Ononis spinosa

Common Names: spiny restharrow

Ethnobotanical Studies

Studies

Ononin ameliorates depression-like behaviors by regulating BDNF-TrkB-CREB signaling in vitro and in vivo.

Summary

Ononin, found in medicinal plants, has anti-inflammatory, antioxidant, and antitumor effects. Flavonoids, like ononin, treat major depression, but the exact mechanisms are unknown.

Gong G et al (2023).
J Ethnopharmacol.
PubMed:
37944872

Anti-adipogenic activity of maackiain and ononin is mediated via inhibition of PPARγ in human adipocytes.

Mladenova SG et al (2022).
Biomed Pharmacother.
PubMed:
35367764

Ononis spinosa alleviated capsaicin-induced mechanical allodynia in a rat model through transient receptor potential vanilloid 1 modulation.

Jaffal SM, Al-Najjar BO and Abbas MA (2021).
Korean J Pain.
PubMed:
34193633

A new cyclic polyketide and other constituents from Ononis spinosa growing wildly in Jordan and their antioxidant activity.

Abu Zarga MH et al (2022).
J Asian Nat Prod Res.
PubMed:
33881372

Protective effects induced by the food supplement Fluxonorm® in the lower urinary tract.

Orlando G et al (2021).
Eur Rev Med Pharmacol Sci.
PubMed:
33877671

Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats.

Manal Ahmad A, Yasser Ibrahim K and Manal Mohammad A (2021).
J Tradit Chin Med.
PubMed:
33825407

Ononis spinosa L., an edible and medicinal plant: UHPLC-LTQ-Orbitrap/MS chemical profiling and biological activities of the herbal extract.

Stojković D et al (2020).
Food Funct.
PubMed:
32749435

Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide.

Spiegler V et al (2020).
Front Pharmacol.
PubMed:
32595508

Methanolic Extract of the Herb Ononis spinosa L. Is an Antifungal Agent with no Cytotoxicity to Primary Human Cells.

Stojković D et al (2020).
Pharmaceuticals (Basel).
PubMed:
32344670

Aqueous Root Extract from Ononis spinosa Exerts Anti-adhesive Activity against Uropathogenic Escherichia coli.

Deipenbrock M, Sendker J and Hensel A (2020).
Planta Med.
PubMed:
31968378

Using principle component analysis to compare genetic diversity across polyploidy levels within plant complexes: an example from British Restharrows (Ononis spinosa and Ononis repens).

Kloda JM et al (2008).
Heredity (Edinb).
PubMed:
18073784