell Longev.
DOI:
10.1155/2015/709628
PubMed:
26448818