Panax quinquefolius

Common Names: American ginseng

Ethnobotanical Studies

Clinical Trials

Vascular effects of combined enriched Korean Red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) administration in individuals with hypertension and type 2 diabetes: A randomized controlled trial.

Combining American ginseng and Korean Red ginseng improves glucose control, blood pressure, and vascular function in type 2 diabetes.

Jovanovski E et al (2020).
Complement Ther Med.
PubMed:
32147072

Studies

Ocotillol-Type Pseudoginsenoside-F11 Alleviates Lipopolysaccharide-Induced Acute Kidney Injury through Regulation of Macrophage Function by Suppressing the NF-κB/NLRP3/IL-1β Signaling Pathway.

Summary

- AKI involves kidney function decline due to inflammation - PF11 from plant modulates macrophage function - Protects kidney cells and reduces inflammation in mouse model - Potential treatment for AKI by regulating macrophages

Wang Y et al (2024).
J Agric Food Chem.
PubMed:
39239930

Intricate microbe-plant-metabolic remodeling mediated by intercropping enhances the quality of Panax quinquefolius L.

Duan W et al (2024).
Physiol Plant.
PubMed:
39221485

Analysis of the complete mitochondrial genome of Panax quinquefolius reveals shifts from cis-splicing to trans-splicing of intron cox2i373.

Li J et al (2024).
Gene.
PubMed:
39153707

Characteristics of lipid metabolism after treatment of colon cancer mice with American ginseng vesicles.

Summary

Researchers studied the presence of lipid molecules in tumours, which impact inflammation and antiviral defense. Changes in intestinal lipids due to stressors are linked to UC, IBD, and colorectal cancer. Understanding this can help in prevention and treatment strategies.

Weng L et al (2024).
Phytochem Anal.
PubMed:
38768606

Effects of enzymatic hydrolysis technology on the physicochemical properties and biological activities of American ginseng beverages.

Guo S et al (2024).
Food Sci Nutr.
PubMed:
38726448

Panax quinquefolius saponins and panax notoginseng saponins attenuate myocardial hypoxia-reoxygenation injury by reducing excessive mitophagy.

Summary

Researchers studied the effects of PQS and PNS from ginseng on heart injury. Results suggest potential protection against heart damage from lack of oxygen, making them promising treatments for ischemic heart conditions.

Xia J et al (2024).
Cell Biochem Biophys.
PubMed:
38713401

Protective effects of ginsenoside F(2) on isoproterenol-induced myocardial infarction by activating the Nrf2/HO-1 and PI3K/Akt signaling pathways.

Summary

GF, found in ginseng, has various health benefits but its impact on heart attacks is unclear. Study investigates potential role in myocardial infarction.

Cui Y et al (2024).
Phytomedicine.
PubMed:
38669969

Next-generation DNA sequencing of Panax samples revealed new genotypes: Burrows-Wheeler Aligner, Python-based abundance and clustering analysis.

Oberc C and Li PCH (2024).
Heliyon.
PubMed:
38660284

Identification and Expression Analysis of R2R3-MYB Transcription Factors Associated with Flavonoid Biosynthesis in Panax quinquefolius.

Song G et al (2024).
Int J Mol Sci.
PubMed:
38612520

Beneficial effects of American ginseng (Panax quinquefolius L.) extract residue as a feed additive on production, health status, and gastrointestinal bacteria in sika deer (Cervus nippon).

Wu Y et al (2024).
Front Microbiol.
PubMed:
38544859

Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study.

Best T, Miller J and Teo WP (2024).
Nutr Neurosci.
PubMed:
38512715

Distinction and quantification of Panax polysaccharide extracts via attenuated total reflectance-Fourier transform infrared spectroscopy with first-order derivative processing.

Yan ZP et al (2024).
Spectrochim Acta A Mol Biomol Spectrosc.
PubMed:
38460230

Comparisons of wild and cultivated American ginseng (Panax quinquefolius L.) genomes provide insights into changes in root growth and metabolism during domestication.

Wang Z et al (2024).
Plant Biotechnol J.
PubMed:
38446695

Comprehensive Investigation of Ginsenosides in the Steamed Panax quinquefolius with Different Processing Conditions Using LC-MS.

Fan J et al (2024).
Molecules.
PubMed:
38338369

Goldenseal (Hydrastis canadensis L.) Extracts Inhibit the Growth of Fungal Isolates Associated with American Ginseng (Panax quinquefolius L.).

Gao Y et al (2024).
Molecules.
PubMed:
38338301

A systematic review of ginsenoside biosynthesis, spatiotemporal distribution, and response to biotic and abiotic factors in American ginseng.

Review
Tian L et al (2024).
Food Funct.
PubMed:
38323507

Phenotypic and Genotypic Variation of Cultivated Panax quinquefolius.

Abaya A et al (2024).
Plants (Basel).
PubMed:
38276757

Antagonistic effects of Talaromyces muroii TM28 against Fusarium crown rot of wheat caused by Fusarium pseudograminearum.

Yang H et al (2024).
Front Microbiol.
PubMed:
38235437

Characterization and In Vitro Antioxidant and Anti-Inflammatory Activities of Ginsenosides Extracted from Forest-Grown Wild Panax quinquefolius L.

Yang Y et al (2023).
Foods.
PubMed:
38231785

Expression, purification, characterization and crystallization of Panax quinquefolius ginsenoside glycosyltransferase Pq3-O-UGT2.

Ji Q et al (2024).
Protein Expr Purif.
PubMed:
38184160

A soil fumigant increases American ginseng (Panax quinquefolius L.) survival and growth under continuous cropping by affecting soil microbiome assembly: a 4-year in situ field experiment.

Peng N et al (2023).
Microbiol Spectr.
PubMed:
38099616

Spatial metabolomics method to reveal differential metabolomes in microregions of Panax quinquefolius roots by using ultra-performance liquid chromatography quadrupole/time of flight-mass spectrometry and desorption electrospray ionization mass spectrometry imaging.

Luo S et al (2023).
Food Chem.
PubMed:
37813026

Multiplex genotyping of SNPs in genomic DNA via hydrogel-based assay mediated with MutS and polyethylene glycol.

Summary

Hydrogel-based platform enables PCR-free multiplex genotyping of SNPs in genomic DNA using a single fluorophore, increasing specificity and allowing genotyping of large DNA sizes. Application includes origin identification of raw materials and potential for precision medicine and food product authentication.

Mun SJ et al (2023).
Biosens Bioelectron.
PubMed:
37714061

Rhizosphere Microbiome and Phenolic Acid Exudation of the Healthy and Diseased American Ginseng Were Modulated by the Cropping History.

Zhang J et al (2023).
Plants (Basel).
PubMed:
37631203

Panax quinquefolius saponins combined with dual antiplatelet therapy enhanced platelet inhibition with alleviated gastric injury via regulating eicosanoids metabolism.

Summary

Panax quinquefolius saponin (PQS) combined with dual antiplatelet therapy (DAPT) was studied for its effects on platelet aggregation, heart attack expansion, gastric injury in rats, and its impact on arachidonic acid metabolism. PQS showed potential benefits.

Wang W et al (2023).
BMC Complement Med Ther.
PubMed:
37596586

Discrimination for geographical origin of Panax quinquefolius L. using UPLC Q-Orbitrap MS-based metabolomics approach.

Pang S et al (2023).
Food Sci Nutr.
PubMed:
37576031

A practical strategy enabling more reliable identification of ginsenosides from Panax quinquefolius flower by dimension-enhanced liquid chromatography/mass spectrometry and quantitative structure-retention relationship-based retention behavior prediction.

Summary

Researchers developed a strategy using advanced techniques to accurately identify metabolites in herbal components. This can help discover new compounds for drug development more efficiently.

Sun MX et al (2023).
J Chromatogr A.
PubMed:
37567002

Effect of Soil and Root Extracts on the Innate Immune Response of American Ginseng (Panax quinquefolius) to Root Rot Caused by Ilyonectria mors-panacis.

Behdarvandi B and Goodwin PH (2023).
Plants (Basel).
PubMed:
37447101

Correction: Diversity and correlation analysis of endophytes and metabolites of Panax quinquefolius L. in various tissues.

Li R et al (2023).
BMC Plant Biol.
PubMed:
37370029

Hippocampal proteins discovery of Panax quinquefolius and Acorus gramineus ameliorating cognitive impairment in diabetic rats.

Summary

Identifying diabetic cognitive impairment (DCI) early and finding effective treatments can delay or prevent irreversible dementia.

Huan S et al (2023).
Psychopharmacology (Berl).
PubMed:
37306736

Comparative Characterization of the Ginsenosides from Six Panax Herbal Extracts and Their In Vitro Rat Gut Microbial Metabolites by Advanced Liquid Chromatography-Mass Spectrometry Approaches.

Mi YG et al (2023).
J Agric Food Chem.
PubMed:
37294034

Diversity and correlation analysis of endophytes and metabolites of Panax quinquefolius L. in various tissues.

Li R et al (2023).
BMC Plant Biol.
PubMed:
37226095

American ginseng with different processing methods ameliorate immunosuppression induced by cyclophosphamide in mice via the MAPK signaling pathways.

Zhang YT et al (2023).
Front Immunol.
PubMed:
37153583

Panax quinquefolius saponin inhibits vascular smooth muscle cell calcification via activation of nuclear factor-erythroid 2-related factor 2.

Lu X et al (2023).
BMC Complement Med Ther.
PubMed:
37085826

Transcriptomics and metabolomics reveal the changes induced by arbuscular mycorrhizal fungi in Panax quinquefolius L.

Ran Z et al (2023).
J Sci Food Agric.
PubMed:
36942522

LC-MS analysis of ginsenosides in different parts of Panax quinquefolius and their potential for coronary disease improvement.

Zhang X et al (2023).
Planta Med.
PubMed:
36940929

A comprehensive and systemic review of ginseng-based nanomaterials: Synthesis, targeted delivery, and biomedical applications.

Review
Balusamy SR et al (2023).
Med Res Rev.
PubMed:
36939049

Guidance on the management of adverse reactions induced by poly(ADP-ribose) polymerase inhibitors.

Society Of Obstetrics And Gynecology OZMA et al (2023).
Zhejiang Da Xue Xue Bao Yi Xue Ban.
PubMed:
36915979

Ginsenosides and Biotic Stress Responses of Ginseng.

Review
Goodwin PH and Best MA (2023).
Plants (Basel).
PubMed:
36903950

First Report of Leaf Spot of Panax quinquefolius Caused by Pestalotiopsis nanjingensis in Tennessee and the United States.

Liyanapathiranage P et al (2023).
Plant Dis.
PubMed:
36890123

Immunomodulatory effects and mechanisms of Tiepishihu Xiyangshen granules on cyclophosphamide induced immuno-suppression via TLR4/MAPKs and PI3K/AKT/FOXO3a signal pathways.

Hu N et al (2023).
J Ethnopharmacol.
PubMed:
36706933

First Report of Rusty Root of Panax quinquefolius Caused by Pseudomonas marginalis in Tennessee and the United States.

Liyanapathiranage P et al (2023).
Plant Dis.
PubMed:
36636749

Comparison of Phytochemical Profiles of Wild and Cultivated American Ginseng Using Metabolomics by Ultra-High Performance Liquid Chromatography-High-Resolution Mass Spectrometry.

Liu Z et al (2022).
Molecules.
PubMed:
36615206

Nucleic acid amplification test (NAAT) conducted in a microfluidic chip to differentiate between various ginseng species.

Oberc C, Sojoudi P and Li PCH (2023).
Analyst.
PubMed:
36601715

Ginsenoside Rb1 protects against diabetes-associated metabolic disorders in Kkay mice by reshaping gut microbiota and fecal metabolic profiles.

Zhou R et al (2023).
J Ethnopharmacol.
PubMed:
36509256

First Report of Powdery Mildew of American Ginseng Caused by Erysiphe heraclei in Tennessee and the United States.

Avin FA et al (2022).
Plant Dis.
PubMed:
36372764

Integrated strategy of derivatization and separation for sensitive analysis of salvianolic acids using capillary electrophoresis with laser-induced fluorescence detection.

Xia J et al (2022).
J Chromatogr A.
PubMed:
36334567

The positive role of traditional Chinese medicine as an adjunctive therapy for cancer.

Review Cancer
Zhang X et al (2021).
Biosci Trends.
PubMed:
34421064

The Synergistic Effects of Polysaccharides and Ginsenosides From American Ginseng (Panax quinquefolius L.) Ameliorating Cyclophosphamide-Induced Intestinal Immune Disorders and Gut Barrier Dysfunctions Based on Microbiome-Metabolomics Analysis.

Zhou R et al (2021).
Front Immunol.
PubMed:
33968068

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects.

Review
Brunetti P et al (2020).
Pharmaceuticals (Basel).
PubMed:
33066617

Ginseng.

Review
(2021).
PubMed:
30000873

Ginseng as a Treatment for Fatigue: A Systematic Review.

Review
Arring NM et al (2018).
J Altern Complement Med.
PubMed:
29624410

Panax ginseng and Panax quinquefolius: From pharmacology to toxicology.

Review
Mancuso C and Santangelo R (2017).
Food Chem Toxicol.
PubMed:
28698154