Panax notoginseng

Ethnobotanical Studies

Clinical Trials

Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study.

Study found GXDSDP significantly improved anxiety and depression symptoms in CHD patients. Potential alternative treatment option for mental health in cardiovascular disease.

Wu SH et al (2024).
Chin J Integr Med.
DOI:
10.1007/s11655-023-3628-x
PubMed:
37947990

Studies

Differences in autotoxic substances and microbial community in the root space of Panax notoginseng coinducing the occurrence of root rot.

Chen J et al (2024).
Appl Environ Microbiol.
DOI:
10.1128/aem.02287-23
PubMed:
39235242

The plant extract PNS mitigates atherosclerosis via promoting Nrf2-mediated inhibition of ferroptosis through reducing USP2-mediated Keap1 deubiquitination.

Zhao Y et al (2024).
Br J Pharmacol.
DOI:
10.1111/bph.17311
PubMed:
39228119

Exposure to Gynura japonica (Thunb.) Juel plants induces hepatoxicity in rats and Buffalo rat liver cells.

Wen C et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118692
PubMed:
39151710

Optimization of saponin extraction from the leaves of Panax notoginseng and Panax quinquefolium and evaluation of their antioxidant, antihypertensive, hypoglycemic and anti-inflammatory activities.

Summary

Scientists developed an extraction process for saponins in and plants, showing antioxidant, antihypertensive, hypoglycemic, and anti-inflammatory properties. These saponins could be used in functional foods and natural products.

DiabetesImmunologyPhytochemistry
Liang ZW et al (2024).
Food Chem X.
DOI:
10.1016/j.fochx.2024.101642
PubMed:
39113743

Isolation, structure, biological activity and application progress of ginseng polysaccharides from the Araliaceae family.

Review
Liu S et al (2024).
Int J Biol Macromol.
DOI:
10.1016/j.ijbiomac.2024.133925
PubMed:
39032904

Screening of active components in Astragalus mongholicus Bunge and Panax notoginseng formula for anti-fibrosis in CKD: nobiletin inhibits Lgals1/PI3K/AKT signaling to improve renal fibrosis.

Yang F et al (2024).
Ren Fail.
DOI:
10.1080/0886022X.2024.2375033
PubMed:
38967135

Effect of saponins in Panax notoginseng (Burkill) F. H. Chen on the steroid hormone levels in the chronic unpredictable mild stress model of depression in rats.

Summary

Study found that ginsenoside Rg1 and PNS from plant relieved depression symptoms in rats. Precise LC-ESI-MS/MS analysis showed positive effects on behavior and hormone levels. Potential antidepressant for humans.

EndocrinologyNeurosciencePhytochemistry
Nguyen Van K et al (2024).
Nat Prod Res.
DOI:
10.1080/14786419.2024.2371997
PubMed:
38949646

Using broadly targeted plant metabolomics technology combined with network pharmacology to explore the mechanism of action of the Yishen Gushu formula in the treatment of postmenopausal osteoporosis in vivo.

Summary

YSGSF boosts bone density by enhancing bone metabolism, but how it treats PMOP is unknown. Study the effects of YSGSF on PMOP to enhance treatment strategies.

ArthritisEndocrinology
Liu H et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118469
PubMed:
38914151

Research of the dynamic regulatory mechanism of Compound Danshen Dripping Pills on myocardial infarction based on metabolic trajectory analysis.

Summary

Tossers studied CDDP for MI treatment, but focused on endpoints, neglecting dynamic changes in disease. Establishing dynamic research strategy for precise clinical medication guidance is crucial.

Cardiology
Zhang CJ et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155626
PubMed:
38850631

Analyzing noncovalent interactions between notoginseng saponins and lysozyme by deposition scanning intensity fading MALDI-TOF mass spectrometry.

Summary

Improved IF-MALDI-MS method used to study binding of Panax notoginseng saponins with lysozyme. Results show binding affinity order and suggest hydrogen bonding role. Valuable for screening natural products for pharmacological activities.

Phytochemistry
Zhao X et al (2024).
J Mass Spectrom.
DOI:
10.1002/jms.5058
PubMed:
38842112

Discovery and characterization of panaxatriol as a novel thrombin inhibitor from Panax notoginseng using combination of computational and experimental approach.

Wang X et al (2024).
Planta Med.
DOI:
10.1055/a-2339-2720
PubMed:
38838717

Enhancing antioxidant levels and mitochondrial function in porcine oocyte maturation and embryonic development through notoginsenoside R1 supplementation.

Immunology
He SY et al (2024).
Reprod Domest Anim.
DOI:
10.1111/rda.14631
PubMed:
38828566

Notoginseng leaf triterpenes promotes angiogenesis by activating the Nrf2 pathway and AMPK/SIRT1-mediated PGC-1/ERα axis in ischemic stroke.

Summary

Notoginseng leaf triterpenes enhance angiogenesis after stroke by activating Nrf2 and AMPK/SIRT1 pathways, promoting neuroprotection and neuronal regeneration. Potential future stroke treatment.

CardiologyNeuroscience
Wang L et al (2024).
Fitoterapia.
DOI:
10.1016/j.fitote.2024.106045
PubMed:
38823597

Heterologous synthesis of ginsenoside F1 and its precursors in Nicotiana benthamiana.

Chen Q et al (2024).
J Plant Physiol.
DOI:
10.1016/j.jplph.2024.154276
PubMed:
38801806

Natural plant medications for the treatment of retinal diseases: The blood-retinal barrier as a clue.

Review
Ren Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155568
PubMed:
38795692

Qualitative and quantitative analysis of major components of Qiye Shen'an tablet by UPLC Q-TOF/MS and UPLC-TQS-MS/MS.

Li R et al (2024).
J Pharm Biomed Anal.
DOI:
10.1016/j.jpba.2024.116216
PubMed:
38772204

Borneol acts as an adjuvant agent to enhance the oral absorption of Panax notoginseng saponins in rats: Effect of optical configuration and compatibility ratios.

Phytochemistry
Mei Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118331
PubMed:
38734392

Inhibition of vascular calcification by Compound Danshen Dripping Pill through multiple mechanisms.

Yang Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155618
PubMed:
38678949

The NeuroProtect Formula: A Preventive Approach to AD Targeting the HIF-1/PI3K-AKT Signaling Pathway Evaluated through In Vivo, In Vitro, and Network Pharmacology Approaches.

Li H et al (2024).
Comb Chem High Throughput Screen.
DOI:
10.2174/0113862073311518240416070410
PubMed:
38676511

Production and Pharmaceutical Research of Minor Saponins in Panax Notoginseng (Sanqi): Current Status and Future Prospects.

Summary

Researchers studied how to increase levels of minor saponins in Panax notoginseng, which have stronger medicinal effects than major saponins. This information is important for improving treatments for cardiovascular diseases.

Review Phytochemistry
Zhang H et al (2024).
Phytochemistry.
DOI:
10.1016/j.phytochem.2024.114099
PubMed:
38641143

Quantitative analysis of the illegal addition of Atenolol in Panax notoginseng based on NIR-MIR spectral data fusion and calibration transfer.

Du J et al (2024).
RSC Adv.
DOI:
10.1039/d3ra08183d
PubMed:
38633489

Comparison of the components of fresh Panax notoginseng processed by different methods and their anti-anemia effects on cyclophosphamide-treated mice.

Xu C et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2024.118148
PubMed:
38583734

Identification of Panax notoginseng origin using terahertz precision spectroscopy and neural network algorithm.

Gu H et al (2024).
Talanta.
DOI:
10.1016/j.talanta.2024.125968
PubMed:
38581849

In vitro suppression of porcine epidemic diarrhea virus by Panax notoginseng saponins: assessing antiviral potential.

Summary

Porcine epidemic diarrhea virus (PEDV) causes deadly diarrhea in piglets, impacting the swine industry. Panax notoginseng saponins (PNS) inhibit PEDV replication in cells, potentially offering antiviral therapy options.

AntimicrobialPhytochemistry
Hu Y et al (2024).
Arch Virol.
DOI:
10.1007/s00705-024-06020-8
PubMed:
38565720

Comprehensive genomic analysis of Burkholderia arboris PN-1 reveals its biocontrol potential against Fusarium solani-induced root rot in Panax notoginseng.

Yang Y et al (2024).
Curr Genet.
DOI:
10.1007/s00294-024-01288-4
PubMed:
38555312

Protective effect of ginsenoside Rb1 against aconitine cardiotoxicity studied by myocardial injury, action potential, and calcium signaling.

Summary

Ginsenoside Rb1 can mitigate aconitine-induced cardiotoxicity by reducing myocardial damage and restoring action potential and calcium signaling balance. This study shows potential for using Rb1 as a detoxifying agent in traditional Chinese medicine.

CardiologyNeuroscience
Zhang C et al (2024).
Toxicon.
DOI:
10.1016/j.toxicon.2024.107693
PubMed:
38519012

Proline-rich protein PRPL1 enhances Panax notoginseng defence against Fusarium solani by regulating reactive oxygen species balance and strengthening the cell wall barrier.

Su L et al (2024).
Plant Cell Environ.
DOI:
10.1111/pce.14886
PubMed:
38516721

Biotransformation approach to produce rare ginsenosides F1, compound Mc1, and Rd2 from major ginsenosides.

Diao M et al (2024).
Arch Microbiol.
DOI:
10.1007/s00203-024-03893-w
PubMed:
38493413

Notoginsenoside R1 promotes Lgr5(+) stem cell and epithelium renovation in colitis mice via activating Wnt/β-Catenin signaling.

Summary

NGR1 from Panax notoginseng repairs damaged intestinal barrier in colitis mice by promoting Lgr5 stem cells through Wnt signaling pathway, reducing inflammation and enhancing epithelial repair. Potential therapeutic for IBD.

Gastroenterology
Yu ZL et al (2024).
Acta Pharmacol Sin.
DOI:
10.1038/s41401-024-01250-7
PubMed:
38491161

Distinction and quantification of Panax polysaccharide extracts via attenuated total reflectance-Fourier transform infrared spectroscopy with first-order derivative processing.

Yan ZP et al (2024).
Spectrochim Acta A Mol Biomol Spectrosc.
DOI:
10.1016/j.saa.2024.124124
PubMed:
38460230

Changes in chemical components and hepatoprotective effect of red Panax notoginseng processed by aspartic acid impregnation treatment.

Cui Y et al (2024).
J Sci Food Agric.
DOI:
10.1002/jsfa.13440
PubMed:
38445528

RN0D, a galactoglucan from Panax notoginseng flower induces cancer cell death via PINK1/Parkin mitophagy.

Summary

RN0D from Panax notoginseng induces mitochondrial dysfunction in cancer cells, leading to cell death through ATP deprivation and mitophagy. Targets Galectin-3 and activates PINK1/Parkin pathway, showing promise as an anticancer therapeutic.

Cancer
Ji M et al (2024).
Carbohydr Polym.
DOI:
10.1016/j.carbpol.2024.121889
PubMed:
38431406

Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway.

Summary

Notoginsenoside Fc (Fc) from Panax Notoginseng may protect against diabetic nephropathy, offering potential therapy for end-stage renal disease in diabetes.

Diabetes
Shen Y et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2024.155445
PubMed:
38412666

Study on the mechanism of Panax notoginseng-Salvia miltiorrhiza herb pair on invigorating blood circulation and eliminating blood stasis by blocking the conversion of arachidonic acid to prostaglandin.

Zeng R et al (2024).
J Nat Med.
DOI:
10.1007/s11418-023-01773-z
PubMed:
38261160

Clinical efficacy and safety of Panax notoginseng saponins in treating chronic obstructive pulmonary disease with blood hypercoagulability: A meta-analysis of randomized controlled trials.

Summary

PNS from Panax notoginseng can treat COPD with HCS by reducing blood clotting. Important for managing risk factors in COPD patients.

Meta-Analysis Phytochemistry
Zhou R et al (2024).
Phytomedicine.
DOI:
10.1016/j.phymed.2023.155244
PubMed:
38216446

Effective constituents and protective effect of Mudan granules against Schwann cell injury.

Shi Y et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117692
PubMed:
38176668

Research on rapid quality identification method of Panax notoginseng powder based on artificial intelligence sensory technology and multi-source information fusion technology.

Li H et al (2024).
Food Chem.
DOI:
10.1016/j.foodchem.2023.138210
PubMed:
38118320

Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules.

Hu J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117590
PubMed:
38113986

Screening and verification of hemostatic effective components group of Panax Notoginseng based on spectrum-effect relationships.

Liu J et al (2024).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.117539
PubMed:
38056541

Selection and application of aptamers for p-hydroxybenzyl hydrogen sulfite after Gastrodia elata Bl. fumigated with sulfur.

Wan F et al (2023).
Talanta.
DOI:
10.1016/j.talanta.2023.125461
PubMed:
38056416

Promoting oral absorption of Panax notoginseng saponins via thiolated trimethyl chitosan and wheat germ agglutinin-modified nanoformulation.

Phytochemistry
Fang R et al (2024).
Drug Deliv Transl Res.
DOI:
10.1007/s13346-023-01417-5
PubMed:
37787882

Using Network Pharmacology to Explore the Mechanism of Panax notoginseng in the Treatment of Myocardial Fibrosis.

Cardiology
Han J et al (2022).
J Diabetes Res.
DOI:
10.1155/2022/8895950
PubMed:
35372585

Chemical constituents of Panax ginseng and Panax notoginseng explain why they differ in therapeutic efficacy.

Review
Liu H et al (2020).
Pharmacol Res.
DOI:
10.1016/j.phrs.2020.105263
PubMed:
33127555

Panax notoginseng for Inflammation-Related Chronic Diseases: A Review on the Modulations of Multiple Pathways.

Review Immunology
Xu Y et al (2018).
Am J Chin Med.
DOI:
10.1142/S0192415X18500519
PubMed:
29976083

Panax notoginseng Preparations for Unstable Angina Pectoris: A Systematic Review and Meta-Analysis.

Meta-Analysis
Song H et al (2017).
Phytother Res.
DOI:
10.1002/ptr.5848
PubMed:
28634988