Ophiopogon japonicus

Common Names: dwarf lilyturf

Ethnobotanical Studies

Studies

Highly efficient and sensitive detection of tetracycline in environmental water: Insights into the synergistic mechanism of biomass-derived carbon dots and N-methyl pyrrolidone solvent.

Nie Q et al (2024).
Talanta.
DOI:
10.1016/j.talanta.2024.126512
PubMed:
38970964

Investigation of the efficacy of Dengzhan Shengmai capsule against heart failure with preserved ejection fraction.

Summary

Chinese medicine DZSMC may treat HFpEF effectively. Research on its mechanism is growing. Potential safe and effective treatment worth exploring further for high mortality condition.

Cardiology
Kang Z et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118419
PubMed:
38838924

A Chinese classical prescription Maimendong decoction in treatment of pulmonary fibrosis: an overview.

Review
Lao Q et al (2024).
Front Pharmacol.
DOI:
10.3389/fphar.2024.1329743
PubMed:
38783956

Integrated transcriptome and metabolome analysis provide insights into the mechanism of saponin biosynthesis and its role in alleviating cadmium-induced oxidative damage in Ophiopogon japonicum.

GeneticsPhytochemistry
Zhao Q et al (2024).
Plant Physiol Biochem.
DOI:
10.1016/j.plaphy.2024.108634
PubMed:
38642440

Identification and characterization of the critical genes encoding Cd-induced enhancement of SOD isozymes activities in Zhe-Maidong (Ophiopogon japonicus).

Genetics
Hou R et al (2024).
Front Plant Sci.
DOI:
10.3389/fpls.2024.1355849
PubMed:
38606075

Transcriptomic and Metabolomic Analyses Reveal the Response Mechanism of Ophiopogon japonicus to Waterlogging Stress.

Cheng T et al (2024).
Biology (Basel).
DOI:
10.3390/biology13030197
PubMed:
38534466

Quality variation of maidong (Ophiopogon japonicus and Liriope spicata) - A HPTLC-based approach.

Lei F et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.115990
PubMed:
38280236

Using Pharmacokinetic-Pharmacodynamic Modeling to Study the Main Active Substances of the Anticancer Effect in Mice from Panax ginseng-Ophiopogon japonicus.

Summary

Ginseng and Ophiopogonin, traditional Chinese herbal pair, enhance immune system in cancer patients. Study identifies main active components and their therapeutic effect on lung cancer.

Cancer
Liu L et al (2024).
Molecules.
DOI:
10.3390/molecules29020334
PubMed:
38257247

Integrated serum pharmacochemistry and investigation of the anti-influenza A virus pneumonia effect of Qingjin Huatan decoction.

Liu M et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.117701
PubMed:
38185258

Ruscogenin attenuates cartilage destruction in osteoarthritis through suppressing chondrocyte ferroptosis via Nrf2/SLC7A11/GPX4 signaling pathway.

Ruan Q et al (2023).
Chem Biol Interact.
DOI:
10.1016/j.cbi.2023.110835
PubMed:
38122922

A real-world data analysis-based study of Chinese medicine treatment patterns after breast cancer surgery.

Summary

The study analyzed breast cancer patients' clinical data after surgery and found that liver depression and spleen deficiency syndrome was common. Common TCM combinations were identified, aiding prescription decision-making post-surgery.

Cancer
Hu L et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000036642
PubMed:
38115283

The Importance of Traditional Chinese Medicine in the Intervention and Treatment of HIV while Considering its Safety and Efficacy.

Shahrajabian MH and Sun W (2023).
Curr HIV Res.
DOI:
10.2174/011570162X271199231128092621
PubMed:
38047360

Elucidating the pharmacodynamic mechanisms of Yuquan pill in T2DM rats through comprehensive multi-omics analyses.

Lei Y et al (2023).
Front Pharmacol.
DOI:
10.3389/fphar.2023.1282077
PubMed:
38044947

YiQiFuMai Injection Ameliorated Sepsis-induced Cardiomyopathy by Inhibition of Ferroptosis via xCT/GPX4 Axis.

Summary

YQFM, a Chinese treatment for heart diseases, shows potential in alleviating sepsis-induced cardiomyopathy (SIC) by reducing iron overload and lipid peroxidation and activating the xCT/GPX4 axis, which may help in preventing or treating SIC.

Cardiology
Guo L et al (2023).
Shock.
DOI:
10.1097/SHK.0000000000002257
PubMed:
37983962

Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.

Summary

Mai Men Dong decoction (MMDD), a traditional Chinese medicine, contains herbs known for treating respiratory conditions. Studying MMDD can enhance understanding and development of ethnopharmacology.

Immunology
Shuangshuang HE et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117308
PubMed:
37865276

Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1.

Meng P et al (2023).
Aging (Albany NY).
DOI:
10.18632/aging.205062
PubMed:
37770231

Ruscogenin timing administration mitigates cerebral ischemia-reperfusion injury through regulating circadian genes and activating Nrf2 pathway.

Summary

Ruscogenin, extracted from Ophiopogon japonicus, has shown potential in reducing cerebral ischemia-reperfusion injury and acute lung injury. However, its chronopharmacological effects have yet to be determined.

CardiologyGenetics
Zhang S et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155028
PubMed:
37659295

The mechanism of Qijing Mingmu decoction on cellular senescence of conjunctivochalasis.

Xiang M et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04138-x
PubMed:
37644481

Ophiopogonin D ameliorates non‑alcoholic fatty liver disease in high‑fat diet‑induced obese mice by improving lipid metabolism, oxidative stress and inflammatory response.

Summary

This study examined the effects of Ophiopogonin D (OP-D) on non-alcoholic fatty liver disease (NAFLD) in mice. OP-D was found to improve NAFLD by regulating lipid metabolism, antioxidant, and anti-inflammatory responses. OP-D also reduced lipogenesis and inflammation, potentially through the NF-κB signaling pathway.

ImmunologyObesity
Huang X et al (2023).
Exp Ther Med.
DOI:
10.3892/etm.2023.12116
PubMed:
37602303

Enhancement of electrokinetic-phytoremediation by Ophiopogon japonicus: stimulation of electrokinetic on root system and improvement of polycyclic aromatic hydrocarbon degradation.

Li M et al (2023).
Environ Sci Pollut Res Int.
DOI:
10.1007/s11356-023-29342-7
PubMed:
37596476

Qingjin Huatan decoction protects mice against influenza a virus pneumonia via the chemokine signaling pathways.

Liu M et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116745
PubMed:
37336335

Network analysis to explore the pharmacological mechanism of Shenmai injection in treating granulocytopenia and evidence-based medicine approach validation.

Meta-Analysis
Hou X et al (2023).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000033825
PubMed:
37335746

Extraction, characterization and anti-oxidant activity of polysaccharide from red Panax ginseng and Ophiopogon japonicus waste.

Kang J et al (2023).
Front Nutr.
DOI:
10.3389/fnut.2023.1183096
PubMed:
37293670

Phylogeography of cultivated and wild ophiopogon japonicus based on chloroplast DNA: exploration of the origin and sustainable cultivation.

Genetics
Zhao LY et al (2023).
BMC Plant Biol.
DOI:
10.1186/s12870-023-04247-2
PubMed:
37150815

First report of peanut root rot caused by Fusarium acuminatum in Shandong Province, China.

Li Y et al (2023).
Plant Dis.
DOI:
10.1094/PDIS-11-22-2681-PDN
PubMed:
37079009

Protected Geographical Indication Discrimination of Zhejiang and Non-Zhejiang Ophiopogonis japonicus by Near-Infrared (NIR) Spectroscopy Combined with Chemometrics: The Influence of Different Stoichiometric and Spectrogram Pretreatment Methods.

Ji Q et al (2023).
Molecules.
DOI:
10.3390/molecules28062803
PubMed:
36985775

Effectiveness and safety of traditional Chinese medicine in treatment primary Sjögren's Syndrome patients: A meta-analysis.

Meta-Analysis
Liu H et al (2023).
Comb Chem High Throughput Screen.
DOI:
10.2174/1386207326666230322092252
PubMed:
36959129

Ophiopogon japonicus and its active compounds: A review of potential anticancer effects and underlying mechanisms.

Review Cancer
Liu Q et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.154718
PubMed:
36854203

Comparison of Ophiopogon japonicus and Liriope spicata var. prolifera from Different Origins Based on Multi-Component Quantification and Anticancer Activity.

Cancer
Chen MH et al (2023).
Molecules.
DOI:
10.3390/molecules28031045
PubMed:
36770712

A comprehensive perspective on the disposition, metabolism, and pharmacokinetics of representative multi-components of Dengzhan Shengmai in rats with chronic cerebral hypoperfusion after oral administration.

Ma C et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116212
PubMed:
36739927

Microbiota-derived short-chain fatty acids mediate the effects of dengzhan shengmai in ameliorating cerebral ischemia via the gut-brain axis.

Summary

Researchers investigated the molecular mechanism behind the popular herbal medicine Dengzhan shengmai (DZSM) formula, which is commonly used to aid recovery from ischemic cerebrovascular diseases. The formula is composed of four herbal medicines and the study found that it promotes angiogenesis, which improves blood flow and aids in the recovery process. The study provides valuable insight into the potential benefits of traditional herbal medicines in treating vascular diseases.

CardiologyNeuroscience
Guo HH et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116158
PubMed:
36638854

Elucidating the mechanism of Hongjinshen decoction in the treatment of pulmonary fibrosis based on network pharmacology and molecular docking.

Chen H et al (2022).
Medicine (Baltimore).
DOI:
10.1097/MD.0000000000032323
PubMed:
36595795

De Novo transcriptome combined with physiological analyses revealed key genes for cadmium accumulation in Zhe-Maidong (Ophiopogon japonicus).

Genetics
Zhao Q et al (2022).
Front Plant Sci.
DOI:
10.3389/fpls.2022.1078330
PubMed:
36578338

A high-resolution mass spectrometry-based methodology for characterization and identification of methylophiopogonanone B metabolites from cryopreserved hepatocytes and liver microsomes.

Wu D et al (2023).
Biomed Chromatogr.
DOI:
10.1002/bmc.5574
PubMed:
36527223

Investigation of Asymptomatic Infection of Phellinus noxius in Herbaceous Plants.

Chen CY et al (2023).
Phytopathology.
DOI:
10.1094/PHYTO-08-22-0281-R
PubMed:
36256954

Compound 511 ameliorates MRSA-induced lung injury by attenuating morphine-induced immunosuppression in mice via PI3K/AKT/mTOR pathway.

Li Z et al (2023).
Phytomedicine.
DOI:
10.1016/j.phymed.2022.154475
PubMed:
36252465

Ruscogenin alleviates LPS-triggered pulmonary endothelial barrier dysfunction through targeting NMMHC IIA to modulate TLR4 signaling.

Wu Y et al (2022).
Acta Pharm Sin B.
DOI:
10.1016/j.apsb.2021.09.017
PubMed:
35530141

Erratum to ophiopogon japonicus inhibits radiation-induced pulmonary inflammation in mice.

Immunology
Editorial Office et al (2022).
Ann Transl Med.
DOI:
10.21037/atm-2022-4
PubMed:
35402603

MDG, an Ophiopogon japonicus polysaccharide, inhibits non-alcoholic fatty liver disease by regulating the abundance of Akkermansia muciniphila.

Zhang L et al (2022).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2021.12.036
PubMed:
34920070

Ophiopogon japonicus inhibits white spot syndrome virus proliferation in vivo and enhances immune response in Chinese mitten crab Eriocheir sinensis.

Review
Chen C et al (2021).
Fish Shellfish Immunol.
DOI:
10.1016/j.fsi.2021.10.028
PubMed:
34688864

The structures and biological functions of polysaccharides from traditional Chinese herbs.

Review
Zeng P et al (2019).
Prog Mol Biol Transl Sci.
DOI:
10.1016/bs.pmbts.2019.03.003
PubMed:
31030757

Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway.

Summary

Ruscogenin, a sapogenin from Ophiopogon japonicus, has been shown to protect against ischemic injury to the brain. Researchers investigated its effects on blood-brain barrier dysfunction after stroke and found that it decreased brain damage, improved neurological function, and increased blood flow in mice. In brain cells, ruscogenin increased cell viability, decreased leakage, and modulated tight junction expression. It also inhibited the expression of inflammatory markers and decreased reactive oxygen species generation. These findings suggest that ruscogenin has potential for preventing and treating stroke.

CardiologyNeuroscience
Cao G et al (2016).
Int J Mol Sci.
DOI:
10.3390/ijms17091418
PubMed:
27589720

(E)-3-(4-Hydr-oxy-3-methoxy-benzyl-idene)-4-(4-hydroxy-phen-yl)pyrrolidin-2-one.

Zhou YF et al (2008).
Acta Crystallogr Sect E Struct Rep Online.
DOI:
10.1107/S1600536808008581
PubMed:
21202304