The combination of Artemisia argyi and Ohwia caudata extracts with isoliquiritigenin can protect against doxorubicin-induced cardiac damage. It activates the AKT/PI3K signaling pathway and upregulates antioxidant markers, while inhibiting inflammatory response genes. Promising for cardiac hypertrophy and inflammatory disease treatment.
Researchers have discovered two new compounds, along with five known compounds, in the dried leaves of Ohwia caudata. These compounds have been evaluated for their neuroprotective effect against lipopolysaccharide-induced BV2 microglia cells and have been shown to exhibit anti-neuroinflammatory activity. The structures of the new compounds were established through the use of 1D-NMR, 2D-NMR, and HR-ESI-MS spectral analysis. The previous studies conducted on O. caudata suggested that it may be capable of protecting against Alzheimer's disease.
In this study, researchers tested the effectiveness of two herbal-based formulations, a pleiotropic herbal drink and a nasal drop, in preventing SARS-CoV2 infection. The formulations were tested on bronchial and colorectal cell lines as well as SKH-1 mouse models, including those with comorbidities such as diabetes. The results showed that a combination of the two formulations resulted in a rapid reduction in viral entry and reduced the viral load by 97-99% in infected mice within three days of treatment. Additionally, the combination also inhibited viral transmission among cage mates. The study suggests that this combined administration could potentially prevent SARS-CoV2 infection.
This study explored the potential of a traditional Chinese medicine, OC, for treating Alzheimer's disease. Using computer modeling, the researchers identified new compounds from OC that may improve oral bioavailability and blood-brain barrier permeability. These compounds were found to have multiple effects on AD-related pathways and processes, suggesting that they may have synergistic effects for treating AD. The study sheds light on the complex mechanisms of OC and highlights its potential as a multi-target therapy for AD.