Ocimum gratissimum

Common Names: African basil

Ethnobotanical Studies

Clinical Trials

Effect of Ocimum gratissimum in Mouthrinses on De Novo Plaque Formation. A Randomized Clinical Trial.

Pimenta MS et al (2016).
Braz Dent J.
PubMed:
27982173

Studies

Amoebicidal activity of essential oils and essential oil-based microemulsions of Aloysia citrodora Ortega ex Pers., Cymbopogon winterianus Jowitt ex Bor and Ocimum gratissimum L. against Acanthamoeba polyphaga trophozoites.

Summary

Essential oils from Aloysia citrodora, Cymbopogon winterianus, and Ocimum gratissimum showed potential in killing Acanthamoeba polyphaga. Microemulsions with these oils were effective. Relevant for potential anti-amoebic treatments.

Siqueira IB et al (2024).
J Appl Microbiol.
PubMed:
39237458

Fractionated Leaf Extracts of Ocimum gratissimum Inhibit the Proliferation and Induce Apoptosis of A549 Lung Adenocarcinoma Cells.

Curtis RM et al (2024).
Nutrients.
PubMed:
39203873

Aqueous Extracts of Ocimum gratissimum Sensitize Hepatocellular Carcinoma Cells to Cisplatin through BRCA1 Inhibition.

Chen JH et al (2024).
Int J Mol Sci.
PubMed:
39125994

Comparative Anti-inflammatory Activity of a Nanocomposite-Based Herbal Oral Rinse and a Commercial Oral Rinse.

Summary

Study compared anti-inflammatory effects of commercial vs nanocomposite oral rinse in vitro. Results may help in developing improved oral care products for inflammation management.

Divakar A et al (2024).
Cureus.
PubMed:
38962586

Antioxidant and Antifungal Properties of Cinnamon, Cloves, Melia azedarach L. and Ocimum gratissimum L. Extracts against Fusarium oxysporum Isolated from Infected Vegetables in Mauritius.

Summary

Researchers studied economically damaging phytopathogens in Mauritius due to importance of agriculture, and interest in organic farming as alternative to fungicides. Results could inform sustainable pest management strategies.

Jeewon R et al (2024).
Pathogens.
PubMed:
38921734

Attenuation of PI3K/AKT signaling pathway by Ocimum gratissimum leaf flavonoid-rich extracts in streptozotocin-induced diabetic male rats.

Summary

Flavonoid-rich extracts from O. gratissimum improved antioxidant levels and gene expressions in diabetic rats, suggesting potential for treating diabetes. Further research on active compounds is needed.

Ajiboye BO et al (2024).
Biochem Biophys Rep.
PubMed:
38799115

Role of organic and inorganic fertilizers in enhancing biomass yield and eugenol content of ornamental basil (Ocimum gratissimum L.).

Chandel S et al (2024).
Heliyon.
PubMed:
38778991

Enrichment of vegan gluten-free pasta with basil seeds: Cooking quality, nutritional and antioxidant properties.

B N, K G V and D S (2024).
Food Sci Technol Int.
PubMed:
38766716

Green Synthesis of Silver Nanoparticles Using Zingiber officinale and Ocimum gratissimum Formulation for Its Anti-inflammatory and Antidiabetic Activity: An In Vitro Study.

Summary

Researchers synthesized silver nanoparticles using herbal extracts from ginger and onion, showing significant anti-inflammatory and antidiabetic effects in vitro. This green synthesis method could lead to new pharmaceutical treatments for diabetes and inflammation.

Anandachockalingam A et al (2024).
Cureus.
PubMed:
38741855

Oxidative responses in small juveniles of Colossoma macropomum anesthetized and sedated with Ocimum gratissimum L. essential oil.

Ferreira AL et al (2024).
Fish Physiol Biochem.
PubMed:
38722480

Ocimum gratissimum essential oil in the transport water of Brycon hilarii: implications at water quality, blood parameters and residues in tissue and plasma.

Oliveira FC et al (2024).
Braz J Biol.
PubMed:
38695422

Knowledge and practices of traditional management of child malnutrition and associated pathologies in Benin.

Vissoh ACS et al (2024).
J Ethnobiol Ethnomed.
PubMed:
38693543

Molecular docking, MMGBSA, and ADMET studies of phytoconstituents of Ocimum gratissimum on multiple breast cancer targets.

Summary

Researchers computationally investigated phytochemicals in plant for breast cancer treatment. Isovitexin, vitexin, rosmarinic acid, nepetoidin A, and luteolin show strong anti-cancer properties with good safety profiles for oral administration. Important for developing potential breast cancer treatments.

Ajiboye BO et al (2024).
Nat Prod Res.
PubMed:
38648537

Effectiveness of a formulation based on Ocimum gratissimum essential oil and cashew gum as inhibitors of quality loss and melanosis in shrimp.

Araujo TDS et al (2024).
Int J Biol Macromol.
PubMed:
38641286

Effects of Seven Plant Essential Oils on the Growth, Development and Feeding Behavior of the Wingless Aphis gossypii Glover.

Wang X et al (2024).
Plants (Basel).
PubMed:
38611446

Flowering Ocimum gratissimum intercropped in tea plantations attracts and reduces Apolygus lucorum populations.

Lun X et al (2024).
Pest Manag Sci.
PubMed:
38587057

Antimicrobial Activity of Silver Nanoparticles Synthesized Using Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulations.

Summary

Researchers utilized herbal extracts from and to synthesize silver nanoparticles with antimicrobial properties against oral pathogens. Results showed high efficacy against certain bacteria, suggesting potential for dental applications and improved oral healthcare.

Varghese RM, S AK and Shanmugam R (2024).
Cureus.
PubMed:
38550426

Antimicrobial Activity of Zinc Oxide Nanoparticles Synthesized Using Ocimum Tenuiflorum and Ocimum Gratissimum Herbal Formulation Against Oral Pathogens.

Summary

TL;DR: Scientists used green methods to create zinc oxide nanoparticles that effectively inhibited oral pathogens. Candida albicans was most sensitive, indicating potential selectivity. This research shows promise for using these nanoparticles in oral health.

Varghese RM, S AK and Shanmugam R (2024).
Cureus.
PubMed:
38445144

Cytotoxicity and Characterization of Zinc Oxide and Silver Nanoparticles Synthesized Using Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulation.

Varghese RM, S AK and Shanmugam R (2024).
Cureus.
PubMed:
38440033

Comparative Anti-inflammatory Activity of Silver and Zinc Oxide Nanoparticles Synthesized Using Ocimum tenuiflorum and Ocimum gratissimum Herbal Formulations.

Varghese RM, S AK and Shanmugam R (2024).
Cureus.
PubMed:
38406168

Use of herbal medicine during pregnancy and associated factors among pregnant women with access to public healthcare in west Shewa zone, Central Ethiopia: sequential mixed-method study.

Bekele GG et al (2024).
BMJ Open.
PubMed:
38316582

Anti-apoptotic and antioxidant mechanisms may underlie the abrogative potential of Ocimum gratissimum Linn. Leaf extract and fractions against trastuzumab-induced cardiotoxicity in Wistar rats.

Olorundare OE et al (2024).
Toxicol Rep.
PubMed:
38313815

Phenotypic Variations and Bioactive Constituents among Selected Ocimum Species.

Mulugeta SM, Pluhár Z and Radácsi P (2023).
Plants (Basel).
PubMed:
38202372

Reversal of mitochondrial permeability transition pore and pancreas degeneration by chloroform fraction of Ocimum gratissimum (L.) leaf extract in type 2 diabetic rat model.

Summary

This study investigated the effects of the chloroform fraction of (L.) leaf (CFOG) in reversing tissue wastage in diabetes. CFOG reduced insulin resistance, improved pancreatic cell regeneration, and inhibited mitochondrial dysfunction. The main active compound in CFOG was lupanol. This suggests the potential use of CFOG as an alternative therapy for diabetes.

Salemcity AJ et al (2023).
Front Pharmacol.
PubMed:
38035005

Voltammetric techniques for low-cost on-site routine analysis of thymol in the medicinal plant Ocimum gratissimum.

Lagnika L et al (2023).
Talanta.
PubMed:
38008023

Insecticidal property of Ocimum essential oil embedded polylactic acid packaging films for control of Sitophilus oryzae and Callosobruchus chinensis.

Prabhakar PR et al (2023).
Int J Biol Macromol.
PubMed:
37995784

Evaluation of synergism in essential oils against the cattle tick Rhipicephalus microplus in Burkina Faso.

Coulibaly A et al (2023).
Exp Parasitol.
PubMed:
37949426

Development of gelatin/agarose active coatings functionalized with Ocimum gratissimum L. essential oil for enhancing storability of 'Booth 7' avocado.

Pham BT et al (2023).
Int J Biol Macromol.
PubMed:
37866575

Aqueous Extracts of Ocimum gratissimum Mitigate Colitis and Protect Against AOM/DSS-Induced Colorectal Cancer in Mice.

Summary

Ocimum gratissimum extract reduced colorectal cancer (CRC) tumor load. Continuous administration was more effective than separated administration. OGE also reduced severe colitis, suggesting potential for preventing CRC by inhibiting inflammation.

Liu JY et al (2023).
Carcinogenesis.
PubMed:
37864831

Network pharmacology based anti-diabetic attributes of bioactive compounds from Ocimum gratissimum L. through computational approach.

Summary

This study identified key compounds in L. plant that target protein molecules of Diabetes Mellitus. These compounds have potential therapeutic effects in managing DM through multiple mechanisms.

Halayal RY et al (2023).
Saudi J Biol Sci.
PubMed:
37588570

Comparative transcriptomic analysis provides key genetic resources in clove basil (Ocimum gratissimum) under cadmium stress.

Wang B et al (2023).
Front Genet.
PubMed:
37576563

Antimicrobial Effect of Ocimum gratissimum L. Essential Oil on Shewanella putrefaciens: Insights Based on the Cell Membrane and External Structure.

Summary

The study found that L. essential oil inhibits the growth of S. putrefaciens by disrupting biofilm formation and cell membranes, potentially offering a new method to prevent food spoilage.

Xie Y et al (2023).
Int J Mol Sci.
PubMed:
37446243

A comparison of high- and low-resolution gas chromatography-mass spectrometry for herbal product classification: A case study with Ocimum essential oils.

Abraham EJ, Wallace ED and Kellogg JJ (2023).
Phytochem Anal.
PubMed:
37393908

Chemical and Olfactory Analysis of the Volatile Fraction of Ocimum gratissimum Concrete from Madagascar.

Gilles L and Antoniotti S (2023).
Chem Biodivers.
PubMed:
37366263

In vitro and molecular docking evaluation of larvicidal effects of essential oils of five aromatic plants on the fall armyworm Spodoptera frugiperda JE. Smith (Lepidoptera: Noctuidae) from Ivory Coast.

Kobenan KC et al (2023).
Chem Biodivers.
PubMed:
37357831

Dietary supplementation of Ocimum Gratissimum improves growth performance and immune response in broilers under high ambient temperature.

Lin PH et al (2023).
J Anim Sci.
PubMed:
37348050

Comparing the effects of essential oils and methanolic extracts on the inhibition of Aspergillus flavus and Aspergillus parasiticus growth and production of aflatoxins.

Kaale LD et al (2023).
Mycotoxin Res.
PubMed:
37261704

Exploration of the nutritional and carotenoids profiles of vegetables in Thai cuisine as potential nutritious ingredients.

Suttisansanee U et al (2023).
Heliyon.
PubMed:
37205996

New secondary metabolites and volatile constituents from the leaves of Ocimum gratissimum Linn.

Ali MS, Hashmi A and Joseph N (2023).
Nat Prod Res.
PubMed:
37067231

Evaluation of the mosquito larvicidal potential and comparative assessment of the juice of Lantana camara Linn and Ocimum gratissimum Linn.

Sharma M et al (2023).
Exp Parasitol.
PubMed:
37011804

Knowledge, attitude and practices of community health workers on managing and preventing childhood malaria and diarrhea in Fako Division, South West Region, Cameroon; A mixed method study.

Chi NN, Nyasa RB and Jane-Francis A (2023).
PLOS Glob Public Health.
PubMed:
36962984

Toxicity of insecticidal plant oils on the larval and adult stages of a major malaria vector (Anopheles gambiae Giles 1920).

Adelaja OJ et al (2023).
Parasitol Res.
PubMed:
36890296

Comparison study of Beninese and Chinese herbal medicines in treating COVID-19.

Summary

Researchers have observed a worldwide increase in the use of natural remedies, including Chinese herbal medicine and local plants, in response to COVID-19. This alternative approach to traditional medicine aims to strengthen immunity and prevent the spread of the disease. While the broader implications of these remedies and their effectiveness in treating COVID-19 remain unclear, these findings suggest the need for further exploration of alternative therapeutic solutions.

Houeze EA et al (2023).
J Ethnopharmacol.
PubMed:
36773790

Pollution impact assessment of secondary iron smelting on soil and some medicinal herbs grown at Fasina community in Ile-Ife, Nigeria.

Akinlade GO et al (2023).
Environ Monit Assess.
PubMed:
36640219

In vitro and in vivo efficacy of poly(lactic acid) nanofiber packaging containing essential oils from Ocimum basilicum L. and Ocimum gratissimum L. against Aspergillus carbonarius and Aspergillus niger in table grapes.

Magalhães Brandão R et al (2023).
Food Chem.
PubMed:
36084599

Evaluating Water bitter leaf (Struchium sparganophora) and Scent Leaf (Ocimum gratissimum) extracts as sources of nutraceuticals against manganese-induced toxicity in fruit fly model.

Ademiluyi AO et al (2023).
Drug Chem Toxicol.
PubMed:
35315297

Ocimum gratissimum leaf extract ameliorates phenylhydrazine-induced anaemia and toxicity in Wistar rats.

Akara EU et al (2021).
Drug Metab Pers Ther.
PubMed:
34821128

Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats.

Alabi QK et al (2021).
BMC Complement Med Ther.
PubMed:
34727903

Ocimum gratissimum leaf extract ameliorates phenylhydrazine-induced anaemia and toxicity in Wistar rats.

Akara EU et al (2021).
Drug Metab Pers Ther.
PubMed:
33831984

Toxicity of Ocimum basilicum and Ocimum gratissimum Extracts against Main Malaria Vector, Anopheles gambiae (Diptera: Culicidae) in Nigeria.

Ileke KD and Adesina JM (2019).
J Arthropod Borne Dis.
PubMed:
32368553

African Basil (Ocimum gratissimum) Is a Reservoir of Divergent Begomoviruses in Uganda.

Mollel HG et al (2020).
Plant Dis.
PubMed:
31910114

Ocimum gratissimum is effective in prevention against liver fibrosis in vivo and in vitro.

Chiu YW et al (2014).
Am J Chin Med.
PubMed:
25004878