Common Names: black cumin
Scientists investigated whether Thymoquinone (TQ), found in Nigella sativa, has a radioprotective effect on rat lung tissue exposed to ionizing radiation. The study explores potential benefits of TQ in reducing side effects of radiotherapy in cancer patients.
In a clinical trial in Pakistan, honey and Nigella sativa (HNS) showed promising results as a treatment for COVID-19, reducing symptom alleviation time and expediting viral clearance, with no observed adverse effects. This suggests HNS could be a beneficial therapy for the disease.
Researchers investigated the effectiveness of using Nigella sativa oil (NSO) as a treatment for COVID-19. NSO is a herbal medicine known for its antiviral and immunomodulatory properties. The study aimed to evaluate NSO's efficacy in treating patients with COVID-19.
This study evaluated the effects of Nigella sativa on thyroid function, VEGF-1, Nesfatin-1, and anthropometric features in patients with Hashimoto's thyroiditis. Results can help determine its potential as a treatment option.
Review of essential plant oils as potential herbal remedies for diabetes mellitus. EOs from 20 plants show anti-diabetic activity, with bioactive compounds like carvacrol and thymol inhibiting key enzymes. Promising for drug development.
Meta-analysis of 30 studies found Nigella sativa reduces blood sugar and HbA1c levels in adults. More research needed on dosage and duration for optimal results.
Researchers studied new therapies for Type II diabetes, aiming for higher efficacy, fewer side effects, and lower costs. This is important for improving patient outcomes and easing strain on healthcare systems globally.
NS (black cumin) shows promise in reducing inflammation and oxidative stress associated with diabetic neuropathy. Research suggests potential benefits for treating complications of diabetes with fewer side effects.
Nodal regions in the nervous system are vulnerable to diabetes. Administering NS and CA to hyperglycemic mice improved memory, myelin loss, and synaptic function, suggesting potential benefits for diabetic patients.
Iron oxide nanoparticles were synthesized using black cumin seed extract. They exhibit antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This research offers a green synthesis method with potential applications in various fields.
Thymoquinone in Nigella sativa could help improve leptin levels and metabolism during sleep restriction by modulating brain circuits. Important for understanding how stress and sleep impact appetite regulation.
Fenugreek and black cumin seeds improve blood sugar levels in diabetic rats, reduce insulin resistance, and enhance pancreatic health. Promising potential for natural diabetes treatment.
Study compared antidepressant efficacy of cyclodextrin-complexed nano-NS oleoresin with NS ethanolic extract in a murine model of depression. Nano-NSOR showed higher drug release and more pronounced antidepressant effect. Offers promising alternative with potential for improved treatment of depression.
Researchers analyzed seed extract from three locations, finding differences in phytochemical composition and thymoquinone content. Results suggest variation in potential benefits and quality among different sources.
Researchers studied medicinal plants used by indigenous communities in Bangladesh for helminth infections. Discovering phytochemicals with anthelmintic activity could lead to new drugs to combat drug-resistant helminthiases in underdeveloped regions.
Anthemis hyaline, Nigella sativa, and Citrus sinensis extracts show promise in inhibiting coronavirus replication. Nigella sativa increases IL-8 levels and gene expression changes. Anthemis hyaline extract is the most effective in reducing viral load.
Researchers studied nanoparticles made from chitosan and WPG for delivering NSE as an antiviral agent. At 1:1 MR and 6.25 mg/mL NSE, nanoparticles showed promising antiviral activity against IBV, suggesting potential use in poultry and human medicine.
Researchers studied the impact of mobile phone EMFs on rat hippocampus. Baobab and black seed reduced adverse effects of EMFs on neurons. Herbal products could protect against EMF damage.
Nigella sativa L. plant has potent therapeutic properties, with seed oil and thymoquinone inhibiting various fungi in studies. Valuable for potential medical applications in treating fungal infections.
Chronic antibiotics can harm mitochondria, metabolism, and mood. Black seed oil improves depression, sociability, and metabolism in mice exposed to ampicillin. NSO could be a helpful treatment for antibiotic-induced impairments.
This study investigated the anti-aging effect of oil on transgenic flies. Results show that low-dose NSO increased the lifespan of AB-42 treated flies. Care because it suggests the efficacy of NSO in increasing survival and lifespan.
Researchers studied the effects of chronic consumption of a herb called NS on manic-like behavior in rats. They found that NS had a significant antimanic-like effect and also positively modulated certain inflammatory mediators. This suggests that NS may have therapeutic benefits for mental illness.
Study on the effects of Nigella sativa on lipid profile and glycemic indices in metabolic syndrome patients. Meta-analysis of randomized trials highlights its potential benefits in managing the condition.
Researchers investigated the effects of α-Hederin, a natural compound, on cisplatin resistance in non-small cell lung cancer (NSCLC). Understanding this interaction is crucial for improving chemotherapy outcomes in NSCLC patients.
This study reviewed the effects of various natural products on diabetes. Fruits, vegetables, grains, legumes, spices, herbs, and vitamins may help prevent and manage diabetes through antioxidant, anti-inflammatory, and insulin-enhancing effects. This information can be used to develop functional foods for diabetes prevention and management.
The researchers looked at a mix of plants to see if it has antioxidant and antidiabetic effects in a diabetes model. This information may be useful for managing diabetes and exploring natural remedies.
Researchers investigated the neuroprotective effects of a formulation containing Bacopa monnieri leaves, Nigella sativa, and Curcuma longa rhizome seeds. This formulation may help protect against oxidative stress and cell death induced by diclofenac, a common anti-inflammatory drug.
This study reviewed clinical evidence on using herbal medicine to manage osteoporosis, which is a chronic skeletal disease causing low bone density and increased fracture risk.
The study analyzed black cumin compounds using theoretical calculations to determine their effectiveness in inhibiting HDAC2. The active substances were found to protect ACE2 against COVID-19, making them potentially valuable for lab decisions. [25 words]
This study examined the impact of Nigella sativa oil supplementation on overweight/obese women. The results suggest that NS oil may help manage inflammation and obesity by affecting blood mRNA expressions and levels of certain proteins.
This study aims to document the medicinal plants used in traditional medicine in the Melit area of North Darfur State, Sudan. This information is important for understanding and preserving ethnobotanical knowledge in this region.
Thymol derived from Nigella sativa can potentially inhibit the growth of breast cancer cells by suppressing the expression of key genes involved in cell proliferation.
The study found that Nigella sativa L. oil (NSO) can protect against damage to the thyroid, ovarian, and uterine tissues caused by sodium fluoride (NaF). NSO restores hormonal balance, reduces oxidative damage and inflammation, and improves tissue structure.
Thymoquinone (ThyQ) from seeds reduces obesity, lowers blood glucose and insulin, improves glucose tolerance, and enhances insulin sensitivity. It also reduces liver damage markers, increases adiponectin levels, and regulates gene expression. ThyQ may be a useful treatment for obesity and related conditions.
Thymoquinone (TQ) from Nigella sativa has anti-cancer properties against colorectal cancer. It can enhance existing cancer treatments and reduce adverse effects. More research is needed to understand its molecular targets and improve its clinical usefulness in overcoming drug resistance and obstacles in chemotherapy and radiotherapy.
Black cumin seed extract may be a promising herbal treatment for metabolic disorders due to its anti-inflammatory, antioxidant, and lipid-regulating properties.
Researchers developed a method to measure thymoquinone (TQ) in serum for potential therapeutic use. They found high TQ concentrations in certain oil products, but TQ was not detectable in human serum after oral intake. Further studies are needed.
Study examines three endophytic fungi from Nigella sativa seeds, revealing potential antimicrobial properties against various pathogens. Molecular identification and chemical profiling of bioactive secondary metabolites support these findings. In-silico interactions also suggest effectiveness as antimicrobials.
Nigella sativa (NS) extracts contain compounds that can potentially prevent SARS-CoV-2 from entering host cells, treat COVID-19 symptoms, and target key proteins. This review summarizes pre-clinical and clinical studies on NS and its potential therapeutic role against COVID-19.
The study evaluated the usefulness of as a model for infection and compared the effects of vancomycin and NS on gut bacteria. Relevant for combating infections and developing new treatments.
This study examines the antimicrobial properties of natural fragrance raw materials on multidrug-resistant microorganisms. The substances with the lowest MIC values were black seed oil, fir balsam absolute, and cubeb oil. The findings can help in developing treatments for infectious diseases and reducing microbiological contaminations in cosmetic products.
Study investigates the topical use of Nigella sativa in patients with diabetic neuropathy. N. sativa has shown beneficial effects on neuropathic pain and neurological disorders, offering a potential alternative to synthetic drugs with side effects and limitations.
Scientists studied the 5th day germinated sprouts of seeds for their potential as an anticancer therapy. The sprouts were found to inhibit HDAC activity and have antioxidant properties, making them a promising alternative for preventing liver diseases. Thymoquinone, a compound found in the sprouts, showed strong interaction with HDAC protein.
CAM is commonly used to treat cancer, but patients mistakenly believe it is safer than conventional treatments. Important to consider patient beliefs and educate them on evidence-based treatments to ensure best care.
Repurposing drugs for cancer treatment is growing in importance for drug discovery. It could lead to more efficient development of new treatments and potentially save time and resources in the fight against cancer.
Researchers analyzed leaves for potential anti-cancer treatments, finding they targeted angiogenesis and neuropilins in breast cancer. In-silico analysis confirmed stability of Neuropilin complexes.
Meta-analysis evaluates the effects of Nigella sativa intake on inflammation and oxidative stress in people with metabolic syndrome. Findings suggest potential benefits for managing metabolic disorders.
Nigella sativa (NS) has proven to effectively manage diabetes by improving glucose tolerance, reducing liver glucose production, balancing blood sugar and lipid levels, and stimulating insulin secretion. It counters oxidative stress and prevents diabetes onset and progression.
Various nutraceuticals, including spirulina, curcumin, psyllium, chitosan, and Nigella sativa, showed slight potential for weight improvement in overweight or obese adults. Green tea and glucomannan also resulted in small weight loss, but with less certainty. Nutraceutical supplementation could lead to modest weight loss in those with overweight or obesity.
Thymoquinone (TQ), found in black seeds, was tested as a treatment for colorectal cancer in mice. When encapsulated in lipid nanocapsules, TQ effectively reduced tumor size and induced tumor cell death, making it a potential anticancer agent for colorectal cancer treatment.
Scientists developed tiny lipid carriers for a drug called donepezil hydrochloride, which could help treat Alzheimer's disease effectively. You should care because it could potentially improve the treatment of Alzheimer's disease.
Al-hijamah, a wet cupping therapy, could be a promising adjuvant treatment for viral hepatitis and hepatocellular carcinoma (HCC). It can help clear harmful substances, enhance antiviral immunity, and decrease viral load. Combining it with other natural remedies may maximize its therapeutic benefits.
The study found that a herbal melanin derived from Nigella sativa upregulated the TLR4 receptor, increased COX-2 expression, and promoted the secretion of PGE2 and IL-6 in AGS cells. This suggests that the melanin may have gastroprotective effects and potential benefits for gastric prevention and treatment.
This study highlights the various beneficial properties of Nigella sativa, specifically the compound thymoquinone (TQ). TQ exhibits antihypertensive, liver protective, diuretic, digestive, anti-diarrheal, appetite boosting, pain relieving, antibacterial effects, and can help with skin issues.
This study examines the effects of Thymoquinone, a compound found in Nigella Sativa, on Leishmania parasites and infected macrophages. It explores potential therapeutic benefits for Leishmania infection.
Researchers investigated the potential of herbal medicines for treating COVID-19. They found that certain herbs have shown effectiveness as immunomodulators, anti-inflammatories, antioxidants, and antimicrobials.
Nigella Sativa's compound, thymoquinone (TQ), has anti-cancer properties and can inhibit various tumorigenic processes. TQ can be encapsulated in nanocarriers to enhance its effectiveness against breast cancer. This study is important for scientists and clinical investigators.
Study investigated the impact of oxidative stress on carboplatin-induced damage to the ovaries. Found that Nigella Sativa oil has a protective effect by reducing apoptosis and restoring anti-Müllerian hormone levels. Important for understanding potential strategies to mitigate chemotherapy-induced reproductive toxicity.
In this study, researchers investigated the potential of Black Seed Oil (BSO) as a safer and less toxic alternative to traditional cancer treatments. They focused on the oil soluble phytochemicals found in BSO, specifically Thymoquinone, Carvacrol, and Trans-Anethole. When used together, these compounds showed promising results in inhibiting breast cancer cell migration and inducing apoptosis. Chemical characterization of the individual phytochemicals and the whole BSO extract confirmed their bioactive properties. The study also uncovered the role of microRNAs in regulating breast cancer progression and highlighted the synergistic action of the BSO components. This research provides valuable insights for developing more effective and targeted treatments for breast cancer.
This review examines the Unani system's understanding of dementia, focusing on phytochemistry, nootropic, and CNS activities. It suggests potential directions for future research and enhances our understanding of dementia.
This study tested a polyherbal emulsion on diabetic rats and found that it reduced blood glucose and lipid levels, increased insulin, and protected pancreas and kidney tissues. It suggests that the formulation could be used as a remedy or alongside traditional diabetes medication.
Scientists identified potential compounds from black cumin that can inhibit protein targets and pathways associated with diabetes and obesity. Kaempferol was found to be the best binder for AKT1.
Propolis, a honeybee product, is gaining attention as a potential antioxidant. Reactive oxygen species (ROS) are harmful to cells and are associated with diseases like cancer. Propolis has been shown to protect against oxidative stress and has anticancer effects. This research highlights the importance of finding exogenous antioxidants from dietary sources to combat ROS and prevent diseases.
Scientists have discovered a potential new treatment for hepatocellular carcinoma, the most common liver tumor. They synthesized a compound called thymoquinone-oxime and tested its effects on liver cancer cells. The results showed that thymoquinone-oxime has anti-tumor properties, increasing cell death, DNA damage, and oxidative stress in a dose-dependent manner. It also decreased mitochondrial function and glutathione levels. These findings offer hope for developing new therapeutic strategies to combat this deadly form of cancer.
In this study, researchers investigated the potential of using Sulfobutylether-β-cyclodextrin (SBE-β-CD) to improve the solubility and delivery of thymoquinone (TQ), a compound derived from black seed with therapeutic and anticancer properties. Through various analyses, they found that the inclusion complexes of TQ with SBE-β-CD significantly enhanced the solubility and bioavailability of TQ. Additionally, the complexes exhibited stronger anticancer effects on various cancer cell lines compared to TQ alone. These findings suggest that SBE-β-CD may serve as an effective drug delivery system for TQ, but more research is needed to explore its mechanisms and potential side effects.
Chemotherapy can cause memory and motor function deficits. This study tested the effectiveness of inhibitors of the enzyme sEH, known to reduce inflammation and improve memory, in an animal model of chemotherapy-induced cognitive impairment. The inhibitors successfully preserved cognitive function by reducing oxidative stress and inflammation in the brain. The herbal extract Mentat was also effective, and Lepidium meyenii less so. Overall, sEH inhibition shows promise in protecting against chemotherapy's adverse effects on the brain.
Black cumin seeds, specifically the compound thymoquinone (TQ), show promising potential in cancer research. TQ, found in the essential oil of Nigella sativa, has various biological effects that make it a popular topic for phytotherapy studies. Researchers are working to understand its mechanisms of action, safety, and efficacy in humans. Additionally, TQ could be a valuable tool in treating cancer, as it may help overcome resistance to chemotherapy and targeted therapies caused by mutations in the KRAS gene, which regulates cell division and growth.
Scientists have discovered that certain plant compounds, such as epicatechin, apigenin, and kaempferol, have anticancer properties. These compounds were tested against two important proteins found in cancer cells, sphingosine kinase-1 (SK-1) and pyruvate kinase-M2 (PK-M2). Using advanced computational tools, researchers predicted the potential effectiveness, toxicity, and binding of these compounds. Molecular dynamics simulations confirmed that these compounds interact with the proteins, suggesting their potential for combatting cancer. This research provides valuable insights into developing new treatments for this complex disease.
Plant-based drugs show potential for treating various types of cancer, with compounds like curcumin and quercetin having extensive research and promising results. This study reviews several plants and their key compounds with anticancer activity, highlighting potential clinical candidates.
Saffron and black seed have therapeutic effects on diseases by decreasing TNF-a levels, treating conditions such as hepatotoxicity, cancer, and non-alcoholic fatty liver. More research and clinical trials are needed.
Nigella sativa shows promise as a treatment for ischemic stroke due to its therapeutic properties and presence of thymoquinone, potentially offering a complementary therapy for patients and exploring preventive and treatment possibilities.
This review article explores the potential use of traditional herbal medicine to manage polycystic ovary syndrome (PCOS) in women due to its increasing prevalence and the high use of herbal medicine globally.
Multiple Sclerosis (MS) is a degenerative autoimmune disease with an unknown cause that affects the central nervous system. Currently, there are 18 FDA-approved drugs that modify MS symptoms, but the prolonged use of synthetic drugs has negative effects. Medicinal plants such as Nigella sativa, ginger, saffron, pomegranate, curcumin, resveratrol, and ginsenoside have the potential to improve symptoms and possibly prevent progression of MS. This article aims to inform chronically ill patients about the complementary and alternative medicinal options available to them.
Researchers investigated the anti-obesity effects of encapsulated fucoxanthin in fucoidan-based nanoemulsion on high-fat diet-induced obese rats. Results showed that fucoxanthin reduced body and liver weight, improved biochemical parameters, and attenuated lipid accumulation in the liver.
Patients with Long COVID may experience symptoms for months after recovery from COVID-19. Treatment is primarily focused on managing symptoms and providing support to patients.
Nigella sativa (black cumin) has been found to be a safe and potentially effective natural remedy for COVID-19. Thymoquinone, the plant's main constituent, has been shown to target SARS-CoV-2. Studies have reported benefits for COVID-19 patients with no side effects, but have been limited by isolation policies and lack of funding. The evidence suggests that the chemical contents of Nigella sativa may be a safe and possible treatment for COVID-19 patients.
This study explores the potential of Traditional Arabic or Islamic medicinal plants as adjuvant therapy for COVID-19. Six medicinal plants with antiviral and immunomodulatory properties were studied, suggesting they could be used to control symptoms and possibly lead to a COVID-19 medicinal synthesis. However, further evaluation is advised before using these plants as therapy. No evidence-based medication to combat COVID-19 currently exists despite multiple vaccine strategies.
The study investigated the effectiveness of zonisamide and Nigella sativa (NS) separately and together as a potential treatment for traumatic brain injury (TBI) using fruit flies as a model. The flies were pre-treated with the substances before TBI was induced, and mortality rate and locomotor activity were observed. Both substances improved survival rates and locomotor activity, elevated levels of certain neurotransmitters, and reduced glutamate levels. Co-administration of both substances showed even greater neuroprotective potential. This study suggests that zonisamide and NS could be a promising therapeutic medicine for the treatment of TBI.
A study investigated the potential therapeutic effects of L. against COVID-19. The researchers conducted in vitro experiments and found that L. extract significantly reduced the replication of the virus. Additionally, the extract showed low toxicity and good stability in human plasma. These findings suggest that L. may be a promising natural remedy for COVID-19 and warrants further clinical trials.
Nigella sativa seed and its active compounds have been historically recognized as an effective herbal panacea that can promote a healthy immune response and suppress chronic inflammation. Recent findings suggest that N. sativa could be a potential candidate in nutraceuticals to prevent and cure COVID-19. The review aims to revisit the pharmacological benefits of N. sativa seed and its active metabolites that could be a potential basis for developing a novel preventive and therapeutic strategy against COVID-19. Bioactive compounds of N. sativa seed, especially thymiquinone, α-hederin, and nigellidine, could be promising herbal drugs to combat COVID-19. Preclinical and clinical trials are required to investigate their efficacy and potency under specific pathophysiological conditions of COVID-19.
Nigella sativa (black cumin seeds) has been analyzed for its potential to treat COVID-19. It has been found to possess antiviral, antioxidant, anti-inflammatory, and immunomodulatory properties along with several other beneficial activities. Various studies confirm that it could be used as an adjuvant therapy along with repurposed conventional drugs to better manage patients with COVID-19.