Oroxylum indicum

Ethnobotanical Studies

Studies

Baicalein isolated from Oroxylum indicum acts as a potent µ- and κ-opioid receptor antagonist agent via the reversal of agonist-mediated cAMP inhibition.

Singh K et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2396452
PubMed:
39205489

Synergistic combination of baicalein and rifampicin against Staphylococcus aureus biofilms.

Muniyasamy R and Manjubala I (2024).
Front Microbiol.
DOI:
10.3389/fmicb.2024.1458267
PubMed:
39165570

Green mediated synthesis of cerium oxide nanoparticles by using Oroxylum indicum for evaluation of catalytic and biomedical activity.

Mim J et al (2024).
RSC Adv.
DOI:
10.1039/d4ra04132a
PubMed:
39139232

A Comparative Study of Two Oroxylum indicum (L.) Kurz. Phenotypes Based on Phytochemicals and Antioxidant Effects, and the Anti-Inflammatory Activity of Leaf and Pod Extracts.

Immunology
Panomai P, Thapphasaraphong S and Nualkaew N (2024).
Plants (Basel).
DOI:
10.3390/plants13152110
PubMed:
39124228

The mysteries of pharmacokinetics and in vivo metabolism of Oroxylum indicum (L.) Kurz: A new perspective from MSOP method.

Zhang X et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e33234
PubMed:
39027462

The Neuroprotective Effects of Oroxylum indicum Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression under LPS Induced Inflammation.

Summary

Researchers found an herbal extract called Sabroxy can significantly increase BDNF expression, supporting neuronal health and protecting against inflammation. Sabroxy's antioxidant properties could mitigate neurodegeneration damage. This suggests a potential therapeutic application for neurological disorders.

GeneticsImmunologyNeuroscience
Sreedharan S et al (2024).
Nutrients.
DOI:
10.3390/nu16121887
PubMed:
38931243

Molecular targets and therapeutic potential of baicalein: a review.

Review
Munjal K et al (2024).
Drug Target Insights.
DOI:
10.33393/dti.2024.2707
PubMed:
38873988

In-silico evaluation of Oroxylum indicum vent compounds in the plausible treatment and prevention of nasopharyngeal cancer.

Summary

Researchers studied the plant Shyonaka for its anti-inflammatory, pain-relief, and anti-cancer properties. They found it could potentially target proteins related to both EBV replication and NPC proliferation, offering a promising treatment option for NPC patients.

Cancer
Thrigulla SR et al (2024).
J Ayurveda Integr Med.
DOI:
10.1016/j.jaim.2024.100986
PubMed:
38805854

α-Glucosidase inhibitory potential of Oroxylum indicum using molecular docking, molecular dynamics, and in vitro evaluation.

Bhaumik S et al (2024).
Saudi Pharm J.
DOI:
10.1016/j.jsps.2024.102095
PubMed:
38766274

Oroxin A from Oroxylum indicum improves disordered lipid metabolism by inhibiting SREBPs in oleic acid-induced HepG2 cells and high-fat diet-fed non-insulin-resistant rats.

Cai T et al (2024).
Heliyon.
DOI:
10.1016/j.heliyon.2024.e29168
PubMed:
38617966

Bat pollinators: a decade of monitoring reveals declining visitation rates for some species in Thailand.

Stewart AB et al (2024).
Zoological Lett.
DOI:
10.1186/s40851-024-00228-x
PubMed:
38431697

Cellular and molecular mechanisms of oroxylin A in cancer therapy: Recent advances.

Summary

Research shows Oroxylin A from traditional Chinese medicine has potent anti-tumor effects through various biological mechanisms. Its safety and effectiveness warrant further clinical trials for potential cancer treatment.

Review Cancer
Wang PX et al (2024).
Eur J Pharmacol.
DOI:
10.1016/j.ejphar.2024.176452
PubMed:
38417609

Unveiling the cytotoxic and anti-proliferative potential of green-synthesized silver nanoparticles mediated by Colletotrichum gloeosporioides.

Cancer
Gupta P et al (2024).
RSC Adv.
DOI:
10.1039/d3ra06145k
PubMed:
38292267

Elucidating anti-sclerostin mechanism of baicalein using LRP6-Sclersotin complex of canonical Wnt/β-catenin signaling pathway.

Muniyasamy R and Manjubala I (2024).
J Biomol Struct Dyn.
DOI:
10.1080/07391102.2024.2306494
PubMed:
38240094

Ethnobotanical study of medicinal plants used by the indigenous community of the western region of Mizoram, India.

Ethnobotany
Ralte L, Sailo H and Singh YT (2024).
J Ethnobiol Ethnomed.
DOI:
10.1186/s13002-023-00642-z
PubMed:
38172927

Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress.

Neuroscience
Chalermwongkul C et al (2023).
Nutrients.
DOI:
10.3390/nu15224742
PubMed:
38004136

Evaluation and molecular docking study of two flavonoids from Oroxylum indicum (L.) Kurz and their semi-synthetic derivatives as histone deacetylase inhibitors.

Phytochemistry
Somsakeesit LO et al (2024).
J Nat Med.
DOI:
10.1007/s11418-023-01758-y
PubMed:
37991632

Ethnopharmacologically important highly subsidized Indian medicinal plants: Systematic review on their traditional uses, phytochemistry, pharmacology, quality control, conservation status and future prospective.

Summary

This review provides updated information on thirteen medicinal plants prioritized by the Indian government. It covers traditional uses, phytochemistry, pharmacology, quality control, and conservation status. Useful for understanding their importance and developing conservation strategies.

Review Phytochemistry
Anmol et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117385
PubMed:
37951375

Effect of Oroxylum indicum on hepatocellular carcinoma via the P53 and VEGF pathways based on microfluidic chips.

Cancer
Luo X et al (2023).
BMC Complement Med Ther.
DOI:
10.1186/s12906-023-04217-z
PubMed:
37936097

Silencing E6/E7 Oncoproteins in SiHa Cells Treated with siRNAs and Oroxylum indicum Extracts Induced Apoptosis by Upregulating p53/pRb Pathways.

Cancer
Sisin NNT et al (2023).
Appl Biochem Biotechnol.
DOI:
10.1007/s12010-023-04762-w
PubMed:
37922032

In-vitro anti-sickling potential of baicalin and naringenin isolated from Oroxylum indicum and Citrus aurantium on human sickle red blood cells.

Lone BA et al (2023).
Nat Prod Res.
DOI:
10.1080/14786419.2022.2158330
PubMed:
36525466

Cardioprotective Effects of Oroxylum indicum Extract Against Doxorubicin and Cyclophosphamide-Induced Cardiotoxicity.

Cardiology
Pondugula SR et al (2022).
Cardiovasc Toxicol.
DOI:
10.1007/s12012-021-09701-x
PubMed:
34623620

Effects of an Oroxylum indicum Extract (Sabroxy(®)) on Cognitive Function in Adults With Self-reported Mild Cognitive Impairment: A Randomized, Double-Blind, Placebo-Controlled Study.

Neuroscience
Lopresti AL et al (2021).
Front Aging Neurosci.
DOI:
10.3389/fnagi.2021.728360
PubMed:
34531736

Oroxylum indicum extract, at a physiologically relevant dosage, does not induce hepatotoxicity in C57BL/6J mice.

Pondugula SR et al (2021).
Nat Prod Commun.
DOI:
10.1177/1934578x211016966
PubMed:
34306298

The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review.

Review
Nik Salleh NNH et al (2020).
Molecules.
DOI:
10.3390/molecules25235677
PubMed:
33276419

Flavones Contents in Extracts from Oroxylum indicum Seeds and Plant Tissue Cultures.

Rojsanga P, Bunsupa S and Sithisarn P (2020).
Molecules.
DOI:
10.3390/molecules25071545
PubMed:
32231034

Oroxylum indicum (L.) extract protects human neuroblastoma SH‑SY5Y cells against β‑amyloid‑induced cell injury.

Mairuae N et al (2019).
Mol Med Rep.
DOI:
10.3892/mmr.2019.10411
PubMed:
31257498

Oroxylum indicum (L.) Kurz extract inhibits adipogenesis and lipase activity in vitro.

Hengpratom T et al (2018).
BMC Complement Altern Med.
DOI:
10.1186/s12906-018-2244-3
PubMed:
29884167

Oroxylum indicum (L.) Kurz, an important Asian traditional medicine: from traditional uses to scientific data for its commercial exploitation.

Review
Dinda B et al (2015).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2014.12.027
PubMed:
25543018