Nuphar lutea

Common Names: yellow cowlily, yellow pondlily, yellow pond-lily

Ethnobotanical Studies

Boreal Forest, Canada

Uses: Blood system disorders, Circulatory system disorders, Circulatory system disorders, Cough, cold and sore throat, Cough, cold and sore throat, Dermatological infections, Diabetes, Gastro-intestinal disorders, Gastro-intestinal disorders, General health, Gynaecological problems, Headache, Injuries, Injuries, Injuries, Metabolic system disorders, Musculoskeletal disorders, Musculoskeletal disorders, Musculoskeletal disorders, Pregnancy, child birth, puerperium, Respiratory system disorders, Respiratory system disorders, Urinary system disorders, Urinary system disorders
DOI:
10.1186/1746-4269-8-7
PubMed:
22289509

Studies

Anti-Leishmania major Properties of Nuphar lutea (Yellow Water Lily) Leaf Extracts and Purified 6,6' Dihydroxythiobinupharidine (DTBN).

Shmuel O et al (2024).
Pathogens.
DOI:
10.3390/pathogens13050384
PubMed:
38787236

A Nuphar lutea plant active ingredient, 6,6'-dihydroxythiobinupharidine, ameliorates kidney damage and inflammation in a mouse model of chronic kidney disease.

Summary

DTBN from Nuphar lutea reduces inflammation in CKD mice by inhibiting NF-κB. Improved renal function and inflammation indices suggest potential as a CKD treatment.

Immunology
Landau D et al (2024).
Sci Rep.
DOI:
10.1038/s41598-024-58055-1
PubMed:
38555397

Ecological and phylogenetic aspects of the spring diet of three palaearctic species of swans.

Kouzov SA et al (2024).
BMC Ecol Evol.
DOI:
10.1186/s12862-024-02204-7
PubMed:
38302909

Macrophyte communities as bioindicator of stormwater pollution in rivers: a quantitative analysis.

Babko R et al (2023).
PeerJ.
DOI:
10.7717/peerj.15248
PubMed:
37283889

Genetic Diversity and Population Structure Assessed Using Microsatellite (SSR) Markers from Relict Populations of Nuphar pumila (Nymphaeaceae).

González-Toral C, Cuesta C and Cires E (2023).
Plants (Basel).
DOI:
10.3390/plants12091771
PubMed:
37176829

In Vitro and In Vivo Therapeutic Potential of 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea on Cells and K18-hACE2 Mice Infected with SARS-CoV-2.

Summary

Researchers found that the alkaloid mixture DTBN extracted from nuphar luteum is effective against COVID-19 in vitro and in vivo. DTBN inhibits SARS-CoV-2 production, reduces viral load in lungs, and exhibits anti-inflammatory properties, making it a promising candidate against the virus. Further studies are needed to optimize its use.

COVID-19
Weiss S et al (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24098327
PubMed:
37176034

Assessment of heavy metal accumulation potential of aquatic plants for bioindication and bioremediation of aquatic environment.

Petrov DS et al (2022).
Environ Monit Assess.
DOI:
10.1007/s10661-022-10750-0
PubMed:
36400901

Cytotoxicity of Thioalkaloid-Enriched Nuphar lutea Extract and Purified 6,6'-Dihydroxythiobinupharidine in Acute Myeloid Leukemia Cells: The Role of Oxidative Stress and Intracellular Calcium.

CancerPhytochemistry
Muduli S et al (2022).
Pharmaceuticals (Basel).
DOI:
10.3390/ph15040410
PubMed:
35455407

Inhibition of Cysteine Proteases by 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea.

Waidha K et al (2021).
Molecules.
DOI:
10.3390/molecules26164743
PubMed:
34443335

6,6'-Dihydroxythiobinupharidine (DTBN) Purified from Nuphar lutea Leaves Is an Inhibitor of Protein Kinase C Catalytic Activity.

Waidha K et al (2021).
Molecules.
DOI:
10.3390/molecules26092785
PubMed:
34066895

Relationships between key functional traits of the waterlily Nuphar lutea and wetland nutrient content.

Henriot CP et al (2019).
PeerJ.
DOI:
10.7717/peerj.7861
PubMed:
31637127

Initial decomposition of floating leaf blades of waterlilies: causes, damage types and impacts.

Klok PF and van der Velde G (2019).
PeerJ.
DOI:
10.7717/peerj.7158
PubMed:
31275754

6,6'-Dihydroxythiobinupharidine as a poison of human type II topoisomerases.

Dalvie ED et al (2019).
Bioorg Med Chem Lett.
DOI:
10.1016/j.bmcl.2019.06.003
PubMed:
31182315

Aspects of Invasiveness of Ludwigia and Nelumbo in Shallow Temperate Fluvial Lakes.

Tóth VR et al (2019).
Front Plant Sci.
DOI:
10.3389/fpls.2019.00647
PubMed:
31156691

Nupharidine enhances Aggregatibacter actinomycetemcomitans clearance by priming neutrophils and augmenting their effector functions.

Levy DH et al (2019).
J Clin Periodontol.
DOI:
10.1111/jcpe.13036
PubMed:
30372545

Distinct diversity patterns of Planctomycetes associated with the freshwater macrophyte Nuphar lutea (L.) Smith.

Ivanova AA et al (2018).
Antonie Van Leeuwenhoek.
DOI:
10.1007/s10482-017-0986-4
PubMed:
29147807

Anti-Metastatic Effect of Semi-Purified Nuphar Lutea Leaf Extracts.

Ozer J et al (2017).
J Cancer.
DOI:
10.7150/jca.18435
PubMed:
28638458

Nuphar lutea thioalkaloids inhibit the nuclear factor kappaB pathway, potentiate apoptosis and are synergistic with cisplatin and etoposide.

Phytochemistry
Ozer J et al (2009).
Cancer Biol Ther.
PubMed:
19713755

Nuphar lutea: in vitro anti-leishmanial activity against Leishmania major promastigotes and amastigotes.

El-On J et al (2009).
Phytomedicine.
DOI:
10.1016/j.phymed.2009.01.011
PubMed:
19303752